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Carotid Angioplasty Procedures News
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All Recent Carotid Angioplasty Procedures News |
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Biaxial mechanical properties of intact and layer-dissected human carotid arteries at physiological and supraphysiological loadings
Specimens of intact wall tubes of human common carotid arteries (CCA), internal carotid arteries (ICA) (n = 11, age 77.6 yr, SD 6.3), and related adventitia and media-intima tubes are mechanically examined. Cyclic, quasi-static extension-inflation tests at different axial stretches are performed on preconditioned tube specimens. Stress-free configurations show significant stress releases in the circumferential direction of the intact CCA and ICA walls and in the axial directions of the intact CCA walls and the CCA and ICA adventitias. All investigated tissues exhibit strong nonlinear, pseudoelastic mechanical behavior with small hysteresis. The "inversion" feature, where the pressure/axial stretch relationship becomes a vertical line, is found only for intact walls. Axial "inversion stretc......
POSTED 02/24/2010 at 04:23 PM --
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Adenosine Receptor A2A Deficiency in Leukocytes Increases Arterial Neointima Formation in Apolipoprotein E-Deficient Mice.
CONCLUSIONS: A2AR plays a complex role in inflammation and tissue injury. The deficiency of A2AR enhances the homing ability of leukocytes and increases the formation of the arterial neointima after injury. A2AR antagonists are being tested for the treatment of neurodegenerative and other chronic diseases. An evaluation of the effect of A2AR antagonists on arterial restenosis after arterial angioplasty should be conducted.
PMID: 20167656 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Racial and Ethnic Differences in the Use of High-Volume Hospitals and Surgeons [Original Article]
Conclusions Minority patients in New York City are doubly disadvantaged in their surgical care; they are substantially less likely to use both high-volume hospitals and surgeons for procedures with an established volume-mortality association. Better information is needed about which providers minority patients have access to and how they select them. (Source: Archives of Surgery)...
POSTED 02/15/2010 at 02:50 PM --
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Cryoplasty of the Venous Anastomosis for Prevention of Intimal Hyperplasia in a Validated Porcine Arteriovenous Graft Model.
CONCLUSION: Our results suggest that preventive cryoplasty of the venous anastomosis might help to reduce IH in those cases that develop most profound IH.
PMID: 20153668 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)...
POSTED 02/10/2010 at 06:00 PM --
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Multiple Coaxial Catheter System for Reliable Access in Interventional Stroke Therapy
In conclusion,
building up a triple or quadruple coaxial system proved to be safe and efficient in our experience for the mechanical thrombectomy
treatment of acute ischemic stroke.
Content Type Journal ArticleCategory Technical NoteDOI 10.1007/s00270-010-9815-0Authors
Zsolt Kulcsár, Geneva University Hospital Neurointerventional Division, Department of Clinical Neurosciences Geneva SwitzerlandHasan Yilmaz, Geneva University Hospital Neurointerventional Division, Department of Clinical Neurosciences Geneva SwitzerlandChristophe Bonvin, Geneva University Hospital Neurology Division, Department of Clinical Neurosciences Geneva SwitzerlandKarl O. Lovblad, Geneva University Hospital Diagnostic Neuroradiology Division, Department of Radiology Geneva SwitzerlandDaniel A. Rüfenacht, Gene......
POSTED 02/04/2010 at 12:44 AM --
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Complications of Angioplasty and Stenting of Cervicocerebral Arteries in Iran [ORIGINAL ARTICLE]
Angioplasty and stenting of the cervicocerebral arteries is a novel treatment for atherosclerotic stenosis, which has periprocedural complications. Data were collected prospectively from 2007 to 2009 in a multicenter cohort of patients undergoing interventions for cervicocerebral stenosis. Retrospective assessment of the 2003–2006 archives of the same interventionists and a review of their published work is the second part of this national survey. In 592 extracranial internal carotid artery angioplasty and stenting procedures in 581 patients (73% male; mean age, 63.4 ± 7 years), transient ischemic attack, stroke, intracerebral hemorrhage, and death occurred in 1.7%, 1.7%, 0.34%, and 1.52%, respectively. In 114 extracranial vertebral artery angioplasty and stenting procedures i......
POSTED 02/02/2010 at 03:27 AM --
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Systematic Preoperative Coronary Angiography and Stenting Improves Postoperative Results of Carotid Endarterectomy in Patients with Asymptomatic Coronary Artery Disease: A Randomised Controlled Trial
Objective: To evaluate the usefulness of systematic coronary angiography followed, if needed, by coronary artery angioplasty (percutaneous coronary intervention (PCI)) on the incidence of cardiac ischaemic events after carotid endarterectomy (CEA) in patients without evidence of coronary artery disease (CAD). (Source: Journal of Vascular Surgery)...
