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Abdominal Wall Repair Procedures News
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All Recent Abdominal Wall Repair Procedures News |
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Gastroschisis: an update
Abstract Gastroschisis (GS) continues to increase in frequency, with several studies now reported an incidence of between 4 and 5 per
10,000 live births. The main risk factor would seem to be young maternal age, and it is in this group that the greatest increase
has occurred. Whilst various geographical regions confer a higher risk, the impact of several other putative risk factors,
including smoking and illicit drug use, may be less important than when first identified in early epidemiological studies.
Over 90% of cases of GS will now be diagnosed on antenatal ultrasound, but its value in determining the need for early delivery
remains unclear. There would appear no clear evidence for either routine early delivery or elective caesarean section for
infants with antenatally......
POSTED 08/04/2010 at 03:29 PM --
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A prenatally recognizable malformation syndrome associated with a recurrent post-zygotic chromosome rearrangement der(Y)t(Y;1)(q12:q21)
Several cases of mos 46,X,der(Y)t(Y;1)(q12;q21)/46,XY with multiple anomalies have been reported. I report on an additional case of a male fetus with a mosaic male karyotype mos 46,X,der(Y)t(Y;1)(q12;q21)[31]/46,XY[21] and multiple anomalies that included "teardrop"-shaped head with a triangular face, a short-nasal bridge with upturned nose, microretrognathia, microtia, kyphoscoliosis, oligodactyly, syndactyly, joint contractures, CNS malformation, omphalocele, diaphragmatic hernia, cardiac anomaly, and urogenital malformation. The findings together suggest a recurrent and recognizable syndrome and argue for using tissues such as skin or cartilage or amniotic fluid, instead of cord blood, for postmortem karyotyping in order to avoid missing mosaicism as a potential cause of multiple congen......
POSTED 08/02/2010 at 06:00 PM --
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Correction: March 2010 (vol. 202, no. 3, page 241)
The authors of a research paper describing associations between atrazine exposure and fetal gastroschisis (Waller SA, Paul K, Peterson SE, Hitti J. Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State. Am J Obstet Gynecol 2010;202:241.e1-6) wish to correct 2 errors. (Source: American Journal of Obstetrics and Gynecology)...
POSTED 07/31/2010 at 06:00 PM --
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Disruption of noncanonical Wnt/CA2+ pathway in the cadmium-induced omphalocele in the chick model
Conclusion: Downregulation of Wnt11, PKCα, and CaMKII gene expression during the narrow window of early embryogenesis may cause VBWD, interfering with cell movement and adhesion, disrupting Wnt/Ca2+ pathway. (Source: Journal of Pediatric Surgery)...
POSTED 07/31/2010 at 06:00 PM --
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Neonatal care in patients with giant ompholocele: arduous management but favorable outcomes
Conclusion: Mortality rate of giant omphalocele without chromosomal anomaly or major malformations is low when treated by gradual reduction of the contents. Parents should be informed of the long hospitalization in the intensive care unit at birth, the potential nonthreatening associated malformations to be diagnosed after birth, and the high risk of sepsis. (Source: Journal of Pediatric Surgery)...
POSTED 07/31/2010 at 06:00 PM --
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Intestinal atresia in association with gastroschisis: a 26-year review
Conclusion Differences in outcome between the management strategies are likely to reflect an inherent variability in patient condition,
site of atresia, and bowel suitability for anastomosis at first surgery, rather than the mode of surgical management. Individual
management plans should be tailored to the clinical condition of each patient.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2676-4Authors
Rania Kronfli, Royal Hospital for Sick Children Glasgow UKTimothy J. Bradnock, Royal Hospital for Sick Children Glasgow UKAtul Sabharwal, Royal Hospital for Sick Children Glasgow UK
Journal Pediatric Surgery InternationalOnline ISSN 1437-9813Print ISSN 0179-0358 (Source: Pediatric Surgery International)...
POSTED 07/30/2010 at 11:54 AM --
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Midgut Atresia and Spontaneously Closed Gastroschisis: Support for a Mechanical Explanation
Eur J Pediatr SurgDOI: 10.1055/s-0030-1261884© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: European Journal of Pediatric Surgery)...
POSTED 07/29/2010 at 12:19 AM --
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Treatment of Hyperthyroidism in Pregnancy and Birth Defects.
Conclusions: Further studies are required to exhaustively evaluate the associations between propylthiouracil and birth defects because of the low number, the lack of biological plausibility, and the possibility of underdiagnosis. Association between methimazole/carbimazole exposure and omphalocele and choanal atresia is consistent with previous reports and definitely suggests that these malformations could be part of a specific, even if rare, embryopathy.
PMID: 20668039 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 07/27/2010 at 06:00 PM --
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Twins with omphalocele in Denmark (1970-1989)
Seven pairs of twins, two monozygotic (MZ), two dizygotic (DZ), and three like-sex pairs of unknown zygosity are described. The twin pairs were all discordant for omphalocele except for one pair of conjoined twins. The 8 infants with omphalocele represent 3.1% of the 253 infants with omphalocele, ascertained in an almost complete nationwide data set of live- and stillborn infants with abdominal wall defects in two decades in Denmark (1970-1989). The occurrence of twins with omphalocele was not significantly different from the occurrence of twins in the Danish population in the same period. To our knowledge this is the first report of the occurrence of twins with omphalocele in a systematic nationwide epidemiological study. © 2010 Wiley-Liss, Inc. (Source: American Journal of Medical Genet......
