Clinical Chemistry and Laboratory Medicine 47 (S1): S13-S74 Abstract Cardiovascular diseases Clinical toxicology How to define and determine reference intervals and decision limits in laboratory medicine Biobanking concepts – need for an integrated European solution Vitamin D metabolites in cancer, immunological and cardiovascular diseases From stem cells to cardiovascular therapy Screening and identifying small to large molecules in clinical chemistry by mass spectrometry Quality management in Europe – implementation of ISO-15189 Diabetes mellitus, atherosclerosis, renal failure – ‘post translational pathologies’ Pediatric reference ranges Standardization activities in endocrinology Proteomics and human diseases Translational research: re-engineering the laboratory medicine ente......
POSTED 07/01/2009 at 01:41 PM --
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Diabetes mellitus
Clinical Chemistry and Laboratory Medicine 47 (S1): S189-S200 (Source: Clinical Chemistry and Laboratory Medicine)...
POSTED 07/01/2009 at 01:41 PM --
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Interferon Alpha Can Delay Full Onset Of Type I Diabetes, Phase II Trial Suggests
A low dose of oral interferon alpha shows promise in preserving beta cell function for patients with newly diagnosed type 1 diabetes, or juvenile diabetes, according to the results of a Phase II trial. (Source: ScienceDaily Headlines)...
POSTED 07/01/2009 at 01:19 PM --
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Rasch analysis informed the development of a classification system for a diabetes-specific preference-based measure of health
Conclusion: Results provide initial report of the validity and reliability of the CS of the DUI. (Source: Journal of Clinical Epidemiology)...
POSTED 07/01/2009 at 01:16 PM --
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Physical Fitness and Carotid Atherosclerosis in Men
Int J Sports MedDOI: 10.1055/s-0029-1224179AbstractWe investigated the association between cardiorespiratory fitness (CRF) and carotid atherosclerosis in 9 871 Korean men aged 40–81 years. We measured carotid intima-media thickness by using B-mode ultrasonography, and cardiorespiratory fitness was measured by a maximal treadmill exercise test using the Bruce protocol. Carotid atherosclerosis was defined as an intima-media wall thickness greater than 1.2 mm or stenosis >25% of carotid arteries, while CRF was classified as low fit (<20%), moderately fit (20-<60%), or high fit (≥60%) categories based on age-specific VO (ml/kg/min) percentiles. The presence of carotid atherosclerosis across CRF categories was 11.7% (low fit), 9.6%, and 7.7%, respectively.......
POSTED 07/01/2009 at 12:36 PM --
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Enalapril, Losartan May Have Retinal, but Not Renal, Benefits in Type 1 Diabetes
In a controlled trial, early blockade of the renin-angiotensin system did not slow the progression of nephropathy but slowed the progression of retinopathy in patients with type 1 diabetes. Medscape Medical News (Source: Medscape Today Headlines)...
POSTED 07/01/2009 at 11:38 AM --
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Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.
CONCLUSION: Our results suggest that lower ED diets do not prevent weight gain but have a weak yet potentially beneficial effect on the prevention of abdominal obesity as measured by waist circumference.
PMID: 19396357 [PubMed - indexed for MEDLINE] (Source: Cancer Control)...
POSTED 07/01/2009 at 11:18 AM --
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Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.
Authors: Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY
Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory distress syndrome, diabetes, thrombosis and cancer. An important mechanism underlying this process is increased paracellular leakage of plasma fluid and protein. Inflammatory stimuli such as histamine, thrombin, vascular endothelial growth factor and activated neutrophils can cause dissociation of cell-cell junctions between endothelial cells as well as cytoskeleton contraction, leading to a widened intercellular space that facilitates transendothelial flux. Such structural changes initiate with agonist-receptor binding, followed by activation of intracellular signalli......
POSTED 07/01/2009 at 11:18 AM --
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Preface
Although the overall health status of the pediatric population in the United States has improved, the last quarter century has witnessed a dramatic rise in the prevalence of childhood obesity and its associated comorbid conditions. Specifically, the medical community is witnessing a steady and alarming rise in the prevalence of chronic diseases among obese children, including diabetes, hypertension, obstructive sleep apnea, hyperlipidemia, and cardiovascular disease. (Source: Seminars in Pediatric Surgery)...
