Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation
Horm Metab ResDOI: 10.1055/s-0030-1249035AbstractIt has been reported that the immunosuppressant rapamycin decreases the viability of pancreatic beta cells. In contrast, exendin-4, an analogue of glucagon-like peptide-1, has been found to inhibit beta cell death and to increase beta cell mass. We investigated the effects of exendin-4 on the cytotoxic effect of rapamycin in beta cells. Incubation with 10 nM rapamycin induced cell death in 12 h in murine beta cell line MIN6 cells and Wistar rat islets, but not when coincubated with 10 nM exendin-4. Rapamycin was found to increase phosphorylation of c-Jun amino-terminal kinase (JNK) and p38 in 30 minutes in MIN6 cells and Wistar rat islets while exendin-4 decreased their phosphorylation. Akt and extracellular signal-regulated kina......
POSTED 03/09/2010 at 08:27 AM --
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Effects of Combined Oral Contraceptive Ethinylestradiol (30 μg) and Dienogest (2 mg) on Carbohydrate Metabolism During 1 Year of Conventional or Extended-Cycle Use
Horm Metab ResDOI: 10.1055/s-0030-1248263AbstractThe effects of extended regimens of combined oral contraceptives (COCs) on carbohydrate metabolism are largely unknown. The present study compared the effects of a COC containing 30 μg ethinylestradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year. Parameters of carbohydrate metabolism were measured in 59 women treated with EE/DNG either conventionally (13 cycles of 21+7 days) or in extended-cycle regimen (4 cycles of 84+7 days). Blood samples were taken in a control cycle, and at 3 and 12 months of treatment. The mean levels of HbA1c and fasting glucose levels remained stable in both conventional and extended-regimen of EE/DNG. The mean levels of fasting insulin and C-peptide underwent c......
POSTED 03/09/2010 at 08:27 AM --
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Antidiabetic Effect of Gynostemma pentaphyllum Tea in Randomly Assigned Type 2 Diabetic Patients*
This study shows a prompt improvement of glycemia and insulin sensitivity, and thereby provides a basis for a novel, effective, and safe approach, using tea, to treat type 2 diabetic patients.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)...
POSTED 03/09/2010 at 08:27 AM --
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Genetic Associations of IL1RN Polymorphisms with Metabolic Syndrome in a Korean Population
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248288AbstractMetabolic syndrome (MetS) is rapidly growing into one of the major public health issues worldwide. Interleukin 1 receptor antagonist (IL1Ra) functions as a competitor of proinflammatory cytokines and has an important role in metabolic functions, including insulin secretion. To identify the relationship between the interleukin 1 receptor antagonist gene and MetS, we genotyped nine single nucleotide polymorphisms (SNPs) in the gene using direct sequencing in 66 MetS patients and 346 normal subjects in the Korean population. Among the nine polymorphisms, after adjusting for age and sex, rs928940 (G>T) showed a significant association with MetS in the codominant ( 0.023) and recessive models ( 0.011). Also, rs315952 (C>T) exh......
POSTED 03/09/2010 at 08:27 AM --
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Licorice – or more?
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224123AbstractA 57 yr old man presented to endocrinology clinic with a six year history of poorly controlled hypertension which was treated with Metoprolol 200 mg/day and Enalapril 20 mg/day. He was asymptomatic but incidentally hypokalaemia was detected while having cholecystectomy, two years prior to his clinic appointment. He had never been on diuretics or laxatives. He was started on potassium supplements (120 mmol/d) and advised to increase dietary potassium by the surgical team. A detailed personal history revealed ingestion of 300–500 g licorice per day. Physical examination was unremarkable apart from increased blood pressure of 180/105 mmHg. Following the initial visit, his serum electrolyes (K+3.......
POSTED 03/09/2010 at 08:27 AM --
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High basic fibroblast growth factor increases CHD risk in Type 2 diabetics
Elevated plasma basic fibroblast growth factor immunoreactivity increases coronary heart disease risk in men with Type 2 diabetes, report researchers. (Source: MedWire News - Diabetes)...
POSTED 03/09/2010 at 08:27 AM --
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Hypoglycemic effect of aqueous extract of
Conclusion: The aqueous extract of Trichosanthes dioica has antihyperglycemic action. (Source: International Journal of Diabetes in Developing Countries)...
POSTED 03/09/2010 at 08:27 AM --
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Type 2 diabetes mellitus: A risk factor for
Conclusion: Diabetic patients are more prone and at risk to acquire H. Pylori infection. Therefore proper monitoring of blood glucose level and screening for H. pylori infection are effective preventive measures for this life threatening infection. (Source: International Journal of Diabetes in Developing Countries)...
