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Anemia Medical and Health News Headlines
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All Recent Anemia Medical Condition News Headlines |
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What is the Differential Diagnosis of Failure to Thrive?
Discussion
Failure to Thrive (FTT) is defined as persistent weight below the 3rd percentile for age in infants and young children. The associated terms “Failure to gain weight” (FGW) or “Lack of Normal Physiologic Growth and Development” are more precise, especially for children who are not below the 3rd percentile but are losing weight over time and/or crossing percentile lines on their growth curve. For general growth parameters see How Do I Calculate Mid-Parental Height and Other Growth Parameters? About 70-80% of FTT cases have psychosocial problems that are associated with the FTT or the primary cause of the FTT. Children of older ages may also have FTT such as those with psychosocial dwarfism or eating disorders.
Children with FTT have a wide range of appearan......
POSTED 02/07/2010 at 06:24 PM --
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Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia.
Authors: Chen Y, Ma WQ, Chen JM, Cai JT
A female patient with anemia and hypoalbuminemia was admitted to our hospital due to an over 20-year history of recurrent dizziness, fatigue and ankle edema. She was diagnosed as multiple chronic non-specific ulcer of the small intestine characterized by non-specific histology and persistent gastrointestinal bleeding.
PMID: 20135730 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 02/06/2010 at 06:26 PM --
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AMAG Fights Back (AMAG)
AMAG Pharmaceuticals, Inc. (NASDAQ: AMAG) has had a very tough week, whether it was a market with a bad trading tape or not. The stock’s weakness was after an analyst from a relatively unknown firm called Summer Street downgraded the stock to Neutral from Buy over concerns that Feraheme patients are being hospitalized with severe allergic reaction events. Shares were above $45.00 on Wednesday, yet the stock went as low as $35 today before word that a rebuttal was coming. Then after the close, the company is out defending itself showing that the risks here are very low and may not be any different than previously thought.
After the close of trading today, the maker of treatments for anemia and imaging agents provided a safety update on Feraheme®. The company noted, “Sin......
POSTED 02/05/2010 at 03:39 PM --
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LSTM Begins £0.5 Million Malaria Study In Burkina Faso
A new study led by LSTM will investigate whether long-term weekly iron and folic acid supplementation can reduce anaemia without increasing the risk of contracting malaria. The information provided by the study, based in Burkina Faso and running until 2014, will strengthen adolescent health services and develop effective preventative programmes for anaemia control in young women. Young women who conceive during or shortly after adolescence may enter pregnancy with deficient iron stores due to their development and the onset of menstruation... (Source: Health News from Medical News Today)...
POSTED 02/05/2010 at 03:00 AM --
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[Correspondence] Preventable deaths in sickle-cell anaemia in African children
Thomas Williams and colleagues (Oct 17, p 1364) provide the strongest evidence to date on the risk of bacteraemia in sub-Saharan African children with sickle-cell anaemia. That Streptococcus pneumoniae was the leading cause of bacteraemia in such children in Kenya comes as no surprise given that this has already been shown in the general population of children in the same region. Data on the use of penicillin prophylaxis or prior immunisation with pneumococcal polysaccharide vaccine in children with sickle-cell anaemia in the population study would have been helpful in further defining the magnitude of this problem. (Source: LANCET)...
POSTED 02/04/2010 at 06:00 PM --
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[Correspondence] Preventable deaths in sickle-cell anaemia in African children
Thomas Williams and colleagues present important new evidence on the epidemiology of bacteraemias in children with sickle-cell anaemia in Kenya. Recently, a group of reports—also from east and central Africa—have raised concern that the landscape of bacterial drug resistance may be changing in this part of the world. The emergence of extended-spectrum β-lactamase-producing gram-negative bacteria (ESBLs; specifically among Escherichia coli, Klebsiella pneumoniae, and non-typhoidal salmonella strains) in hospital inpatients and in the community is a most unwelcome change for the worse in the landscape of drug resistance in Africa. (Source: LANCET)...
POSTED 02/04/2010 at 06:00 PM --
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[Correspondence] Preventable deaths in sickle-cell anaemia in African children – Authors' reply
Stephen Obaro asks about the use of penicillin prophylaxis and pneumococcal polysaccharide vaccine in our study population. Because of the retrospective approach we adopted, most (80/108 [74%]) patients with sickle-cell anaemia identified through our study had not yet been diagnosed at the time of their hospital admission and were not, therefore, on prophylaxis. (Source: LANCET)...
