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Congestive Heart Failure Medical and Health News Headlines
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All Recent Congestive Heart Failure Medical Condition News Headlines |
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Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism
Obstructive sleep apnoea (OSA) is a sleep disorder characterized by recurrent episodes of oxygen desaturation during sleep, representing an independent risk factor for cardiovascular disease, such as myocardial infarction, stroke, congestive heart failure and resistant hypertension. Several neurohormonal mechanisms have been suggested to account for blood pressure increases, such as sympathetic nervous system hyperactivity, oxidative stress, renin—angiotensin—aldosterone system (RAAS) activation, endothelin system activation, and endothelial dysfunction. The aim of this study was to evaluate the behaviour of RAAS and the presence of primary aldosteronism (PA) in these patients and possible correlations between RAAS and the severity of OSA. From October 2007 to November 2008 we ......
POSTED 09/01/2010 at 05:55 AM --
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Problems with combining esophagogastroduodenoscopy and colonoscopy to analyze risks of transient hypoxia from procedures in patients with risk factors for obstructive sleep apnea: a call for stratifying risks according to individual procedures
Obstructive sleep apnea is increasingly being diagnosed, and its cardiopulmonary risks are being increasingly elucidated, but the risks of GI endoscopy in patients with obstructive sleep apnea is previously unstudied. Thus the article by Khiani et al related to this subject is particularly welcomed and important. Khiani et al show no significant difference in the rates of transient hypoxia between relatively high-risk and relatively low-risk groups for obstructive sleep apnea. I have 2 comments about this article. First, the authors analyze patients at relatively high risk of obstructive sleep apnea but exclude patients with diagnosed obstructive sleep apnea and 2 other significant cardiopulmonary conditions, chronic obstructive pulmonary disease and congestive heart failure. Thus, their c......
POSTED 08/31/2010 at 06:00 PM --
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Response
We greatly appreciate Dr Cappell's insights and discussion of the strengths and weaknesses of our study. Obstructive sleep apnea is a condition that deserves attention in patients undergoing endoscopy. In particular, there are an increasing number of patients with undiagnosed obstructive sleep apnea who are undergoing endoscopy. While Dr Cappell is correct in stating that the overall prevalence of diagnosed obstructive sleep apnea may be around 3% to 7%, it has been estimated that the overall prevalence of obstructive sleep apnea in the U.S. population is approximately 20% with approximately 90% of all obstructive sleep apnea being undiagnosed. This is an under-recognized disease. Because there is a lack of literature on the percentage of patients at high risk for obstructive sleep apnea w......
POSTED 08/31/2010 at 06:00 PM --
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For people with congestive heart failure, a hot dog can trigger a trip to the hospital due to excessive salt
The average daily salt intake in America is one and 1/2 teaspoon a day. This is 3,400 milligrams of sodium a day, or 1,100 milligrams more then the recommended maximum.For people with congestive heart failure, a salty hot dog can trigger a trip to the hospital.The experts say the new target for sodium intake should be set at 1,500 milligrams daily.In a previous study, reducing dietary salt by 3 gm per day (1200 mg of sodium per day) was projected to reduce the annual number of new cases of coronary heart disease by 60,000 to 120,000, stroke by 32,000 to 66,000, and myocardial infarction by 54,000 to 99,000 and to reduce the annual number of deaths from any cause by 44,000 to 92,000. Such an intervention would be more cost-effective than using medications to lower blood pressure in all pers......
POSTED 08/31/2010 at 07:27 AM --
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Intrapersonal and Populational Heterogeneity of the Chemokine RANTES [Proteomics and Protein Markers]
CONCLUSIONS:
Because of widespread interest in the clinical value of RANTES, the protein diversity established here may aid in the design of future, fully quantitative assays. Equally important, an inclusive qualitative understanding of RANTES heterogeneity may present new insights into the relationship between RANTES and disease. (Source: Clinical Chemistry)...
