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Anemia Medical and Health News Headlines
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All Recent Anemia Medical Condition News Headlines |
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Diagnosis and Management of Waldenstrom Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines
Waldenström macroglobulinemia is a B-cell malignancy with lymphoplasmacytic infiltration in the bone marrow or lymphatic tissue and a monoclonal immunoglobulin M protein (IgM) in the serum. It is incurable with current therapy, and the decision to treat patients as well as the choice of treatment can be complex. Using a risk-adapted approach, we provide recommendations on timing and choice of therapy. Patients with smoldering or asymptomatic Waldenström macroglobulinemia and preserved hematologic function should be observed without therapy. Symptomatic patients with modest hematologic compromise, IgM-related neuropathy that requires therapy, or hemolytic anemia unresponsive to corticosteroids should receive standard doses of rituximab alone without maintenance therapy. Patients w......
POSTED 09/01/2010 at 12:01 PM --
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High-throughput profiling of amino acids in strains of the Saccharomyces cerevisiae deletion collection [METHOD]
The measurement of small molecule metabolites on a large scale offers the opportunity for a more complete understanding of cellular metabolism. We developed a high-throughput method to quantify primary amine-containing metabolites in the yeast Saccharomyces cerevisiae by the use of capillary electrophoresis in combination with fluorescent derivatization of cell extracts. We measured amino acid levels in the yeast deletion collection, a set of ~5000 strains each lacking a single gene, and developed a computational pipeline for data analysis. Amino acid peak assignments were validated by mass spectrometry, and the overall approach was validated by the result that expected pathway intermediates accumulate in mutants of the arginine biosynthetic pathway. Global analysis of the deletion collect......
POSTED 09/01/2010 at 09:02 AM --
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Duffy-negative is associated with hemolytic phenotype of sickle cell anemia.
Authors: Mecabo G, Hayashida DY, Azevedo-Shimmoto MM, Vicari P, Arruda MM, Bordin JO, Figueiredo MS
PMID: 20638342 [PubMed - indexed for MEDLINE] (Source: Clinical Immunology)...
POSTED 08/31/2010 at 06:00 PM --
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Broader HIV-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the EIAV attenuated vaccine
Conclusions:
This study shows that an HIV envelope modified by the information of another lentivirus vaccine induces effective broadly neutralizing antibodies. A single amino acid mutation was found to increase the immunogenicity of the HIV Env. (Source: Retrovirology)...
POSTED 08/31/2010 at 06:00 PM --
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Pernicious anaemia presenting as catatonia without signs of anaemia or macrocytosis [SHORT REPORTS]
We describe a young
woman who presented with insidious onset catatonia without evidence of
psychosis or depression. Blood count and mean cell volume were normal and
neurological findings were equivocal. Low B12 levels and intrinsic
factor antibodies were found only by chance when they were included in a
battery of further investigations. B12 replacement was followed by
prompt improvement. This case provides an argument for wider screening for
B12 deficiency in certain individuals with psychiatric
disorders. (Source: The British Journal of Psychiatry)...
POSTED 08/31/2010 at 05:00 PM --
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Hba1c is unreliable in CKD patients on anaemia therapy
HbA1c levels are an unreliable indicator of diabetes control in patients given erythropoietin-stimulating agents or intravenous iron, research has shown. (Source: HealthcareRepublic Independent Nurse News)...
POSTED 08/30/2010 at 07:05 PM --
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The variability of blood pressure due to small changes of hematocrit
In conclusion, limited acute anemic conditions increase mean arterial blood pressure during the initial period of 2 h, an effect that is quantitatively similar but opposite to the acute increase of Hct during the same period. (Source: AJP: Heart and Circulatory Physiology)...
POSTED 08/30/2010 at 04:02 PM --
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Imaging characteristics of angiomatoid fibrous histiocytoma of bone
We present the first report of a patient with angiomatoid fibrous histiocytoma of bone in the radiology literature. This tumor
initially eluded diagnosis due to its similarities with chronic hematoma and aneurysmal bone cyst. Only two cases of angiomatoid
fibrous histiocytoma have been reported in the radiology literature and both of these lesions were in the soft tissues. The
fairly distinctive findings in our patient of multiple large cystic chambers with fluid-fluid levels are similar to the findings
in the two soft tissue case reports, suggesting that imaging may be used to suggest this specific diagnosis regardless of
location, especially in the clinical setting of unexplained hematoma or anemia. Mention of this diagnosis in the radiology
report may aid in the final diagnosis at......