POSTED 02/04/2010 at 06:00 PM --
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Insertion of an NPVY sequence into the cytosolic domain of erythropoietin receptor selectively affects erythropoietin mediated signaling and function
Erythropoietin (EPO), the major hormone regulating erythropoiesis functions via activation of its cell surface receptor (EPO-R) present on erythroid progenitor cells. One of the most striking properties of EPO-R is its low expression on the cell surface, as opposed to its high intracellular levels. The low cell surface expression of EPO-R may thus limit the efficacy of EPO that is routinely used to treat primary and secondary anemia. In a recent study (Nahari et al., Biochem. J. 2008) we have shown that insertion of an NPVY sequence into the intracellular domain of EPO-R increases its cell surface expression. Here we demonstrate that this NPVY EPO-R insert has a selective effect on EPO mediated downstream signaling in Ba/F3 cells expressing this receptor (NPVY-EPO-R). This is monitored by ......
POSTED 02/04/2010 at 06:00 PM --
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Haematopoeitic cell transplantation for Fanconi anaemia – when and how?
Allogeneic haematopoietic cell transplantation (HCT) remains the only treatment that can correct the haematological manifestations in patients with Fanconi anaemia. Over the last two decades, sequential changes to the approach to HCT have resulted in reduced regimen-related toxicity, superior engraftment and less graft-versus-host disease (GVHD), resulting in improved survival. The two pivotal changes that most influenced these improvements were the addition of fludarabine to the preparative regimen to augment engraftment, and the use of T cell depletion to reduce GVHD. With these improved HCT outcomes, indications for HCT are quite consistent regardless of donor source. Emphasis is now being placed on developing HCT regimens that will improve quality of life by reducing late effects, part......
POSTED 02/04/2010 at 06:00 PM --
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Evaluation of mean sphered corpuscular volume for predicting hereditary spherocytosis
Hereditary spherocytosis (HS) is a common red blood cell disorder. It has been shown that the mean sphered corpuscular volume (MSCV), an artificial volume, is always lower than the MCV in HS and also in some autoimmune haemolytic anaemia (AIHA). Our purpose was to assess the reliability of MSCV in routine practise, and its relevance in screening for HS. Comparison of MSCV and MCV was undertaken in a prospective study of 366 patients with anaemia. In addition, included were patients previously diagnosed to have HS (n = 33) or AIHA (n = 16). When MSCV was lower than MCV, a flow cytometric (FC) test for HS was performed. Delta (MCV[ndash]MSCV) values >9.6 fl were obtained for all HS patients. A wider spread of delta (MCV[ndash]MSCV) values was obtained for AIHA patients whose red cells gave F......
POSTED 02/04/2010 at 06:00 PM --
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Rho GTPases in hematopoiesis and hemopathies
Rho family GTPases are intracellular signaling proteins regulating multiple pathways involved in cell actomyosin organization, adhesion, and proliferation. Our knowledge of their cellular functions comes mostly from previous biochemical studies that used mutant overexpression approaches in various clonal cell lines. Recent progress in understanding Rho GTPase functions in blood cell development and regulation by gene targeting of individual Rho GTPases in mice has allowed a genetic understanding of their physiologic roles in hematopoietic progenitors and mature lineages. In particular, mouse gene–targeting studies have provided convincing evidence that individual members of the Rho GTPase family are essential regulators of cell type–specific functions and stimuli-specific pathw......
POSTED 02/04/2010 at 11:01 AM --
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Reply
In their response to the paper by Anderson et al. () and my editorial comment (), Dr. Abraham and colleagues make an important point in highlighting the importance of “nondownstream” factors in peripheral artery disease. The fact that cellular metabolism was the parameter that correlated best with the clinically most relevant treadmill exercise results in the study by Anderson et al. () supports the potential influence of other factors such as proximal claudication, anemia, and hypoxemia. The common features in the etiology of atherosclerosis and pulmonary disease may be a key factor here; for instance, peripheral artery disease and coronary artery disease are more common in moderate and heavy cigarette smokers than in never smokers (). Further analyses of, for example, anemia (by meas......
POSTED 02/04/2010 at 07:51 AM --
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Effect of iron chelator deferasirox on chronic anemia and thrombocytopenia in a transfusion-dependent patient with myelodysplastic syndrome.
Authors: Nishiuchi T, Okutani Y, Fujita T, Yoshida K, Ohnishi H, Haba R
PMID: 20127527 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)...
