Bipolar being diagnosed younger
This week, Dr. Charles Raison offers part two of his answer to the viewer question: Can a 9- or 10-year-old be bipolar? (Source: CNN.com - Health)...
POSTED 03/09/2010 at 07:50 AM --
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One-Page Questionnaire Is Effective Screening Tool For Common Psychiatric Disorders
A one-page, 27-item questionnaire that is available free online is a valid and effective tool to help primary care doctors screen patients for four common psychiatric illnesses, a study led by University of North Carolina at Chapel Hill researchers concludes. Results of the My Mood Monitor (M-3) checklist study are published in the March/April 2010 issue of Annals of Family Medicine... (Source: Bipolar News From Medical News Today)...
POSTED 03/09/2010 at 03:00 AM --
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Distorted self-representation uncommon in euthymic BD patients
Previous observations of distorted self-representation in clinical samples of patients with bipolar disorder may represent a scar of previous depressive or manic episodes rather than act as a predisposing factor, say UK researchers who found no strong evidence of increased distorted self-representation in a sample of BD individuals. (Source: MedWire News - Psychiatry)...
POSTED 03/08/2010 at 06:00 PM --
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Behavioral addictions linked to bipolar disorder
Patients with bipolar disorder are at increased risk for behavioral addictions, researchers have found. (Source: MedWire News - Bipolar Disorder)...
POSTED 03/08/2010 at 12:19 PM --
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What Media Is Saying About Bipolar Pentagon Shooter
John Patrick Bedell, who began shooting at Pentagon guards on Thursday and was killed by return fire, had bipolar disorder and had been in and out of treatment for years, according to his family. His mother had notified police in January that her son was mentally ill and had purchased a gun.
Some of the news reports I found were careful to point out that people with bipolar disorder are no more likely than others to commit violent crimes, which is a good thing. Many others focus on Bedell's anti-government "rantings" on the internet, as well as the way conservatives and liberals are pointing fingers at each other over the incident.
On the other hand, there are editorials like the Kansas City Star's Will 2010 Be Year of the 'Nut Job'?. This was published the day after the shootings, befor......
POSTED 03/08/2010 at 09:26 AM --
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The Observer-Rated Scale for Mania (ORSM): development, psychometric properties and utility
Conclusion: The ORSM is a useful instrument to help non-professionals who are in regular contact with the patient diagnosed a manic/mixed episode. It thus complements existing rating scales for mania, which are either designed for professionals or are self-rating instruments. (Source: Journal of Affective Disorders)...
POSTED 03/08/2010 at 09:14 AM --
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Response to intravenous antidepressant treatment by suicidal vs. nonsuicidal depressed patients
Conclusions: Being suicidal may limit response to treatment in depressed major affective disorder patients, independent of diagnosis or overall symptomatic severity. (Source: Journal of Affective Disorders)...
POSTED 03/08/2010 at 09:14 AM --
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The incidence of cardiovascular morbidity among patients with bipolar disorder: A population-based longitudinal study in Ontario, Canada
Abstract: Background: Despite the high rates of cardiovascular risk factors among people with bipolar disorder, little is known about the incidence of cardiovascular morbidity in this population.Methods: Based upon Ontario, Canada hospital discharge records from April 1, 2002 to March 31, 2006, we constructed a population-based cohort study to assess whether individuals diagnosed with bipolar disorder (n=5999) would have a significantly greater risk of subsequent readmission with a cardiovascular condition in comparison to a matched population-proxy group of individuals receiving an appendicitis primary diagnosis. A Cox regression procedure was used to estimate group differences in time-to-readmission with a cardiovascular-related diagnosis. Patients were followed for a period up to 4 yea......
POSTED 03/08/2010 at 09:14 AM --
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Efficacy of ziprasidone in dysphoric mania: Pooled analysis of two double-blind studies
Abstract: Background: Dysphoric mania is a common and often difficult to treat subset of bipolar mania that is associated with significant depressive symptoms.Objective: This post hoc analysis was designed to evaluate the efficacy of ziprasidone in the treatment of depressive and other symptoms in a cohort of patients with dysphoric mania.Methods: Pooled data were examined from two similarly designed, 3-week placebo-controlled trials in acute bipolar mania. Patients scoring ≥2 on at least two items of the extracted Hamilton Rating Scale for Depression (HAM-D) met criteria for dysphoric mania and were included in the post hoc analysis. Changes from baseline in symptom scores were evaluated by a mixed-model analysis of covariance.Results: 179 patients with dysphoric mania were included in ......
POSTED 03/08/2010 at 09:14 AM --
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Suicide attempt characteristics may orientate toward a bipolar disorder in attempters with recurrent depression
Conclusion: Serious suicide attempt and a familial history of completed suicide in patients with major depression seem to be a clinical marker of bipolarity. Facing suicide attempters with recurrent depression, clinician should be awareness to these characteristics to detect BPD. (Source: Journal of Affective Disorders)...