POSTED 08/27/2010 at 02:02 PM --
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Bioheart Reports Significant Improvements in Heart Failure Patients from Center of Excellence Program
SUNRISE, Fla., Aug. 26 /PRNewswire-FirstCall/ -- Bioheart, Inc.,
(OTC Bulletin Board: BHRT) announces that the treatments and 3
month follow up with stem cell therapy on the first two congestive
heart failure patients has been performed successfully... (Source: Drugs.com - Clinical Trials)...
POSTED 08/27/2010 at 01:40 PM --
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Bioheart Reports Significant Improvements In Heart Failure Patients From Center Of Excellence Program
Bioheart, Inc., (OTC Bulletin Board: BHRT) announces that the treatments and 3 month follow up with stem cell therapy on the first two congestive heart failure patients has been performed successfully at Hospital Angeles Tijuana through its Center of Excellence, Regenerative Medicine Institute of Tijuana, Mexico. In March, Bioheart entered into an agreement to establish a Center of Excellence for the introduction of its therapies... (Source: Health News from Medical News Today)...
POSTED 08/27/2010 at 04:00 AM --
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Prognosis Assessment of Cardiac Involvement in Systemic AL Amyloidosis by Magnetic Resonance Imaging
Abstract: Background: Cardiac involvement is one of the most important prognostic factors in systemic AL amyloidosis. The aim of our study was to assess the role of cardiovascular magnetic resonance (CMR) imaging in prognosis evaluation in AL amyloidosis.Methods: We retrospectively analyzed 29 consecutive patients with AL amyloidosis who had undergone CMR. Clinical, laboratory, echocardiographic, and CMR characteristics were compared between CMR-positive (ie, with CMR signs of cardiac localization of AL amyloidosis) and CMR-negative patients. Univariate and multivariate analyses were performed to assess the prognostic value of positive CMR in comparison with other prognostic factors.Results: CMR was positive in 11 patients (38%). The overall survival rates for CMR-positive patients were 28......
POSTED 08/27/2010 at 01:37 AM --
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Optimizing Hemodynamics in Cardiac Resynchronization Therapy by Left Ventricular Pacing Site: You Find Only What You Are Looking Forâ
Cardiac resynchronization therapy (CRT) significantly improves the cardiac function, clinical outcomes, and survival of patients presenting with advanced, drug-refractory, congestive heart failure; left ventricular (LV) ejection fraction (Source: Journal of the American College of Cardiology)...
POSTED 08/27/2010 at 12:23 AM --
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Snoring and Obstructive Sleep Apnea.
Authors: Ulualp SO
Obstructive sleep apnea (OSA) may be associated with myriad clinical consequences such as increased risk of systemic hypertension, coronary vascular disease, congestive heart failure, cerebrovascular disease, glucose intolerance, impotence, obesity, pulmonary hypertension, gastroesophageal reflux, and impaired concentration. Nonetheless, OSA remains undiagnosed in 82% of men and 93% of women with the condition. Early identification and treatment of OSA provides significant relief for individuals, prevents complications of OSA, and reduces overall health care costs. Better understanding of the pathogenesis, risk factors, diagnosis, and treatment of OSA has the potential to improve early recognition of OSA and prevention of adverse effects on the individual and society......
POSTED 08/27/2010 at 12:12 AM --
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Acupuncture improves exercise tolerance of patients with heart failure: a placebo-controlled pilot study
Conclusion
Acupuncture may become an additional therapeutic strategy to improve the exercise tolerance of patients with CHF, potentially by improving skeletal muscle function. (Source: Heart)...
POSTED 08/26/2010 at 07:54 AM --
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Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling
Conclusions:
As a competitive inhibitor of MMP-9, SalB presents significant effects on preventing LV structural damage and preserving cardiac function. Further studies to develop SalB and its analogues for their potential for cardioprotection in clinic are warranted. (Source: BMC Pharmacology)...
POSTED 08/24/2010 at 06:00 PM --
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DHEA-S Levels and Cardiovascular Disease Mortality in Postmenopausal Women: Results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Conclusions: Among postmenopausal women with coronary risk factors undergoing coronary angiography for suspected myocardial ischemia, lower DHEA-S levels were linked with higher CVD mortality and all-cause mortality. Our study provides valuable feasibility data useful for future investigations and possible mechanistic pathways.
