Distinct Demographic Profiles Between Crohn's Disease And Ulcerative Colitis
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up. A research article published on January 28, 2010 in the World Journal of Gastroenterology addresses this problem... (Source: Health News from Medical News Today)...
POSTED 02/08/2010 at 04:00 AM --
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Distinct Demographic Profiles Between Crohn's Disease And Ulcerative Colitis
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up... (Source: Crohn's News From Medical News Today)...
POSTED 02/08/2010 at 04:00 AM --
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[Treatment adherence and use of complementary and alternative medicine in patients with inflammatory bowel disease.]
Conclusions: Non-adherence and CAM use is common in patients with IBD. Special attention should be paid to explore the identified predictive factors during follow-up visits to improve adherence to therapy and improving patient-doctor relationship.
PMID: 20133244 [PubMed - in process] (Source: Orvosi Hetilap)...
POSTED 02/06/2010 at 09:46 PM --
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Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: A report of 46 cases.
CONCLUSION: Endoscopy contributes to the diagnosis of colonic schistosomiasis although it is nonspecific. A correct diagnosis of colonic schistosomiasis can be established by endoscopy in combination with its clinicopathologic characteristics.
PMID: 20135720 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 02/06/2010 at 06:26 PM --
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Missing Genes Linked to Extreme Obesity
Title: Missing Genes Linked to Extreme ObesityCategory: Health NewsCreated: 2/5/2010 10:53:00 AMLast Editorial Review: 2/5/2010 10:53:18 AM (Source: MedicineNet Crohn's Disease General)...
POSTED 02/05/2010 at 01:00 AM --
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Tests Show Top Tuna Brands Have High Mercury Levels
Title: Tests Show Top Tuna Brands Have High Mercury LevelsCategory: Health NewsCreated: 2/4/2010 4:10:00 PMLast Editorial Review: 2/5/2010 (Source: MedicineNet Crohn's Disease General)...
POSTED 02/05/2010 at 01:00 AM --
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Distinct demographic profiles between Crohn's disease and ulcerative colitis
(World Journal of Gastroenterology) A research team from United Kingdom conducted a large study on more than 2900 people who were hospitalized with severe Crohn's disease (CD) and ulcerative colitis (UC) in Wales. They found CD and UC have distinct demographic profiles. The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. (Source: EurekAlert! - Medicine and Health)...
POSTED 02/04/2010 at 11:00 PM --
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Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.
CONCLUSION: These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts.
PMID: 20128026 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 02/04/2010 at 10:10 PM --
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'Prewashed' Salads May Need Another Rinse
Title: 'Prewashed' Salads May Need Another RinseCategory: Health NewsCreated: 2/4/2010 10:35:00 AMLast Editorial Review: 2/4/2010 10:35:52 AM (Source: MedicineNet Crohn's Disease General)...
POSTED 02/04/2010 at 01:00 AM --
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Meta-analysis: Antibiotic therapy in Crohn's disease
Source: Clin Infect Dis
Area: News
Limited trial evidence suggests that long-term treatment with some antibiotics is effective in Crohn's disease, according to a systematic review and meta-analysis.
Crohn's disease may be associated with impaired innate immunity, and a number of bacteria have been implicated in its development and persistence. As a result, there has been interest in the use of antibacterial agents in treatment. The authors of this paper note that there has not been a published comprehensive review of this topic, and thus carried out a systematic review and meta-analysis to assess the evidence for effectiveness of antimicrobials in Crohn's.
They performed a comprehensive literature search without language restrictions for randomised placebo-controlled......
POSTED 02/03/2010 at 06:00 PM --
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The CD40-CD40L Pathway Contributes to the Proinflammatory Function of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
Authors: Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J
In inflammatory bowel diseases (IBD), intestinal epithelial cells (IECs) are involved in the outbalanced immune responses toward luminal antigens. However, the signals responsible for this proinflammatory capacity of IECs in IBD remain unclear. The CD40/CD40L interaction activates various pathways in immune and nonimmune cells related to inflammation and was shown to be critical for the development of IBD. Here we demonstrate CD40 expression within IECs during active IBD. Endoscopically obtained biopsies taken from Crohn's disease (n = 112) and ulcerative colitis patients (n = 67) consistently showed immunofluorescence staining for CD40 in IECs of in......
