The immunology of fibrosis: innate and adaptive responses.
Authors: Wick G, Backovic A, Rabensteiner E, Plank N, Schwendtner C, Sgonc R
Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononuclear immune cells. In most instances the reason for the attraction of these cells to fibrotic tissue and their proliferation remains to be determined; however their cytokine profile shows clear-cut proinflammatory and profibrotic characteristics. In this review, we discuss the innate and adaptive immune reactions associated with the development of fibrosis and the molecular basis of the profibrotic mechanisms taking ......
POSTED 01/24/2010 at 06:00 PM --
|
Focus on obesity.
Authors: Fisher EA
PMID: 20089947 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/22/2010 at 03:52 PM --
|
Patch instead of pill: a safer menopausal estrogen?
Authors: Cushman M
PMID: 20089948 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/22/2010 at 03:52 PM --
|
HDL structure, function, therapeutics, and imaging.
Authors: Hazen S
PMID: 20089949 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/22/2010 at 03:52 PM --
|
Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal disease patients
Conclusions. CAPD treatment could be a positive regulator of number of circulating EPCs in subjects with ESRD, with the relationship independent of the status of arteriosclerosis. (Source: Nephrology Dialysis Transplantation)...
POSTED 01/21/2010 at 03:33 AM --
|
Paraoxonase‐1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV‐Infected Patients
Conclusions. PON1 haplotypes segregate with HIV infection, HDL metabolism, the presence of subclinical atherosclerosis, and CD4+ cell recovery after treatment. (Source: The Journal of Infectious Diseases Latest Issue)...
POSTED 01/15/2010 at 09:23 AM --
|
MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells.
CONCLUSIONS: miRNAs regulate the proliferation of human CMPC and their differentiation into cardiomyocytes. By modulating miR-1 and -499 expression levels, human CMPC function can be altered and differentiation directed, thereby enhancing cardiomyogenic differentiation.
PMID: 20081117 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/14/2010 at 06:00 PM --
|
Gap Junction Protein Cx37 Interacts With Endothelial Nitric Oxide Synthase in Endothelial Cells.
CONCLUSIONS: Overall, our data show for the first time a functional and specific interaction between eNOS and Cx37. This interaction may be relevant for the control of vascular physiology both in health and in disease.
PMID: 20081116 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/14/2010 at 06:00 PM --
|
The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages.
CONCLUSIONS: Sera with similar HDL-C or apoA-I differ in their ability to promote macrophage efflux because of differences in the concentration of prebeta-1 HDL.
PMID: 20075420 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/13/2010 at 06:00 PM --
|
Effects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice.
CONCLUSIONS: These results indicate that medial SMC apoptosis may contribute to vascular inflammation and thus aneurysm formation, in part through production of MCP-1.
PMID: 20075419 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/13/2010 at 06:00 PM --
|
In response to Fox and Sonis
In this study, neither inhibition of TNF-α (by the antibody infliximab) nor of COX-2 (by the tyrosine kinase inhibitor celecoxib) resulted in modulation of the epithelial response of oral mucosa during fractionated irradiation. The conclusion from these observations was that those inflammatory changes mediated through TNF-α or COX-2 are not relevant for the radiation effects of oral epithelium. In their letter, Fox and Sonis stress that one explanation for the missing effect of infliximab (not of celecoxib) might be a lack of cross-reactivity with murine TNF-α. This possibility was discussed in the original paper , where we explained that infliximab (administered in protocols comparable to those used in our study) was effective in a number of mouse models of various diseases, such as di......
POSTED 01/13/2010 at 06:00 PM --
|
Occupational lifestyle diseases: An emerging issue
Sharma Mukesh, Majumdar P KIndian Journal of Occupational and Environmental Medicine 2009 13(3):109-112Lifestyle diseases characterize those diseases whose occurrence is primarily based on the daily habits of people and are a result of an inappropriate relationship of people with their environment. The main factors contributing to lifestyle diseases include bad food habits, physical inactivity, wrong body posture, and disturbed biological clock. A report, jointly prepared by the World Health Organization (WHO) and the World Economic Forum, says India will incur an accumulated loss of $236.6 billion by 2015 on account of unhealthy lifestyles and faulty diet. According to the report, 60% of all deaths worldwide in 2005 (35 million) resulted from noncommunicable diseases and accounted ......
POSTED 01/12/2010 at 11:03 AM --
|
Protease Imaging of Human Atheromata Captures Molecular Information of Atherosclerosis, Complementing Anatomic Imaging.
CONCLUSIONS: These results could justify and facilitate clinical trials to evaluate the use of protease-sensing molecular optical imaging in human atherosclerosis patients.
PMID: 20056915 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21.
CONCLUSIONS: Our data provide robust evidence for an association of ANRIL but not CDKN2A, CDKN2B, C9orf53, and MTAP, with atherosclerosis and Chr9p21 genotype in a large cohort.
PMID: 20056914 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
Loss of the Serum Response Factor Cofactor, Cysteine-Rich Protein 1, Attenuates Neointima Formation in the Mouse.
CONCLUSIONS: Smooth muscle CRPs are not essential for normal smooth muscle differentiation during development, but may act antagonistically to modulate the smooth muscle response to pathophysiological stress.
PMID: 20056913 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
Metallothionein Enhances Angiogenesis and Arteriogenesis by Modulating Smooth Muscle Cell and Macrophage Function.
CONCLUSIONS: MT plays an important role in collateral flow recovery and angiogenesis, an activity that appears to be mediated, in part, by the effects of MT on the functionality of 3 cell types essential for these processes: endothelial cells, smooth muscle cells, and macrophages.
PMID: 20056912 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis.
CONCLUSIONS: Spatial variation of JNK1 activity delineates the spatial distribution of apoptosis and turnover of EC in arteries.
PMID: 20056910 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
Propionyl-L-Carnitine Improves Postischemic Blood Flow Recovery and Arteriogenetic Revascularization and Reduces Endothelial NADPH-Oxidase 4-Mediated Superoxide Production.
CONCLUSIONS: Our results provided strong evidence that PLC improves postischemic flow recovery and revascularization and reduces endothelial NADPH-oxidase-related superoxide production. We recommend that PLC should be included among therapeutic interventions that target endothelial function.
PMID: 20056909 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
Plasmin Triggers Chemotaxis of Monocyte-Derived Dendritic Cells Through an Akt2-Dependent Pathway and Promotes a T-Helper Type-1 Response.
CONCLUSIONS: Plasmin generation in the atherosclerotic vessel wall might contribute to accumulation of DC, activation of the adaptive immune response, and aggravation of atherosclerosis.
PMID: 20056908 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 01/06/2010 at 06:00 PM --
|
Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats.
Authors: Li XL, Li BY, Gao HQ, Cheng M, Xu L, Li XH, Zhang WD, Hu JW
Arterial remodeling is the change in structural properties of vessel in diabetes mellitus and contributes to the development of vascular complications. To prevent this development and to improve diabetic vascular complications, effective therapies directed toward the key molecular target are required. Grape seed proanthocyanidin extracts (GSPE) have been reported to be effective in treating arteriosclerosis, while little is known about the functional protein changes. We used streptozocin to induce diabetic rats. GSPE (250 mg/kg body weight/day) were administrated to diabetic rats for 24 weeks. Consequently, 2-D difference gel electrophoresis and mass spectrometry were used to investigate aortic protein profiles among ......
POSTED 01/01/2010 at 04:58 PM --
|
