Outcome of pregnancies with trisomy 2 cells in chorionic villi
To describe the outcome of pregnancies with trisomy 2 in cultures of first-trimester chorionic villous samples (CVS) and determine whether amniocentesis is necessary in the management of such cases.Cultures of chorionic villi were performed at 11-13 weeks in 37 474 pregnancies. In those with trisomy 2 cells, amniocentesis was performed at 16 weeks. Pregnancy outcome was obtained from maternity records.Trisomy 2 cells in CVS cultures were observed in 45 of 37 474 pregnancies (1.2 per 1000). In 43 cases ultrasound examination at 16-20 weeks showed no fetal abnormalities, amniocentesis demonstrated the presence of only normal cells, and all 43 pregnancies ended in normal healthy live births. The birth weight was below the 5th centile in six neonates (13.9%). There was a significant associatio......
POSTED 01/28/2010 at 06:00 PM --
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Comparison of Multiplex Ligation-Dependent Probe Amplification and Karyotyping in Prenatal Diagnosis.
CONCLUSION:: In routine clinical practice, diagnostic accuracy of MLPA for detection of trisomies X, Y, 13, 18, and 21 is comparable with that of karyotyping, and it reduces waiting time at lower costs. LEVEL OF EVIDENCE:: II.
PMID: 20093902 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)...
POSTED 01/24/2010 at 10:55 PM --
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Antenatal diagnostic problem of congenital rubella
We present a preterm neonate who developed congenital rubella syndrome in a mother who had rubella at 5 months of gestation.
An amniocentesis was done in the mother at that time but amniotic fluid rubella PCR was negative. Thus, inspite of prenatal
screening, one cannot definitely conclude absence of perinatal transmission of rubella.
Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-009-0312-xAuthors
Ira Shah, B. J. Wadia Hospital for Children Parel Department of Pediatric Hepatobiliary Clinic Mumbai IndiaSushmita Bhatnagar, B. J. Wadia Hospital for Children Parel Department of Pediatric Hepatobiliary Clinic Mumbai India
Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)...
POSTED 01/21/2010 at 05:29 AM --
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Decision Making and Attitudes towards Invasive Prenatal Diagnosis in the Early Second Trimester.
CONCLUSION: The referral indication and the a priori opinion are the strongest influencing factors with regard to invasive testing and the ultrasound scan has a low impact in those preselected patients. However, ultrasound has an important reassuring aspect in women willing to use ultrasound as assistance in the process of decision making.
PMID: 20091463 [PubMed - as supplied by publisher] (Source: Ultraschall in der Medizin)...
POSTED 01/19/2010 at 06:00 PM --
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Trends in prenatal screening and diagnostic testing among women referred for advanced maternal age
We evaluated the trends in uptake of amniocentesis and chorionic villi sampling (CVS) for prenatal diagnosis compared with uptake of first and second trimester prenatal serum screening for Down syndrome among patients referred for genetic counseling for advanced maternal age (AMA).Patients referred for AMA genetic counseling from 2001 through 2008 were informed of both prenatal serum screening and invasive diagnostic testing options. Testing offered and testing decisions were entered in a computer database and uptake rates calculated for each year with trends compared using logistic regression analysis.From 2001 through 2007, we observed a decline in amniocentesis and CVS uptake (p = 0.0001). This trend reversed in 2008 for both invasive procedures (p = 0.0001). Uptake of prenatal serum sc......
POSTED 01/07/2010 at 06:00 PM --
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In utero cortisol and testosterone exposure and fear reactivity in infancy.
Authors: Bergman K, Glover V, Sarkar P, Abbott D, O'Connor TG
Fetal programming is emerging as a major conceptual model for understanding developmental origins of health and disease, including behavioral outcomes. As part of a larger study of prenatal stress and child development, we examined the association between prenatal hormone exposure and fear reactivity, a temperament dimension that is a predictor of long-term behavioral adjustment. Amniotic fluid was collected from a sample of women undergoing clinically indicated amniocentesis for later analysis of cortisol and testosterone. Children with normal birth outcomes were recalled for follow-up assessment at 17 months, at which time we administered an observational assessment of temperament (lab-TAB; n=108). Information on pregnancy......
