Angola: Diabetes Association Set Up in HuÃla
An Angolan Diabetes Association (ASDA) was set up on Tuesday, in Lubango City, in the southern HuÃla Province, aimed at warning, training and educating sufferers of this disease on how to fight against diabetes. (Source: AllAfrica News: Health and Medicine)...
POSTED 09/02/2010 at 01:56 AM --
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ACE I-ARB combination therapy not detrimental to severely hypertensive diabetics
Australian researchers suggest that combined ACE inhibitor and angiotensin receptor blocker antihypertensive therapy does not produce more renal damage than monotherapy with either drug in diabetes patients with severe hypertension. (Source: MedWire News - Diabetes)...
POSTED 09/02/2010 at 01:00 AM --
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Increased risk of death in men with insomnia and a short sleep duration
Men with chronic insomnia who slept for less than six hours were four times more likely to die during the 14-year follow-up period, according to a new study. Results were adjusted for potential confounders such as body mass index, smoking status, depression and obstructive sleep apnea. Further adjustments for hypertension and diabetes had little effect on the elevated mortality risk. No significant mortality risk was found in women with insomnia and a short sleep duration of less than six hours. (Source: ScienceDaily Headlines)...
POSTED 09/02/2010 at 01:00 AM --
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Bigger role for pharmacists planned
Pharmacies in Scotland will provide a five-star chronic medication service for patients with conditions like diabetes and high blood pressure (Source: Pharmacy Europe)...
POSTED 09/02/2010 at 12:54 AM --
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Deal watch: Metabolex and SanofiâAventis partner on GPCR agonists for type 2 diabetes
Nature Reviews Drug Discovery 9, 670 (2010). doi:10.1038/nrd3255
Metabolex has entered into an agreement with SanofiâAventis for the development of small molecules that target G protein-coupled receptor 119 (GPR119), the most advanced of which is in a Phase II trial for the treatment of type 2 diabetes (T2D). Metabolex will receive upfront and (Source: Nature Reviews Drug Discovery)...
POSTED 09/02/2010 at 12:50 AM --
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Variation in Quality of Care Indicators for Diabetes in a National Sample of Veterans and Non-Veterans
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)...
POSTED 09/01/2010 at 10:01 PM --
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Diabetes drug can reduce risk of cancer, researchers find
Metformin reduced the development of lung tumors in mice by more than 70%. Clinical trials on humans for lung, breast and prostate cancer are being organized.A growing body of evidence suggests that the widely used diabetes drug metformin can reduce the risk of cancer, researchers said Wednesday. (Source: Los Angeles Times - Science)...
POSTED 09/01/2010 at 06:45 PM --
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Sphingolipids as Signaling and Regulatory Molecules
series:Advances in Experimental Medicine and BiologyThis book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases. (Source: Springer Biomedical Sciences titles)...
POSTED 09/01/2010 at 06:13 PM --
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Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model.
Conclusion:
The presence of metabolic syndrome in patients with hypertension significantly inflates economic burden and costs are likely to increase in the future due to an aging population and an increase in the prevalence of components of metabolic syndrome. (Source: BMC Public Health - Latest articles)...
POSTED 09/01/2010 at 06:00 PM --
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Previous gestational diabetes impairs long-term endothelial function in a mouse model of complicated pregnancy
Women who develop gestational diabetes mellitis (GDM) display endothelial dysfunction up to 1 yr after pregnancy, despite a return to normoglycemia. It is unknown whether this dysfunction was preexisting or whether GDM pregnancy leads to long-term endothelial dysfunction. A mouse model that spontaneously develops GDM (Leprdb/+) was used to determine whether the endothelial dysfunction that develops during GDM is evident in later life. Heterozygous and wild-type (WT) controls were allowed to litter once, then age to 9–10 mo, and were compared with virgin controls. Vascular function of small mesenteric arteries was assessed using wire myography. Concentration response curves to the thromboxane A2mimetic U46619 and the endothelium-dependent vasodilator methacholine were constructed. Sup......
POSTED 09/01/2010 at 04:01 PM --
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Metabolic profiling of muscle contraction in lean compared with obese rodents
Interest in the pathophysiological relevance of intramuscular triacylglycerol (IMTG) accumulation has grown from numerous studies reporting that abnormally high glycerolipid levels in tissues of obese and diabetic subjects correlate negatively with glucose tolerance. Here, we used a hindlimb perfusion model to examine the impact of obesity and elevated IMTG levels on contraction-induced changes in skeletal muscle fuel metabolism. Comprehensive lipid profiling was performed on gastrocnemius muscles harvested from lean and obese Zucker rats immediately and 25 min after 15 min of one-legged electrically stimulated contraction compared with the contralateral control (rested) limbs. Predictably, IMTG content was grossly elevated in control muscles from obese rats compared with their lean counte......
