Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation
Myeloablative conditioning before bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen–induced TEC damage directly contributes to slow thymopoietic recovery after BMT. Keratinocyte growth factor (KGF) is a TEC mitogen that stimulates proliferation and, when given before conditioning, reduces TEC injury. Some TEC subsets are refractory to KGF and functional T-cell responses are not fully restored in KGF-treated BM transplant recipients. Therefore, we investigated whether the addition of a pharmacologic inhibitor, PFT-β, to transiently inhibit p53 during radiotherapy could spare TECs from radiation-induced damage in congenic and allogeneic BMTs. Combined befo......
POSTED 02/04/2010 at 11:01 AM --
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Natural pregnancy and delivery after unrelated bone marrow transplantation using fludarabine-based regimen in a Fanconi anemia patient.
Authors: Yabe H, Koike T, Shimizu T, Ishiguro H, Morimoto T, Hyodo H, Akiba T, Kato S, Yabe M
PMID: 20127528 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)...
POSTED 02/03/2010 at 06:00 PM --
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Cutaneous Mycobacterium intracellulare infection in a bone marrow transplantation recipient
(Source: The Journal of Dermatology)...
POSTED 02/02/2010 at 06:00 PM --
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Anti-Inflammatory Agent Can Limit And Reverse The Progression Of Graft-Versus-Host Disease After Transplant
If a team of American scientists are right, bone marrow transplants may become safer and more available to people in need of donations. In a new research paper appearing in the February 2010 print edition of the Journal of Leukocyte Biology, they explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host... (Source: Health News from Medical News Today)...
POSTED 02/02/2010 at 06:00 AM --
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Ten-year post-transplant survival similar between stem cell, bone marrow
transplantation in leukemia patients
(Source: HemOncToday.com)...
POSTED 02/02/2010 at 05:00 AM --
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Geisinger Medical Center Becomes Region's Only Bone Marrow Collection Site
Geisinger Medical Center (GMC) was recently designated a National Marrow Donation Program (NMDP) collection site, becoming the only site in the region to collect bone marrow or blood stem cells from willing donors. "It is very exciting and a major achievement to be designated a National Marrow Donation Program collection site," said Edward Gorak, D.O., Medical Oncologist/Hematologist and Co-Director of the Bone Marrow Transplant Program at GMC... (Source: Health News from Medical News Today)...
POSTED 02/02/2010 at 02:00 AM --
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Viral infections associated with haemophagocytic syndrome
Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and NK cells. This T cell/NK cell dysregulation causes an aberrant cytokine release, resulting in proliferation/activation of histiocytes with subsequent haemophagocytosis. Histiocytic infiltration of the reticuloendothelial system results in hepatomegaly, splenomegaly, lymphadenopathy and pancytopenia ultimately leading to multiple organ dysfunctions. Common clinical features include high fevers despite broad spectrum antimicrobials, maculopapular rash, neurological symptoms, coagulopathy and abnormal liver function tests. Haemophagocytic syndrome can be either primary, i.e. due to an underlying genetic defect or secondary, associated with malignancies......
POSTED 02/01/2010 at 06:00 PM --
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Effect of cyclosporine on blood pressure
Source: Cochrane Library
Area: Evidence > Medication Safety
Abstract
Background Cyclosporine is an immunosuppressive agent used for different autoimmune diseases. The official Canadian indications for cyclosporine are solid organ transplantation, bone marrow transplantation, psoriasis, rheumatoid arthritis and nephritic syndrome (e-CPS 2008). The expanding range of indications for cyclosporine therapy will lead to more patients receiving chronic therapy with possible side effects, hypertension being one of the most common. Therefore it is essential to know the magnitude of increase of blood pressure (BP) associated with cyclosporine in order to appropriately manage patients receiving the drug.
Objectives The primary objective of this systematic review is to evaluate ......
POSTED 02/01/2010 at 06:00 PM --
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Leukemia survival improves with transplants
Survival among people with leukemia who receive bone marrow transplants is the same as those who have a riskier type of stem cell transplant, a 10-year study suggests. (Source: CBC | Health)...
POSTED 02/01/2010 at 12:28 PM --
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Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0903-7Authors
Stefano Sansone, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano ItalyJohanna Rottensteiner, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano ItalyJudith Stocker, Central Hospital of Bolzano Division of Oncology Lorenz-Böhler Street 5 39100 Bolzano ItalyCarlo Rosanelli, Central Hospital of Bolzano Division of Hematology and Bone Marrow Transplantation Lorenz-Böhler Street 5 39100 Bolzano ItalyChristian Josef Wiedermann, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano Italy
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (S......
