Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in HIV-positive men.
Conclusions A substantial proportion of HIV-positive MSM with AIN completely cleared their lesions with topical 5-FU treatment. In those with partial response, pre-treatment with topical 5-FU might facilitate subsequent ablative therapy.
PMID: 20716208 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)...
POSTED 08/11/2010 at 06:00 PM --
|
The Ferguson Operating Anoscope as a minimally invasive option for the treatment of rectal tumors.
Authors: Stanley JD, Bell C, Hinkle N, Moore RA, Burns RP
Transanal excision of rectal tumors may be performed using the Ferguson Operating Anoscope (FOA). This retrospective case series evaluates the effectiveness of FOA for the excision of selected benign and malignant rectal tumors. The office records of 97 patients with rectal tumors who underwent FOA transanal excision by a single surgeon from 1999 through 2009 were reviewed. In the 97 patients evaluated, 99 FOA transanal excisions were performed for 39 adenocarcinomas, 55 benign tumors, and five carcinoid tumors. The tumors were 0.5 to 13.5 cm in diameter and located an average of 6.9 cm (range, 1 to 15 cm) from the anal verge. Ninety-one per cent of cases were performed as an outpatient. Postoperative complications occurred in 1......
POSTED 07/31/2010 at 06:00 PM --
|
Sigmoidoscope and anoscope warning issued
The Medicines and Healthcare products Regulatory Agency has issued a warning over sigmoidoscope and anoscope systems and accessories manufactured by Welch Allyn Limited. (Source: Nursing Times Breaking News)...
POSTED 07/25/2010 at 01:15 AM --
|
High-Res Anoscopy Best for Detecting High-Grade Anal Dysplasia in HIV+ Men
High-grade anal dysplasia is prevalent in HIV-positive gay men and high-resolution anoscopy is the best way to detect it, clinicians from Canada have found. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)...
POSTED 05/20/2010 at 11:54 AM --
|
Anal carcinoma in HIV-positive men: results of a prospective study from Germany.
Conclusions Anal carcinoma and AIN are frequent in HIV-positive men, even in patients participating in anal cancer prevention programs. High-grade dysplasia in these patients can progress to invasive cancer within a short period of time. Anal margin carcinoma and anal canal carcinoma substantially differ in their lesional HPV-spectrum, prognosis, and treatment response.
PMID: 20184584 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)...
POSTED 02/21/2010 at 06:00 PM --
|
A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia
The objective of this study was to develop an applicator for delivery of light and monitoring of photodynamic therapy (PDT) in the anal cavity for treatment of anal intraepithelial neoplasia grade III (AIN III), which can progress to invasive anal cancer.Forty-eight hours before treatment, patients participating in the study were injected with 0.03 (n=2) or 0.075 (n=2)mgkgâ1 m-THPC. For light delivery and monitoring of PDT, an applicator based on standard anoscopy equipment was developed which facilitates, in addition to a light treatment fiber, fiber optic probes to monitor blood saturation, blood volume, fluorescence and fluence (rate) at two different locations in situ. Patients were given a light dose of 10â17Jcmâ2 at a fluence rate of 45â50mWcmâ2 based on in situ measured li......
POSTED 02/21/2010 at 06:00 PM --
|
Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany
Conclusions Anal carcinoma and AIN are frequent in HIV-positive men, even in patients participating in anal cancer prevention programmes. High-grade dysplasia in these patients can progress to invasive cancer within a short period of time. Anal margin carcinoma and anal canal carcinoma differ substantially in their lesional HPV spectrum, prognosis and treatment response. (Source: British Journal of Dermatology)...
POSTED 02/21/2010 at 06:00 PM --
|
Comparison of a modified anoscope and the purse-string anoscope in stapled haemorrhoidopexy.
CONCLUSION: Operation time decreased and the surgeon's satisfaction increased with use of the modified anoscope, and fewer haemostatic sutures were required if the surgeon waited longer before and after firing the stapler.
PMID: 19938197 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)...
