Officers and Directors of ASBMT
(Source: Biology of Blood and Marrow Transplantation)...
POSTED 02/09/2010 at 08:28 AM --
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Editorial Board
(Source: Biology of Blood and Marrow Transplantation)...
POSTED 02/09/2010 at 08:28 AM --
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Masthead (Purpose and Scope)
(Source: Biology of Blood and Marrow Transplantation)...
POSTED 02/09/2010 at 08:28 AM --
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Antifungal Management
A 48-year-old man developed right lower lobe pneumonia 14 days after a cord blood transplant for acute leukemia. He had been on antibiotics for persistent fever; neutrophil count was 0; blood cultures and bronchoscopy were negative but serum galactomannan was 0.92 (positive >0.5). He was diagnosed with Aspergillus pneumonia and treated with voriconazole. (Source: Biology of Blood and Marrow Transplantation)...
POSTED 02/09/2010 at 08:28 AM --
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NICE Appraisal Of Dasatinib And Nilotinib For Chronic Myeloid Leukaemia
The National Institute for Health and Clinical Excellence (NICE) has updated its draft guidance on the use of dasatinib (Sprycel,made by Bristol Myers-Squibb) and nilotinib (Tasigna,made by Novartis) for chronic myeloid leukaemia... (Source: Lymphoma / Leukemia News From Medical News Today)...
POSTED 02/09/2010 at 05:00 AM --
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Metabolite Common Among Cancers
A study published online on February 8 in the Journal of Experimental Medicine reports that several distinct mutations found in a subset of patients with acute myelogenous leukemia (AML) result in excess production of the same metabolite... (Source: Lymphoma / Leukemia News From Medical News Today)...
POSTED 02/09/2010 at 05:00 AM --
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Chromosome 8p11.2 translocations: Prevalence, FISH analysis for FGFR1 and MYST3, and clinicopathologic correlates in a consecutive cohort of 13 cases from a single institution
Chromosome 8p11.2 translocations result in diverse oncogenic fusion genes involving FGFR1 or MYST3. Among 24,262 unique patient cytogenetic studies performed at the Mayo Clinic, 8p11.2 translocations were identified in 14 cases ([sim]0.06%). FISH analysis was performed in 13 patients (12 had myeloid neoplasms) and revealed abnormalities of MYST3 (n = 4) or FGFR1 (n = 4) in eight patients. MYST3 abnormalities were associated with acute myeloid leukemia (AML), M4 in three and M6 in one. Three of the four FGFR1-rearranged cases were associated with myeloproliferative neoplasms but none, including the two with sole 8p11.2, displayed the typical phenotype for stem cell leukemia/lymphoma (SCLL) and only one had eosinophilia; the fourth case had AML-M4. FISH did not reveal FGFR1 involvement in th......
POSTED 02/08/2010 at 06:00 PM --
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Arboviruses in blood donors: a study in the Amazon region and in a small city with a dengue outbreak
(Source: Transfusion Medicine)...
POSTED 02/08/2010 at 06:00 PM --
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Are 10 min of seating enough to guarantee stable haemoglobin and haematocrit readings for the athlete's biological passport?
Haemoglobin (Hb) and haematocrit (Hct) are measured as indirect markers of doping in athletes. We studied the effect of posture on these parameters in a typical antidoping setting. Venous blood samples were obtained from nine endurance athletes (six males, three females) and nine control subjects (six males, three females) immediately and after 5, 10, 15, 20 and 30 min after having adopted a seated position from normal daily activity. Hb (CV 0.72%) and Hct (CV 0.87%) were determined using an automated cell counter, plasma volume changes were calculated. Differences between the time points, gender and groups were calculated using a mixed-model procedure. Significant changes were observed in the first 10 min after sitting down but no further changes were noted between 10 and 30 min. Mean dir......
POSTED 02/08/2010 at 06:00 PM --
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Comparison of a point of care device against current laboratory methodology using citrated and EDTA samples for the determination of D-dimers in the exclusion of proximal deep vein thrombosis
Conclusion: The Biosite Triage D-dimer assay performed on either citrate or EDTA samples is comparable with the Stago Liatest laboratory D-dimer assay when used in conjunction with clinical pretest probability scoring and CUS for the exclusion of DVT. (Source: Clinical and Laboratory Haematology)...
