Double Entry Sampling in Amniocentesis No Extra Help in Twin Gestations
Using a double entry technique for amniocentesis or chorionic villus sampling in twin gestations does not significantly reduce fetal loss or premature membrane rupture, Italian researchers reported online in the American Journal of Obstetrics and Gynecology. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)...
POSTED 02/05/2010 at 11:39 AM --
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Use of amniocytes for prenatal diagnosis of 22q11.2 microdeletion syndrome: a feasibility study.
CONCLUSION: Chromosome 22q11.2 microdeletion is one of the major factors leading to fetal congenital malformations, and prenatal FISH screening for 22q11.2 microdeletion syndrome is technically feasible using amniocytes.
PMID: 20193483 [PubMed - in process] (Source: Chinese Medical Journal)...
POSTED 01/31/2010 at 06:00 PM --
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Prenatal cytogenetic diagnosis study of 2782 cases of high-risk pregnant women.
CONCLUSIONS: Invasive prenatal diagnostic techniques are feasible tools for confirming fetal chromosomal abnormalities. Abnormal chromosomes detected in one of the parents carrying abnormal chromosome, ultrasound soft markers, advanced maternal age or positive serum screening results were associated with a higher frequency of fetal genetic diseases.
PMID: 20193481 [PubMed - in process] (Source: Chinese Medical Journal)...
POSTED 01/31/2010 at 06:00 PM --
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Outcome of pregnancies with trisomy 2 cells in chorionic villi
To describe the outcome of pregnancies with trisomy 2 in cultures of first-trimester chorionic villous samples (CVS) and determine whether amniocentesis is necessary in the management of such cases.Cultures of chorionic villi were performed at 11-13 weeks in 37 474 pregnancies. In those with trisomy 2 cells, amniocentesis was performed at 16 weeks. Pregnancy outcome was obtained from maternity records.Trisomy 2 cells in CVS cultures were observed in 45 of 37 474 pregnancies (1.2 per 1000). In 43 cases ultrasound examination at 16-20 weeks showed no fetal abnormalities, amniocentesis demonstrated the presence of only normal cells, and all 43 pregnancies ended in normal healthy live births. The birth weight was below the 5th centile in six neonates (13.9%). There was a significant associatio......
POSTED 01/28/2010 at 06:00 PM --
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Antenatal diagnostic problem of congenital rubella
We present a preterm neonate who developed congenital rubella syndrome in a mother who had rubella at 5 months of gestation.
An amniocentesis was done in the mother at that time but amniotic fluid rubella PCR was negative. Thus, inspite of prenatal
screening, one cannot definitely conclude absence of perinatal transmission of rubella.
Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-009-0312-xAuthors
Ira Shah, B. J. Wadia Hospital for Children Parel Department of Pediatric Hepatobiliary Clinic Mumbai IndiaSushmita Bhatnagar, B. J. Wadia Hospital for Children Parel Department of Pediatric Hepatobiliary Clinic Mumbai India
Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)...
POSTED 01/21/2010 at 05:29 AM --
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Decision Making and Attitudes towards Invasive Prenatal Diagnosis in the Early Second Trimester.
CONCLUSION: The referral indication and the a priori opinion are the strongest influencing factors with regard to invasive testing and the ultrasound scan has a low impact in those preselected patients. However, ultrasound has an important reassuring aspect in women willing to use ultrasound as assistance in the process of decision making.
PMID: 20091463 [PubMed - as supplied by publisher] (Source: Ultraschall in der Medizin)...
POSTED 01/19/2010 at 06:00 PM --
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Effect of religion on the attitude of primiparous women toward genetic testing
The objective of this study was to determine the acceptance rate of prenatal diagnostic testing in Lebanon according to religion.Prenatal charts were reviewed to obtain information about prenatal genetic testing. Women were divided according to their religion and were compared regarding the acceptance of triple screen test (TST) or amniocentesis (AMN) and reasons for declining such tests. Differences between groups were examined using the student's t-test, [chi]2-test and multivariate analysis (age [ge] 35 years, religion, education and class).The religious distribution was 73.8% Moslems, 14.0% Christians and 11.2% Druze. Utilization of TST, AMN, and either (TST/AMN) was 61.2%, 7.6% and 67.0%, respectively. Uptake of TST/AMN was highest in Christians and lowest in Moslems and that of AMN h......
