Tregs and human atherothrombotic diseases: toward a clinical application?
Authors: Caligiuri G, Nicoletti A
PMID: 20720192 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/26/2010 at 10:45 AM --
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Notch leads lymphatics and links them to blood vessels.
Authors: Liao S, Padera TP, Jain RK
PMID: 20720193 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/26/2010 at 10:45 AM --
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Osteoprotegerin: a biomarker with many faces.
Authors: Caidahl K, Ueland T, Aukrust P
PMID: 20720194 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/26/2010 at 10:45 AM --
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Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G1 Cyclin-Retinoblastoma Axis.
CONCLUSIONS: Combined, these results demonstrate that Shh/Gli2 signaling stimulates VSMC proliferation via regulation of the G(1) cyclin-retinoblastoma axis and suggest that antagonists that target the Shh pathway may be therapeutically beneficial in the prevention of intimal hyperplasia.
PMID: 20720195 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/26/2010 at 10:45 AM --
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The Scavenger Receptor BI Is a Primary Determinant of Paraoxonase-1 Association With High-Density Lipoproteins.
CONCLUSIONS: The present study identifies SR-BI as a major determinant of the capacity of HDL to acquire PON1. It reinforces the concept of the receptor as a docking molecule, allowing communication between HDL and the cell, and extends the importance of SR-BI to HDL metabolism and function.
PMID: 20724701 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/18/2010 at 06:00 PM --
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Essential Role of Copper-Zinc Superoxide Dismutase for Ischemia-Induced Neovascularization Via Modulation of Bone Marrow-Derived Endothelial Progenitor Cells.
CONCLUSIONS: Protection against oxidative stress by CuZnSOD may be essential for EPC function and reparative neovascularization after ischemia.
PMID: 20724700 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/18/2010 at 06:00 PM --
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Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury.
CONCLUSIONS: PAR-2 deficiency reduces myocardial infarction and heart remodeling after I/R injury.
PMID: 20724699 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/18/2010 at 06:00 PM --
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Molecular dissection of Porphyromonas gingivalisârelated arteriosclerosis: a novel mechanism of vascular disease
(Source: Periodontology 2000)...
POSTED 08/17/2010 at 12:33 AM --
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Apelin Is a Crucial Factor for Hypoxia-Induced Retinal Angiogenesis.
CONCLUSIONS: These results suggest that apelin is a prerequisite factor for hypoxia-induced retinal angiogenesis.
PMID: 20705920 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/11/2010 at 06:00 PM --
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Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice by Inhibiting Systemic and Vascular Inflammation.
CONCLUSIONS: To our knowledge, this is the first study to provide direct evidence for the role of tissue n-6/n-3 ratio in atherosclerosis using the fat-1 transgenic mouse model. Our findings demonstrate that a decreased n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apoE(-/-) mice. This protective effect may be attributed to the anti-inflammatory properties of omega-3 fatty acids, rather than their lipid-lowering effect.
PMID: 20705919 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/11/2010 at 06:00 PM --
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Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway.
CONCLUSIONS: Our results indicate that treatment with statins inhibits endothelial senescence and that enhancement of SIRT1 plays a critical role in prevention of endothelial senescence through the Akt pathway, a direct target of statins.
PMID: 20705918 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/11/2010 at 06:00 PM --
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An In Vivo Murine Model of Low-Magnitude Oscillatory Wall Shear Stress to Address the Molecular Mechanisms of Mechanotransduction--Brief Report.
Authors: Willett NJ, Long RC, Maiellaro-Rafferty K, Sutliff RL, Schafer R, Oshinski JN, Giddens DP, Guldberg RE, Taylor WR
Current understanding of shear-sensitive signaling pathways has primarily been studied in vitro largely because of a lack of adequate in vivo models. Our objective was to develop a simple and well-characterized murine aortic coarctation model to acutely alter the hemodynamic environment in vivo and test the hypothesis that endothelial inflammatory protein expression is acutely upregulated in vivo in by low-magnitude oscillatory wall shear stress (WSS). Our model uses the shape memory response of nitinol clips to reproducibly induce an aortic coarctation and allow subsequent focal control over WSS in the aorta. We modeled the corresponding hemodynamic environment us......
POSTED 08/11/2010 at 06:00 PM --
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Depletion of Intracellular Ca2+ Stores Stimulates the Translocation of TRPV4-C1 Heteromeric Channels to the Plasma Membrane.
