In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth
(Source: Clinical and Experimental Immunology)...
POSTED 09/02/2010 at 12:02 AM --
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Topographical specificity of regulation of respiratory and renal sympathetic activity by the midbrain dorsolateral periaqueductal gray
In this study, we tested whether, consistent with this hypothesis, activation of neurons in the dorsolateral PAG evokes a pattern of cardiovascular and respiratory responses that is distinct from that evoked from surrounding regions. Arterial pressure, heart rate, renal sympathetic nerve activity (RSNA), and phrenic nerve activity (PNA) were recorded simultaneously in urethane-anesthetized rats. Microinjections of very small amounts of d,l-homocysteic acid (750 pmol in 15 nl) were made in sites throughout the dorsomedial, dorsolateral, and lateral PAG subregions. Increases in RSNA of similar magnitude accompanied by small to moderate increases in arterial pressure and heart rate were evoked from all three PAG subregions. In contrast, large increases in both PNA burst rate (respiratory rate......
POSTED 09/01/2010 at 04:01 PM --
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Dietary genistein and equol (4', 7 isoflavandiol) reduce oxidative stress and protect rats against focal cerebral ischemia
In conclusion, dietary soy isoflavones are neuroprotective in transient focal cerebral ischemia in male and OVX female rats. These isoflavones may protect the brain via increases in endogenous antioxidant mechanisms and reduced oxidative stress. (Source: AJP: Regulatory, Integrative and Comparative Physiology)...
POSTED 09/01/2010 at 04:01 PM --
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Sex differences in acute ANG II-mediated hemodynamic responses in mice
Male sex is associated with higher blood pressure and greater renal injury, perhaps related to greater sensitivity to ANG II. In anesthetized male and female C57BLK/6 mice, we assessed responses of mean arterial pressure (MAP) and renal vascular resistance (RVR; Transonic flow probe) to acute bolus injections of ANG II (0.3–3.0 µg/kg iv) and phenylephrine (PE; 30–300 µg/kg) during low-, normal-, and high-sodium diets. The role of reactive oxygen species was determined by coadministration of tempol. ANG II type 1 and type 2 (AT1 and AT2) receptor and endothelial nitric oxide synthase (NOS3) expression were determined in dissected kidney vessels. While no difference was found on the low-sodium (LS) diet, MAP and RVR responses to ANG II were greater in males during the......
POSTED 09/01/2010 at 04:01 PM --
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Perioperative Stroke After Total Joint Arthroplasty: Prevalence, Predictors, and Outcome
Conclusions:
Perioperative stroke is a rare but potentially devastating complication of total joint arthroplasty, with a high rate of morbidity and mortality. Vigilant attention to prevent, detect, and treat this complication in a timely manner may alter the course of the disease.
Level of Evidence:
Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. (Source: JBJS [Am])...
POSTED 09/01/2010 at 12:31 PM --
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BEMA Buprenorphine Phase 2 Study Results Selected For Presentation At Pain Week 2010
BioDelivery Sciences International, Inc. (Nasdaq:BDSI) announced today that its abstract showing the results of a Phase 2 clinical study of BEMA Buprenorphine in the treatment of pain has been selected for oral presentation at Pain Week 2010, a national conference educating frontline clinicians who are faced with treating patients with pain. The presentation will take place on Friday, September 10, as part of the 7:00 - 9:00 AM podium presentation session... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 08:00 AM --
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After Needle Accidents, Hospitals Face Legal Dilemma If They Test Incapacitated Patients
Anaesthetists are calling for greater clarity on the legal implications of testing incapacitated patients for blood-borne viruses, after a survey found that this is often done following staff needlestick injuries, in possible breach of UK legislation. The paper, in the September issue of Anaesthesia reports on the results of an anonymous survey of intensive care units in England, Wales and Northern Ireland... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 07:00 AM --
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Psychedelic drugs return as potential treatments for mental illness | Moheb Costandi
New research confirms that psychedelic drugs are promising treatments for depression, obsessive-compulsive disorder (OCD) and schizophreniaMoheb Costandi writes the Neurophilosophy blogLong before hippie poster boy Timothy Leary invited the world to "Turn on, tune in and drop out", a group of pioneering psychiatrists working in Canada began to treat alcoholics with lysergic acid diethylamide (LSD), and reported unprecedented recovery rates. Far from being at the fringes of medical research, their work was fully supported and funded by the Canadian government, and became a promising new area of research that played a role in modernising the field of psychiatry. But despite the encouraging results, studies of LSD therapy ended abruptly in the late 1960s, and did not resume again until some 4......