POSTED 02/03/2010 at 06:00 PM --
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Mycobacterium marinum infection complicated by anti-tumor necrosis factor therapy.
We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab. After starting ethambutol and rifampin and discontinuing infliximab a worsening appeared. M. marium infection may have a potential local spread and systemic dissemination in patients treated with TNF-alpha antagonists.
PMID: 20133411 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)...
POSTED 02/03/2010 at 06:00 PM --
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Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania
Conclusions:
During uptake by macrophages, Leishmania evades the activation of a broad range of cytokines and chemokines. Further, in the presence of a strong inflammatory stimulus, Leishmania suppresses certain proinflammatory cytokine responses in a parasite-specific manner, however it augments the production of other proinflammatory cytokines. Our findings highlight the complexity of inflammatory cytokine signalling regulation in the context of the macrophage and Leishmania interaction and confirm the utility of the Leishmania/ macrophage infection model as an experimental system for further studies of inflammatory regulation. Such studies may advance the development of therapies against inflammatory disease. (Source: Journal of Inflammation)...
POSTED 02/01/2010 at 06:00 PM --
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Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).Twenty-two percent had growth impairment (height for age Z-score (Source: Inflammatory Bowel Diseases)...
POSTED 02/01/2010 at 06:00 PM --
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New proteomic approaches for biomarker discovery in inflammatory bowel disease
There is an increasing interest in the discovery of new inflammatory bowel disease (IBD) biomarkers able to predict the future patterns of disease and to help in diagnosis, treatment, and prognosis. A biomarker is a substance that can be measured biologically and is associated with an increased risk of the disease. Biomarkers can be a genetic testing factor or proteins in biological samples such as serum, plasma, and cellular subpopulations. All of them should be studied to find out their utility in the management of IBD. Ulcerative colitis and Crohn's disease are relapsing and remitting chronic IBDs characterized by a global immune defect. The gold standard of their diagnosis is histological evaluation performed during endoscopic procedures. Several studies have focused on the identificat......
POSTED 02/01/2010 at 06:00 PM --
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Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine
No Abstract. (Source: Inflammatory Bowel Diseases)...
POSTED 02/01/2010 at 06:00 PM --
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Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn's Disease Patients
Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 ± 71 times in CD peripheral blood mononuclear cells (PBMCs). Flow cytometry experiments showed no correlation between mRNA and protein expression for SSTR5 in PBMCs. In an attempt to find a reason of such a high mRNA expression, SSTR5 present on CD PBMCs were tested and found as biologically active as on healthy cells. In biopsies of CD intestinal tissue, SSTR5 was not over-expressed but CCR7, unchanged in PBMCs, was over-expressed by 10 ± 3 times in the lamina......
POSTED 02/01/2010 at 11:18 AM --
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ACR Appropriateness Criteria® on Crohn's Disease
This article discusses the usefulness of both traditional and newer imaging techniques in the management of Crohn's disease and its various clinical presentations. (Source: Journal of the American College of Radiology : JACR)...
POSTED 02/01/2010 at 10:30 AM --
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Urinary Tract Infections in Children
Title: Urinary Tract Infections in ChildrenCategory: Diseases and ConditionsCreated: 2/1/2010 5:57:00 PMLast Editorial Review: 2/1/2010 5:57:10 PM (Source: MedicineNet Crohn's Disease General)...
POSTED 02/01/2010 at 01:00 AM --
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Optimizing the Use of Tumour Necrosis Factor Inhibitors in Crohns Disease: A Practical Approach
(Source: Drugs)...
POSTED 01/31/2010 at 08:05 PM --
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