Predictors of Placebo Responses in Bipolar Treatment Trials Identified
Symptomatic improvement over baseline was similar in the placebo groups in a meta-analysis of placebo-controlled trials, regardless of whether or not the active drug proved effective. Medscape Medical News (Source: Medscape Today Headlines)...
POSTED 09/01/2010 at 11:05 AM --
|
Best Practices: Disseminating Best Practices for Bipolar Disorder Treatment in a Correctional Population [Columns]
Use of medication treatment algorithms may facilitate clinical decision making, improve consistency, and reduce polypharmacy in the correctional setting. A feasibility study was conducted investigating use of Texas Implementation of Medication Algorithms (TIMA) guidelines for bipolar disorder in the Connecticut Department of Correction. Forty inmates with diagnoses of bipolar disorder were treated over a 12-week period adhering to the TIMA algorithm for bipolar disorder. Significant improvement was seen in the primary and secondary outcome measures (p<.001). This pilot project confirmed the feasibility of algorithm adaptation to the correctional setting and provided specific recommendations for successful dissemination of the TIMA algorithm for bipolar disorder in correctional settings.......
POSTED 09/01/2010 at 08:00 AM --
|
Findings of a U.S. National Cardiometabolic Screening Program Among 10,084 Psychiatric Outpatients [Articles]
CONCLUSIONS: The prevalence of metabolic syndrome and cardiometabolic risk factors, such as overweight, hypertension, dyslipidemia, and glucose abnormalities, was substantial and frequently untreated in this U.S. national mental health clinic screening program. (Source: Psychiatr Serv)...
POSTED 09/01/2010 at 08:00 AM --
|
Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients
This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD.Method: Serum GDNF concentrations were measured in BD patients before treatment, after 8weeks of drug treatment, and in control subjects using a sandwich ELISA method.Results: Before treatment, serum GDNF was significantly lower in BD patients during both manic (P (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample
Abstract: Background: In the present study we investigated genetic variants associated with bipolar disorder in a homogenous Norwegian sample, and potential genetic overlap with schizophrenia, using the Affymetrix 6.0 array.Methods: We carried out a genome-wide association study (GWAS) by genotyping 620 390 single-nucleotide polymorphisms (SNPs) in a case-control sample of Norwegian origin (the TOP study) including bipolar disorder (n=194), healthy controls (n=336) and schizophrenia (n=230), followed by replication and combined analysis in a genetically concordant Icelandic sample of bipolar disorder (n=435), and healthy controls (n=10,258).Results: We selected 1000 markers with the lowest P values in the TOP discovery GWAS and tested these (or their surrogates) for association in the Icel......
POSTED 09/01/2010 at 01:56 AM --
|
Dissimilar morbidity following initial mania versus mixed-states in type-I bipolar disorder
Abstract: Background: Mixed-states of bipolar disorders (BPD) may predict worse future illness and more depressive than manic morbidity, challenging a tendency to conflate mixed-states and mania.Methods: Patients (N=247) were followed-up systematically for 24months following hospitalization for initial major episodes of DSM-IV type-I BPD and scored for weekly interval morbidity-types.Results: Overall morbidity during follow-up was 1.6-times greater following mixed (n=97) versus manic (n=150) first-episodes of BPD (60.0 vs. 37.8%-of-weeks; p (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
Manic symptoms in patients with depressive and/or anxiety disorders
Conclusions: Identifying lifetime manic symptoms with the MDQ in persons presenting with (unipolar) depressive or anxiety disorders, can not only help the recognition of actual bipolar disorder (as described in previous studies), but also the identification of a subgroup of patients with more severe symptomatology, more comorbid anxiety and alcohol dependence disorders, and more suicidality. (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
Emotional and affective temperament in 23 professional areas
Conclusions: Professional areas and educational level are associated with distinct emotional and affective profiles. (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
Postpartum bipolar episodes are not distinct from spontaneous episodes: Implications for DSM-V
Conclusion: The role of postpartum onset as a DSM course modifier should be reconsidered, as it seems to have no impact on prognosis or functioning. (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
Bipolar disorder with frequent mood episodes in the New Zealand Mental Health Survey
Abstract: Background: Rapid cycling bipolar disorder has been studied almost exclusively in clinical samples.Methods: A national cross-sectional survey in 2003â2004 in New Zealand used the Composite International Diagnostic Interview (CIDI 3.0). Diagnosis was by DSM-IV. Depression severity was assessed with the Quick Inventory of Depressive Symptoms (QIDS) and role impairment using Sheehan Scales. Complex survey analyses compared percentages and means, and used logistic regression and discrete-time survival analyses. Frequent mood episodes (FMEs) in the past 12months (4+) were used as an indicator of rapid cycling.Results: The lifetime prevalence of bipolar disorder (I + II) was 1.7%. Twelve-month prevalence was 1.0%: 0.3% with FME and 0.7% with No FME (1â3 episodes). Another 0.7% had ......
