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Anemia Medical and Health News Headlines
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All Recent Anemia Medical Condition News Headlines |
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Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia
This study strengthens the hypothesis that acute leukaemias give rise to more profound cytopenias, affecting more cell lines, than chronic leukaemias. (Source: Veterinary and Comparative Oncology)...
POSTED 06/30/2009 at 06:00 PM --
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Analysis of host- and strain-dependent cell death responses during infectious salmon anemia virus infection in vitro
Conclusions:
Results from this study indicate that there are differences between cell lines commonly used for in vitro ISAV studies, and that the differences seen between isolates in vivo, are less prominent in vitro. (Source: Virology Journal)...
POSTED 06/30/2009 at 06:00 PM --
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AMAG's Anemia Treatment Approved
AMAG Pharmaceutical received an oft-delayed marketing approval for its Feraheme anemia treatment. (Source: WSJ.com: Health)...
POSTED 06/30/2009 at 05:13 PM --
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FDA Approves Feraheme to Treat Iron Deficiency Anemia in Adult Chronic Kidney Disease Patients
Product launch expected in the second half of July 2009
LEXINGTON, Mass.--(HSMN NewsFeed)--AMAG Pharmaceuticals, Inc. (NASDAQ:AMAG ) today announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Feraheme (ferumoxyt... Biopharmaceuticals, FDAAMAG Pharmaceuticals, Feraheme, ferumoxytol (Source: HSMN NewsFeed)...
POSTED 06/30/2009 at 04:13 PM --
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Vitamin B12 Protects the Heart, Mind, Eyes and More
(NaturalNews) Vitamin B12 is one of the eight B vitamins, and is important for brain function and the formation of blood. B12 deficiency can cause many diseases. Deficiency can be treated by diet or by B12 injections. Since B12 is hard to assimilate through the stomach, sublingual B12 is advised. B12 is water-soluble, is made up of a complicated chemical structure, and contains the element cobalt. The type of B12 used in food supplements is called cyanocobalamin.Brain scans can now measure brain volume and a study of patients deficient in vitamin B12 showed their brain volume at half of those with high blood levels of vitamin B12. It is an important component of the nervous system and for DNA synthesis. Without B12, the body can`t manufacture blood and leads to anemia. Vitamin B12 is also ......
POSTED 06/30/2009 at 02:00 AM --
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Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma
To the authors' knowledge, there currently is no standard therapy for platinum-resistant ependymoma; hence, a need exists for new therapies. In the current study, a retrospective evaluation of temozolomide (TMZ) in adults with recurrent, supratentorial, platinum-refractory, World Health Organization grade 2 ependymoma was performed, with an objective of determining 6-month progression-free survival (PFS).A total of 25 patients, ages 28 to 63 years, with recurrent ependymoma were treated. All patients had previously been treated with surgery, radiotherapy, and platinum-based chemotherapy (cisplatin in 15 patients and carboplatin in 10 patients). Nine patients underwent repeat surgery. Patients were treated at the time of second recurrence with TMZ (5 consecutive days), once every 4 weeks, w......
POSTED 06/29/2009 at 06:00 PM --
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The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes
This report outlines the power of a combined diagnostic approach for suspected initial cases of MDS including immunophenotyping, cytogenetics, and molecular genetics with selected markers in addition to cytomorphology. Diagnostic algorithms should be developed, and immunophenotyping should be further validated for this specific indication. Cancer 2009. © 2009 American Cancer Society. (Source: Cancer)...
POSTED 06/29/2009 at 06:00 PM --
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Chronic Kidney Disease, Anemia, and the Association Between Chronic Kidney Disease–Related Anemia and Activities of Daily Living in Older Nursing Home Residents by Schnelle et al, February 2009
To the Editor: The study of Schnelle et al has a substantial mistaken identification in its title between chronic kidney disease (CKD)-related anemia and activities of daily living. CKD-related anemia is a well-defined entity with deficient erythropoietin levels as the cause of anemia and responsive in most cases to replacement therapy. The article uses anemia of any cause in the presence of CKD, not just CKD-related anemia as the variable studied. Such anemia in this study could be related to any number of etiologies, such as iron deficiency, B12 deficiency, myelodysplastic syndrome, and idiopathic cause in addition to chronic kidney disease, as no relevant laboratory values are given. Iron deficiency anemia may represent 15% to 36%, and chronic disease 35% to 41% of nursing home or geri......
