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Hematology Medical and Health News Headlines
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All Recent Hematology Medical News Headlines |
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Long-term survival and late relapse in 2-year survivors of autologous haematopoietic cell transplantation for Hodgkin and non-Hodgkin lymphoma
This study described long-term outcomes of autologous haematopoietic-cell transplantation (HCT) for advanced Hodgkin (HL) and non-Hodgkin lymphoma (NHL). The study included recipients of autologous HCT for HL (N = 407) and NHL (N = 960) from 1990[ndash]98 who were in continuous complete remission for at least 2 years post-HCT. Median follow-up was 104 months for HL and 107 months for NHL. Overall survival at 10-years was 77% (72[ndash]82%) for HL, 78% (73[ndash]82%) for diffuse large-cell NHL, 77% (71[ndash]83%) for follicular NHL, 85% (75[ndash]93%) for lymphoblastic/Burkitt NHL, 52% (37[ndash]67%) for mantle-cell NHL and 77% (67[ndash]85%) for other NHL. On multivariate analysis, mantle-cell NHL had the highest relative-risk for late mortality [2·87 (1·70[ndash]4·87)], while the risks......
POSTED 06/30/2009 at 06:00 PM --
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Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity
Nucleophosmin (NPM) is a ubiquitously expressed chaperone protein that shuttles rapidly between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key roles in ribosome biogenesis, centrosome duplication, genomic stability, cell cycle progression and apoptosis. Somatic mutations in exon 12 of the NPM gene (NPM1) are the most frequent genetic abnormality in adult acute myeloid leukaemia (AML), found in approximately 35% of all cases and up to 60% of patients with normal karyotype (NK) AML. In children, NPM1 mutations are far less frequent, occurring in 8-10% of all AML cases, and in approximately 25% of those with a NK. NPM1 mutations lead to aberrant localization of the NPM protein into the cytoplasm, thus the designation, NPMc+ AML. NPMc+ AML is seen predomina......
POSTED 06/30/2009 at 06:00 PM --
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Telomeres and telomerase in chronic myeloid leukaemia: impact for pathogenesis, disease progression and targeted therapy
Telomeres are specialized structures localized at the end of human chromosomes. Due to the end replication problem, each cell division results in a loss of telomeric repeats in normal somatic cells. In germ line and stem cells, the multicomponent enzyme telomerase maintains the length of telomere repeats. However, elevated telomerase activity has also been reported in the majority of solid tumours as well as in acute and chronic leukaemia. Chronic myeloid leukaemia (CML) serves as a model disease to study telomere biology in clonal myeloproliferative disorders. In CML, telomere shortening correlates with disease stage, duration of chronic phase (CP), prognosis measured by the Hasford risk score and the response to disease-modifying therapeutics such as the tyrosine kinase inhibitor Imatini......
POSTED 06/30/2009 at 06:00 PM --
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How would I manage a sample submitted for flow cytometry analysis for suspicious chronic lymphocytic leukaemia
Samples submitted for a suspect of chronic lymphocytic leukemia are the most frequently observed in flow cytometry laboratories. These cases require not only a precise and prompt diagnosis but also an evaluation on the possibility of performing additional prognostic tests. We will propose two sequential flow cytometry panels and a personal opinion on how to manage these samples for both diagnostic and prognostic assessment, taking into account the published guidelines and recommendations. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Hematological Oncology)...
POSTED 06/30/2009 at 06:00 PM --
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Successful routine cytogenetic analysis from trephine biopsy specimens following failure to aspirate bone marrow
(Source: British Journal of Haematology)...
POSTED 06/29/2009 at 06:00 PM --
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Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia
The objective of this study was to confirm previous results regarding the differential expression and prognostic significance of the circadian gene CRY1 in chronic lymphocytic leukemia (CLL) patients and its relationship with the expression of other circadian genes and well-established prognostic markers. We also aimed to investigate whether the peripheral circadian machinery may be deregulated in CLL cells. The expression of CRY1, PER1, and PER2 was determined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in 116 CLL patients. The expression at sequential time points over a 24-h period was measured in six CLL patients and six normal donors. We confirmed the differential expression of CRY1 in ZAP-70+/CD38+ and ZAP-70[minus]/CD38[minus] CLL samples. Subgroups formed a......
POSTED 06/29/2009 at 06:00 PM --
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The use of cord blood for transfusion purposes: current status
Although the use of umbilical cord blood (UCB) for transfusion purposes has been proposed decades ago, the employ is still limited. In this article we review studies evaluating UCB collection efficiency and sterility, examine processing and storage of UCB-derived red blood cells (RBC) and discuss clinical studies in which UCB was used for transfusion purposes. Efforts to provide preterm newborns with autologous RBC derived from UCB have not been very successful. UCB collected after full-term deliveries can however easily be processed into RBC products and could be used autologous in case surgery of the neonate is indicated early after birth, or for allogeneic small volume paediatric transfusions. To harvest enough UCB volume, immediate clamping of the umbilical cord is commonly used as sta......
POSTED 06/29/2009 at 06:00 PM --
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Simultaneous genotyping of human platelet antigen-1 to 17w by polymerase chain reaction sequence-based typing
Conclusions The PCR-SBT method is reliable and accurate for HPA genotyping, suitable for routine HPA analysis, and can screen large numbers of donors. We identified 14 new polymorphisms, two of which led to amino acid changes. (Source: Vox Sanguinis)...
POSTED 06/29/2009 at 06:00 PM --
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Iron overload and chronically transfused patients: Numbers, scales, and clinical research
No abstract. (Source: American Journal of Hematology)...