POSTED 11/26/2009 at 07:54 AM --
|
Anal cytology in patients with AIDS
The objective of the present study was to study the prevalence of abnormal anal cytology in patients with AIDS. Anal smears, obtained with a cytobrush, of 102 HIV-positive patients of the Emilio Ribas Institute (Sao Paulo, Brazil) were collected, and only after that, the patients were submitted to anoscopy. Thirty-two patients had LSIL and 14 others had HSIL. Squamous intra-epithelial lesions were also observed in 38% of the patients without condyloma (18/47): in 9 of the 33 patients without history of condyloma (27%) and in 9 of the 14 patients who had previously treated condyloma (64%). An invasive squamous cell carcinoma was observed in one patient without history of condyloma. In all 13 patients with HSIL, biopsies guided by high resolution anoscopy confirmed high grade dysplasia. Our ......
POSTED 10/07/2009 at 06:00 PM --
|
Short-term results of DST EEA 33 stapler and neu@ anoscope for stapled haemorrhoidectomy: a prospective study of 1,118 patients from a single centre
Conclusion Stapled haemorrhoidectomy using the DST EEA 33 stapler is safe. The neu@ anoscope provides good visibility and handling, and
is a useful tool in this procedure.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10151-009-0532-0Authors
Ming Hian Kam, Singapore General Hospital Department of Colorectal Surgery Outram Road Singapore 169608 SingaporeJit Fong Lim, Singapore General Hospital Department of Colorectal Surgery Outram Road Singapore 169608 SingaporeKok Sun Ho, Singapore General Hospital Department of Colorectal Surgery Outram Road Singapore 169608 SingaporeBoon Swee Ooi, Singapore General Hospital Department of Colorectal Surgery Outram Road Singapore 169608 SingaporeKong Weng Eu, Singapore General Hospital Department of Colorectal Sur......
POSTED 09/19/2009 at 12:51 AM --
|
Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men
Conclusion: Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion.
(C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS)...
POSTED 05/31/2009 at 06:00 PM --
|
Management of Anal Squamous Intraepithelial Lesions
Clinics in Colon and Rectal Surgery 2009; 22: 094-101DOI: 10.1055/s-0029-1223840ABSTRACTAnal squamous intraepithelial lesions include both low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL) and are caused by chronic infection with the human papillomavirus (HPV). The disease is increasing in both incidence and prevalence, especially among patients with the following risk factors: homosexual men, acquired or iatrogenic immunosuppression, and presence of other HPV-related diseases. Although the natural history of the disease is unknown, there is significant evidence that untreated HSIL progresses to squamous cell carcinoma in 11% of patients and in up to 50% of patients with extensive disease and immunosuppression. Anal cytology and reflex......
POSTED 05/28/2009 at 03:29 AM --
|
High level of HPV 16 and 18 DNA load in anal swabs from male and female HIV-1 infected patients.
CONCLUSIONS: Longitudinal studies are needed to evaluate the link between high anal HPV DNA load and progression to anal squamous intraepithelial lesions and anal cancer.
PMID: 19269245 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)...
POSTED 03/04/2009 at 11:00 PM --
|
[Anogenital warts: a clinical, pathological and virological study.]
The objective of this study was to investigate the possible relationship between the presence of anogenital warts (AGW) in children and the sexual abuse as mode of transmission. Our series includes 8 patients with AGW who were treated in our hospital during the year 2007. A complete physical examination was carried out, including colposcopy or anoscopy, and samples were taken for histopathological examination and human papiloma virus (HPV) subtyping. We considered perinatal transmission as a possible route in two cases. Although sexual abuse was definitively confirmed in only one case, we observed some findings in four cases that led us to consider the possibility of sexual abuse. We did not consider the possibility of heteroinoculation or autoinoculation from common warts in any case. Our......