POSTED 06/29/2009 at 11:20 AM --
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Assessing the Quality of Prescribing and Monitoring Erythropoiesis-Stimulating Agents in the Nursing Home Setting
Conclusion: Suboptimal prescribing and monitoring of ESAs were common in the NHs we studied. Future studies are needed to determine if the development and use of computerized decision support systems can improve prescribing and monitoring of ESAs in the NH setting. (Source: Journal of the American Medical Directors Association)...
POSTED 06/29/2009 at 11:20 AM --
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Splenic artery: peak systolic velocity of normal fetuses
Conclusion A nomogram for SpA-PSV for each GA during 14–40 weeks was constructed. This reference range may be a useful non-invasive tool
in risk assessment for fetal anemia, especially due to homozygous alpha-thalassemia-1 or fetal isoimmunization.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1162-5Authors
Theera Tongsong, Chiang Mai University Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai 50200 ThailandFuanglada Tongprasert, Chiang Mai University Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai 50200 ThailandKasemsri Srisupundit, Chiang Mai University Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai 50200 ThailandSuchaya Luewan, Chiang Mai University Departmen......
POSTED 06/29/2009 at 05:07 AM --
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Orotic aciduria and uridine monophosphate synthase: A reappraisal
Abstract Three subtypes of hereditary orotic aciduria are described in the literature, all related to deficiencies in uridine monophosphate
synthase, the multifunctional enzyme that contains both orotate: pyrophosphoryl transferase and orotidine monophosphate decarboxylase
activities. The type of enzyme defect present in the subtypes has been re-examined by steady-state modelling of the relative
outputs of the three enzymic products, uridine monophosphate, urinary orotic acid and urinary orotidine. It is shown that
the ratio of urinary outputs of orotidine to orotate provides a means of testing for particular forms of enzyme defect. It
is confirmed that the type I defect is caused by loss of uridine monophosphate synthase activity. Cells and tissue of type
I cases have a r......
POSTED 06/29/2009 at 03:24 AM --
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Ovarian transplantation: First baby is born after a new technique
(European Society for Human Reproduction and Embryology) On June 22, a baby girl was born to a mother who had been menopausal for two years as a result of treatment for sickle cell anemia, after a new, two-step method of ovarian transplant that worked to restore ovarian function quickly. It is the first birth after ovarian autotransplantation in France and the first in the world after treatment for sickle cell anemia. (Source: EurekAlert! - Biology)...
POSTED 06/28/2009 at 11:00 PM --
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[Gynecologic Cancer] Phase II Trial of Ixabepilone As Second-Line Treatment in Advanced Endometrial Cancer: Gynecologic Oncology Group Trial 129-P
Conclusion
In a cohort of women with advanced or recurrent endometrial cancer who were previously treated with paclitaxel, ixabepilone showed modest activity of limited duration as a second-line agent. (Source: Journal of Clinical Oncology)...
POSTED 06/28/2009 at 06:00 PM --
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Preoperative Hemoglobin Level as a Predictor of Survival After Coronary Artery Bypass Grafting. A Comparison With the Matched General Population.
Conclusions-A lower preoperative hemoglobin level is an independent predictor of late mortality in patients undergoing CABG, whereas anemia is a risk factor for early and late mortality. Compared with the general population, anemic patients had worse survival than expected, whereas nonanemic patients had better survival than expected.
PMID: 19564556 [PubMed - as supplied by publisher] (Source: Circulation)...
POSTED 06/28/2009 at 06:00 PM --
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Alpha-thalassemia (3.7 kb deletion) in a population from the Brazilian Amazon region: Santarém, Pará State.
We examined the usefulness of investigating alpha-thalassemia carrier status for microcytosis. Among the 103 patients with anemia, 20 (19.4%) were heterozygotes (-alpha3.7/alphaalpha) and one (1.0%) was a homozygote (-alpha3.7/-alpha3.7). Among the 11 patients without anemia, one heterozygote (-alpha3.7/alphaalpha) was identified; in the third group, composed of normal individuals (106 samples), deletion -alpha3.7 was found in seven samples (6.6%), all of which were heterozygotes (-alpha/alphaalpha).These frequencies are within the expected range, given available data on the distribution of this hemoglobin disorder in human populations and the ethnic composition of the population of Santarém. We found that alpha-thalassemia is a common cause of microcytosis, given that a high proporti......