POSTED 09/01/2010 at 01:56 AM --
|
Access to weight loss counseling services among patients with bipolar disorder
Abstract: Background: Cardiovascular disease is the leading cause of mortality in persons with bipolar disorder but little is known about utilization of services for risk reduction. We assessed determinants of access to weight counseling in a sample of patients with bipolar disorder.Methods: Patients enrolled in the Continuous Improvement for Veterans in Care: Mood Disorders (CIVIC-MD), a prospective study conducted from July 2004âJuly 2006. Patient data were obtained from a baseline questionnaire and chart review.Results: Out of 298 patients, 73% received some weight counseling, with utilization more likely for those with higher BMI (OR=1.12, p (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
How effective is a psychological intervention program for patients with refractory bipolar disorder? A randomized controlled trial
Abstract: Background: The aim of this research was to evaluate the short-term and long-term efficacy of a combined treatment (pharmacological + psychoeducational and cognitive-behavioral therapy) as compared with a standard pharmacological treatment in patients with refractory bipolar disorder.Method: 40 patients were randomly assigned to one of the following: Experimental group under combined treatment, and Control group under pharmacological treatment. We used an analysis of variance (ANOVA), including one or two factors, with repeated measures at different evaluation times: baseline, post-treatment, 6-month follow-up and 12-month follow-up.Results: We found significant between-group differences at all evaluation times after the treatment. The experimental group showed less hospitalizati......
POSTED 09/01/2010 at 01:56 AM --
|
Symptoms and signs of the initial prodrome of bipolar disorder: A systematic review
Conclusions: The initial prodrome of BD is characterized by dysregulation of mood and energy. Because of the apparently low specificity of prodromal symptoms and signs of BD, it is currently neither possible nor advisable to predict the development of BD based solely on early phenomenology. More well-designed in-depth studies, including qualitative ones, are needed to characterize the initial bipolar prodrome. (Source: Journal of Affective Disorders)...
POSTED 09/01/2010 at 01:56 AM --
|
Remitted bipolar disorder patients have ânormalâ reactivity to daily events
Results from a Dutch study suggest that mood reactions to daily events are similar between bipolar disorder patients who have achieved remission and mental healthy individuals. (Source: MedWire News - Psychiatry)...
POSTED 08/31/2010 at 07:00 PM --
|
Bipolar (2008) - psychiatry in pictures [EXTRAS]
(Source: The British Journal of Psychiatry)...
POSTED 08/31/2010 at 05:00 PM --
|
Group-based psychosocial intervention for bipolar disorder [Correspondence]
(Source: The British Journal of Psychiatry)...
POSTED 08/31/2010 at 05:00 PM --
|
The course of bipolar disorder [Articles]
Bipolar disorder is arguably a pivotal diagnosis in adult psychiatry bounded by schizophrenia on one side and unipolar depression on the other. It represents a wide spectrum of disorders, all sharing common features of elated and depressed mood. The early descriptions of symptom-free euthymia have long been dismissed and the chronic and enduring deficits associated with the disorder are beginning to be better understood. We review the current literature with regard to the course of the disorder, factors that may influence prognosis and common comorbidities. (Source: Advances in Psychiatric Treatment)...
POSTED 08/31/2010 at 05:00 PM --
|
Bipolar Disorder or Substance-Induced Mood Disorder in an Adolescent?
Journal of Child and Adolescent Psychopharmacology Aug 2010, Vol. 20, No. 4: 343-346. (Source: Journal of Child and Adolescent Psychopharmacology)...
POSTED 08/31/2010 at 02:28 PM --
|
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes
In conclusion, MCAK appears to possess a unique distribution and function in oocyte maturation. It is required for meiotic progression from meiosis I to meiosis II associated with silencing of the spindle assembly checkpoint. Alterations in abundance and activity of MCAK, as implicated in aged oocytes, may therefore contribute to the loss of control of cell cycle and chromosome behaviour, thus increasing risk for errors in chromosome segregation and aneuploidy. (Source: Molecular Human Reproduction)...
POSTED 08/31/2010 at 09:26 AM --
|
Forest Laboratories, Inc. And Gedeon Richter Plc Announce Results From A Phase II Study Of Cariprazine For The Treatment Of Bipolar Depression
Forest Laboratories, Inc. (NYSE: FRX) and Gedeon Richter Plc. today announced preliminary top-line results from an 8-week Phase II clinical trial of the novel, investigational antipsychotic agent cariprazine for the treatment of bipolar depression. Cariprazine is currently undergoing Phase III trials for separate indications of schizophrenia and bipolar mania. A total of 233 patients were randomized to enter one of two active (low dose or high dose) treatment arms or placebo. The primary endpoint was the Montgomery Asberg Depression Rating Scale (MADRS) score... (Source: Health News from Medical News Today)...
POSTED 08/31/2010 at 05:00 AM --
|
