Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia.
Authors: Lindgren P, Cederholm M, Haglund B, Axelsson O
Please cite this paper as: Lindgren P, Cederholm M, Haglund B, Axelsson O. Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia. BJOG 2010; DOI:10.1111/j.1471-0528.2010.02665.x The aim was to estimate the risk of maternal hypertensive complications following first- or second-trimester invasive diagnostic procedures, i.e. chorionic villus sampling (CVS) and amniocentesis (AC). Odds ratios (ORs) for gestational hypertension, mild pre-eclampsia or severe pre-eclampsia were calculated for women who underwent CVS (n = 1 984) or AC (n = 21 748) compared with non-exposed women (n = 47 854). No increase in the development of gestational hypertension, mild pre-eclampsia or severe pre-e......
POSTED 08/16/2010 at 06:00 PM --
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Interpretation of amniotic fluid white blood cell count in "bloody tap" amniocenteses in women with symptoms of preterm labor.
CONCLUSION:: In the setting of an amniotic fluid sample contaminated with 1,000 RBCs/mm or more, WBC count is a less accurate indicator of inflammation and infection. In such samples, correction of WBC count enhances diagnostic performance for inflammation and infection. LEVEL OF EVIDENCE:: II.
PMID: 20664395 [PubMed - in process] (Source: Obstetrics and Gynecology)...
POSTED 07/29/2010 at 02:48 PM --
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Chorionic villus sampling at 11 to 13 weeks of gestation and hypertensive disorders in pregnancy.
CONCLUSION:: There is no association between performing a CVS in the first trimester and subsequent development of hypertensive disorders of pregnancy. LEVEL OF EVIDENCE:: II.
PMID: 20664398 [PubMed - in process] (Source: Obstetrics and Gynecology)...
POSTED 07/29/2010 at 02:48 PM --
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Umbilical artery aneurysm.
CONCLUSION:: Given the high incidence of aneuploidy associated with umbilical artery aneurysm, it is important to consider karyotype analysis of the affected fetus. If a normal karyotype is identified, early delivery may be warranted to decrease the risk of fetal demise.
PMID: 20664454 [PubMed - in process] (Source: Obstetrics and Gynecology)...
POSTED 07/29/2010 at 02:45 PM --
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Modifying Risk for Aneuploidy with Second-Trimester Ultrasound After a Positive Serum Screen
This article presents an overview of how prenatal diagnosis has evolved and then focuses on the current status of using ultrasound to evaluate patients considered to be screen-positive for Down syndrome based on first-trimester screening (10â14 weeks) or second-trimester (15â22 weeks) maternal serum analyte screening. (Source: Clinics in Laboratory Medicine)...
POSTED 07/21/2010 at 03:00 AM --
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Trisomy 16 Mosaicism at Chorionic Villus Sampling and Amniocentesis with a Normal Physical and Intellectual Outcome
Fetal Diagn Ther (DOI:10.1159/000316404) (Source: Karger Publishers)...
POSTED 07/20/2010 at 06:00 PM --
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Second trimester screening for trisomy 21 by maternal age and the additional assessment of the ductus venosus, the tricuspid blood flow or the nose bone.
CONCLUSION: Second trimester ultrasound screening for trisomy 21 based on maternal age and ductus venosus, tricuspid blood flow and the fetal nose bone in otherwise normal appearing fetuses is only marginally better than screening by maternal age alone. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.
PMID: 20645398 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)...
POSTED 07/18/2010 at 06:00 PM --
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Significance of the volume of fetomaternal hemorrhage after performing prenatal invasive tests
Fetal erythrocytes cross the placenta during gestation, but invasive prenatal procedures might develop into fetomaternal hemorrhage (FMH). We examine whether flow cytometry immunophenotyping might be useful for measuring the volume of FMH after such procedures.Fetal erythrocytes (%) were determined in 153 pregnant women after amniocentesis (129) and chorionic villous sampling (24) using a monoclonal antibody against fetal hemoglobin. Fetal erythrocytes were identified for their high expression of fetal hemoglobin (HbF++). Blood samples from two control groups, 53 healthy males and 21 pregnant women not submitted to invasive tests, were used to establish normal values of circulating HbF++ erythrocytes in adults.The highest percentage of HbF++ erythrocytes in the control groups was 0.015%. T......
POSTED 07/13/2010 at 06:00 PM --
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Maternal Administration of Erythromycin Fails to Eradicate Intrauterine Ureaplasma Infection in an Ovine Model.
This study demonstrates that maternally administered erythromycin does not eradicate chronic, intra-amniotic ureaplasma infections or improve fetal outcomes in an ovine model, potentially due to the poor placental passage of erythromycin.
PMID: 20610808 [PubMed - as supplied by publisher] (Source: Biology of Reproduction)...
POSTED 07/06/2010 at 06:00 PM --
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Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
Researchers in the Netherlands believe they are on the verge of developing a simple, prenatal blood test that would be able to detect accurately chromosomal abnormalities in the developing fetus. At present, the only reliable way to do this is through amniocentesis or chorionic villus sampling, both of which are invasive and carry the risk of triggering a miscarriage. (Source: ScienceDaily Headlines)...
POSTED 06/30/2010 at 07:00 PM --
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Prenatal diagnosis of severe epignathus in a twin: case report and review of the literature.
