Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation
Conclusions:
There are 21 cases of HUS following lung transplantation in the literature that may have been induced by high tacrolimus levels.Macrolides in patients taking Cyclosporin or Tacrolimus lead to high levels. Mechanism of action could be glomeruloconstrictor effect with reduced GFR increased production of Endothelin-1 and increased Platelet aggregation. (Source: Journal of Cardiothoracic Surgery)...
POSTED 09/01/2010 at 06:00 PM --
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Stem cells and cell therapy approaches in lung biology and diseases.
Authors: Sueblinvong V, Weiss DJ
Cell-based therapies with embryonic or adult stem cells, including induced pluripotent stem cells, have emerged as potential novel approaches for several devastating and otherwise incurable lung diseases, including emphysema, pulmonary fibrosis, pulmonary hypertension, and the acute respiratory distress syndrome. Although initial studies suggested engraftment of exogenously administered stem cells in lung, this is now generally felt to be a rare occurrence of uncertain physiologic significance. However, more recent studies have demonstrated paracrine effects of administered cells, including stimulation of angiogenesis and modulation of local inflammatory and immune responses in mouse lung disease models. Based on these studies and on safety and initial ......
POSTED 08/31/2010 at 05:09 PM --
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Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM [Medical_Sciences]
Extracellular superoxide dismutase (ECSOD or SOD3) is highly expressed in lungs and functions as a scavenger of O2• . ECM... (Source: Proceedings of the National Academy of Sciences)...
POSTED 08/31/2010 at 02:17 PM --
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Finland's emphysema rates hold steady
NEW YORK (Reuters Health) - Finland's prevalence of chronic obstructive pulmonary disease (COPD), a group of serious lung diseases closely related to smoking, has held relatively steady in recent decades, a new study finds. (Source: Reuters: Health)...
POSTED 08/31/2010 at 02:04 PM --
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Secondhand smoke may provoke inflammatory response in lungs
Secondhand smoke is associated with a number of diseases and conditions, including cancer, heart disease and emphysema. It is an irritant to lung tissue and blood vessels, but the processes through which the body reacts to second-hand smoke is a mystery scientists are beginning to unravel. Researchers are now studying how second-hand smoke affects the lungs of rats. So far it appears that second-hand smoke triggers a complex inflammatory response. (Source: ScienceDaily Headlines)...
POSTED 08/27/2010 at 03:36 AM --
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Massive Subcutaneous Emphysema after Endoscopic Retrograde Cholangiopancreatography
Clinicians should be aware of the unusual but occasionally dramatic complications of common procedures. A 78-year-old woman underwent sphincterotomy followed by placement of a biliary stent for a retained common bile duct stone. She was subsequently asymptomatic, and presented for a follow-up endoscopic ultrasound and stent removal with endoscopic retrograde cholangiopancreatography. The presence of a peri-ampullary diverticulum made cannulation of the bile duct difficult. After repeated attempts, the duct was cannulated, with successful clearance of biliary sludge and good postprocedural drainage. (Source: The American Journal of Medicine)...
POSTED 08/27/2010 at 01:37 AM --
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Air quality advisory lifted for Alberta
The provincewide air quality health advisory issued on August 19 has been discontinued due to improved air quality and reduced drift of smoke from forest fires in British Columbia.
“The air quality has greatly improved this week throughout the province," said Dr. André Corriveau, Alberta’s Chief Medical Officer of Health. "If smoke does drift into Alberta from British Columbia it’s not expected to be at a level that would be hazardous to health. In the meantime, I advise anyone with asthma, bronchitis or emphysema to monitor local air quality conditions before planning any outdoor activities.” (Source: Alberta.ca from- Health and Wellness)...
POSTED 08/26/2010 at 04:35 PM --
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Pulmonary Interstitial Emphysema Complicating Pneumonia in an Unventilated Term Infant
Abstract A case of pulmonary interstitial emphysema with pneumothorax and pneumomediastinum complicating pneumonia in a 6-week-old
infant is reported. The patient had no history of resuscitation, bag and mask ventilation, nasal continuous positive airway
pressure or mechanical ventilation.
Content Type Journal ArticleDOI 10.1007/s12098-010-0154-6Authors
Hyun Seung Lee, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South KoreaSoo Ah Im, Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)...
POSTED 08/26/2010 at 01:19 PM --
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Noninvasive detection of pulmonary tissue destruction in a mouse model of emphysema using hyperpolarized (129)Xe MRS under spontaneous respiration.
This study is the first application of hyperpolarized (129)Xe MR spectroscopy to a mouse model of emphysema and shows that the V(s)/V(a) volume ratio is an effective biomarker for emphysema that could become useful in drug research and development through noninvasive detection of pathologic changes in small rodents. Magn Reson Med, 2010. (c) 2010 Wiley-Liss, Inc.
PMID: 20740664 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)...
POSTED 08/24/2010 at 06:00 PM --
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Comprehensive analysis of elastase-induced pulmonary emphysema in mice: Effects of ambient existing particulate matters.
Authors: Inoue KI, Koike E, Takano H
Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammation, cell damage, emphysematous change, and cholinergic reactivity in the lungs of mice. Furthermore, we evaluated the effects of pulmonary exposure to diesel exhaust particles (DEP) on the disease model. Intratracheal administration of PPE induced (1) proinflammatory response in the lungs that was characterized by significant infiltration of leukocytes such as macrophages, eosinophils, and lymphocytes and an increased level of interleuki......
