The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases
In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects. (Source: Journal of Biomedicine and Biotechnology)...
POSTED 03/09/2010 at 11:06 AM --
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Cholinesterase Inhibitors Do Not Exacerbate Postoperative Complications in Patients With Dementia
The risk of postoperative complications is not exacerbated by cholinesterase inhibitor therapy in elderly adults with dementia who receive general anesthesia during hip fracture surgery. Medscape Medical News (Source: Medscape Med Students Headlines)...
POSTED 03/09/2010 at 09:35 AM --
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Minorities' higher Alzheimer's risk
Francisca Terrazas and other Latinas are about 1.5 times more likely than Anglos to develop Alzheimer's and other forms of dementia, a new report says. Read how her family copes. (Source: CNN.com - Health)...
POSTED 03/09/2010 at 08:26 AM --
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Alzheimer's Association Honors Social Security Commissioner Michael Astrue With Humanitarian Award
Social Security Commissioner Michael Astrue is the recipient of the Alzheimer's Association's 2010 Humanitarian Award. The award is given each year to a public official who has made a significant contribution to help those who are struggling with Alzheimer's disease... (Source: Alzheimer's / Dementia News From Medical News Today)...
POSTED 03/09/2010 at 05:00 AM --
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Alzheimer's Association Honors Social Security Commissioner Michael Astrue With Humanitarian Award
Social Security Commissioner Michael Astrue is the recipient of the Alzheimer's Association's 2010 Humanitarian Award. The award is given each year to a public official who has made a significant contribution to help those who are struggling with Alzheimer's disease. This year, the award will be given to Commissioner Astrue in recognition of his exceptional leadership in creating the Compassionate Allowances Initiative and the decision to include early-onset Alzheimer's disease and other dementias in that initiative... (Source: Health News from Medical News Today)...
POSTED 03/09/2010 at 05:00 AM --
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African-Americans And Hispanics More Likely To Have Alzheimer's Disease And Dementia Than Whites
According to the Alzheimer's Association's® 2010 Alzheimer's Disease Facts and Figures, African-Americans are about two times more likely and Hispanics are about one and one-half times more likely than their white counterparts to have Alzheimer's and other dementias. Although whites make up the great majority of the more than five million people with Alzheimer's and other dementias, African-Americans and Hispanics are at higher risk for developing the disease... (Source: Health News from Medical News Today)...
POSTED 03/09/2010 at 05:00 AM --
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Has The Clock Struck 12 For Dimebon?
The Cinderella story eventually has a happy ending, but to revelers in the Dimebon story right now the time must feel like five past midnight. Some scientists have considered the sudden transformation of a modest hay fever medicine from Russia into the latest star in the AD drug development arena as a bit of a fairy tale all along. But it was hard for scientists and the media not to get swept up in the excitement over a young biotech company's $725 M dollar deal to develop Dimebon for a heart-breaking disease that has yet to see a truly effective treatment... (Source: Health News from Medical News Today)...
POSTED 03/09/2010 at 04:00 AM --
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Has The Clock Struck 12 For Dimebon?
The Cinderella story eventually has a happy ending, but to revelers in the Dimebon story right now the time must feel like five past midnight. Some scientists have considered the sudden transformation of a modest hay fever medicine from Russia into the latest star in the AD drug development arena as a bit of a fairy tale all along... (Source: Alzheimer's / Dementia News From Medical News Today)...
POSTED 03/09/2010 at 04:00 AM --
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Retrospective evaluation of revised criteria for the diagnosis of Alzheimer's disease using a cohort with post-mortem diagnosis
The criteria currently used to diagnose Alzheimer's disease (AD) require the presence of dementia, i.e. cognitive impairment sufficient to affect normal social and/or occupational function. Dubois et al. (Dubois et al., ) have recently proposed a set of revised criteria that may aid the diagnosis of the earlier stages of AD, and do not require the presence of dementia. We aimed to evaluate the new predementia-AD criteria through their retrospective application to the OPTIMA cohort with post-mortem (PM) confirmed diagnoses.The criteria were evaluated for sensitivity and specificity using cognitive, neuroimaging and cerebrospinal fluid data and clinical information for exclusion criteria. Limitations in choice of cognitive test, use of CT scans rather than MRI and missing CSFs affected the o......
POSTED 03/08/2010 at 06:00 PM --
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A Little Black Box to Jog Failing Memory
Researchers have tested the Sensecam, which contains a digital camera and an accelerometer, as an aid to people with Alzheimer’s disease and other memory disorders. (Source: NYT > Health)...
POSTED 03/08/2010 at 03:01 PM --
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Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation
Conclusions: Genealogic and molecular findings provided evidence that the PSEN1 Met146Leu families from around the world analyzed in this study are related and represent a single kindred originating from Southern Italy. The marked phenotypic variability might reflect early involvement by the pathologic process of different cortical areas. Although the clinical phenotype is quite variable, the neuropathologic and biochemical characteristics of the lesions account for neurodegenerative processes unmistakably of Alzheimer nature. (Source: Neurology)...
POSTED 03/08/2010 at 02:59 PM --
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Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
Conclusions: Higher Aβ deposition is associated with greater longitudinal decline in mental status and verbal memory in the preceding years. The differential association for verbal but not visual memory may reflect the greater reliance of verbal word list learning on prefrontal regions, which show early Aβ deposition. Prospective imaging may help distinguish between individuals with evolving neuropathology who develop accelerated cognitive decline vs those with normal aging. (Source: Neurology)...