POSTED 01/18/2010 at 06:00 PM --
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Trends in prenatal screening and diagnostic testing among women referred for advanced maternal age
We evaluated the trends in uptake of amniocentesis and chorionic villi sampling (CVS) for prenatal diagnosis compared with uptake of first and second trimester prenatal serum screening for Down syndrome among patients referred for genetic counseling for advanced maternal age (AMA).Patients referred for AMA genetic counseling from 2001 through 2008 were informed of both prenatal serum screening and invasive diagnostic testing options. Testing offered and testing decisions were entered in a computer database and uptake rates calculated for each year with trends compared using logistic regression analysis.From 2001 through 2007, we observed a decline in amniocentesis and CVS uptake (p = 0.0001). This trend reversed in 2008 for both invasive procedures (p = 0.0001). Uptake of prenatal serum sc......
POSTED 01/07/2010 at 06:00 PM --
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Proliferation of prenatal ultrasonography.
Authors: You JJ, Alter DA, Stukel TA, McDonald SD, Laupacis A, Liu Y, Ray JG
BACKGROUND: The extent to which temporal increases in the use of prenatal ultrasonography reflect changes in maternal risk is unknown. In this population-based study, we examined the use of prenatal ultrasonography from 1996 to 2006 in Ontario. METHODS: With fiscal year 1996/97 as the baseline, we evaluated the relative risk (RR) and 95% confidence interval (CI) for the change in rates of ultrasonography for each subsequent year. The RR was adjusted for maternal age, income, rural residence, maternal comorbidities, receipt of genetics consultation or amniocentesis - all in the index pregnancy - and history of complications in a prior pregnancy. RESULTS: The study sample consisted of 1 399 389 singleton deliver......
POSTED 01/03/2010 at 06:00 PM --
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Congenital Adrenal Hyperplasia - Facts and Information
Congenital adrenal hyperplasia may be diagnosed through a demonstration of excess cortisol precursors in the person's blood, particularly after a test injection of a drug known as, 'ACTH.' A diagnosis of CAH in an unborn child may be made through an amniocentesis. (Source: Disabled World)...
POSTED 01/03/2010 at 04:23 PM --
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Unbalanced and Balanced Acrocentric Rearrangements Involving Chromosomes Other Than Chromosome 21 at Amniocentesis
Objective: To investigate unbalanced and balanced acrocentric rearrangements involving chromosomes other than chromosome 21 at amniocentesis.
Materials and Methods: From January 1987 to September 2009, 31,194 amniocenteses were performed at ...more (Source: Taiwanese Journal of Obstetrics and Gynecology)...
POSTED 12/28/2009 at 08:44 AM --
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Down Syndrome Due to Unbalanced Homologous Acrocentric Rearrangements and its Recurrence in Subsequent Pregnancies: Prenatal Diagnosis by Amniocentesis
Objective: To present our experience of amniocentesis for the prenatal diagnosis of Down syndrome due to unbalanced homologous acrocentric rearrangements and its recurrence in subsequent pregnancies.
Case Report: From January 1987 to Septem ...more (Source: Taiwanese Journal of Obstetrics and Gynecology)...
POSTED 12/28/2009 at 08:44 AM --
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Vacuum Tube Technique May Simplify Amniocentesis
A vacuum tube technique for amniocentesis, known as amniovacucentesis, is as effective as the standard syringe method and may be easier to perform, researchers suggest in the December issue of the American Journal of Obstetrics and Gynecology. Reuters Health Information (Source: Medscape Today Headlines)...