POSTED 07/14/2010 at 06:00 PM --
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HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model
Conclusion Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in
the Cd chick model by interfering with molecular signaling required for proper VBW formation. Furthermore, these results support
the concept that HoxB2, HoxB4 and Alx4 genes work together to mediate proper VBW formation.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2658-6Authors
Takashi Doi, Our Ladyâs Childrenâs Hospital The Childrenâs Research Centre Dublin 12 IrelandPrem Puri, Our Ladyâs Childrenâs Hospital The Childrenâs Research Centre Dublin 12 IrelandJohn Bannigan, University College Dublin School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Researc......
POSTED 07/13/2010 at 09:54 AM --
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Preterm elective caesarean section and early enteral feeding in gastroschisis
Conclusion: Close surveillance of pregnancy, elective preterm caesarean section, early surgery and active approach to primary closure and early enteral feeds appears to be a safe and effective line of management in gastroschisis. (Source: Acta Paediatrica)...
POSTED 07/07/2010 at 06:00 PM --
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Changes in Amniotic Fluid Index after Maternal Oral Hydration in Pregnancies with Fetal Gastroschisis: Initial Observations
Fetal Diagn Ther (DOI:10.1159/000313642) (Source: Karger Publishers)...
POSTED 07/05/2010 at 06:00 PM --
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No free ride? The hidden costs of delayed operative management using a spring-loaded silo for gastroschisis
Conclusions: Patients managed with a silo had longer ventilator requirements and greater fluid needs. This Specific technical complications leading to bowel ischemia were notable in the silo group. The silo should be carefully placed to avoid bowel twisting and the funnel effect. Larger prospective studies should be performed to provide decision-making criteria for the use of a silo vs primary closure. (Source: Journal of Pediatric Surgery)...
POSTED 06/30/2010 at 06:00 PM --
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Nonoperative management of a giant omphalocele using a silver impregnated hydrofiber dressing: a case report
We report the case of a term, 1-day-old female neonate with a giant omphalocele treated initially with a hydrofiber dressing containing silver (Aquacel Ag; ConvaTec Inc, Skillman, NJ) and then with delayed primary closure. (Source: Journal of Pediatric Surgery)...
POSTED 06/30/2010 at 06:00 PM --
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Management of a giant omphalocele with an external skin closure system
We describe the use of an external surgical skin closure device in the context of the staged closure of a giant neonatal omphalocele and postulate that such a device may prove useful in the treatment of other congenital tissue defects. (Source: Journal of Pediatric Surgery)...
POSTED 06/30/2010 at 06:00 PM --
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The embryologic origin of ventral body wall defects
Ventral body wall defects include ectopia cordis, bladder exstrophy, and the abdominal wall malformations gastroschisis and omphalocele. The etiology of ectopia cordis, gastroschisis, and bladder exstrophy is not known, but they may be linked to abnormalities in the lateral body wall folds responsible for closing the thoracic, abdominal, and pelvic portions of the ventral body wall. These folds form in the fourth week (postfertilization) of development as a combination of the parietal layer of lateral plate mesoderm and overlying ectoderm and must move ventrally to meet in the midline. There are differential rates of cell proliferation in the folds and asymmetries in their movement that may be involved in teratogenic effects of toxic factors. Also, the fusion process between the folds is c......
POSTED 06/26/2010 at 01:25 AM --
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Hospital-Based Clusters and the Epidemiology of Gastroschisis--Reply [The Pediatric Forum]
(Source: Archives of Pediatrics)...
POSTED 06/07/2010 at 02:50 PM --
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Successful management of short gut due to vanishing gastroschisis - case report and review of the literature.
We present a case report of an infant with vanishing gastroschisis that was managed with a combination of reconstructive bowel surgery and hepatosparing parenteral nutrition. The technique is described and a review of the literature is provided.
PMID: 20529453 [PubMed - as supplied by publisher] (Source: Annals of the Royal College of Surgeons of England)...
POSTED 06/06/2010 at 06:00 PM --
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Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model
Conclusion: Downregulation of Msx1 and Msx2 gene expression during the narrow window of early embryogenesis may cause an omphalocele by disrupting cellular proliferation and differentiation in the developing body wall. (Source: Journal of Pediatric Surgery)...
POSTED 05/31/2010 at 06:00 PM --
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Conservative management of giant omphalocele with topical povidone-iodine and its effect on thyroid function
Conclusion: Topical povidone-iodine promotes escharification and epithelialization of the omphalocele sac. Because transient hypothyroidism may occur, thyroid function studies may guide inpatient therapy. After sac desiccation, systemic effects of iodine are minimal and thyroid supplementation is not necessary. Topical povidone-iodine is an effective initial strategy for giant omphaloceles and does not produce clinically significant hypothyroidism. (Source: Journal of Pediatric Surgery)...
POSTED 05/31/2010 at 06:00 PM --
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