POSTED 03/09/2010 at 08:27 AM --
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Join the Society's 'Late effects of cancer therapy' SIG and receive regular news updates
Members who have registered their interest with 5 of the Society's Special Interest Groups (SIGs: Obesity, Bone and Mineral, Andrology, Endocrine disruptors and Steroids) already receive regular emails alerting them to news stories on these topics. These stories are sent up to 2-3 times per week, with the option of opting out at any time. We will be introducing this service to members of the Late effects of cancer therapy SIG and in time, extending this service to the remaining 3 SIGs: Laboratory Aspects of Clinical Endocrinology (LACE)*, PCOS and Metabolic Syndrome, and Pituitary.
If you are interested in receiving regular news alerts, sign up to a Society SIG here.
We'd also like to take this opportunity to remind you to update your preferences and details in the members' section of the ......
POSTED 03/09/2010 at 06:00 AM --
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Higher Fast Food Prices Lead To Lower Weight, Diabetes Risk
A new study that followed participants for 20 years shows both weight and risk for diabetes decreased for people in communities where fast food prices increased. The University of North Carolina at Chapel Hill study, published in the March 8, 2010, issue of Archives of Internal Medicine, also showed the reverse when fast food prices fell, then consumption, weight and diabetes risks rose... (Source: Diabetes News From Medical News Today)...
POSTED 03/09/2010 at 03:00 AM --
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Is There A Link Between Drinking Too Many Sugary Drinks And Diabetes?
A new study claims that having sugary drinks every day could put people at a greater risk of developing Type 2 diabetes and heart disease. American researchers found that the excessive consumption of sugary drinks, which can contain up to 200 calories each, contributed to 130,000 cases of Type 2 diabetes and 14,000 cases of heart disease between 1990 and 2000 in the USA... (Source: Diabetes News From Medical News Today)...
POSTED 03/09/2010 at 02:00 AM --
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Eye Disease Linked To Weakened Brain Power In People With Diabetes
Diabetic retinopathy, the leading cause of blindness in the UK's working-age population, could be associated with poorer memory and diminished brain power in people with Type 2 diabetes, according to new research¹ announced this week at leading health charity Diabetes UK's Annual Professional Conference. The study looked at 1,066 people with Type 2 diabetes aged between 60 and 75 years old... (Source: Diabetes News From Medical News Today)...
POSTED 03/09/2010 at 02:00 AM --
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Vitamin D Deficiency in Saudi Arabs
This study aimed at the evaluation of vitamin D levels in a cohort of healthy Saudi Arabs. The comprised 139 healthy subjects coming for regular blood donation. Participants had full clinical examination and evaluation of their calcium and vitamin D intake and the degree of exposure to sunlight. Serum 25-OH vitamin D was determined using Liasion chemiluminescent immunoassay and serum parathormone levels were determined using the Architect 2 000 immunochemiluminescent assay. Our results showed increased prevalence of vitamin D deficiency between Saudi Arabs (both males and females) in the studied group of subjects. Serum parathyroid hormone (PTH) did not correlate with serum vitamin D level in either male or female groups (p<0.01). Our data illustrate a high prevalence of vitamin D......
POSTED 03/08/2010 at 09:25 PM --
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Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections in Pregnant Women with Type 1 Diabetes
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 263-269. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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STAR 3 Randomized Controlled Trial to Compare Sensor-Augmented Insulin Pump Therapy with Multiple Daily Injections in the Treatment of Type 1 Diabetes: Research Design, Methods, and Baseline Characteristics of Enrolled Subjects
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 249-255. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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The Effects of Depression on Metabolic Control and Quality of Life in Indigent Patients with Type 2 Diabetes
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 257-262. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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Insulin Requirement Profiles of Patients with Type 2 Diabetes After Achieving Stabilized Glycemic Control with Short-Term Continuous Subcutaneous Insulin Infusion
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 271-281. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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Glucose Monitoring by Means of an Intravenous Microdialysis Catheter Technique
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 291-295. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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Performance Evaluation of the GlucoDr Plus Glucometer
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 307-312. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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Continuous Glucose Monitoring Reveals Associations of Glucose Levels with QT Interval Length
Diabetes Technology & Therapeutics Apr 2010, Vol. 12, No. 4: 283-286. (Source: Diabetes Technology)...
POSTED 03/08/2010 at 09:44 AM --
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