Better Classification And Treatment Of Juvenile Arthritis Via Gene Expression
Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA). (Source: Health News from Medical News Today)...
POSTED 07/01/2009 at 02:00 AM --
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Infants should be screened for hip trouble
(American Academy of Orthopaedic Surgeons) Developmental hip dysplasia is the most common congenital defect in newborns. The condition occurs when a hip joint is shallow, unstable or when the joint is dislocated. Infants with the condition are often at risk of developing arthritis of the hip as a young adult. A new study published in the July 2009 issue of the Journal of Bone and Joint Surgery finds that screening all infants for hip dysplasia can significantly decrease their chance of developing early arthritis. (Source: EurekAlert! - Medicine and Health)...
POSTED 06/30/2009 at 11:00 PM --
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Trends and determinants of adequate gastroprotection in patients chronically using NSAIDs
To identify determinants and trends of gastroprotection in patients chronically using NSAIDs.Design: retrospective cohort study. Data source: Agis Health Database (AHD) containing annual prescription records of approximately 1.5 million patients. Patients: All patients using more than 180 daily defined doses (DDD) annually, of any NSAID from 2001 to 2007. Main outcome measures: prevalence of NSAID use, adequate prescription of gastroprotective drugs (PPI, misoprostol or COX-2 inhibitor use), determinants of adequate gastroprotection.The percentage of patients chronically using NSAIDs rose from 7.3% of the total NSAIDs users in 2001 to 7.5% in 2007. The percentage of patients on NSAIDs receiving adequate gastroprotective medication in line with actual guidelines increased from 39.6% in 2001......
POSTED 06/30/2009 at 06:00 PM --
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AstraZeneca Development Partner, Pozen, Inc., Submits New Drug Application for PN400
AstraZeneca announced that its development partner, Pozen, Inc., has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for VIMOVO (PN400) (enteric coated naproxen/esomeprazole magnesium) tablets, a product under investigation for the treatment of the signs and symptoms of osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) in patients who are at risk of developing NSAID-associated ulcers. (Source: World Pharma News)...
POSTED 06/30/2009 at 06:00 PM --
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Knee replacement 'cost-effective for osteoarthritis patients'
Total knee replacement surgery is a cost-effective solution for people with osteoarthritis, new research has shown. (Source: Arthritis Research Campaign)...
POSTED 06/30/2009 at 06:00 PM --
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New psoriatic arthritis drug shows positive results in Phase II trial
Apremilast has shown good results for the treatment of psoriatic arthritis in a Phase II clinical trial. (Source: Arthritis Research Campaign)...
POSTED 06/30/2009 at 06:00 PM --
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Depression screening 'should be offered to arthritis patients'
People with arthritis and other rheumatic diseases should be screened for depression, Canadian researchers suggest. (Source: Arthritis Research Campaign)...
POSTED 06/30/2009 at 06:00 PM --
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Antibodies to cyclic citrullinated protein and erythrocyte sedimentation rate predict hand bone loss in patients with rheumatoid arthritis of short duration: a longitudinal study
Conclusions:
Anti-CCP and ESR were found to be independent predictors of early localised BMD loss. This finding adds to the understanding of anti-CCP and ESR as important predictors of bone involvement in RA. (Source: Arthritis Research and Therapy)...
POSTED 06/30/2009 at 06:00 PM --
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Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity
Conclusions:
SpA patients exhibit high levels of circulating sCTLA-4 that may result from an alternative splicing of CTLA-4 transcripts. This may influence immune activation and regulation in SpA. (Source: Arthritis Research and Therapy)...
POSTED 06/30/2009 at 06:00 PM --
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Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids
Considerable interest exists in endogenous peptides as potential biomarkers, since they act as signaling molecules and are formed by degradation of proteins. A crucial step in the profiling of these peptides is the sample preparation, which aims to enrich the low-abundant peptides, while removing interfering matrix compounds. In a feasibility study we examined the suitability of electrodialysis (ED) for this purpose. A custom-made device was developed from the low-binding material Kel-F. It consisted of two compartments separated by a dialysis membrane, over which a voltage was applied. One compartment served as donor (containing the sample), while the smaller acceptor compartment collected the peptides. The procedure was optimized by investigating the effect of the applied voltage, ammoni......
POSTED 06/30/2009 at 06:00 PM --
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Bayesian inference from incomplete longitudinal data: A simple method to quantify sensitivity to nonignorable dropout
Bayesian approach has been increasingly used for analyzing longitudinal data. When dropout occurs in the study, analysis often relies on the assumption of ignorable dropout. Because ignorability is a critical and untestable assumption without obtaining additional data or making other unverifiable assumptions, it is important to assess the impact of departures from the ignorability assumption on the key Bayesian inferences. In this paper, we extend the Bayesian index of local sensitivity to non-ignorability (ISNI) method proposed by Zhang and Heitjan to longitudinal data with dropout. We derive formulas for the Bayesian ISNI when the complete longitudinal data follow a linear mixed-effect model. The calculation of the index only requires the posterior draws or summary statistics of these dr......