POSTED 08/29/2010 at 01:38 PM --
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Single Anastomosis DuodenoâIleal Bypass with Sleeve Gastrectomy (SADI-S). One to Three-Year Follow-up
Abstract Single anastomosis duodenoâileal bypass with sleeve gastrectomy (SADI-S) is a new operation for morbid obesity based on the
biliopancreatic diversion in which a sleeve gastrectomy is followed by an end-to-side duodenoâileal diversion. The preservation
of the pylorus makes possible the reconstruction in one loop, which reduces operating time and needs no mesentery opening.
We review the results obtained on the first 50 operated patients with 1 to 3 years follow-up. Eighteen men and 32 women with
a mean BMI of 44 kg/m2 were operated on. Hypertension was present in 50%, sleep apnea in 30%, hypertriglyceridemia in 60% and hypercholesterolemia
in 43%.There were 27 type two diabetics, most of them on insulin therapy. There were two gastric staple-line leaks......
POSTED 08/27/2010 at 01:30 AM --
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Hypoplastic myelodysplastic syndrome (h-MDS) is a distinctive clinical entity with poorer prognosis and frequent karyotypic and FISH abnormalities compared to aplastic anemia (AA)
Abstract: The aims of the present study are two-fold: (1) to define the clinical features of hypoplastic myelodysplastic syndrome (h-MDS) in comparison with aplastic anemia (AA) and (2) to evaluate the prognostic roles of karyotyping and fluorescent in situ hybridization (FISH) in these hypoplastic marrow syndromes.Based on a medical record review at Seoul National University Hospital, the records of 409 patients diagnosed with either h-MDS or AA were evaluated. Of these patients, 358 had been diagnosed with AA and 51 with h-MDS (median age, 39 years). At diagnosis, 235 and 165 patients underwent karyotyping and FISH analysis, respectively. Karyotypic abnormalities and trisomy 8 and trisomy 1q FISH abnormalities were found more frequently in h-MDS patients than in AA patients. Median overa......
POSTED 08/27/2010 at 01:28 AM --
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Persistent Diarrhea: Risk Factors and Outcome
Conclusions The presence of these risk factors should alert the clinician to take appropriate measures to decrease the mortality.
Content Type Journal ArticleDOI 10.1007/s12098-010-0125-yAuthors
B. Umamaheswari, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006 IndiaNiranjan Biswal, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006 IndiaB. Adhisivam, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006 IndiaS. C. Parija, Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006 IndiaS......
POSTED 08/26/2010 at 01:19 PM --
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Prevalence of hematological abnormalities in patients with Sheehanâs syndrome: response to replacement of glucocorticoids and thyroxine
Abstract Anemia and other hematological abnormalities are common in patients with Sheehanâs syndrome. The response of these abnormalities
to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of
hematological abnormalities and response to treatment in patients with Sheehanâs syndrome. Forty patients of Sheehanâs syndrome
and an equal number of age and parity matched healthy controls were studied for prevalence of hematological abnormalities.
Hemoglobin concentration, hematocrit, red cell, white cell and platelet count were significantly decreased in patients with
Sheehanâs syndrome compared to controls. Frequency of anemia, leucopenia, thrombocytopenia and pancytopenia was significantly
higher in thes......
POSTED 08/26/2010 at 01:16 PM --
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Burden of anemia in patients with osteoarthritis and rheumatoid arthritis in French secondary care
Conclusions:
Arthritis patients with concomitant anemia have a longer length of stay, undergo more procedures, and have higher hospitalization costs than nonanemic arthritis patients in public hospitals in France. In private hospitals, concomitant anemia was associated with modest increases in length of stay and number of procedures; however, this did not translate into higher costs. Such evidence of anemia-related health care utilization and costs can be considered as a proxy for the clinical significance of anemia. (Source: BMC Geriatrics)...