POSTED 02/01/2010 at 12:02 PM --
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Stem Cell, Bone Marrow Transplants Both Benefit Leukemia Patients
Little difference in survival found 10 years after therapies, study says Source: HealthDay
Related MedlinePlus Topics: Bone Marrow Transplantation, Leukemia, Adult Acute, Stem Cells (Source: MedlinePlus Health News)...
POSTED 02/01/2010 at 08:00 AM --
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Leukaemia Patients: Long-Term Outcome And Survival After Undergoing Stem-Cell Or Marrow Transplant
The largest randomised study comparing the effect of type of transplant on survival is published Online First in The Lancet Oncology. It reports that patients transplanted with peripheral blood stem cells (PBSC) have no difference in survival compared with patients given bone marrow after ten years. Bone marrow transplants involve the collection of stem cells from the bone marrow. In peripheral blood stem cell transplantation (PBSCT) stem cells are collected from the donor's blood and this avoids the complications of bone marrow collection such as surgery and anaesthesia... (Source: Health News from Medical News Today)...
POSTED 02/01/2010 at 02:00 AM --
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Stem Cell, Bone Marrow Transplants Both Benefit Leukemia Patients
Title: Stem Cell, Bone Marrow Transplants Both Benefit Leukemia PatientsCategory: Health NewsCreated: 2/1/2010 8:10:00 AMLast Editorial Review: 2/1/2010 (Source: MedicineNet Cancer General)...
POSTED 02/01/2010 at 01:00 AM --
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New discovery may expand availability of bone marrow transplants by stopping fatal complications
(Federation of American Societies for Experimental Biology) In a new research paper appearing in the February 2010 print edition of the Journal of Leukocyte Biology, scientists explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host. (Source: EurekAlert! - Medicine and Health)...
POSTED 01/31/2010 at 11:00 PM --
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Study weighs benefits of transplants for leukemia
LONDON (Reuters) - Leukemia patients who have blood stem cell transplants survive just as long on average as those who undergo the more invasive procedure of having a bone marrow transplant, scientists said on Monday. (Source: Reuters: Health)...
POSTED 01/31/2010 at 06:01 PM --
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Bone marrow transplant still useful in leukaemia
Despite complexity bone marrow still offers benefits over stem cell therapyRelated items from OnMedicaForty-somethings see alarming rise in oral cancers Young people warned of sunbed cancer risksChildhood cancers - recurrence presents 'a lifetime risk'New key to prostate cancer mortalityOff-label cancer drug warning (Source: OnMedica Latest News)...
POSTED 01/31/2010 at 06:00 PM --
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Palliative Care Partners with the Hematologic Malignancy (HM) Unit
Describe the interactions with hematologic malignancy (HM) clinicians enabling the integration of a palliative medicine consult service into the HM unit serving patients with acute leukemias, multiple myeloma, lymphomas, MDS, and post bone marrow transplant patients. (Source: Journal of Pain and Symptom Management)...
POSTED 01/31/2010 at 06:00 PM --
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Haploidentical Bone Marrow Transplantation in Primary Immune Deficiency: Stem Cell Selection and Manipulation
Since the early 1980s T-cell depletion has allowed haploidentical bone marrow transplantation to be performed in patients with primary immunodeficiency for whom a matched sibling donor was not available, without causing severe graft versus host disease (GVHD). This review article presents the available data in the literature on survival, GVHD, and immune reconstitution in different categories of patients, with special emphasis on the impact of different T-cell depletion methods. (Source: Immunology and Allergy Clinics of North America)...
POSTED 01/29/2010 at 07:38 AM --
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Bone Marrow Transplantation Using HLA-Matched Unrelated Donors for Patients Suffering from Severe Combined Immunodeficiency
In conclusion, the excellent long-term survival, immune reconstitution, and normal quality of life after MUD BMT suggests that in the absence of RID or PMD, MUD BMT should be offered for patients suffering from SCID. (Source: Immunology and Allergy Clinics of North America)...
POSTED 01/29/2010 at 07:38 AM --
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Foreword
Since the discovery of the blood group in 1901 by Nobel laureate Karl Landsteiner and the first successful bone marrow transplantation in 1956 by another Nobel laureate, Donnall Thomas, we have come a long way to understanding the fundamental principles of transplantation immunology and clinical transplantation. Hematopoietic stem cell transplantation in primary immunodeficiency disorders, especially in severe combined immunodeficiency (SCID), has been a prime example of progress that this discipline has made and the difficulties it faces. The use of haplocompatible related donors has reduced the length of time required to perform transplantation and has improved the outcome. Similarly, the availability of cord blood stem cells has opened new opportunities. The requirement for precondition......
POSTED 01/29/2010 at 07:38 AM --
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