Chemopreventive action of dexamethasone and α-tocopherol in oxidative stressed cells
This study was designed to evaluate the influence of the anti-inflammatory drug dexamethasone and the antioxidant α-tocopherol on oxidative induced DNA damage, a major factor in the development of malignancies. Material and methods: Miniorgan cultures (MOC) of fresh biopsied human nasal mucosa were used to keep cells in their microenvironment and thus to mimic in vivo conditions. MOC were pretreated with dexamethasone and α-tocopherol in different concentrations on 1 or on 5 days before oxidative DNA damage was introduced by hydrogen peroxide. The effect of these substances on DNA damage was evaluated using the alkaline single cell microgel electrophoresis (Comet Assay). Results: Dexamethasone induced slight, but considerable DNA fragmentation by itself. It effectively protected cells fr......
POSTED 07/01/2009 at 10:01 AM --
|
Development of a rat model by 3,4-benzopyrene intra-pulmonary injection and evaluation of the effect of green tea drinking on p53 and bcl-2 expression in lung carcinoma
Conclusions Intra-pulmonary injection of 3,4-benzopyrene can steady induce lung carcinoma in rats, and green tea has preventive effect against lung cancer possibly by regulating expression of some critical genes such as p53 and bcl-2. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
High expression of α 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer
Conclusion: These results suggested that high level of α 2, 3-linked sialic acid residues was associated with metastatic potential of gastric cancer cells. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Specific thermographic changes during Walker 256 carcinoma development: Differential infrared imaging of tumour, inflammation and haematoma
Conclusion: While the raise of peripheral temperature in advanced tumour was caused by neoangiogenesis, the reduction in skin surface temperature in an early period after tumour cell inoculation indicated a decay of transplanted tumour cells due to the immune response and the lack of blood supply. Thus, infrared thermal imaging may have considerable value in evaluation of the tumour development and discrimination of cancer from inflammation and haematoma. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China
Conclusion: It is suggested that NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null, and variant CYP2A6 genotypes may play important roles in the development of bladder cancer in Henan area, China. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Haplotype-tagging single nucleotide polymorphisms in the GSTP1 gene promoter and susceptibility to lung cancer
Conclusions: Our results do not support significant main and modifying effects for GSTP1 promoter haplotypes on susceptibility to lung cancer in this population, but reinforce the protective effects of dietary intake of fruits and vegetables. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population
Conclusion: The strongest result obtained by this study was for an additive effect between smoking status, slow NAT2 variants, MTR 2756*G and MTHFR 677*T alleles, in affecting bladder cancer risk. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians
Conclusions: The results indicate that the VDR poly-A polymorphism is significantly associated with breast cancer risk in north Indians especially with early onset disease. Although, ApaI and TaqI did not show any significant association with the disease when analyzed in isolation, but TaqI might modulate the risk associated with L alleles. Further, understanding the functional role of these variants residing on the VDR haplotype associated with disease susceptibility may suggest novel approaches for breast cancer prevention and therapy. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Cervical cancer screening in medically underserved California Latina and non-Latina women: Effect of age and regularity of Pap testing
Conclusions: Women were more likely to be identified with high-grade precancerous cervical lesions and cancer process when they did not have regular screening, Ethnic differences in screening outcomes seem to be minimized by participation in a program that provides consistent screening resources to the medically underserved women who enroll. These findings support prevention strategies that expand screening to all medically underserved younger women or that provide HPV vaccination at an early age. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Epidemiology of primary brain tumors in the Middle Eastern population in California, USA 2001–2005
Abstract: Background: The fast growing Middle Eastern (ME) population has rarely been studied in the U.S.. The purpose of this study was to compare the epidemiology of primary brain tumors in this ethnic population with the non-Hispanic, non-Middle Eastern White (NHNMW) in California. Methods: ME cases were identified by surname in the California cancer registry and ME population estimates were based on ancestry. Data for 683 cases of primary brain tumors (429 benign, 238 malignant, 16 uncertain) in the ME and 15,589 cases (8352 benign, 6812 malignant, 425 uncertain) in the NHNMW were available for this study. Results: ME patients were significantly (p (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: Results from a case–control study in Montreal
Conclusions: Our results support the hypothesis that moderate and high alcohol intake levels over the lifetime might increase cancer risk at several sites. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Quantitative assessment of red meat or processed meat consumption and kidney cancer
Conclusions: Although many of the summary results were positive, all were weak in magnitude, most were not statistically significant, and associations were attenuated among studies that adjusted for key potential confounding factors. In summary, the findings of this meta-analysis are not supportive of an independent relation between red or processed meat intake and kidney cancer. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Table of contents
(Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Editorial Board
(Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
|
Benign prostate tissue after surgery ‘not source of biochemical recurrence’
Patients with extremely low-risk prostate cancer after radical prostatectomy and retained benign tissue are highly unlikely to have a measurable prostate-specific antigen or biochemical recurrence, US study findings suggest. (Source: MedWire News - Oncology)...
POSTED 07/01/2009 at 10:00 AM --
|
Estimation of Cachexia among Cancer Patients Based on Four Definitions
Conclusions. The proportion of patients with cachexia varied considerably depending upon the definition employed, indicating that a standard operational definition is needed. (Source: Journal of Oncology)...
POSTED 07/01/2009 at 09:59 AM --
|
Adjuvant Radiotherapy Reduces Recurrences With Small Breast Tumors
ORLANDO (EGMN) - The use of adjuvant radiation therapy following mastectomy reduced the risk of locoregional and distant recurrence among breast cancer patients with tumors measuring less than 5 cm and... (Source: OncologySTAT Latest News)...
POSTED 07/01/2009 at 09:58 AM --
|
Sensors Act as a Chemical Nose to 'Sniff' for Abnormal Cells
Cancer cells and normal cells have differences in their cell surfaces that can now be picked up by highly sensitive sensors. Researchers at Georgia Institute of Technology and the University of Massachusetts... (Source: OncologySTAT What Patients Are Reading)...
POSTED 07/01/2009 at 09:58 AM --
|
NIH-AARP Study Finds Animal Fat Increases Risk of Pancreatic Cancer
Too much dietary fat from red meat and dairy products can increase the risk of pancreatic cancer. This link was revealed in the Diet and Health Study, a large study conducted by the National Institutes... (Source: OncologySTAT What Patients Are Reading)...
POSTED 07/01/2009 at 09:58 AM --
|
Bacterial Minicell Technique Effectively Treats Cancers in Animals
Australian researchers have successfully treated cancer in mice and dogs with a new technique that involves using minicells to deliver anticancer toxins and agents that suppress drug-resistance in tumors.... (Source: OncologySTAT What Patients Are Reading)...
POSTED 07/01/2009 at 09:58 AM --
|