POSTED 09/01/2010 at 05:18 AM --
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QRxPharma To Sponsor Symposium At 13th World Congress On Pain Meeting
QRxPharma (ASX: QRX and OTCQX: QRXPY) announced it will sponsor a symposium at the 13th World Congress of Pain on 31 August, 2010 at Palais des congres de Montreal. The symposium, titled "Dual Opioid Therapy: Changing the Paradigm" will focus on preclinical and clinical data for MoxDuo®IR, an immediate-release Dual Opioid product for moderate to severe acute pain. Featured speakers who will highlight Dual Opioids at this symposium are internationally recognised pain experts, Drs. Nicholson, Pasternak and Webster... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 04:00 AM --
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Glenmark Announces The Discovery Of A Novel Chemical Entity 'GRC 17536', A TRPA1 Receptor Antagonist, A Potential First-in-Class Molecule Globally
Glenmark Pharmaceuticals announced the discovery of a Novel Chemical Entity(NCE) 'GRC 17536'. The new NCE program is targeting TRPA1 receptor antagonists for pain and respiratory disorders. TRPA1 belongs to Transient Receptor Potential (TRP) family of ion channels, which have generated a lot of interest as pain targets due to their distinguishing role in peripheral and/or central pain signal transmission. Glenmark has selected a lead molecule named GRC 17536 which is currently finishing up Phase 1 enabling GLP studies... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 04:00 AM --
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MonoSol Rx Announces Reckitt Benckiser FDA Approval Of Suboxone® Sublingual Film For Treatment Of Opioid Dependence
MonoSol Rx, the developers of PharmFilm® technology and a drug delivery company specializing in film pharmaceutical products, today announced that its partner, Reckitt Benckiser Pharmaceuticals Inc., a wholly-owned subsidiary of Reckitt Benckiser Group plc (LSE: RB), has received approval from the U.S. Food and Drug Administration (FDA) to market Suboxone® (buprenorphine HCl/naloxone HCl dihydrate) sublingual film for the treatment of opioid dependence. This is the second U.S... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 04:00 AM --
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"Pill Mill" Bill Requires State Certification By Sept. 1
Texans seeking pain relief soon can take comfort from a new state law requiring pain management clinics to be certified by the Texas Medical Board (TMB) by Sept. 1. Texas physicians hope the new law will put "pill mills," storefronts disguised as pain medicine clinics, out of commission. These storefronts skirt the patient-physician relationship by providing powerful narcotic prescriptions without requiring a patient exam, explains Texas Medicine magazine, the official publication of the Texas Medical Association (TMA)... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 03:00 AM --
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Electroconvulsive therapy-induced persistent retrograde amnesia: Could it be minimised by ketamine or other pharmacological approaches?
Conclusions: A clinical trial is warranted to determine if ketamine anaesthesia during electroconvulsive therapy can lessen persistent retrograde amnesia and improve therapeutic response. Electroconvulsive therapy with ketamine anaesthesia may provide effective antidepressant action with minimal side effects. (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
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Effectiveness of dry needling and injections of myofascial trigger points associated with plantar heel pain: a systematic review
Conclusions:
There is limited evidence for the effectiveness of dry needling and/or injections of MTrPs associated with plantar heel pain. However, the poor quality and heterogeneous nature of the included studies precludes definitive conclusions being made. Importantly, this review highlights the need for future trials to use rigorous randomised controlled methodology with measures such as blinding to reduce bias. We also recommend that such trials adhere to the Standards for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA) to ensure transparency. (Source: BioMed Central)...