POSTED 06/30/2009 at 06:00 PM --
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A Necropsy Survey of Neurologic Diseases in 4,319 Horses Examined in Normandy (France) from 1986 to 2006
Abstract: The frequencies of neurologic diseases and various corresponding causes were analyzed in 4,319 Norman horses examined by autopsy between 1986 and 2006. Five hundred forty-three cases of nervous system disorders were detected, or a total prevalence of 12.6%. One hundred eighty-seven of the 543 horses (34.4%) exhibited lesions of a traumatic origin affecting the skull or the vertebral column at different levels. Their frequency was less in foals younger than 1 month of age and higher in horses aged 6 months to 2 years. Eighty-three cases of cervical vertebral compressive myelopathy (CVCM) (15.3%) were identified. Males and geldings were more often affected than females. CVCM was diagnosed mostly in animals aged 6 months to 2 years. Horses affected with lesions in the mid-cervical r......
POSTED 06/30/2009 at 06:00 PM --
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Masitinib May Be Effective Against Refractory Rheumatoid Arthritis
Researchers report RA patients find relief with masitinib from their symptoms. WebMD Health News (Source: Medscape Today Headlines)...
POSTED 06/30/2009 at 03:24 PM --
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Common prognostic factors of work disability among employees with a chronic somatic disease: a systematic review of cohort studies.
CONCLUSIONS: As many prognostic factors for work disability are similar for employees with various chronic diseases, it is possible to detect high risk groups. This information supports the development and implementation of a general disability management intervention for employees suffering from a chronic disease to overcome health-related limitations at work.
PMID: 19562236 [PubMed - in process] (Source: Scandinavian Journal of Work, Environment and Health)...
POSTED 06/30/2009 at 01:44 PM --
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In this issue
No abstract. (Source: Arthritis and Rheumatism)...
POSTED 06/30/2009 at 11:05 AM --
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Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis
To improve prognostic ability in ankylosing spondylitis (AS), we sought to identify demographic, clinical, and immunogenetic characteristics associated with radiographic severity in a large cohort of patients.Patients with AS for [ge]20 years were enrolled in a cross-sectional study (n = 398). Pelvic and spinal radiographs were scored using the Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s), and radiographic severity was measured as the BASRI-s/duration of AS. Clinical factors and HLA-B, DR, DQ, and DP alleles associated with the highest quartile of the distribution of radiographic severity were identified by first using random forests and then using multivariable logistic regression modeling. Similar procedures were used to identify factors associated with the lowest ......
POSTED 06/30/2009 at 11:05 AM --
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New Open Access Journal Now Accepting Papers in Stem Cell Research & Therapy
From the publisher’s news release:
A new BioMed Central journal, Stem Cell Research & Therapy, is now accepting submissions.
Stem Cell Research & Therapy aims to be the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it will publish open access research articles of outstanding quality. The journal will have a special emphasis on translational, laboratory, and clinical research into stem cells. It will include animal trials, pre-clinical and clinical trials. We will consider adult, embryonic, and induced pluripotent stem cell research, especially with a focus on cell-based transplantation, drug discovery and testing, cell-mediated tissue response and biological effects stimulated by endogenous cells. We will have a uniqu......
POSTED 06/30/2009 at 08:38 AM --
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Abbott Must Pay $1.67 Billion in Patent Case
A federal jury in Texas ordered that Abbott Laboratories pay a J&J unit $1.67 billion for violating a patent on arthritis treatment Remicade in one of the largest infringement verdicts. (Source: WSJ.com: Health)...
POSTED 06/30/2009 at 07:29 AM --
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Increased Levels Of Certain Cytokines And Chemokines Predict Onset Of Rheumatoid Arthritis
Up-regulation of certain cytokines and chemokines (signaling molecules involved in the functioning of the immune system) can predict the development of rheumatoid arthritis three years before the onset of symptoms, according to the results of a new study presented at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark. (Source: ScienceDaily Headlines)...
POSTED 06/30/2009 at 07:00 AM --
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Rheumatoid Arthritis: New Treatment Target?
Title: Rheumatoid Arthritis: New Treatment Target?Category: Health NewsCreated: 6/30/2009Last Editorial Review: 6/30/2009 (Source: MedicineNet Chronic Pain General)...
POSTED 06/30/2009 at 02:00 AM --
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