POSTED 03/08/2010 at 09:14 AM --
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Valproate for the treatment of acute bipolar depression: Systematic review and meta-analysis
Conclusions: Valproate is effective for the reduction of depressive symptoms of acute bipolar depression, and was well tolerated. (Source: Journal of Affective Disorders)...
POSTED 03/08/2010 at 09:14 AM --
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A genome-wide linkage study of bipolar disorder and co-morbid migraine: Replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11
Abstract: Migraine and Bipolar Disorder (BPAD) are clinically heterogeneous disorders of the brain with a significant, but complex, genetic component. Epidemiological and clinical studies have demonstrated a high degree of co-morbidity between migraine and BPAD. Several genome-wide linkage studies in BPAD and migraine have shown overlapping regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association studies, respectively. We hypothesized that using migraine co-morbidity to look at subsets of BPAD families in a genetic linkage analysis would prove useful in identifying genetic susceptibility regions in both of these diso......
POSTED 03/08/2010 at 09:14 AM --
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Author index
(Source: Bipolar Disorders)...
POSTED 03/07/2010 at 06:00 PM --
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Have You Read "An Unquiet Mind"?
If you haven't, you should. Everyone who experiences mania and depression will benefit from reading this book. Every doctor, judge, police officer and criminal or family attorney should be required to read it. And every family member and friend of someone diagnosed with manic depression, especially bipolar I and II disorders, or of someone exhibiting the symptoms, will gain from reading Kay Redfield Jamison's courageous autobiography.
Attorney and author Melody Moezzi, on National Public Radio's You Must Read This, said "An Unquiet Mind is, without a doubt, the most brilliant and brutally honest book I've ever read about bipolar disorder (formerly known as manic-depression). I've read nothing else that has better captured the torment and elation of this strange illness, nor have I ever fe......
POSTED 03/07/2010 at 06:00 PM --
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[Valproate induced hypoactive delirium in a bipolar disorder patient with psychotic features.]
In conclusion, valproate can induce delirium at therapeutic blood levels in some patients via various mechanisms and this side effect has to be considered during valproate use.
PMID: 20204907 [PubMed - in process] (Source: Turkish Journal of Psychiatry)...
POSTED 03/06/2010 at 11:14 AM --
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Defect annealing in neutron and ion damaged silicon: Influence of defect clusters and doping
R. M. Fleming, C. H. Seager, E. Bielejec, G. Vizkelethy, D. V. Lang et al. We have explored defect annealing in radiation damaged silicon in a regime characterized by defect clusters and higher doping. Several types of pnp and npn Si bipolar transistors have been irradiated with ions and neutrons, then isochronally annealed from 300 to 600 K to study the evolution of deep ... [J. Appl. Phys. 107, 053712 (2010)] published Fri Mar 5, 2010. (Source: Journal of Applied Physics)...
POSTED 03/06/2010 at 10:15 AM --
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A Bipolar Mom's Story
During my first manic episode I hid with my daughter in the attic fearing Mafia hit men. During the second I conversed with God. All told I've been hospitalized four times for mania. My husband has been my rock throughout our lives together, even when we feared Lithium might cause our unborn child to have birth defects. (Source: About.com Bipolar Disorder)...
POSTED 03/05/2010 at 06:00 PM --
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Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia
Negative symptoms encompass diminution in emotional expression and motivation, some of which relate to human attributes that may not be accessible readily in animals. Additionally, their refractoriness to treatment precludes therapeutic validation of putative models. This review considers critically the application of mutant mouse models to the study of the pathobiology of negative symptoms. It focuses on 4 main approaches: genes related to the pathobiology of schizophrenia, genes associated with risk for schizophrenia, neurodevelopmental-synaptic genes, and variant approaches from other areas of neurobiology. Despite rapid advances over the past several years, it is clear that we continue to face substantive challenges in applying mutant models to better understand the pathobiology of neg......
POSTED 03/05/2010 at 01:18 PM --
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Behavioral addictions linked to bipolar disorder
Patients with bipolar disorder are at increased risk for behavioral addictions, researchers have found. (Source: MedWire News - Psychiatry)...
POSTED 03/05/2010 at 10:49 AM --
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[News Focus] Psychiatry: Anything But Child's Play
An alternative to juvenile bipolar disorder and a reorganization of autism-related disorders are among the controversial changes proposed for the fifth editionof psychiatrists' bible, the Diagnostic and Statistical Manual of Mental Disorders.Author: Greg Miller (Source: Science: Current Issue)...
POSTED 03/05/2010 at 10:02 AM --
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