POSTED 06/29/2009 at 06:00 PM --
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Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis
We here report a case of rheumatoid arthritis (RA) with acute myeloid leukemia with multilineage dysplasia (AML-MLD) and Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD). A 64-year-old healthy man suffered from arthralgia, and was ultimately diagnosed with RA based on bilateral hand X-rays showing mild swelling and destruction of the MP and PIP joints. Since non-steroidal anti-inflammatory drugs were not effective, prednisolone and bucillamine were administered. After 4 months, his pancytopenia gradually progressed, and bone marrow (BM) examination revealed the presence of AML-MLD. A chemotherapeutic drug regimen including low-dose cytarabine led to nearly complete remission, but several weeks later, high fever and dyspnea suddenly appeared. Computer tomograp......
POSTED 06/29/2009 at 06:00 PM --
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Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease
Abstract The contribution of human platelet antigen (HPA)-1 (GPIIb/IIIa), HPA-2 (GPIb/IX), and HPA-3 (GPIIb/IIIa) polymorphisms to
the risk of coronary artery disease (CAD) was investigated in 341 CAD patients and 316 matched control subjects. HPA genotyping
was performed by PCR-SSP. Regression analysis was employed in assessing the contribution of these variants to CAD risk. The
frequency of HPA-1b (P = .009) and HPA-3b (P = .004) alleles, and HPA-1a/1b (P = .045), HPA-1b/1b (P = .007), and HPA-3b/3b (P = .008) genotypes were higher in patients than control subjects. No significant association was demonstrated between the
HPA variants and 1-, 2- and 3-vessel disease. HPA-1b/2a/3b (Pc = .021) and HPA-1b/2b/3a (Pc&nb......
POSTED 06/29/2009 at 09:11 AM --
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Routine Prostate Cancer Screening Not Clearly Worthwhile (CME/CE, with audio)
SAN FRANCISCO (MedPage Today) -- Widespread prostate cancer screening substantially increases diagnoses without much evidence for a survival benefit, a review found. (Source: MedPage Today Hematology/Oncology)...
POSTED 06/29/2009 at 07:30 AM --
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RBC-Y/MCV as a discriminant function for differentiating carriers of thalassaemia and HbE from iron deficiency
Individuals with [alpha]-thalassaemia (ATT), [beta]-thalassaemia (BTT) and HbE trait (HET) are often initially identified based on haematological parameters. However, the values of these parameters usually overlap with iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD). We evaluated the use of RBC-Y in 156 normal individuals and 332 patients; ATT (n = 37), BTT (n = 61), HET (n = 25), HbH disease (n = 5), ACD (n = 67), IDA (n = 83) and ACD with IDA (n = 54). Diagnostic efficiency was analysed by receiver operating characteristics (ROC). MCH was better compared with RBC-Y in discriminating normal from abnormal with sensitivity and specificity of 94% at a cut-off of 26 pg. The Green and King (G&K) index performed the best in discriminating carriers from IDA and ACD with area u......
POSTED 06/28/2009 at 06:00 PM --
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Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention
Authors: A Safdar, G H Rodriguez, C N Mihu, L Mora-Ramos, V Mulanovich, R F Chemaly, R E Champlin
& I Khouri (Source: Bone Marrow Transplantation)...
POSTED 06/28/2009 at 06:00 PM --
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Cytotoxic crossmatch analysis before allo-SCT is a poor diagnostic tool for prediction of rejection
Authors: J Mattsson, A Nordlander, M Remberger, M Uhlin, J Holgersson, O Ringdén
& D Hauzenberger (Source: Bone Marrow Transplantation)...
POSTED 06/28/2009 at 06:00 PM --
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Dasatinib may not suppress the GVL effect of donor lymphocyte infusions for CML
Authors: P Garland, F Dazzi
& D Marin (Source: Bone Marrow Transplantation)...
POSTED 06/28/2009 at 06:00 PM --
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Double allogeneic hematopoietic SCT as a rescue therapy for poor-risk hematological malignancies
Authors: G Stussi, J Halter, A Tichelli, S Meyer-Monard, A S Buser, C Arber, D Heim, J R Passweg, J Rischewski, M Paulussen
& A Gratwohl (Source: Bone Marrow Transplantation)...
POSTED 06/28/2009 at 06:00 PM --
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"Transfusion"[ta]; +130 new citations
130 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
"Transfusion"[ta]
These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Transfusion)...
POSTED 06/27/2009 at 12:16 PM --
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Haematologica; +114 new citations
114 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
Haematologica
These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Haematologica)...
POSTED 06/27/2009 at 12:13 PM --
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A Pilot Beta-Thalassaemia Screening Program in the Albanian Population for a Health Planning Program.
Authors: Baghernajad-Salehi L, D'Apice MR, Babameto-Laku A, Biancolella M, Mitre A, Russo S, Di Daniele N, Sangiuolo F, Mokini V, Novelli G
In Albania, no definite national screening programme of beta-thalassaemia has yet been developed for carrier detection. Only limited information about the occurrence and the types of haemoglobin abnormalities is available. Thus, an educational and screening programme was carried out in one high school with a total of 217 young students from the coastal province of Lushnja in Albania. The pilot programme included a systematic sampling of whole saliva, DNA genomic extraction and the determination of defective beta-thalassaemia genes by reverse dot-blot hybridization with 22 probes specific for the Mediterranean populations.Of the 201 subjects tested,......
POSTED 06/27/2009 at 12:11 PM --
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