POSTED 01/31/2010 at 06:00 PM --
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Despite Higher Utilization of Carotid Angioplasty and Stenting (CAS) in 2006, Postprocedure Stroke, Mortality Rates, Hospital Charges, and Discharges to Nursing Skilled Facilities Remain Higher for CAS than for Carotid Endarterectomy Compared with 2005
This study compared, at the national level, trends in utilization, mortality, and stroke of carotid angioplasty and stenting (CAS) and carotid endarterectomy (CEA) during 2005-2006. (Source: Journal of Vascular Surgery)...
POSTED 01/31/2010 at 06:00 PM --
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Inhaled CO Decreases Fibrin Deposition and Activates Fibrinolysis: A Potential Mechanism of Vasoprotection
Conclusions: Our findings demonstrate that a brief exposure to inhaled CO did not change platelet adherence to injured carotid arteries 1 day post-injury but did reduce fibrin deposition compared with RA treated rats. This brief inhaled CO treatment was also associated with a prolonged reduction in PAI-1 expression that was more dramatic than achieved with in vitro CO treatment. Taken together, inhaled CO reduces fibrin deposition following vascular injury potentially by increasing fibrinolytic activity through the prolonged down-regulation of PAI-1. This may be represent another mechanism by which brief CO treatment can have such a dramatic effect on inhibiting IH. (Source: Journal of Surgical Research)...
POSTED 01/25/2010 at 10:41 AM --
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Protein Kinase-C Delta Mediates Arterial Injury Responses through Regulation of Vascular Smooth Muscle Cell Apoptosis
Introduction: Endovascular intervention has been proven to be a cost-effective approach in revascularization of peripheral arterial disease. However, the long-term efficacy of endovascular procedures is often limited by restenosis, which is primarily caused by excessive intimal hyperplasia after vascular injury. Intimal hyperplasia is a complex process involving vascular smooth muscle cell (VSMC) proliferation, migration, apoptosis and extracellular matrix deposition. Apoptosis of VSMC has been shown to influence intimal hyperplasia, presumably through reduction of the lesion cell numbers. However, how apoptosis is regulated after vascular injury is not fully understood. We have previously demonstrated Protein Kinase-C delta (PKCδ) is an integral mediator of VSMC apoptosis in vitro. Here,......
POSTED 01/25/2010 at 10:41 AM --
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The Role of Doxycycline as an Inhibitor of Intimal Hyperplasia after Balloon Angioplasty Arterial Injury
Objective: Intimal hyperplasia (IH) is the most common indicator for secondary intervention in peripheral vascular disease. The major cellular processes contributing to IH development are extracellular matrix (ECM) degradation and vascular smooth muscle cell (VSMC) migration and proliferation. Matrix metalloproteinases (MMPs) are implicated in vascular remodeling due to their ability to selectively degrade components of the ECM. Members of the tetracycline family of antibiotics are potent MMP inhibitors, doxycycline being one of the more potent inhibitors with better absorption and a longer half-life than the parent compound. We have previously shown doxycycline inhibits MMP activity and VSMC migration in vitro. Moreover, doxycycline has been found to inhibit cell proliferation in other ce......
POSTED 01/25/2010 at 10:41 AM --
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Nitric Oxide-Dependent Bone Marrow Progenitor Mobilization by Carbon Monoxide Enhances Endothelial Repair After Vascular Injury.
Conclusions-Collectively, the present data demonstrate that CO accelerates EC proliferation and vessel repair in a manner dependent on NO generation and enhanced recruitment of bone marrow-derived endothelial progenitor cells.
PMID: 20083679 [PubMed - as supplied by publisher] (Source: Circulation)...
POSTED 01/17/2010 at 06:00 PM --
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Transarterial Thrombin Injection Secured with an Embolic Protection Device as a Treatment for a Superior Mesenteric Artery Pseudoaneurysm
We report a 71-year-old male with a SMA pseudoaneurysm who was successfully
treated with a transarterial thrombin injection secured with an embolic protection device used in carotid angioplasty. To
our knowledge, this is the first case of a SMA pseudoaneurysm treated by this method.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00270-009-9791-4Authors
Robert Juszkat, Poznań University of Medical Sciences Department of Radiology Szpital Kliniczny nr 1, Ul. Długa ½ 61-848 Poznan PolandZbigniew Krasiński, Poznań University of Medical Sciences Department of Radiology Szpital Kliniczny nr 1, Ul. Długa ½ 61-848 Poznan PolandMateusz Wykrętowicz, Poznań University of Medical Sciences Department of Radiology Szpital Kliniczny nr 1, Ul. Długa ½ 61-848 Poznan PolandRy......