POSTED 08/25/2010 at 06:00 PM --
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Target haemoglobin to aim for with erythropoiesis-stimulating agents: a position statement by ERBP following publication of the Trial to Reduce Cardiovascular Events with Aranesp(R) Therapy (TREAT) Study
The European Renal Best Practice (ERBP), which are issued by ERA–EDTA, are suggestions for clinical practice in areas in which evidence is lacking or weak, together with position statements on recently published randomized controlled trials, or on existing guidelines and recommendations. In 2009, the Anaemia Working Group of ERBP published its first position statement about the haemoglobin target to aim for with erythropoietin-stimulating agents (ESA) and on issues that were not covered by K-DOQI in 2006–07. This second position paper of the group follows the publication of the Trial to Reduce Cardiovascular Events with Aranesp® Therapy (TREAT) Study. This multi-centre, placebo-controlled trial compared cardiovascular and renal outcomes in 4038 patients with type 2 diabetes......
POSTED 08/24/2010 at 04:53 PM --
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Characteristics of Malignant Pleural Mesothelioma in Women [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions
In the absence of other negative prognostic factors, women with epithelial MPM demonstrated a survival advantage. These findings support an aggressive approach to treating MPM including extrapleural pneumonectomy in individuals with favorable prognostic predictors, particularly women with epithelial histology and no other risk factors. (Source: The Annals of Thoracic Surgery)...
POSTED 08/24/2010 at 03:35 PM --
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Kaposi's Sarcoma of the Upper Gastrointestinal Tract Causing Severe Anemia
This case demonstrates that a seemingly asymptomatic patient may have extensive involvement of Kaposi's sarcoma in the gastrointestinal tract. Medscape Gastroenterology (Source: Medscape Today Headlines)...
POSTED 08/24/2010 at 12:38 PM --
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FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia
CNB Harisankar, BR Mittal, A Bhattacharya, B SinghJournal of Postgraduate Medicine 2010 56(3):219-221 (Source: Journal of Postgraduate Medicine)...
POSTED 08/24/2010 at 03:25 AM --
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Dialysis Delivery in Canada and the United States
With enormous respect for Drs Mendelssohn and Wish, we disagree with their recently published commentary. The authors cite process-related improvements in dialysis care contributed by several organizations, stating: âAll of these forces have had a profound and measurable impact on quality of dialysis care in the United States [italics added].â The improvements enumerated include dialysis dose, anemia and mineral metabolism management, and arteriovenous fistula rates. For patient-centered outcomes, a puny 2% decrease in the mortality rate over 26 years is noted, even after untold hours of manpower and extensive education. They also fail to mention the increase in catheter use, the 40% first-year mortality, a frightening increase in infections and cardiovascular hospitalizations, lack o......
POSTED 08/24/2010 at 03:17 AM --
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In Reply To âDialysis Delivery in Canada and the United Statesâ
We appreciate the opportunity to respond to the very important issues raised by Drs Parker, Steinman, and Glassock. Disappointingly, addressing easily measurable and actionable âlow-hanging fruit,â such as adequacy of dialysis, anemia management, and vascular access, has failed to produce a substantial improvement in the mortality outcome measures that Parker et al describe. The explanation for this disconnect is not clear, but likely is related to the fact that mortality in dialysis patients is multifactorial, and producing small but significant improvements in only a handful of risk factors does not have the same impact as it does in more ânormalâ populations in which, for example, the use of statins decreases coronary events. (Source: American Journal of Kidney Diseases)...
POSTED 08/24/2010 at 03:17 AM --
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In Reply To âCardiovascular Impact of High-Flow Arteriovenous Fistulasâ
We thank Drs Ouellet, Rioux, and Leblanc for their interest in our work. We agree that the magnitude of changes in cardiac geometry, left ventricular mass, and ejection fraction that we have found were small. We do not agree with the opinion that they might be of limited clinical significance. Left ventricular hypertrophy is a leading cause of cardiac morbidity and mortality in hemodialysis patients, and its cause is multifactorial. Anemia, hypertension, chronic fluid overload, and bone mineral metabolism derangement are among the possible contributory causes of left ventricular hypertrophy, together with the presence of an arteriovenous fistula (AVF), even of low flux. In their retrospective analysis of high-flow AVFs, Ouellet et al did not take these factors into account; thus, their res......
POSTED 08/24/2010 at 03:17 AM --
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