POSTED 12/23/2009 at 10:19 AM --
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Determinates of underutilization of amniocentesis among Israeli Arab women
To study the determinants of amniocentesis underutilization among Israeli Arab Muslim women.Pregnant women referred for amniocentesis (n = 476) were identified through family health centers (FHCs). Data on sociodemographic characteristics, knowledge of prenatal testing, and attitudes toward termination of pregnancy (TOP) were collected through interviews and from medical records.Of all women eligible for amniocentesis free of charge, only 17.9% (95% CI: 14.7-21.6) underwent the test. Women referred as a result of advanced maternal age underwent the test less often than those referred for other indications [13.5% and 25.0%, respectively, (p = 0.002)]. In multivariate analyses, determinants for amniocentesis underutilization among women referred for advanced maternal age were: being religiou......
POSTED 12/22/2009 at 06:00 PM --
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Iliac crest angle: a novel sonographic parameter for the prediction of Down syndrome risk during the second trimester of pregnancy
To validate a new sonographic technique for the display and measurement of fetal iliac crest angle (ICA), and to determine the relative contribution of standardized fetal pelvic measurements for estimating risk of Down syndrome during the second trimester of pregnancy.Three-dimensional ultrasonography of the fetal pelvis was performed during a second-trimester scan for genetic amniocentesis. A coronal view of the 'virtual pelvis' was obtained by applying a maximum intensity projection algorithm to visualize both iliac wings. Two different ICAs were measured from a coronal projection of the fetal pelvis (ICA-coronal 1 and ICA-coronal 2); the latter approach relied on using ischial tuberosities as reference landmarks. Next, a coronal projection of the fetal pelvis was rotated to demonstrate ......
POSTED 12/14/2009 at 06:00 PM --
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Iliac crest angle: a novel sonographic parameter for the prediction of Down syndrome risk during the second trimester of pregnancy.
CONCLUSIONS: Standardized iliac crest measurements of the fetal pelvis can be used to identify some fetuses at risk for trisomy 21 during the second trimester of pregnancy. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
PMID: 20014361 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)...
POSTED 12/14/2009 at 06:00 PM --
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Ambivalence toward undergoing invasive prenatal testing: an exploration of its origins
This study explores ambivalence toward undergoing amniocentesis among pregnant women with overall positive attitudes. Its novelty lies in the characterization of the type and origins of the ambivalence.Thirty-six women between 35 and 44 years of age were recruited from a US prenatal testing center to participate in structured telephone interviews.Thirty women chose to undergo testing. Attitudes toward undergoing amniocentesis were generally positive, although all participants simultaneously described feeling ambivalent. The women desired the information that amniocentesis could provide yet did not want to place their fetus at risk. Participants cited religious, moral, ethical and intellectual values important in shaping their attitudes toward undergoing amniocentesis. Important referents s......
POSTED 11/18/2009 at 06:00 PM --
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[Management of congenital toxoplasmosis in France: current data.]
Authors: Garcia-Méric P, Franck J, Dumon H, Piarroux R
Congenital toxoplasmosis is caused by transplacental contamination of the fetus withToxoplasma gondiifollowing maternal primary infection. The risk of mother-to-child transmission depends on the term of pregnancy at the time of maternal infection. The risk is lower than 5% in the first trimester but can reach 90% in the last days of pregnancy. Inversely, however, fetal disease is more severe when contamination occurs early in pregnancy. The French prevention program officially recommends monthly serological screening of susceptible women during pregnancy and information about hygiene and dietary rules. Prenatal diagnosis of congenital toxoplasmosis is based on a combination of examinations: PCR testing for the parasite in amni......
POSTED 11/16/2009 at 06:00 PM --
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Amniotic fluid interleukin-18 at mid-trimester genetic amniocentesis: relationship to intraamniotic microbial invasion and preterm delivery.
CONCLUSIONS: Elevated mid-trimester concentrations of AF IL-18 can identify women at risk for intraamniotic infection and spontaneous PTD.
PMID: 19906019 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)...
POSTED 11/13/2009 at 03:02 PM --
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Amniotic fluid interleukin-6 and tumor necrosis factor-α at mid-trimester genetic amniocentesis: Relationship to intra-amniotic microbial invasion and preterm delivery
Conclusions: Elevated mid-trimester concentrations of AF IL-6, or/and of TNF-α can identify women at risk for intra-amniotic infection and for spontaneous PTD. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)...
POSTED 11/11/2009 at 06:00 PM --
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