POSTED 03/08/2010 at 02:59 PM --
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Vital Signs: Aging: Cognitive Decline and Hospitalization
A new study found that older people hospitalized for a critical condition had a statistically significant drop in scores on cognitive tests when compared with people who had not been hospitalized. (Source: NYT > Health)...
POSTED 03/08/2010 at 12:28 PM --
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16. Transcranial neuromodulation techniques for treatment of neurological and psychiatric disorders
Transcranial neuromodulation techniques (TNT), repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), are promising treatment methods in neurology and psychiatry. Although, in contrast to DBS in movement disorders or ECT in depression, the efficacy of TNT to treat neurological or psychiatric disorders has not been undoubtedly demonstrated yet, the potential advantages are considerable. TNT techniques avoid surgical risks and provide theoretical advantages of potential specific neural circuit modulation. So far, the most encouraging results have been reported in neuropathic pain and depression. In addition, promising are the results obtained in treatment of epilepsy, parkinsonism, dyskinesia, dystonia, hallucination, and tinnitus. There are i......
POSTED 03/08/2010 at 12:13 PM --
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23. Single photon emission computed tomography (SPECT) and DaTSCAN in diagnosis of parkinsonian syndromes
The role of nuclear medicine is functional brain imaging based on two strategies. A first approach is related to brain functional activity and energy metabolism and the second is related to the function of the chemically heterogeneous neurons. SPECT is nuclear medicine technique, presently widely used for imaging of neurovascular disorders, brain tumours, dementia, epilepsy, encephalitis, parkinsonism and various psychiatric diseases. Radiopharmaceuticals developed for SPECT can be categorized into a number of broad categories. Technetium-99m-labeled hexamethylpropyleneamineoxime (Tc-99m-HMPAO), and technetium-99m-labeled ethyl cysteinate dimer (Tc-99m-ECD) are widely used to visualize and to measure cerebral blood flow. 3-[(123)I]iodo-alpha-methyl-l-tyrosine ((I-123-IMT), Thallium-201 chl......
POSTED 03/08/2010 at 12:13 PM --
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24. Brain SPECT and PET imaging in the differential diagnosis of dementias
Aim: To study the usefulness of PET and SPECT in clinical practice in dementias. Using numerous specific radiotracers (99mTc-HMPAO, 99mTc-ECD, 18F-FDG, 123J-FP-CIT, 123J-IBZM, 123J-MIBG, 11C-PIB) SPECT or PET can visualize various aspects of brain function in differential diagnosis of dementia: brain perfusion, glucose metabolism, presynaptic and postsynaptic level of dopaminergic system integrity, amyloidal plaque imaging. 18F-FDG PET (cerebral metabolism) and perfusion SPECT are commonly used in clinical practice. Images of Alzheimer’s disease (AD) demonstrate hypometabolism (PET) and hypoperfusion (SPECT) involving especially the posterior cingulate and bilateral parietal and temporal association cortices. Frontotemporal dementia-hypometabolism and hypoperfusion in frontal cortex and ......
POSTED 03/08/2010 at 12:13 PM --
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Technology And Positive Attitudes Improving Older People's Lives
The population of the UK is ageing. Sixteen per cent of the UK population is 65 or older, and for the first time, there are more people over the age of 65 than there are under the age of 18. This raises a lot of questions on issues such as pension provision, health care and wellbeing... (Source: Alzheimer's / Dementia News From Medical News Today)...
POSTED 03/08/2010 at 05:00 AM --
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Major Depression More Than Doubles Risk Of Dementia Among Adults With Diabetes
Adults who have both diabetes and major depression are more than twice as likely to develop dementia, compared to adults with diabetes only, according to a study published in the recent Journal of General Internal Medicine. Dementia is the progressive decline of thinking and reasoning abilities. These can include memory loss, difficulty with basic math, wandering, living in the past, personality changes, and not recognizing familiar people. "Diabetes alone has shown to be a risk factor for dementia, as has major depression by itself," noted the lead author of the study, Dr... (Source: Health News from Medical News Today)...
POSTED 03/08/2010 at 04:00 AM --
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Major Depression More Than Doubles Risk Of Dementia Among Adults With Diabetes
Adults who have both diabetes and major depression are more than twice as likely to develop dementia, compared to adults with diabetes only, according to a study published in the recent Journal of General Internal Medicine. Dementia is the progressive decline of thinking and reasoning abilities... (Source: Diabetes News From Medical News Today)...
POSTED 03/08/2010 at 04:00 AM --
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Major depression more than doubles risk of dementia among adults with diabetes
Adults with both depression and diabetes are more than twice as likely to develop dementia compared to those with diabetes alone. Earlier studies have shown that depression alone is a risk factor for dementia, and that diabetes itself is a dementia risk factor. Researchers found even greater risk of dementia in people with both conditions. The mechanisms behind this increased risk are not yet clear. The researchers suggest that physicians screen and treat their diabetes patients for depression, which is common in people with diabetes. (Source: ScienceDaily Headlines)...
POSTED 03/08/2010 at 04:00 AM --
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