POSTED 01/04/2010 at 06:00 PM --
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Proliferation of prenatal ultrasonography.
Authors: You JJ, Alter DA, Stukel TA, McDonald SD, Laupacis A, Liu Y, Ray JG
BACKGROUND: The extent to which temporal increases in the use of prenatal ultrasonography reflect changes in maternal risk is unknown. In this population-based study, we examined the use of prenatal ultrasonography from 1996 to 2006 in Ontario. METHODS: With fiscal year 1996/97 as the baseline, we evaluated the relative risk (RR) and 95% confidence interval (CI) for the change in rates of ultrasonography for each subsequent year. The RR was adjusted for maternal age, income, rural residence, maternal comorbidities, receipt of genetics consultation or amniocentesis - all in the index pregnancy - and history of complications in a prior pregnancy. RESULTS: The study sample consisted of 1 399 389 singleton deliver......
POSTED 01/03/2010 at 06:00 PM --
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Congenital Adrenal Hyperplasia - Facts and Information
Congenital adrenal hyperplasia may be diagnosed through a demonstration of excess cortisol precursors in the person's blood, particularly after a test injection of a drug known as, 'ACTH.' A diagnosis of CAH in an unborn child may be made through an amniocentesis. (Source: Disabled World)...
POSTED 01/03/2010 at 04:23 PM --
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Down Syndrome Due to Unbalanced Homologous Acrocentric Rearrangements and its Recurrence in Subsequent Pregnancies: Prenatal Diagnosis by Amniocentesis
Objective: To present our experience of amniocentesis for the prenatal diagnosis of Down syndrome due to unbalanced homologous acrocentric rearrangements and its recurrence in subsequent pregnancies.
Case Report: From January 1987 to Septem ...more (Source: Taiwanese Journal of Obstetrics and Gynecology)...
POSTED 12/28/2009 at 08:44 AM --
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Second-trimester amniotic fluid proinflammatory cytokine levels in normal and overweight women.
CONCLUSION:: Amniotic fluid CRP and TNF-alpha levels are increased in obese women, and both are related to maternal BMI, which suggests in utero exposure to higher proinflammatory cytokines and mediators in fetuses of these women. LEVEL OF EVIDENCE:: II.
PMID: 20027044 [PubMed - in process] (Source: Obstetrics and Gynecology)...
POSTED 12/24/2009 at 08:45 AM --
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Vacuum Tube Technique May Simplify Amniocentesis
A vacuum tube technique for amniocentesis, known as amniovacucentesis, is as effective as the standard syringe method and may be easier to perform, researchers suggest in the December issue of the American Journal of Obstetrics and Gynecology. Reuters Health Information (Source: Medscape Today Headlines)...
POSTED 12/23/2009 at 10:19 AM --
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Determinates of underutilization of amniocentesis among Israeli Arab women
To study the determinants of amniocentesis underutilization among Israeli Arab Muslim women.Pregnant women referred for amniocentesis (n = 476) were identified through family health centers (FHCs). Data on sociodemographic characteristics, knowledge of prenatal testing, and attitudes toward termination of pregnancy (TOP) were collected through interviews and from medical records.Of all women eligible for amniocentesis free of charge, only 17.9% (95% CI: 14.7-21.6) underwent the test. Women referred as a result of advanced maternal age underwent the test less often than those referred for other indications [13.5% and 25.0%, respectively, (p = 0.002)]. In multivariate analyses, determinants for amniocentesis underutilization among women referred for advanced maternal age were: being religiou......
POSTED 12/22/2009 at 06:00 PM --
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Iliac crest angle: a novel sonographic parameter for the prediction of Down syndrome risk during the second trimester of pregnancy.
CONCLUSIONS: Standardized iliac crest measurements of the fetal pelvis can be used to identify some fetuses at risk for trisomy 21 during the second trimester of pregnancy. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
PMID: 20014361 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)...
