Epidemiology, costs, and the economic burden of fibromyalgia
The assumption, that fibromyalgia is associated with a maior impact on the utilization of both healthcare and non-healthcare resources has not been thoroughly supported by many evidence-based data. Despite the differences between health care and sociopolitical systems in various countries, more recent results from epidemiological research now clearly demonstrate the socioeconomic burden of fibromyalgia and its comorbidities. The costs of the disease, calculated in single studies and countries, allow estimates for populations in other countries. The alarming results highlight the urgent need both for more research (including pathophysiology and epidemiology) and for the acceptance of emerging treatment challenges. (Source: Arthritis Research and Therapy)...
POSTED 06/29/2009 at 06:00 PM --
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Cymbalta Drug Profile
Cymbalta is an antidepressant in the SNRI class - a serotonin norepinephrine reuptake inhibitor. Cymbalta - generic duloxetine hydrochloride - is prescribed for the treatment of major depression and the pain associated with diabetic neuropathy. Cymbalta also has some significant off-label uses including bipolar disorder and fibromyalgia. (Source: About.com Bipolar Disorder)...
POSTED 06/29/2009 at 06:00 PM --
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A comparison of quality of life, demographic and clinical characteristics of Brazilian men with fibromyalgia syndrome with male patients with depression
Abstract The primary aim of this study was to assess the quality of life (Qol) in men with fibromyalgia (FM) as compared to the Qol
of depressive patients, using the SF-36 questionnaire. The secondary objectives were as follows: to describe demographic and
clinical characteristics of male patients with FM; to evaluate basal levels of dehydroepiandrosterone sulfate (DHEAS) and
total testosterone in both groups; and to investigate the relationship among pain, tender points, anxiety, and depression
in these patients. Fifty men with FM and 20 depressed males, matched by age and body mass index entered the study. All participants
answered the SF-36, the Beck Depression Inventory and the State-Trait Anxiety Inventory questionnaire. Radioimmunoassay was
used to determine serum co......
POSTED 06/29/2009 at 05:00 AM --
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Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains
Fibromyalgia (FM) patients have signs of relentless sympathetic hyperactivity associated with hyporeactivity to stress. Adrenergic receptors (ARs) are parts of the sympathetic nervous system that are fundamental for maintenance of homeostasis. We undertook this study to correlate [alpha]-AR and [beta]-AR gene polymorphisms with the presence of FM and with different domains of the FM syndrome as measured by the Fibromyalgia Impact Questionnaire (FIQ).We studied 78 Mexican FM patients and 48 age-matched controls as well as 78 Spanish FM patients and 71 controls. All subjects studied were women. Single-nucleotide polymorphisms (SNPs) of [alpha]1A-AR (rs574584, rs1383914, rs1048101, and rs573542), [beta]2-AR (rs1042713 and rs1042714), and [beta]3-AR (rs4994) were analyzed by 5[prime] exonuclea......
POSTED 06/28/2009 at 06:00 PM --
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Duloxetine: In Patients with Fibromyalgia.
Page: 1217DOI: 10.2165/00003495-200969090-00006Authors: Curran, Monique P. (Source: Drugs)...
POSTED 06/26/2009 at 09:16 AM --
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Jazz Pharmaceuticals and UCB announce second phase III study
Jazz Pharmaceuticals and UCB announce second Phase III study of sodium oxybate in patients with fibromyalgia meets primary endpoints (Source: Pharmacy Europe)...
POSTED 06/25/2009 at 08:58 AM --
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Jazz Pharmaceuticals And UCB Announce Second Phase III Study Of Sodium Oxybate In Patients With Fibromyalgia Meets Primary Endpoints
Jazz Pharmaceuticals, Inc. (Nasdaq: JAZZ) and UCB (Euronext Brussels: UCB) announced today positive preliminary top-line results from the second of two Phase III clinical trials of sodium oxybate (JZP-6) for the treatment of fibromyalgia. (Source: Health News from Medical News Today)...
POSTED 06/25/2009 at 06:00 AM --
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The Premenstrual Syndrome and Fibromyalgia—Similarities and Common Features
In this study, patients with PMDD were found to have higher levels of tenderness,
higher psychiatric comorbidity, greater level of physical disabilities, and a lower quality of life. These parameters were
highly correlated with a lower pain threshold.
Content Type Journal ArticleDOI 10.1007/s12016-009-8143-0Authors
Daniela Amital, Tel-Aviv University Department of Psychiatry ‘B’, Ness-Ziona Mental Health Center Ness-Ziona IsraelCalanit Herskovitz, Tel-Aviv University Department of Psychiatry ‘B’, Ness-Ziona Mental Health Center Ness-Ziona IsraelLeah Fostick, Tel-Aviv University Department of Psychiatry ‘A’ Sheba Medical Center Ness-Ziona IsraelAlysa Silberman, Tel-Aviv University Department of Psychiatry ‘A’ Sheba Medical Center Ness-Ziona IsraelYariv Doron, Tel-Aviv......
POSTED 06/25/2009 at 02:39 AM --
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Jazz Pharmaceuticals And UCB Announce Second Phase III Study Of Sodium Oxybate In Patients With Fibromyalgia Meets Primary Endpoints
Jazz Pharmaceuticals, Inc. (Nasdaq: JAZZ) and UCB (Euronext Brussels: UCB) announced today positive preliminary top-line results from the second of two Phase III clinical trials of sodium oxybate (JZP-6) for the treatment of fibromyalgia. (Source: Pharmaceutical Online News)...
POSTED 06/24/2009 at 03:21 AM --
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Brain Imaging Study Sheds Light on Fibromyalgia
Title: Brain Imaging Study Sheds Light on FibromyalgiaCategory: Health NewsCreated: 6/20/2009 7:00:00 AMLast Editorial Review: 6/22/2009 (Source: MedicineNet Chronic Pain General)...