POSTED 08/24/2010 at 06:00 PM --
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National Emphysema Treatment Trial redux: Accentuating the positive
Objective: Under the Freedom of Information Act, we obtained the follow-up data of the National Emphysema Treatment Trial (NETT) to determine the long-term outcome for âa heterogeneous distribution of emphysema with upper lobe predominance,â postulated by the NETT hypothesis to be optimal candidates for lung volume reduction surgery.Methods: Using the NETT database, we identified patients with heterogeneous distribution of emphysema with upper lobe predominance and analyzed for the first time follow-up data for those receiving lung volume reduction surgery and those receiving medical management. Furthermore, we compared the results of the NETT reduction surgery group with a previously reported consecutive case series of 250 patients undergoing bilateral lung volume reduction surgery us......
POSTED 08/20/2010 at 04:45 AM --
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B.C. smoke prompts Alberta air quality warning
Albertans are being advised to take precautions against potential health risks associated with deteriorating air quality across the province, caused by drifting smoke from forest fires in British Columbia.
“I strongly advise people with asthma, bronchitis or emphysema to remain indoors, keep their windows closed and take any preventative measures their physicians have previously recommended," said Dr. Andr? Corriveau, Alberta’s Chief Medical Officer of Health. "Healthy people should also avoid strenuous physical activity outdoors while the local air quality is bad. Anyone who experiences difficulty breathing should consult their physician.” (Source: Alberta.ca from- Health and Wellness)...
POSTED 08/19/2010 at 01:11 PM --
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Detection of radiation-induced lung injury in non-small cell lung cancer patients using hyperpolarized helium-3 magnetic resonance imaging.
CONCLUSIONS: This work demonstrates the feasibility of detecting ventilation changes between pre- and post-treatment using hyperpolarized helium-3 MRI for patients with NSCLC. Pre-treatment, the degree of emphysema and (3)He-MRI ventilation were correlated. For three cases of radiation pneumonitis, (3)He-MRI ventilation changes between pre- and post-treatment imaging were consistent with CT evidence of radiation-induced lung injury.
PMID: 20724011 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)...
POSTED 08/16/2010 at 06:00 PM --
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Pea sprouts in man's lung: Doctors find vegetable growing in pensioner
The retired teacher was already fighting emphysema when his health took a turn for the worse. (Source: the Mail online | Health)...
POSTED 08/13/2010 at 06:49 AM --
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Statin Reverses Smoke-induced Pulmonary Hypertension and Prevents Emphysema but not Airway Remodeling.
CONCLUSIONS: Simvastatin, as an intervention therapy, reverses the pulmonary vascular effects of cigarette smoke, including pulmonary hypertension, and prevents smoke-induced emphysema, but does not prevent small airway remodeling. This is the first demonstration that an intervention can reverse a COPD-associated cigarette smoke-induced anatomic abnormality. The study also shows the importance of examining all three anatomic lung compartments when assessing the effects of a potential drug intervention in patients with COPD.
PMID: 20709821 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)...
POSTED 08/12/2010 at 06:00 PM --
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Genome-wide Association Study Identifies BICD1 as a Susceptibility Gene for Emphysema.
CONCLUSIONS: Our study suggests that genetic variants in BICD1 are associated with qualitative emphysema in COPD. Variants in BICD1 are associated with length of telomeres, which suggests that a mechanism linked to accelerated aging may be involved in the pathogenesis of emphysema. Clinical Trials Registry Information: ID#NCT00292552 registered at www.clinicaltrials.gov.
PMID: 20709820 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)...
POSTED 08/12/2010 at 06:00 PM --
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Bilateral Pneumothorax and Subcutaneous Emphysema following Endoscopic Retrograde Cholangiopancreatography: A Rare Complication
We describe the case of a 68-year-old female who underwent elective ERCP for ductal stone clearance. Immediately postprocedure, the patient developed subcutaneous emphysema and bilateral pneumothoraces. Further imaging revealed the presence of free intra-abdominal air. The patient made a very quick recovery after bilateral chest drain insertion and no further intervention was required.
We propose that pneumothorax, pneumomediastinum, and subcutaneous emphysema during ERCP, in the absence of duodenal perforation may be explained by leakage of air from a site of low resistance such as the sphincterotomy site, or as a result of copious Valsalva manoeuvres performed by a patient tolerating the procedure poorly. (Source: Diagnostic and Therapeutic Endoscopy)...
POSTED 08/12/2010 at 03:31 AM --
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You cannot pea serious! Doctors amazed to find vegetable growing in pensioner's lung
The retired teacher was already fighting emphysema when his health took a turn for the worse. (Source: the Mail online | Health)...
POSTED 08/11/2010 at 08:19 PM --
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Unilateral Lung Intubation for Pulmonary Air Leak Syndrome in Neonates: A Case Series and a Review of the Literature
We report our experience of three cases of air leak syndrome in neonates, each treated with unilateral intubation, including two cases of recalcitrant pneumothorax. A review of the literature of similar neonatal cases is presented. In view of our experience and the review of the literature, we suggest that unilateral intubation is an efficient and relatively safe therapy in cases of neonatal air leak syndrome. It is also suggested that appropriate treatment duration should be at least 48 hours.[...]© Thieme Medical PublishersGet connected:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)...
POSTED 08/11/2010 at 08:18 PM --
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Emphysema presence, severity and distribution has little impact on the clinical presentation of a cohort of patients with mild to moderate COPD.
CONCLUSIONS: In patients with mild to moderate COPD, although the presence of emphysema has an impact on physiological presentation, its severity and distribution seem to have little impact on clinical presentation.
PMID: 20705800 [PubMed - as supplied by publisher] (Source: Chest)...
POSTED 08/11/2010 at 06:00 PM --
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