POSTED 12/14/2009 at 06:00 PM --
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Organizational effects of fetal testosterone on human corpus callosum size and asymmetry
Summary: Previous theory and research in animals has identified the critical role that fetal testosterone (FT) plays in organizing sexually dimorphic brain development. However, to date there are no studies in humans directly testing the organizational effects of FT on structural brain development. In the current study we investigated the effects of FT on corpus callosum size and asymmetry. High-resolution structural magnetic resonance images (MRI) of the brain were obtained on 28 8–11-year-old boys whose exposure to FT had been previously measured in utero via amniocentesis conducted during the second trimester. Although there was no relationship between FT and midsaggital corpus callosum size, increasing FT was significantly related to increasing rightward asymmetry (e.g., Right>Left) ......
POSTED 12/14/2009 at 10:25 AM --
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Ambivalence toward undergoing invasive prenatal testing: an exploration of its origins
This study explores ambivalence toward undergoing amniocentesis among pregnant women with overall positive attitudes. Its novelty lies in the characterization of the type and origins of the ambivalence.Thirty-six women between 35 and 44 years of age were recruited from a US prenatal testing center to participate in structured telephone interviews.Thirty women chose to undergo testing. Attitudes toward undergoing amniocentesis were generally positive, although all participants simultaneously described feeling ambivalent. The women desired the information that amniocentesis could provide yet did not want to place their fetus at risk. Participants cited religious, moral, ethical and intellectual values important in shaping their attitudes toward undergoing amniocentesis. Important referents s......
POSTED 11/18/2009 at 06:00 PM --
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[Management of congenital toxoplasmosis in France: current data.]
Authors: Garcia-Méric P, Franck J, Dumon H, Piarroux R
Congenital toxoplasmosis is caused by transplacental contamination of the fetus withToxoplasma gondiifollowing maternal primary infection. The risk of mother-to-child transmission depends on the term of pregnancy at the time of maternal infection. The risk is lower than 5% in the first trimester but can reach 90% in the last days of pregnancy. Inversely, however, fetal disease is more severe when contamination occurs early in pregnancy. The French prevention program officially recommends monthly serological screening of susceptible women during pregnancy and information about hygiene and dietary rules. Prenatal diagnosis of congenital toxoplasmosis is based on a combination of examinations: PCR testing for the parasite in amni......
POSTED 11/16/2009 at 06:00 PM --
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Amniotic fluid interleukin-6 and tumor necrosis factor-α at mid-trimester genetic amniocentesis: Relationship to intra-amniotic microbial invasion and preterm delivery
Conclusions: Elevated mid-trimester concentrations of AF IL-6, or/and of TNF-α can identify women at risk for intra-amniotic infection and for spontaneous PTD. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)...
POSTED 11/11/2009 at 06:00 PM --
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Chorioamnionitis and Intrauterine Fetal Death after Second-Trimester Amniocentesis
Fetal Diagn Ther (DOI:10.1159/000257087) (Source: Fetal Diagnosis and Therapy)...
POSTED 11/04/2009 at 05:00 PM --
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Urocortin in Second Trimester Amniotic Fluid: Its Role as Predictor of Preterm Labor
Conclusion. These results suggest that urocortin concentrations in the amniotic fluid
of genetic amniocentesis are not predictive of preterm labor and birth. (Source: Mediators of Inflammation)...
POSTED 11/04/2009 at 10:20 AM --
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Interrogating the dynamics between power, knowledge and pregnant bodies in amniocentesis decision making
A common assumption is that women who decline prenatal testing distrust biomedicine and trust embodied/experiential knowledge sources, while women who accept testing trust biomedicine and distrust embodied/experiential sources. Another major assumption about prenatal testing utilisation is that women who are open to abortion will undergo prenatal testing while those who are opposed to abortion will decline testing. Yet, previous research has produced inconsistent findings as to what, if anything, distinguishes women who accept or decline the offer of prenatal diagnosis. Analysing interviews with 147 pregnant women, this paper questions these assumptions about the role of abortion views and pregnant women's relative trust in various knowledge sources on their decisions to accept or decline ......
POSTED 11/03/2009 at 06:00 PM --
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