Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System.
Authors: Ooi K, Sugimoto K, Shiraki K, Yamamoto N, Tameda M, Beppu T, Tanaka J, Nojiri K, Kusagawa S, Takei Y, Masuda C, Nobori T
Patterns of hypocholesterolemic lipid fractions in 295 patients with liver diseases, malignant tumors, arteriosclerotic and renal diseases with cholesterol (Chol) levels of <30 mg/dl were classified using a simultaneous analytical method for the Chol and triglyceride (TG) fractions (Chol/Trig Combo System). Hypocholesterolemia was classified as follows: IV, Type IV on WHO hyperlipidemia phenotype classification; intermediate density lipoprotein (IDL), cases with appearance of IDL, including appearance of Lp(a); high + low density lipoproteins (HDL+LDL), lipids mostly consisting of HDL and LDL fractions; HDL abnormality, cases with slow alphaHDL or fast HD......
POSTED 03/04/2010 at 07:22 AM --
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Sustained Inhibition of Oxidized Low-Density Lipoprotein Is Involved in the Long-Term Therapeutic Effects of Apheresis in Dialysis Patients.
CONCLUSIONS: These results demonstrate that LDL apheresis decreases oxidized LDL and inflammation and improves endothelial cell function in the responders. This may be one of the mechanisms involved in the long-term therapeutic effect of LDL apheresis on peripheral circulation in hemodialysis patients.
PMID: 20203302 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 03/03/2010 at 06:00 PM --
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Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7).
CONCLUSIONS: These results show that increased circulating angiotensin-(1-7) levels lead to prominent changes in glucose and lipid metabolism.
PMID: 20203301 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 03/03/2010 at 06:00 PM --
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Histamine H1 Receptor Promotes Atherosclerotic Lesion Formation by Increasing Vascular Permeability for Low-Density Lipoproteins.
CONCLUSIONS: These data indicate that H1 but not H2 receptor activation drives the formation of atherosclerotic lesions through an increased vascular permeability for LDL, which is associated with an enhanced secondary aortic and systemic inflammation. These data open novel perspectives for the prevention and treatment of atherosclerotic vascular disease.
PMID: 20203300 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 03/03/2010 at 06:00 PM --
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Cholate-Containing High-Fat Diet Induces the Formation of Multinucleated Giant Cells in Atherosclerotic Plaques of Apolipoprotein E-/- Mice.
CONCLUSIONS: Apolipoprotein E-/- mice fed a Paigen diet provide a model to analyze the tissue-destructive role of MGCs in vascular diseases.
PMID: 20203298 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 03/03/2010 at 06:00 PM --
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Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: Effect of a high-fat, high-cholesterol diet.
Conclusions: There is a complex network of interactions linking MCP-1 and other cytokines. The lack of MCP-1 limits the aortic response to atherogenic stimuli, but does not completely protect against neointima formation. Activation of alternative inflammatory pathways in the vascular wall in response to MCP-1 deficiency should be considered to fully understand the actual role of this chemokine.
PMID: 20207162 [PubMed - as supplied by publisher] (Source: Cytokine)...
POSTED 03/03/2010 at 06:00 PM --
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Central Sleep Apnea Indicates Autonomic Dysfunction in Asymptomatic Carotid Stenosis: A Potential Marker of Cerebrovascular and Cardiovascular Risk
Conclusions: CSA indicates autonomic dysfunction in patients with asymptomatic eICA stenosis. Detection of CSA may help to identify asymptomatic patients with an increased risk of cerebrovascular or cardiovascular events who particularly benefit from carotid revascularization.
Keywords: Central sleep apnea, carotid stenosis, autonomic dysfunction, heart rate variability (Source: Sleep)...
POSTED 02/27/2010 at 10:38 AM --
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The effect of the long term aspirin administration on the progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse
Conclusion: Our results suggest that endothelial dysfunction with low dose aspirin improved, reduced progression of atherosclerosis in apoE-/- and LDLR-/- double deficient mice and provides a pathophysiological basis for the beneficial effects of aspirin in atherosclerosis, and low doses appeared to be more efficient than high doses. (Source: Thrombosis Research)...
POSTED 02/26/2010 at 08:24 AM --
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A comprehensive study of cardiovascular risk factors, cardiac function and vascular disease in children with chronic renal failure
Conclusions. This study shows that children with CKD are exposed to risk factors and demonstrate signs of cardiovascular disease already at a young age. The possible role of uric acid and homocysteine in the evolution of cardiovascular disease is discussed. Further studies looking at possible interventions to prevent cardiovascular morbidity and mortality in this high risk population are needed. (Source: Nephrology Dialysis Transplantation)...
