Management of Operable Invasive Breast Cancer in Women Over the Age of 70: Long-Term Results of a Large-Scale Single-Institution Experience
Conclusions Elderly patients with operable breast cancer who are completely and correctly treated with realistic treatment options that
are based on surgery and adjuvant radiotherapy have a similar chance of being cured as younger patients.
Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0967-6Authors
Fatima Laki, Institut Curie Department of Surgery Paris FranceYoulia M. Kirova, Institut Curie Department of Radiation Oncology Paris FranceAlexia Savignoni, Institut Curie Department of Statistics Paris FranceFrancois Campana, Institut Curie Department of Radiation Oncology Paris FranceBeatrice Levu, Institut Curie Department of Medical Information Paris FranceMarc Estève, Institut Curie Department of Anaesthesiology Paris FranceBrigitte Sig......
POSTED 02/23/2010 at 01:57 AM --
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Simultaneous integrated boost in breast conserving treatment of breast cancer: A dosimetric comparison of helical tomotherapy and three-dimensional conformal radiotherapy.
CONCLUSIONS: In breast cancer treated with SIB, both HT and 3D-CRT provided adequate target volume coverage and low heart doses. Tumor bed coverage was slightly lower with HT, but HT avoided unnecessary breast overdosage while improving ipsilateral lung dosimetry.
PMID: 20171752 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)...
POSTED 02/17/2010 at 06:00 PM --
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MammoSite Brachytherapy
MammoSite breast brachytherapy is an alternative radiation treatment to external beam radiation of the breast. MammoSite breast brachytherapy takes 5 days to completely treat early stage breast cancer with radiation after a lumpectomy. Learn more about MammoSite breast brachytherapy here. (Source: About.com Breast Cancer)...
POSTED 02/14/2010 at 06:00 PM --
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Synchronous Ovarian Cancer in a Patient with Pleomorphic Lobular Breast Cancer: A Therapeutic Dilemma
Sir — A 49-year-old premenopausal female patient presented with a breast lump and abdominal distention. Her personal history was unremarkable and a family history revealed ovarian cancer in her aunt and thyroid cancer in her brother. On physical examination, a 4cm mass in her right breast and an axillary fixed lymphadenopathy of 2cm were palpated and ascites was detected. Biopsy from the breast lump showed pleomorphic lobular carcinoma, grade 3, oestrogen receptor and progesterone receptor were both positive with HER2 overexpression immunohistochemically. Abdominal computed tomography revealed peritoneal carcinomatosis, ascites and a 15mm left ovarian cyst. A chest X-ray and a bone scan were normal. Diagnostic paracentesis was carried out to rule out a second intra-abdominal malignancy a......
POSTED 02/03/2010 at 09:36 AM --
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Routine Preoperative MRI for Breast Carcinoma
The article published by Bleicher and colleagues regarding the role of routine MRI on newly diagnosed breast carcinoma and its impact on time of operation, mastectomy rate, and margin of lumpectomy status is highly commendable. (Source: Journal of the American College of Surgeons)...
POSTED 01/27/2010 at 09:29 AM --
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[Lobular intra-epithelial neoplasia: Atypical lobular hyperplasia and lobular carcinoma in situ.]
Authors: Ansquer Y, Santulli P, Colas C, Jamali M, Tournigand C, Duperray L, Duperray B, Jannet D, Carbonne B
OBJECTIVE: To review main knowledge about lobular intra-epithelial neoplasia with special interest for daily practice management. MAIN RESULTS: Intra-epithelial lobular neoplasias (ILN) are non invasive proliferations within the terminal ducto-lobular unit of monomorphic loosely cohesive small cells. A lack of expression of the E-cadherin adhesion molecule is often observed as in invasive lobular breast cancer. ILN are infrequent, however, a rise in incidence partly, due to the generalization of mammographic screening, is observed. Actually ILN are usually asymptomatic and diagnosed after breast biopsy for unspecified microcalcifications. ILN are associated with an increased ri......
POSTED 01/26/2010 at 06:00 PM --
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Cryoablation FA Visica
Cryoablation is an alternative way to remove breast fibroadenomas. Instead of having a lumpectomy to remove a fibroadenoma, cryoablation uses intense cold to freeze the unwanted tissue to death. Learn more about cryoablation of breast fibroadenomas here. (Source: About.com Breast Cancer)...
POSTED 01/25/2010 at 06:00 PM --
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Tamoxifen Malabsorption After Roux-en-Y Gastric Bypass Surgery: Case Series and Review of the Literature
Pharmacotherapy 30(2): 217-217 Abstract Roux-en-Y gastric bypass is a gastric reduction duodenal switch with a combination of restrictive and malabsorptive procedures. It is the most common gastric bypass procedure performed in the United States. Malabsorption causing nutritional deficiencies does occur, yet a PubMed literature search (1955-2009) returned no reports of malabsorption of anticancer agents after gastric bypass. To our knowledge, this is the first report of three cases of malabsorption of the anticancer agent tamoxifen after this procedure. The first patient was a 58-year-old woman who underwent Roux-en-Y bypass for morbid obesity. Two years later, she developed estrogen receptor-positive ductal carcinoma in situ of the breast, underwent lumpectomy and irradiation, and tamoxif......
POSTED 01/25/2010 at 06:00 PM --
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Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy
Conclusion: ADH diagnosed by vacuum-assisted breast biopsy frequently corresponds to cancer on open surgical biopsy. Surgical excision of all breast lesions containing atypical hyperplasia on percutaneous biopsy can be recommended. (Source: European Journal of Surgical Oncology)...