POSTED 02/03/2010 at 06:00 PM --
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Incidence of koilonychia and atrophy of the lingual papillae in a patient with iron-deficiency anemia.
Authors: Takahashi T, Yamashita K, Hatao K
PMID: 20127526 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)...
POSTED 02/03/2010 at 06:00 PM --
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Comparison of the efficacy between topotecan- and belotecan-, a new camptothecin analog, based chemotherapies for recurrent epithelial ovarian cancer: A single institutional experience
Conclusions: In our experience, belotecan-based chemotherapy seemed to be efficient with acceptable toxicity, compared to topotecan-based chemotherapy in recurrent EOC. However, randomized controlled trials are required for the comparison of the efficacy and toxicity between topotecan- and belotecan-based chemotherapies in recurrent EOC. (Source: Journal of Obstetrics and Gynaecology Research)...
POSTED 02/03/2010 at 06:00 PM --
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Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase 3 in human UT-7/EPO cell line.
In conclusion, EPO exerts anti-apoptotic effects on irradiated human UT-7/EPO cells via up-regulation of Bcl-2 protein and the relative Bcl-2/Bax ratio, and decreasing the activation of caspase 3. These findings may contribute to our understanding of the beneficial function of EPO in radiotherapy-induced anemia.
PMID: 20132233 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)...
POSTED 02/03/2010 at 06:00 PM --
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Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies
Conclusion Inhabitants in the formerly polluted area still had high cadmium accumulations and showed a characteristic natural history
of chronic cadmium toxicity, indicating that the risk remains for developing nephropathy or itai-itai disease in the future.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00420-010-0510-xAuthors
Hyogo Horiguchi, Jichi Medical University Division of Environmental Medicine, Center for Community Medicine 3311-1 Yakushiji Shimotsuke, Tochigi 329-0498 JapanKeiko Aoshima, Hagino Hospital 315-1 Haginoshima, Fuchu-machi Toyama 939-2723 JapanEtsuko Oguma, Jichi Medical University Division of Environmental Medicine, Center for Community Medicine 3311-1 Yakushiji Shimotsuke, Tochigi 329-0498 JapanSatoshi Sasaki, The University o......
POSTED 02/03/2010 at 11:55 AM --
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Carboplatin with weekly docetaxel and ifosfamide in advanced head and neck cancers: a phase I Brown University Oncology Group dose escalation study (HN-93)
Conclusions This novel regimen of carboplatin with weekly docetaxel and ifosfamide has a favorable toxicity profile and is active in this
setting. Phase II study results are awaited.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1251-yAuthors
Ritesh Rathore, Roger Williams Hospital Division of Hematology/Oncology 825 Chalkstone Avenue Providence RI 02908 USAAriel Birnbaum, Rhode Island Hospital Division of Hematology/Oncology Providence RI USABharti Rathore, Roger Williams Hospital Division of Hematology/Oncology 825 Chalkstone Avenue Providence RI 02908 USAThomas DiPetrillo, Rhode Island Hospital Department of Radiation Oncology Providence RI USATeresa Kennedy, Brown University Oncology Group Providence RI USANeal Ready, Duke Medical Cent......
POSTED 02/03/2010 at 11:55 AM --
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LSTM begins £0.5 million malaria study in Burkina Faso
(Liverpool School of Tropical Medicine) A new study led by LSTM will investigate whether long-term weekly iron and folic acid supplementation can reduce anemia without increasing the risk of contracting malaria. (Source: EurekAlert! - Medicine and Health)...
POSTED 02/02/2010 at 11:00 PM --
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Evaluation of Risk Factors for Morbidity and Mortality after Pylorectomy and Gastroduodenostomy in Dogs
To (1) identify and describe the type and frequency of postoperative complications after pylorectomy and gastroduodenostomy in dogs and (2) identify preoperative and intraoperative risk factors, including the presence of neoplasia, prognostic for patient mortality after surgery. Case series. Dogs (n=24) treated by pylorectomy and gastroduodenostomy. Medical records (2000[ndash]2007) for 2 teaching hospitals of dogs treated that had pylorectomy and gastroduodenostomy were reviewed. Pre-, intra-, and postoperative data were obtained from the medical record. Of the 24 dogs, 75% survived 14 days, but 10 (41%) died by 3 months. Overall median survival time (MST) was 578 days. On log-rank univariate analysis, preoperative weight loss (P=.001) and malignant neoplasia (P=.01) were associated with ......
POSTED 02/02/2010 at 06:00 PM --
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