PMID: 20739385 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 08/24/2010 at 06:00 PM --
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Predictors of Major Morbidity and Mortality After Pneumonectomy Utilizing The Society for Thoracic Surgeons General Thoracic Surgery Database [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions
The mortality rate after pneumonectomy by thoracic surgeons participating in the STS database compares favorably to that in previously published studies. We identified risk factors for major adverse outcomes in patients undergoing pneumonectomy. (Source: The Annals of Thoracic Surgery)...
POSTED 08/24/2010 at 03:35 PM --
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Real-time stroke volume measurements for the optimization of cardiac resynchronization therapy parameters
Conclusion
Real-time SV measurements can be used to optimize CRT at the time of implant. Improvement in SV correlates with improvement in LVEF, LVEDD, and 6 min walk, and improvement in echocardiographic dyssynchrony. (Source: Europace)...
POSTED 08/24/2010 at 11:04 AM --
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Positive Airway Pressure in Congestive Heart Failure
Congestive heart failure (CHF) is a common disabling and costly condition, which is responsible for most hospital admissions and has a mortality rate on par with many malignancies. In recent years, positive airway pressure (PAP) has emerged as a novel therapeutic tool for pneumatically splinting open the sleep-related upper airway collapse; increasing lung volume, thereby increasing oxygen storage; and reducing the pressure gradient across the left ventricular wall, thereby reducing afterload. Strong evidence exists of physiologic efficacy and improved survival with PAP in acute pulmonary edema. Good evidence exists of physiologic improvement with PAP in chronic CHF associated with obstructive or central sleep apnea; however, good quality survival data are lacking. (Source: Sleep Medicine ......
POSTED 08/24/2010 at 04:32 AM --
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Cardiac Toxicity From Systemic Cancer Therapy: A Comprehensive Review
Abstract: Cardiovascular toxicity is a potential short- or long-term complication of anticancer therapy. Exposure to chemotherapy medications, primarily the anthracycline class, can lead to potentially irreversible clinically significant cardiac dysfunction. The advent of novel biologic agents, including monoclonal antibodies and tyrosine kinase inhibitors, has revolutionized the treatment of several types of malignancies. Although targeted therapies are considered less toxic and better tolerated by patients compared with classic chemotherapy agents, rare serious complications have been observed; and longer-term follow-up is needed to determine the exact profile of related cardiac adverse effects. Cardiac toxicity associated with cancer therapies can range from asymptomatic subclinical abn......
POSTED 08/24/2010 at 12:28 AM --
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Does serum lactate predict death in drug overdose?
2.5 out of 5 stars
Utility of serum lactate to predict drug-overdose fatality. Manini AF et al. Â Clin Toxicol 2010 Aug 12. [Epub ahead of print]
Abstract
This derivation study was designed to evaluate the usefulness of serum lactate in identifying acute drug overdose patients at increased risk of death. Â The authors compared 50 poison-related fatalities (collected from cases reported to a regional poison control center over a 7-year period) with 100 controls (acute non-fatal drug overdose patients seen in 2 emergency departments over a 1-year period). Â All cases and controls had at least 1 serum lactate drawn in the emergency department; only the initial lactate was used for analysis.
The authors concluded that their data indicated a lactate level of 3.0 mmol/L was the optimal cutoff (s......
POSTED 08/23/2010 at 09:44 AM --
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A Systolic Parameter Defined as the Ratio of Brachial Pre-Ejection Period to Brachial Ejection Time Predicts Cardiovascular Events in Patients With Chronic Kidney Disease.
Conclusions: The study findings show that bPEP/bET is a useful predictor of CV events in CKD patients. Screening CKD patients by means of bPEP/bET might help to identify patients at high risk of increased CV events.
PMID: 20736503 [PubMed - as supplied by publisher] (Source: Circulation Journal)...
POSTED 08/20/2010 at 06:00 PM --
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Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias
Conclusion
Heterogeneous Cx43 expression during CHF is associated with dispersed impulse conduction and may underlie enhanced susceptibility to ventricular tachyarrhythmias. (Source: European Journal of Heart Failure)...
POSTED 08/20/2010 at 11:10 AM --
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