Authors: Tonni G, Centini G, Inaudi P, Rosignoli L, Ginanneschi C, De Felice C
Abstract A prenatal ultrasound diagnosis of epignathus in a dichorionic-diamniotic twin pregnancy is reported. A complex mass protruding from the fetal face was seen at week 19. Amniocentesis resulted in a 46,XX fetus with elevated alpha-fetoprotein (alpha-FP). An increase in tumor size and severe polyhydramnios ensued. Selective feticide performed at 22 weeks led to untreatable uterine contractions with iatrogenic abortion and early neonatal mortality of the healthy cotwin. Without development of polyhydramnios and tumor growth, weekly scan and transvaginal cervical assessment would have been carried out and cesarean section planned at around 32 weeks. Necroscopy and histology aided the ultrasound-based pre......
POSTED 06/30/2010 at 06:00 PM --
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Prenatally detected congenital perineal mass using 3D ultrasound which was diagnosed as lipoblastoma combined with anorectal malformation: case report.
We report a case of prenatally diagnosed congenital perineal mass which was combined with anorectal malformation. The mass was successfully treated with posterior sagittal anorectoplasty postnatally. On ultrasound examination at a gestational age of 23 weeks the fetal perineal mass were found on the right side. Any other defects were not visible on ultrasonography during whole gestation. Amniocentesis was performed to evaluate the fetal karyotyping and acetylcholinesterase which were also normal. As the fetus grew up, the mass size was slowly increased more and more. At birth, a female neonate had a perineal mass on the right side as expected. During operation, the anal sphincteric displacement was found near the mass and reconstructed through posterior sagittal incision. This is the first......
POSTED 06/30/2010 at 06:00 PM --
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Simple blood test could one day detect birth defects
It may be possible, one day, to test for Down's syndrome and other birth defects by simply taking a blood sample from the mother-to-be, rather than asking her to undergo amniocentesis. (Source: CTV Health)...
POSTED 06/30/2010 at 12:37 PM --
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Cheap, Simple, Noninvasive Blood Test May Replace Invasive Diagnostic Techniques In Early Pregnancy
Researchers in The Netherlands believe they are on the verge of developing a simple, prenatal blood test that would be able to detect accurately chromosomal abnormalities in the developing foetus. At present, the only reliable way to do this is through amniocentesis or chorionic villus sampling, both of which are invasive and carry the risk of triggering a miscarriage... (Source: Health News from Medical News Today)...
POSTED 06/30/2010 at 07:00 AM --
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Cheap, simple, noninvasive blood test for early pregnancy
Scientists in The Netherlands believe they are on the verge of developing a simple, prenatal blood test that would be able to detect accurately chromosomal abnormalities in the developing foetus. At present, the only reliable way to do this is through amniocentesis or chorionic villus sampling, both of which are invasive and carry the risk of triggering a miscarriage........ (Source: Medicineworld.org: New Article Alert)...
POSTED 06/29/2010 at 07:36 AM --
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Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
(European Society of Human Reproduction and Embryology) Researchers in the Netherlands believe they are on the verge of developing a simple, prenatal blood test that would be able to detect accurately chromosomal abnormalities in the developing fetus. At present, the only reliable way to do this is through amniocentesis or chorionic villus sampling, both of which are invasive and carry the risk of triggering a miscarriage. (Source: EurekAlert! - Medicine and Health)...
POSTED 06/28/2010 at 11:00 PM --
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Amniotic fluid alpha-fetoprotein microheterogeneity in the prenatal diagnosis of congenital disorders of glycosylation type Ia.
Conclusions: Our potential for further testing is limited; thus far, no other congenital disorders of glycosylation-positive samples have been available. Verification of our results in another laboratory with the exclusion of several potentially pertinent variables is advisable. Clin Chem Lab Med 2010;48.
PMID: 20528096 [PubMed - as supplied by publisher] (Source: Molecular Medicine)...
POSTED 06/06/2010 at 06:00 PM --
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[Pena-Shokeir syndrome type I - combination of polyhydramnios and pulmonary hypoplasia in fetal akinesia.]
We present the case of an 18-year-old woman with her second pregnancy, whose first pregnancy was complicated by polyhydramnios. At week 30, the dysmorph fetus died in utero and was delivered via cesarean section due to placental abruption, but the exact diagnosis was not recognized at that time. During the patient's second pregnancy, increasing polyhydramnios was detected from the 19th gestational week. Ultrasound signs of fetal malformation also appeared later: abnormal position of limbs, narrow chest, oedema around the skull, and absence of stomach content. At week 34, decompression amniocentesis became necessary. Chromosome analysis was also carried out and a normal karyotype was obtained. At 39th gestational week, amnioscopy proved meconium staining of the amniotic fluid, thus labour w......
POSTED 06/05/2010 at 05:39 AM --
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Comparative proteomic analysis of human amniotic fluid supernatants with down syndrome using mass spectrometry.
This study analyzed human AF supernatants (AFS) by mass spectrometric (MS) approach to search for candidate biomarkers of DS pregnancy. AFS were collected from advanced age pregnant women at 16-18th weeks of gestation by amniocentesis for cytogenetic analysis. AFS from pregnancies carrying DS (n=4) or chromosomally normal (n=6) fetuses, as revealed by cytogenetic analysis, were then subjected to global protein profiling by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Affinity chromatography was applied prior to LC-ESI-MS/MS to minimize the masking effect of highly abundant albumin and immunoglobulin and thereby, increased the diversity of identified proteins. Hereby, at least 30 AFS proteins were newly identified and 44 AFS proteins were found to b......
POSTED 05/31/2010 at 06:00 PM --
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Information and decision support needs of parents considering amniocentesis: interviews with pregnant women and health professionals
Abstract (Source: Health Expectations)...
POSTED 05/31/2010 at 06:00 PM --
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