POSTED 02/25/2010 at 02:19 AM --
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Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen
Abstract Osteoporosis and vascular disease are commonly found together in elderly people. Several common mechanisms and risk factors
have been suggested to contribute to the development of osteoporosis and atherosclerosis. The present cross-sectional study
was performed to determine whether the degree of bone turnover is correlated to carotid intima-media thickness (CCA-IMT),
as a marker of subclinical atherosclerosis. We selected 50 outpatients (mean age 71.7 ± 12.3), underwent to eco-Doppler evaluation
of extracranial carotid tract, without history of calcium and/or vitamin D supplementation, or antireabsorptive therapy. CCA-IMT
was measured by high-resolution B-mode ultrasonography. Bone turnover was evaluated by analysing serum levels of C-terminal
telopepti......
POSTED 02/25/2010 at 02:02 AM --
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When endothelial progenitor cell says i2 shall limit neointima formation!
Authors: Sainz J, Sata M
PMID: 20167663 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/21/2010 at 01:50 PM --
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Mechanical stretch and intimal hyperplasia: the missing link?
Authors: Lee S, Lee RT
PMID: 20167664 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/21/2010 at 01:50 PM --
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Laminar Shear Stress Modulates Phosphorylation and Localization of RNA Polymerase II on the Endothelial Nitric Oxide Synthase Gene.
CONCLUSIONS: These data suggest that laminar shear stress enhances eNOS mRNA 3' polyadenylation by modulating phosphorylation and localization of Pol II.
PMID: 20167666 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/21/2010 at 01:50 PM --
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Association of Circulating Matrix Metalloproteinases With Carotid Artery Characteristics. The Atherosclerosis Risk in Communities Carotid MRI Study.
CONCLUSIONS: Circulating levels of specific MMPs and TIMP-1 were associated with carotid wall remodeling and structural changes related to plaque burden in elderly participants.
PMID: 20167662 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Identification and Assessment of Plasma Lysozyme as a Putative Biomarker of Atherosclerosis.
CONCLUSIONS: Increased plasma lysozyme levels may be a useful biomarker of atherosclerotic cardiovascular disease and response to therapy. Additional studies to investigate this are warranted. Surface-enhanced laser desorption ionization time-of-flight mass spectrometry was used successfully to screen for plasma biomarkers of atheroma in patients with coronary artery disease and led to the identification of lysozyme as a candidate. The elevation of lysozyme was shown to be associated with disease severity in patients with atherosclerosis.
PMID: 20167661 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Evidence That Niacin Inhibits Acute Vascular Inflammation and Improves Endothelial Dysfunction Independent of Changes in Plasma Lipids.
CONCLUSIONS: Previous human intervention studies have demonstrated that niacin inhibits coronary artery disease. This benefit is thought to be because of its ability to reduce low-density lipoprotein and plasma triglyceride levels and increase high-density lipoprotein levels. The present study showed that niacin inhibits vascular inflammation and protects against endothelial dysfunction independent of changes in plasma lipid levels.
PMID: 20167660 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Nitro-Fatty Acids Reduce Atherosclerosis in Apolipoprotein E-Deficient Mice.
CONCLUSIONS: These results reveal the antiatherogenic actions of electrophilic nitro-fatty acids in a murine model of atherosclerosis.
PMID: 20167658 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor-/- Mice.
CONCLUSIONS: By lowering plasma cholesterol, the iminosugar AMP-DNM dramatically reduces the development of atherosclerosis in APOE*3 Leiden and low-density lipoprotein receptor -/- mice. Thus, targeting GSL synthesis may be a new treatment modality to prevent cardiovascular disease.
PMID: 20167657 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Adenosine Receptor A2A Deficiency in Leukocytes Increases Arterial Neointima Formation in Apolipoprotein E-Deficient Mice.
CONCLUSIONS: A2AR plays a complex role in inflammation and tissue injury. The deficiency of A2AR enhances the homing ability of leukocytes and increases the formation of the arterial neointima after injury. A2AR antagonists are being tested for the treatment of neurodegenerative and other chronic diseases. An evaluation of the effect of A2AR antagonists on arterial restenosis after arterial angioplasty should be conducted.
PMID: 20167656 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces Atherosclerosis.
CONCLUSIONS: Nasal administration of an apoB-100 peptide fused to CTB attenuates atherosclerosis and induces regulatory Tr1 cells that inhibit T effector responses to apoB-100.
PMID: 20167655 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 02/17/2010 at 06:00 PM --
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