POSTED 08/31/2010 at 06:00 PM --
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Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia: sugammadex versus neostigmine
Conclusions:
Recovery from profound vecuronium-induced block is significantly faster with sugammadex, compared with neostigmine. Neostigmine did not rapidly reverse profound neuromuscular block (Trial registration number: NCT00473694). (Source: BMC Anesthesiology)...
POSTED 08/31/2010 at 06:00 PM --
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The Development of a Pressure Ulcer Risk-Assessment Scale for Perioperative Patients
Abstract: The high incidence of pressure ulcer development in patients in the perioperative setting indicates the need for improved risk assessment and the use of preventive measures. A clinical nurse specialist used Dever's Epidemiological Model as the theoretical framework to develop a perioperative pressure ulcer risk-assessment scale. The risk factors for the scale were based on findings from a review of the literature. The scale, along with a demographic questionnaire and an evaluation form, was distributed to 12 nurses and three anesthesiologists to obtain expert opinion to further the design of the scale. Twelve participants returned the forms. Only four of the participants had previous experience with a pressure ulcer risk-assessment scale. The results indicated that diabetes shoul......
POSTED 08/31/2010 at 06:00 PM --
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Evidence for Practice
Bispectral index (BIS) is used to measure the patient's level of consciousness under general anesthesia to prevent surgical awareness. Several factors have been found to alter the BIS reading without affecting the depth of anesthesia, however. Anesthesiologists at a university hospital in Saudi Arabia noticed a change in BIS readings that appeared to be associated with changes in the position of the patient, either head-down as for gynecologic procedures or head-up as for laparoscopic cholecystectomy. Positioning of the patient is an important step of the surgical process, providing the required access to the structures that must be visualized or manipulated during the surgical procedure. A patient to be anesthetized usually starts in the supine position, which can be changed to head-down,......
POSTED 08/31/2010 at 06:00 PM --
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Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension
High-frequency echocardiography and high-field-strength magnetic resonance imaging (MRI) are new noninvasive methods for quantifying pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy (RVH). We compared these noninvasive methods of assessing the pulmonary circulation to the gold standard, cardiac catheterization (micromanometer-tipped catheters), in rats with monocrotaline-induced PAH and normal controls. Closed-chest, Sprague-Dawley rats were anesthetized with inhaled isoflurane (25 monocrotaline, 6 age-matched controls). Noninvasive studies used 37.5-MHz ultrasound (Vevo 770; VisualSonics) or a 9.4-T MRI (Bruker BioSpin). Catheterization used a 1.4-F micromanometer-tipped Millar catheter and a thermodilution catheter to measure cardiac output (CO). We compared n......
POSTED 08/31/2010 at 04:01 PM --
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Pre and Post-Operative Use of Caldolor (Ibuprofen) Injection Significantly Reduces Pain and Opioid Use in Newly Published Study
- Study demonstrates IV ibuprofen can be safely administered at
induction of anesthesia as well as throughout the post-operative
period
- IV ibuprofen decreases morphine use by more than 30% while
improving pain control
NASHVILLE, Tenn., Aug. 30... (Source: Drugs.com - Clinical Trials)...
POSTED 08/31/2010 at 09:05 AM --
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Cannabis for nerve pain studied
Conclusion
This placebo-controlled trial found that cannabis containing 9.4% THC could reduce neuropathic pain compared to the placebo. However, this was a small trial with only 23 participants, so it is difficult to tell whether these results demonstrate a real association, or if they are due to chance. A much larger trial would be needed for a longer period to assess the long-term outcomes of such a treatment. Additionally there are health concerns related to the use of smoked cannabis, including mental health problems and lung damage. Further research is needed to assess such potential side effects over the long term.
The researchers say that their study provides a way of looking at the short-term effects of smoked cannabis in a placebo-controlled trial. It is important to point out tha......
POSTED 08/31/2010 at 06:00 AM --
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