POSTED 02/08/2010 at 06:00 PM --
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Production of Interleukin-10 in serum and erythropoietin sensitivity in ESRD patients on hemodialysis
One of the clinical consequences of aberrant cytokines production in patients with end stage renal disease (ESRD) may be impaired erythropoiesis. To determine the interleukin (IL)-10 levels in ESRD patients on regular hemodialysis (HD) with good and poor response to recombinant human erythropoietin (Epo). Two groups of ESRD-HD patients were evaluated; 48 high epo HD patients and 32 low epo HD patients were evaluated for some laboratory tests and Interleukin-10 by ELISA. The production of IL-10 is decreased in HD with low epo group than high epo group 32.4 ± 7.9 vs. 45 ± 6.9 pg/ml (P < 0.001). IL-10 level is well correlated with CRP, ESR, Ferritin, Epo dose, and EPO/Hb ratio in ESRD-HD patients. These findings suggest that IL-10 is playing a part in affecting the response to EPO, even in ......
POSTED 02/08/2010 at 06:00 PM --
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Long-term, sub-clinical cardiac and renal complications in patients with multiple relapses of thrombotic thrombocytopenic purpura
(Source: British Journal of Haematology)...
POSTED 02/08/2010 at 06:00 PM --
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Low-Dose Radiation in Breast Cancer Gets Support (CME/CE)
About 40% of women in two large breast cancer radiotherapy trials reported being concerned about some aspect of body image over the five years following therapy, but there was little difference between those on standard therapy and low-dose regimens, researchers said. (Source: MedPage Today Hematology/Oncology)...
POSTED 02/08/2010 at 07:13 AM --
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Monoclonal gammopathy of undertermined significance: to screen or not to screen for multiple myeloma?
(Source: British Journal of Haematology)...
POSTED 02/07/2010 at 06:00 PM --
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Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura
(Source: British Journal of Haematology)...
POSTED 02/07/2010 at 06:00 PM --
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Managing anticoagulated patients during neuraxial anaesthesia
The widespread use of central neuraxial block (CNB) and the prevalence of anticoagulation for different indications have led to an inevitable overlap between the two. The most serious complication of CNB in anticoagulated patients is the risk of spinal/epidural haematoma. Performing CNB in these patients is a complex decision that should take into account the twin risks of bleeding and venous/arterial thrombosis if anticoagulation therapies were to be stopped. Various guidelines have been issued to achieve normal haemostasis and thus allow safe administration of CNB. However, the evidence base for many such recommendations is weak, relying mainly on case reports, small studies and pharmacokinetics of the drugs. Given these limitations it is crucial to fully assess individual risk factors a......
POSTED 02/07/2010 at 06:00 PM --
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Acute lymphoblastic leukaemia in children – is there a role for MTHFR?
(Source: British Journal of Haematology)...
POSTED 02/07/2010 at 06:00 PM --
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Acute lymphoblastic leukaemia in children – is there a role for MTHFR? – response to Lightfoot et al
(Source: British Journal of Haematology)...
POSTED 02/07/2010 at 06:00 PM --
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Venous thrombosis prevention – more than just guidelines
Hospital-associated venous thromboembolism remains a major international cause of avoidable mortality and morbidity. Although the publication of national guidelines does increase the use of thromboprophylaxis, we present the results of a recent audit of thrombosis prevention in UK hospitals which, despite published guidelines, shows continuing significant variations in guideline implementation and practice. The results of this audit are paralleled with UK and international data on hospital-acquired thrombosis prevention and the potential solutions to these problems, particularly the lessons which can be learned from other areas of clinical practice, are discussed. (Source: British Journal of Haematology)...
POSTED 02/07/2010 at 06:00 PM --
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Actin filaments and microtubule dual-granule transport in human adhered platelets: the role of α-dystrobrevins
Upon activation with physiological stimuli, human platelets undergo morphological changes, centralizing their organelles and secreting effector molecules at the site of vascular injury. Previous studies have indicated that the actin filaments and microtubules of suspension-activated platelets play a critical role in granule movement and exocytosis; however, the participation of these cytoskeleton elements in adhered platelets remains unexplored. [alpha]- and [beta]-dystrobrevin members of the dystrophin-associated protein complex in muscle and non-muscle cells have been described as motor protein receptors that might participate in the transport of cellular components in neurons. Recently, we characterized the expression of dystrobrevins in platelets; however, their functional diversity wi......
POSTED 02/07/2010 at 06:00 PM --
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