POSTED 11/30/2008 at 11:00 PM --
|
Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
CONCLUSION: In a community-based sample, a high proportion of HIV-positive and HIV-negative men who have sex with men have AIN. The sensitivity of cytology to detect AIN is higher for clinician-collected versus self-collected specimens and for HIV-positive versus HIV-negative men. The specificity of cytology to detect AIN is higher in HIV-negative versus HIV-positive men. However, the probability of AIN in a patient with a negative cytology result may not be low enough (23% for HIV-negative men and 45% for HIV-positive men with a patient-collected specimen) for clinicians to be comfortable recommending no anoscopy for those with a negative cytology result if done as a one-time test. These data raise the question of whether the optimal population screening strategy is cytology screening wit......
POSTED 09/01/2008 at 11:00 PM --
|
A simplified method for anal ultrasonography: assessment of patient satisfaction and the simplicity of the procedure
Conclusions This simple and less-costly adaptation of anal ultrasonography allows good quality examinations to be performed with better
patient comfort in units with echoendoscopes already available, avoiding the need for a more expensive dedicated probe.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10151-008-0422-xAuthors
D. Castellani, University of Perugia Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine Perugia ItalyE. Antonelli, University of Perugia Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine Perugia ItalyG. Sabatino, University of Perugia Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine Perugia ItalyV. Giuliano, Univer......
POSTED 08/05/2008 at 02:05 AM --
|
Videoanoscope-assisted stapled haemorrhoidopexy: analysis of 18 patients
Abstract An optimal stapled haemorrhoidopexy requires the purse-string suture to be placed circumferentially at a constant distance
from the dentate line and to pass through an appropriate thickness of rectal mucosa. An unsuitable purse-string suture may
increase the risk of postoperative complications. We developed a new anoscope (the videoanoscope) to prevent the difficulties
during application of the purse-string suture, and we used the videoanoscope in 18 stapled haemorrhoidopexy procedures. The
videoanoscope is made up of three pieces. The front part is in the form of an open half-cylinder. The second piece is a sliding
lid that covers the front piece. The rear part of the anoscope includes a hollow handle in which a scope can be inserted,
and the whole procedure can ......
POSTED 06/11/2008 at 01:08 AM --
|
Management of internal genital warts: do we all agree? A postal survey
A postal survey was undertaken to determine whether there was any consensus of opinion regarding the management of internal genital warts in genitourinary medicine clinics in the UK. Overall, 110 forms were returned (57% response). The majority of clinics would refer patients with cervical warts for colposcopy especially if the patient was over the age of 25 or HIV-positive. Proctoscopy or anoscopy was performed in 60% of clinics for patients with perianal warts to determine the presence of warts within the anal canal or rectum. Only 24% of patients with intra-anal warts are referred directly to surgery for biopsy, increasing to 61% if the patient has HIV infection. Cryotherapy is the main treatment for all types of internal warts. Our findings suggest there is no consensus and we recommen......
POSTED 05/19/2008 at 11:00 PM --
|
Hybrid Capture II Detection of Oncogenic Human Papillomavirus: A Useful Tool When Evaluating Men Who Have Sex with Men with Atypical Squamous Cells of Undetermined Significance on Anal Cytology
Conclusions Hybrid-Capture II testing for high-risk human papillomavirus in men who have sex with men with atypical cells of undetermined
significance and referring only those with high-risk human papillomavirus reduces the number who require high-resolution anoscopy
by more than half. Five percent with high-grade squamous intraepithelial lesions would be missed.
Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s10350-008-9306-4Authors
Stephen E. Goldstone, Department of Surgery Mt. Sinai School of Medicine New York New York USAAdam Z. Kawalek, Department of Internal Medicine New York University School of Medicine New York New York USARobert N. Goldstone, Department of Surgery Mt. Sinai School of Medicine New York New York USAAndrew B. Goldstone, ......
POSTED 05/15/2008 at 01:02 AM --
|
A new anoscope for transanal surgery.
CONCLUSION: Preliminary histologic studies in the pig suggest that the design of the anoscope prevents inclusion of the muscular layer in the pursestring.
PMID: 18466861 [PubMed - as supplied by publisher] (Source: American Journal of Surgery)...
POSTED 05/05/2008 at 11:00 PM --
|