CONCLUSIONS: Ca(2+) store depletion stimulates the insertion of TRPV4-C1 heteromeric channels into the plasma membrane, resulting in an augmented Ca(2+) influx in response to flow in the human embryonic kidney cell overexpression system and native endothelial cells.
PMID: 20705915 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/11/2010 at 06:00 PM --
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FRNK Inhibition of Focal Adhesion Kinase-Dependent Signaling and Migration in Vascular Smooth Muscle Cells.
CONCLUSIONS: FRNK inhibition of VSMC migration requires both FA targeting and Y168 phosphorylation by Src family kinases. FRNK-Y232 phosphorylation occurs outside of FAs, probably by a PP2-insensitive kinase.
PMID: 20705914 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/11/2010 at 06:00 PM --
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Increased Atherosclerosis in Mice With Vascular ATP-Binding Cassette Transporter G1 Deficiency--Brief Report.
Authors: Westerterp M, Koetsveld J, Yu S, Han S, Li R, Goldberg IJ, Welch CL, Tall AR
To investigate the role of vascular ATP-binding cassette transporter G1 (ABCG1) in atherogenesis without a confounding difference in macrophage ABCG1 expression. ABCG1 is highly expressed in macrophages and endothelial cells. ABCG1 preserves endothelial function by maintaining endothelial NO synthase activity and by reducing adhesion molecule expression and monocyte adhesion. Abcg1(-/-)/Ldlr(-/-) and Ldlr(-/-) mice were transplanted with wild-type bone marrow and fed a Western-type diet for 12 or 23 weeks. The atherosclerotic lesion area was similar in both groups after 12 weeks but was increased in Abcg1(-/-)/Ldlr(-/-) recipients after 23 weeks, especially in the aortic arch (2.2-fold; P<0.01). En......
POSTED 08/11/2010 at 06:00 PM --
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Chronic Kidney Disease Japan Cohort study: baseline characteristics and factors associated with causative diseases and renal function
Conclusions The difference between causative diseases is associated with different comorbidity and level of arteriosclerosis. Future analysis
of the cohort will clarify whether incidence of ESRD and CVD differs among causative diseases.
Content Type Journal ArticleDOI 10.1007/s10157-010-0328-6Authors
Enyu Imai, Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550 JapanSeiichi Matsuo, Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550 JapanHirofumi Makino, Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanTsuyoshi Watanabe, The Third Department of Intern......
POSTED 08/11/2010 at 01:54 AM --
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Endothelium-Dependent Coronary Vasodilatation Requires NADPH Oxidase-Derived Reactive Oxygen Species.
CONCLUSIONS: Endothelium-dependent vascular endothelial growth factor regulation of coronary vascular tone may require NADPH oxidase-derived ROS to activate phosphatidylinositol 3-kinase-Akt-endothelial NO synthase axis.
PMID: 20702812 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/10/2010 at 06:00 PM --
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Resolvin E1 Regulates Adenosine Diphosphate Activation of Human Platelets.
CONCLUSIONS: RvE1's regulatory actions (ie, reducing ADP-stimulated P-selectin mobilization and actin polymerization) are hChemR23-dependent. Moreover, specific platelet actions of RvE1 selectively engaged with ADP-activated platelets that illuminate a new cellular mechanism and affect omega-3 eicosapentaenoic acid, which may contribute to both resolution of vascular inflammation and ADP-dependent platelet activation relevant in pathological cardiovascular events.
PMID: 20702811 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/10/2010 at 06:00 PM --
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Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells.
CONCLUSIONS: An acidic pH reduces cholesterol efflux via different pathways and particularly impairs the function of the ABCA1 transporter. The pH-sensitive function of human macrophage foam cells in releasing cholesterol may accelerate lipid accumulation in deep areas of advanced atherosclerotic plaques where the intimal fluid is acidic.
PMID: 20702810 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/10/2010 at 06:00 PM --
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High-Density Lipoproteins Suppress Chemokines and Chemokine Receptors In Vitro and In Vivo.
CONCLUSIONS: Lipid-free apoA-I and rHDL reduce the expression of chemokines and chemokine receptors in vivo and in vitro via modulation of nuclear factor kappaB and peroxisome proliferator-activated receptor gamma.
PMID: 20702809 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)...
POSTED 08/10/2010 at 06:00 PM --
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