POSTED 01/22/2010 at 07:47 AM --
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The Use of Oncoplastic Reduction Techniques to Reconstruct Partial Mastectomy Defects in Women with Ductal Carcinoma In Situ
This study suggests that although oncoplastic reduction techniques are a reasonable approach for women with DCIS, stricter patient selection and improved confirmation of negative margins will minimize the need for either re-excisions or completion mastectomy and reconstruction. (Source: The Breast Journal)...
POSTED 01/18/2010 at 06:00 PM --
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The effect of intraoperative specimen inking on lumpectomy
re-excision rates
Conclusions:
Intraoperative inking in this practice offered a simple way to reduce re-excision rates after lumpectomy and affect an improvement in quality of patient care (Source: World Journal of Surgical Oncology)...
POSTED 01/17/2010 at 06:00 PM --
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Novilase Procedure
Breast fibroadenomas are usually removed by lumpectomy if they are troublesome. A new procedure called Novilase destroys fibroadenomas using a laser. Novilase laser ablation of breast fibroadenomas is being tested in clinical trials. Learn more about laser ablation of breast fibroadenomas here. (Source: About.com Breast Cancer)...
POSTED 01/11/2010 at 06:00 PM --
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Smile! You've got cancer | Barbara Ehrenreich
Cancer is not a problem or an illness – it's a gift. Or so Barbara Ehrenreich was told repeatedly after her diagnosis. But the positive thinkers are wrong, she says: sugar-coating illnesses can exact a dreadful costIf you had asked me, just before the diagnosis of cancer, whether I was an optimist or a pessimist, I would have been hard-pressed to answer. But on health-related matters, as it turned out, I was optimistic to the point of delusion. Nothing had so far come along that could not be controlled by diet, stretching, painkillers or, at worst, a prescription. So I was not at all alarmed when a routine mammogram aroused some "concern" on the part of my gynaecologist.How could I have breast cancer? I had no known risk factors, there was no breast cancer in the fami......
POSTED 01/01/2010 at 06:18 PM --
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Initial margin status for invasive ductal carcinoma of the breast and subsequent identification of carcinoma in reexcision specimens.
CONCLUSIONS: Frequency of residual invasive carcinoma was related to margin status of the original lumpectomy/biopsy. Even when margins were positive, most reexcisions were free of carcinoma. Residual invasive carcinoma was found in greater than 25% of patients with margins less than 2 mm, supporting reexcision for patients with margins of less than 2 mm. Sixteen percent of cases with margins greater than 2 mm harbored residual invasive carcinoma. Evaluation of margin status was complicated by tissue distortion and fragmentation.
PMID: 20073613 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)...
POSTED 12/31/2009 at 06:00 PM --
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3D-conformal Accelerated Partial Breast Irradiation treatment planning: the value of surgical clips in the delineation of the lumpectomy cavity
Conclusions:
The placement of surgical clips improved the accuracy of lumpectomy cavity delineation in 3D-APBI. However, a learning curve is needed to improve the conformity index of the lumpectomy cavity. (Source: Radiation Oncology)...
POSTED 12/30/2009 at 06:00 PM --
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Cyclophosphamide, Epirubicin, and Fluorouracil Versus Dose-Dense Epirubicin and Cyclophosphamide Followed by Paclitaxel Versus Doxorubicin and Cyclophosphamide Followed by Paclitaxel in Node-Positive or High-Risk Node-Negative Breast Cancer [Breast Cancer]
Conclusion
Three-weekly AC/T is significantly inferior to CEF or EC/T in terms of RFS. It is too early to detect any difference between CEF and dose-dense EC/T. (Source: Journal of Clinical Oncology)...
POSTED 12/28/2009 at 05:31 PM --
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Study Finds Racial Disparities Exist In Radiation Therapy Rates For Early Stage Breast Cancer
Black women are less likely than white women to receive radiation therapy after a lumpectomy, the standard of care for early stage breast cancer, according to a new study by researchers at The University of Texas M. D. Anderson Cancer Center. (Source: Cancercompass News: Breast Cancer)...
POSTED 12/22/2009 at 06:00 PM --
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True Recurrences and New Primary Tumors Have Different Clinical Features in Invasive Breast Cancer Patients with Ipsilateral Breast Tumor Relapse After Breast-Conserving Treatment
Abstract: Ipsilateral breast tumor relapse (IBTR) after breast-conserving treatment (BCT) may represent two distinct types of lesion, including a true recurrence (TR) or a new primary tumor (NPT). The aim of this study was to ascertain the difference between TRs and NPTs and to show the clinical significance of classifying IBTR into these two types of recurrence. Patients (n = 2,075) with unilateral invasive breast cancer who underwent BCT between 1987 and 2005 at Saitama Cancer Center were analyzed. IBTR was classified into TR and NPT, which was based on all clinical and pathological features of both a primary tumor and IBTR that can be evaluated. IBTR-free survival and the risk factors were analyzed in order to compare the findings for TR and NPT. In addition, the salvage surgical method......
POSTED 12/20/2009 at 06:00 PM --
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Racial Disparities in Radiation Therapy
After a lumpectomy, black women are far less likely than white women to receive radiation therapy, the standard of care for early stage breast cancer. (Source: Medical Headlines From Ivanhoe.com)...
POSTED 12/15/2009 at 11:00 PM --
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Breast Radiation Less Likely For Blacks
Black women don't get radiation after lumpectomy as often as white women, especially in certain parts of the country. (Source: WDSU.com - Health)...
POSTED 12/14/2009 at 08:17 AM --
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