POSTED 06/22/2009 at 02:00 AM --
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Brain Imaging Study Sheds Light on Fibromyalgia
Title: Brain Imaging Study Sheds Light on FibromyalgiaCategory: Health NewsCreated: 6/20/2009 7:00:00 AMLast Editorial Review: 6/22/2009 (Source: MedicineNet Arthritis General)...
POSTED 06/22/2009 at 02:00 AM --
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Chiropractic treatment for fibromyalgia: a systematic review
Abstract Many patients use chiropractic as a treatment of fibromyalgia, and many chiropractors seem to be convinced that it is effective
for that condition. The aim of the study was to conduct a systematic review of randomised clinical trials testing the effectiveness
of chiropractic care for fibromyalgia. Six electronic literature searches were conducted. No language restrictions were applied.
Data extraction and validation were carried out by two independent reviewers. Three studies met the inclusion criteria. Their
methodological quality was poor. They generated no evidence to suggest that chiropractic care is effective for fibromyalgia.
Currently, there is insufficient evidence to conclude that chiropractic is an effective treatment for fibromyalgia.
Content Type Jou......
POSTED 06/22/2009 at 01:35 AM --
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Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia
PALO ALTO, Calif., June 15 /PRNewswire-FirstCall/ -- Jazz Pharmaceuticals' (NASDAQ:JAZZ) sodium oxybate (JZP-6) demonstrated statistically significant and clinically meaningful improvement in pain and the core symptoms associated with fibromyalgia,... (Source: Drugs.com - Clinical Trials)...
POSTED 06/19/2009 at 08:44 AM --
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Personality problems are considerably associated with somatic morbidity and health care utilisation.
CONCLUSION: In this population based study, personality problems in young adults based on DSM-IV personality disorder criteria were associated with increased occurrence of somatic morbidity and primary health care utilisation. The relevance for GP to take personality problems into account during consultations is underlined and a method for doing so is suggested.
PMID: 19540726 [PubMed - as supplied by publisher] (Source: European Psychiatry)...
POSTED 06/17/2009 at 06:00 PM --
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A Controlled Examination of Medical and Psychosocial Factors Associated With Low Back Pain in Combination With Widespread Musculoskeletal Pain.
CONCLUSIONS:/b> Patients with CLBP and WMP should be examined for indicated physical and psychosocial factors. Therapeutic management should consider them in the early stage of the disease. These findings also might apply to patients with fibromyalgia or myofascial pain.
PMID: 19541773 [PubMed - as supplied by publisher] (Source: Physical Therapy)...
POSTED 06/17/2009 at 06:00 PM --
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Opioids Widely Used for Fibromyalgia Despite Absence of Efficacy Proof
More than one third of fibromyalgia patients receiving medical care in the U.S. are prescribed opioids despite a lack of evidence of substantial efficacy for this disease and despite their potential for addiction and abuse. Reuters Health Information (Source: Medscape Rheumatology Headlines)...
POSTED 06/17/2009 at 10:57 AM --
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Safety and tolerability of duloxetine in the treatment of patients with fibromyalgia: pooled analysis of data from five clinical trials
Abstract The purpose of this report is to describe the overall safety profile of both short- and longer-term duloxetine treatment of
fibromyalgia. Data from four double-blind, randomized, placebo-controlled studies (two with 6-month open-label extension phases)
and a 1-year, open-label safety study were included. Safety measures included treatment-emergent adverse events (TEAEs), adverse
events leading to discontinuation, serious adverse events (SAEs), clinical laboratory tests, vital signs, and electrocardiograms.
The most common TEAEs for short-term treatment with duloxetine were nausea (29.3%), headache (20.0%), dry mouth (18.2%), insomnia
(14.5%), fatigue (13.5%), constipation (14.5%), diarrhea (11.6%), and dizziness (11.0%; all p < 0.05 vs. placebo). Most TEAEs ......
POSTED 06/17/2009 at 02:09 AM --
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New fibromyalgia drug 'shows good results in clinical trial'
Sodium oxybate significantly improves pain and other symptoms of fibromyalgia, according to the results of a new Phase III clinical trial. (Source: Arthritis Research Campaign)...
POSTED 06/16/2009 at 06:00 PM --
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Psychometric properties of a single-item scale to assess sleep quality among individuals with fibromyalgia
This study reports psychometric properties of a single-item scale to assess sleep quality among individuals with FM.
Methods:
Analyses were based on data from two randomized, double-blind, placebo-controlled trials of pregabalin (studies 1056 and 1077). In a daily diary, patients reported the quality of their sleep on a numeric rating scale ranging from 0 ("best possible sleep") to 10 ("worst possible sleep"). Test re-test reliability of the Sleep Quality Scale was evaluated by computing intraclass correlation coefficients. Pearson correlation coefficients were computed between baseline Sleep Quality scores and baseline pain diary and Medical Outcomes Study (MOS) Sleep scores. Responsiveness to treatment was evaluated by standardized effect sizes computed as the difference between least sq......
POSTED 06/16/2009 at 06:00 PM --
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Data Suggest Sodium Oxybate Significantly Improves Pain And The Core Symptoms Of Fibromyalgia
Jazz Pharmaceuticals' (Nasdaq: JAZZ) sodium oxybate (JZP-6) demonstrated statistically significant and clinically meaningful improvement in pain and the core symptoms associated with fibromyalgia, according to Phase III data presented last week at the 2009 Associated Professional Sleep Societies meeting in Seattle, WA. (Source: Health News from Medical News Today)...
POSTED 06/16/2009 at 04:00 AM --
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