POSTED 09/01/2010 at 04:01 PM --
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Maternal obesity and fetal metabolic programming: a fertile epigenetic soil
The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the increasing prevalence of metabolic diseases in younger children and adolescents. Infants born to obese, overweight, and diabetic mothers (even when normal weight) have increased adiposity and are at increased risk of later metabolic disease. In addition to maternal glucose, hyperlipidemia and inflammation may contribute to the childhood obesity epidemic through fetal metabolic programming, the mechanisms of which are not well understood. Pregravid obesity, when combined with normal changes in maternal metabolism, may magnify increases in inflammation and blood lipids, which can have profound effects on the developing embryo and the fetus in u......
POSTED 09/01/2010 at 04:01 PM --
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New Evidence That Fat Cells Are Not Just Dormant Storage Depots for Calories
September 1, 2010 (EurekAlert) - Scientists are reporting new evidence that the fat tissue in those spare tires and lower belly pooches â far from being a dormant storage depot for surplus calories â is an active organ that sends chemical signals to other parts of the body, perhaps increasing the risk of heart attacks, cancer, and other diseases.
read more (Source: Diabetes News from dLife.com)...
POSTED 09/01/2010 at 03:31 PM --
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New Study Singles out Factors Linked to Cognitive Deficits in Type 2 Diabetes
September 1, 2010 (EurekAlert) - Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association.
read more (Source: Diabetes News from dLife.com)...
POSTED 09/01/2010 at 03:24 PM --
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Diabetes drug shows potential as a cancer fighter
An inexpensive drug that's already used to treat type 2 diabetes could find new life as a cancer fighter, with two new studies suggesting it fights off colon cancer and even prevents lung cancer in smokers. (Source: CTV Health)...
POSTED 09/01/2010 at 01:23 PM --
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Charcot neuroarthropathy: An often overlooked complication of diabetes
In patients with long-standing, poorly controlled diabetes and peripheral neuropathy, a red, hot, swollen foot without open ulceration should raise the suspicion of Charcot neuroarthropathy, an often-overlooked diabetic foot complication. The authors discuss key diagnostic features and how to differentiate this condition from cellulitis, osteomyelitis, and other conditions. They review key elements of the workup and emphasize the importance of early diagnosis and prompt treatment to preserve a functioning foot. (Source: Cleveland Clinic Journal of Medicine)...
POSTED 09/01/2010 at 12:41 PM --
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Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women
CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life. (Source: Mayo Clinic Proceedings)...
POSTED 09/01/2010 at 12:01 PM --
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Balanced diet cuts heart risk
Conclusion
This well-conducted trial benefits from its relatively large size, accurate provision of the three randomised diets and high study completion rates (95%). It also featured a reliable study outcome by using the average of a series of blood pressure measures, which is preferable to relying on a single blood pressure reading.
The study found that eight weeks of the DASH diet, which was rich in fruit and vegetables and low in saturated fat, lowered blood pressure and cholesterol. This contributed to a decrease in predicted 10-year CHD risk. The DASH diet reduced this risk by 18% compared to a high-saturated fat âAmericanâ diet and by 11% compared to a diet similar to the American diet but with higher intake of fruit and vegetables.
Some points to note when interpreting this stud......
POSTED 09/01/2010 at 11:33 AM --
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Diabetes drug can reduce risk of cancer, researchers find
A growing body of evidence suggests that the widely used diabetes drug metformin can reduce the risk of cancer, researchers said Wednesday.
A study in mice exposed to tobacco carcinogens shows that the drug can reduce the development of lung tumors by... (Source: OrlandoSentinel: Medical Research)...
POSTED 09/01/2010 at 10:45 AM --
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Less is More: Study Shows That Teens Who Sleep Less Eat More Fatty Foods and Snacks
September 1, 2010 (EurekAlert) - A study in the Sept. 1 issue of the journal Sleep shows that teens who slept less than eight hours per weeknight ate higher proportions of fatty foods and snacks than adolescents who slept eight hours or more. The results suggest that short sleep duration may increase obesity risk by causing small changes in eating patterns that cumulatively alter energy balance, especially in girls.
read more (Source: Diabetes News from dLife.com)...
POSTED 09/01/2010 at 09:05 AM --
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