POSTED 01/08/2010 at 03:08 AM --
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Design of the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)
The objective is to compare the efficacy of CAS versus CEA in patients with symptomatic ([ge]50%) or asymptomatic ([ge]60%) extracranial carotid stenosis. The Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) is a prospective, randomized, parallel, two-arm, multi-center trial with blinded endpoint adjudication. Primary endpoints are analyzed using standard time-to-event statistical modeling with adjustment for major baseline covariates. Primary analysis is on an intent-to-treat basis. The primary outcome is the occurrence of any stroke, myocardial infarction, or death during a 30-day peri-procedural period, and ipsilateral stroke during follow-up of up to four years. Secondary outcomes include restenosis and health-related quality of life. (Source: International Journal o......
POSTED 01/06/2010 at 06:00 PM --
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Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis
Conclusion
The expression of PKC is upregulated in the arterial wall in response to injury. This induction appears to be a mechanism of arterial response that negatively influences the degree of intimal hyperplasia by stimulating VSMC apoptosis. (Source: Cardiovascular Research)...
POSTED 01/05/2010 at 10:18 AM --
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Protamine reduces bleeding complications associated with carotid endarterectomy without increasing the risk of stroke
Conclusion: Protamine reduced serious bleeding requiring reoperation during CEA without increasing the risk of MI, stroke, or death, in this large, contemporary registry. In light of significant complications referable to bleeding, liberal use of protamine during CEA appears warranted. (Source: Journal of Vascular Surgery)...
POSTED 01/03/2010 at 06:00 PM --
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A Reference Standard-Based Quality Assurance Program for Radiology
The authors have developed a comprehensive radiology quality assurance (QA) program that evaluates radiology interpretations and procedures by comparing them with reference standards. Performance metrics are calculated and then compared with benchmarks or goals on the basis of published multicenter data and meta-analyses. Additional workload for physicians is kept to a minimum by having trained allied health staff members perform the comparisons of radiology reports with the reference standards. The performance metrics tracked by the QA program include the accuracy of CT colonography for detecting polyps, the false-negative rate for mammographic detection of breast cancer, the accuracy of CT angiography detection of coronary artery stenosis, the accuracy of meniscal tear detection on MRI, ......
POSTED 12/31/2009 at 06:00 PM --
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Access complications during endovascular aortic repair.
This article will discuss a multitude of access related complications and their treatment. Preoperative imaging is paramount to the success of endovascular procedures. Intraoperative adjuncts, such as iliac artery angioplasty/stenting, the "pull-down" technique, and aorto mono iliac/femoral systems will be discussed. Occasionally, challenging iliac or femoral anatomy may preclude access through these vessels and the endovascular specialist may need to gain direct access through the aorta or via the carotid artery. In addition, the advantages and disadvantages of an entirely percutaneous technique will be discussed. Finally, peri-operative complications such as rupture, dissection, pseudoaneurysm and infection will be discussed and various treatment modalities reviewed. As stent graft techn......
POSTED 12/31/2009 at 06:00 PM --
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Crossing an Ultracritical Carotid Stenosis for Carotid Angioplasty
In this report, the authors describe an approach using a 0.012-inch hydrophilic system to overcome this technical obstacle. (Source: Vascular and Endovascular Surgery)...
POSTED 12/29/2009 at 11:49 PM --
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Carotid Artery Stenting for Stenosis Following Cervical Radiotherapy: Report of Early Failure With Associated Stent Fracture
We report the case of a 64-year-old man who was treated with bilateral CAS for stenoses, which developed 7 years following thyroidectomy, neck dissection, and radiotherapy. Although long considered an ideal alternative to CE in this clinical setting, CAS in this case was complicated by multiple episodes of recurrent stenosis in his left carotid, managed by balloon angioplasty. Severe, early recurrence in his right carotid associated with a type III stent fracture was managed by CE. Close surveillance and intervention prevented neurologic morbidity. This case, combined with emerging published experience, argues for reappraisal of the general consensus that CAS is an ideal alternative to CE for radiotherapy-associated carotid stenoses. (Source: Vascular and Endovascular Surgery)...
POSTED 12/29/2009 at 11:49 PM --
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