Protein Metabolism and Homeostasis in Aging
series:Advances in Experimental Medicine and BiologyThe focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, postâtranslational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on wellâcharacterized factors and pathways, but new areas are also ... (Source: Springer Biomedical Sciences titles)...
POSTED 09/02/2010 at 02:59 AM --
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BCLâ2 Protein Family
Essential Regulators of Cell Deathseries:Advances in Experimental Medicine and BiologyIn this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCLâ2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles ... (Source: Springer Biomedical Sciences titles)...
POSTED 09/01/2010 at 06:13 PM --
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Sphingolipids as Signaling and Regulatory Molecules
series:Advances in Experimental Medicine and BiologyThis book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases. (Source: Springer Biomedical Sciences titles)...
POSTED 09/01/2010 at 06:13 PM --
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Cell Entry by Non-Enveloped Viruses
series:Current Topics in Microbiology and ImmunologyNon enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and ... (Source: Springer Biomedical Sciences titles)...
POSTED 09/01/2010 at 06:03 PM --
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Scientists identify protein that spurs formation of AlzheimerÂs plaques
Rockefeller researchers report that the cancer drug Gleevec reduces AlzheimerÂs plaques in a mouse model of the disease by binding to a molecule called gamma-secretase activating protein, or GSAP. By knocking out the gene that produces GSAP, the researchers reduced the primary component of senile plaques. They say that the development of compounds that work like Gleevec and target GSAP could revolutionize the treatment of this disease. (Source: The Rockefeller University Newswire)...
POSTED 09/01/2010 at 01:45 PM --
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Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging
Conclusion. Genetic variations in aldosterone synthase (CYP11B2) gene are associated with the progression of atherosclerotic plaque size, MMP-9 and apoptosis in the carotid artery. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)...
POSTED 09/01/2010 at 05:55 AM --
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The relationship between angiotensin converting enzyme gene I/D polymorphism and QT dispersion in patients with hypertrophic cardiomyopathy
Conclusion: QTd and QTcd are increased in patients with HCM, especially in those with the DD genotype. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)...
POSTED 09/01/2010 at 05:55 AM --
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Association of ACE I/D polymorphism in Tunisian patients with dilated cardiomyopathy
Primary cardiomyopathies are multifactorial diseases. Genetic factors other than the causal mutations in the modified genes affect the phenotypic expression of dilated cardiomyopathy. The aim of this study was to determine the association of angiotensin-converting enzyme I/D polymorphism with the risk of dilated cardiomyopathy in a Tunisian population. A total of 76 patients with dilated cardiomyopathy was compared to 151 ethnically, age- and gender-matched controls. The frequencies of the DD genotype and D allele were significantly higher in patients as compared with controls, and were associated with increased risk of dilated cardiomyopathy (ACE DD versus ID and II: OR = 3.05 (95% CI, 1.58—5.87; p = 0.001)); D versus I: OR = 2 (95% CI: 1.35—2.97; p = 0.001)). No association w......
POSTED 09/01/2010 at 05:55 AM --
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Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system
Conclusion. Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)...
POSTED 09/01/2010 at 05:55 AM --
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Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism
Obstructive sleep apnoea (OSA) is a sleep disorder characterized by recurrent episodes of oxygen desaturation during sleep, representing an independent risk factor for cardiovascular disease, such as myocardial infarction, stroke, congestive heart failure and resistant hypertension. Several neurohormonal mechanisms have been suggested to account for blood pressure increases, such as sympathetic nervous system hyperactivity, oxidative stress, renin—angiotensin—aldosterone system (RAAS) activation, endothelin system activation, and endothelial dysfunction. The aim of this study was to evaluate the behaviour of RAAS and the presence of primary aldosteronism (PA) in these patients and possible correlations between RAAS and the severity of OSA. From October 2007 to November 2008 we ......
POSTED 09/01/2010 at 05:55 AM --
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Interstitial expression of angiotensin II and AT1 receptor are increased in patients with progressive glomerulopathies
In conclusion, interstitial expression of ang II and AT1R is increased in patients with progressive glomerulopathies. The relationship of these results and interstitial fibrosis and disease progression in humans warrants further investigations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)...
POSTED 09/01/2010 at 05:55 AM --
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Spironolactone ameliorates podocytic adhesive capacity via restoring integrin {alpha}3 expression in streptozotocin-induced diabetic rats
Podocyte responses to various injuries include detachment from the glomerular basement membrane (GBM) with impaired adhesion ability. Growing evidence suggests inappropriately enhanced aldosterone levels in glomeruli may contribute to podocytic injury and subsequently glomerulosclerosis in diabetic nephropathy (DN). In the present study, we aimed to investigate podocytic integrin 3 expression and urinary podocyte excretion in streptozotocin (STZ)-induced diabetic rats, and to evaluate their responses to spironolactone (SPL). STZ-induced male diabetic Wistar rats were treated with vehicle (the STZ group, n=7), or spironolactone (the STZ+SPL group, n=6) for 12 weeks, six additional rats of similar body weight serving as control. Urine specimens were obtained for measurement of urine albumin ......
POSTED 09/01/2010 at 05:55 AM --
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Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty
Conclusions:
Taken together, we suggest that hypoxia-associated oxidative stress initiates mast cell proliferation and FGF secretion, spurring fibroblast proliferation and tissue fibrosis. Fibroblasts within this hypoxic environment undergo metaplastic transformation to fibrocartilage, followed by heterotopic ossification, resulting in increased joint stiffness. Thus, hypoxia and associated oxidative stress are potential therapeutic targets for fibrosis and metaplastic progression of idiopathic arthrofibrosis after TKA. (Source: Fibrogenesis and Tissue Repair)...
POSTED 08/31/2010 at 06:00 PM --
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Researchers discover how to conduct first test of âuntestableâ string theory
New study presents unexpected discovery that string theory may predict the behaviour of entangled quantum particles - News Release (Source: Imperial College News)...
POSTED 08/31/2010 at 06:00 PM --
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New Singapore medical school to be created by Imperial and Nanyang Technological University
Imperial set to develop and deliver a course overseas for the first time (Source: Imperial College News)...
POSTED 08/31/2010 at 06:00 PM --
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The multifaceted role of pirfenidone and its novel targets
Conclusions:
There is a growing understanding of the molecular effects of PFD on the wound healing mechanism, leading to novel approaches for the management of fibrosis in lung, liver and renal tissues. Although the optimum treatment for fibrosis remains undefined, it is possible that combined therapeutic regimens that include this wide-application molecule, pirfenidone, could offer a useful treatment for fibrotic disease. (Source: Fibrogenesis and Tissue Repair)...
POSTED 08/31/2010 at 06:00 PM --
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Sponges Inspire Synthesis of Potential New Cancer Drugs
(Source: NIGMS - Results)...
POSTED 08/31/2010 at 01:21 PM --
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August 23, 2010 Approval Letter - Engerix-B
to revise the Package Insert and pre-filled syringe carton to include the appropriate warnings regarding latex containing components. (Source: What's New at CBER)...
POSTED 08/31/2010 at 12:41 PM --
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Microfluidic Device Gently Collects Neutrophils, Allowing for Study of Immune Response
(Source: NIGMS - Results)...
POSTED 08/31/2010 at 12:40 PM --
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Novel Insights into Adipose Cell Functions
series:Research and Perspectives in Endocrine InteractionsObesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. Environmental, behavioural, genetic, epigenetic and multiple biological factors interact to cause obesity. In this context adipose tissue depots have been under focus in the ... (Source: Springer Biomedical Sciences titles)...
POSTED 08/30/2010 at 06:06 PM --
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