POSTED 06/27/2009 at 08:45 PM --
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How to Make Peritoneal Dialysis Affordable in Developing Countries.
Authors: Abraham G, Khanna P, Mathew M, Pushpkala P, Mehrotra A, Sairam A, Mohamed Ali AA
Peritoneal dialysis (PD) is an underutilized renal replacement therapy in the developing world. It offers advantages of simplicity, reduced need of training, lack of dependence on infrastructure and location. The population is extremely underserved by healthcare and means to achieve it. PD is unavailable in many African nations. We explore the logistics of PD, domestic manufacture of PD fluid and accessories and ways to sustain it. Realization of local factors, ways to reduce peritonitis, reduced dosage in patients with residual renal function and use of generics to treat anemia that help improve the logistics. The role of national government especially in countries where dialysis is rationed and ......
POSTED 06/27/2009 at 06:48 PM --
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Regulation of the innate immune response by threonine-phosphatase of Eyes absent
Authors: Yasutaka Okabe, Teruyuki Sano & Shigekazu Nagata
Innate immunity is stimulated not only by viral or bacterial components, but also by non-microbial danger signals (damage-associated molecular patterns). One of the damage-associated molecular patterns is chromosomal DNA that escapes degradation. In programmed cell death and erythropoiesis, DNA from dead cells or nuclei expelled from erythroblasts is digested by DNase II in the macrophages after they are engulfed. DNase II-/- (also known as Dnase2a-/-) mice suffer from severe anaemia or chronic arthritis due to interferon-β (IFN-β) and tumour necrosis factor-α (TNF-α) produced from the macrophages carrying undigested DNA in a Toll-like receptor (TLR)-independent mechanism. Here we show that Eyes absent 4 (EYA......
POSTED 06/27/2009 at 06:00 PM --
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Clinical manifestations and outcomes of antithrombotic treatment of the Tan Tock Seng Hospital Singapore antiphospholipid syndrome cohort.
Authors: Tan B, Thong B, Shivananda S, Han W, Chng H
To examine the clinical manifestations, intensity of oral anticoagulation and outcomes in the prevention of recurrent thromboses in patients with antiphospholipid syndrome (APS) in a tertiary rheumatology centre in Singapore. Retrospective case review of consecutive patients with APS attending a rheumatology clinic from 1st January 2004 to 31st December 2005. There were 59 (44%) patients with definite APS and 75 (56%) with probable APS. Systemic lupus erythematosus (SLE) was the most common cause of secondary APS. Hypertension and hyperlipidaemia were the most common cardiovascular comorbidities. The most common manifestations were haematological (thrombocytopaenia and haemolytic anaemia), neurological (seizure, headache) and pulmona......
POSTED 06/27/2009 at 05:51 PM --
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In-vitro radiosensitivity in patients with systemic lupus erythematosus.
Authors: Carrillo-Alascio P, Sabio J, Núñez-Torres M, López E, Muñoz-Gámez J, Hidalgo-Tenorio C, Jáimez L, Martín J, Jiménez-Alonso J,
To determine the "in-vitro" intrinsic cell radiosensitivity (RS) as a risk indicator of radiation-related side-effects in patients with systemic lupus erythematosus (SLE) compared with healthy subjects (control group). Moreover, we elucidated if clinical, therapeutic and biological parameters could affect the "in-vitro" intrinsic RS in patients with SLE. Intrinsic RS was determined by the quantification of the initial radiation-induced DNA double-strand breaks in peripheral lymphocytes, measured by pulsed-field gel electrophoresis from 52 patients with SLE and a control group consisting of 48 sex- and age-matched......
POSTED 06/27/2009 at 05:51 PM --
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Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia.
We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for foci of the monoubiquitinated form of FANCD2 revealed a complete absence of such foci in all cancer tissues that were examined.
PMID: 19368986 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)...
POSTED 06/27/2009 at 05:11 PM --
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