POSTED 07/01/2009 at 10:51 AM --
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Changes in physiology with increasing fat mass
Obesity has reached epidemic proportions in the USA with a nearly fourfold rise in the prevalence of childhood obesity. There are many possible etiologies of obesity as the adipose tissue plays a significant, complex role in the physiology of fuel metabolism and hormone regulation. The development of obesity represents a pathophysiologic increase in fat mass in which multiple metabolic pathways are deranged. The consequences of these metabolic derangements, including insulin resistance and inflammation, are reflected in obesity-related comorbidities and can be seen in the setting of pediatric obesity. Obese adolescents demonstrate increased rates of early maturation, orthopedic growth abnormalities, diabetes mellitus, obstructive sleep apnea, hypertension, steatosis, and polycystic ovarian......
POSTED 07/01/2009 at 10:51 AM --
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Use of the metabolic syndrome in pediatrics: a blessing and a curse
The clustering of traditional cardiovascular disease risk factors is known as the metabolic syndrome. The metabolic syndrome was first characterized as a distinct entity by Dr. Gerald Reaven in 1988. The intent was to identify individuals at greatest risk for cardiovascular disease mortality and those in urgent need of lifestyle intervention. Since then the metabolic syndrome has evolved into a diagnosable entity recognized by the National Cholesterol Education Program, Adult Treatment Panel III, World Health Organization, and the International Diabetes Foundation. However, the metabolic syndrome as a diagnosis faces considerable controversy, particularly when applied to the pediatric population. Due to the changes in growth and development, the adult criteria for the metabolic syndrome ca......
POSTED 07/01/2009 at 10:51 AM --
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Statins benefit low-risk patients
Study finds statins should be given to people with cardiovascular risk factors such as high blood pressure and diabetes (Source: Nursing in Practice)...
POSTED 07/01/2009 at 10:39 AM --
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FDA to Review Sanofi Drug's Safety
The FDA advised patients to continue taking Sanofi-Aventis's Lantus, despite recent studies showing the diabetes drug may be linked to cancer risks. (Source: WSJ.com: Health)...
POSTED 07/01/2009 at 10:30 AM --
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Low HDL cholesterol increases stroke risk for elderly Type 2 diabetics
Low high-density lipoprotein cholesterol levels increase the risk for stroke in elderly Type 2 diabetic individuals, show results from the Japan Cholesterol and Diabetes Mellitus Study. (Source: MedWire News - Diabetes)...
POSTED 07/01/2009 at 10:19 AM --
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A mixed record
Nature Reviews Drug Discovery 8, 521 (2009). doi:10.1038/nrd2943
The recent publication of a large clinical trial indicating that the diabetes drug rosiglitazone (Avandia; GlaxoSmithKline) does not increase the risk of cardiovascular morbidity and mortality seems unlikely to end the controversy over its safety. Overall, the story highlights the importance of risk communication in (Source: Nature Reviews Drug Discovery)...
POSTED 07/01/2009 at 10:16 AM --
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Diabetes patients miss out on vital checks
Almost a million patients with diabetes are not receiving the necessary NHS care, according to a new audit. (Source: Nursing Times Breaking News)...
POSTED 07/01/2009 at 08:21 AM --
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Heatwave Advice For Diabetics
Experts are predicting record-breaking temperatures this week, so it's important to take precautions to ensure that your diabetes remains well-controlled in this extreme weather. Long periods of inactivity in the sun can affect diabetes control, making blood glucose levels higher than usual. On the flipside, insulin will be absorbed more quickly from the injection site in hot weather and this increases the risk of hypos. (Source: Diabetes News From Medical News Today)...
POSTED 07/01/2009 at 07:00 AM --
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Two Thirds Of People With Diabetes Not Receiving Vital Health Checks, UK
The latest National Diabetes Audit has revealed that 60 per cent of people with diabetes in England do not receive all of their vital annual health checks including blood glucose, blood pressure and eye tests. (Source: Diabetes News From Medical News Today)...
POSTED 07/01/2009 at 07:00 AM --
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Latest Swine Flu Advice, UK
Since being declared a pandemic earlier this month, swine flu has continued to cause concern for many people across the world, not least those in high risk groups such as people with diabetes. Now renamed influenza A(H1N1), swine flu is a respiratory disease that could lead to complications such as bronchitis and pneumonia. (Source: Health News from Medical News Today)...
POSTED 07/01/2009 at 07:00 AM --
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PPD Confirms Takeda Receives FDA Complete Response For Alogliptin
PPD, Inc. (NASDAQ: PPDI) today announced that Takeda Pharmaceutical Company Limited issued a news release reporting that Takeda Global Research & Development Center, Inc., its wholly-owned U.S. subsidiary, has received a complete response letter from the U.S. Food and Drug Administration (FDA) regarding its new drug application (NDA) for alogliptin. (Source: Health News from Medical News Today)...
POSTED 07/01/2009 at 05:00 AM --
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