NICE consults on draft scope for its clinical guidance on anaphylaxis
Source: NICE
Area: News
NICE is developing a clinical practice guideline on anaphylaxis for use in the NHS in England, Wales and Northern Ireland. The draft scope is now available for consultation - please see the link below for details (consultation closes on the 29th September 2010). (Source: NeLM - News)...
POSTED 08/31/2010 at 06:00 PM --
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ORIGINAL ARTICLE: Orally supplemented Lactobacillus acidophilus strain Lâ92 inhibits passive and active cutaneous anaphylaxis as well as 2,4âdinitroflurobenzene and mite fecal antigen induced atopic dermatitisâlike skin lesions in mice
ABSTRACT (Source: Microbiology and Immunology)...
POSTED 08/27/2010 at 04:16 AM --
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New Guidelines Give Options for When Epi Fails in Anaphylaxis
Updated guidelines for diagnosing and managing anaphylaxis warn that some patients don't respond to epinephrine and need tranexamic acid or methylene blue instead. Reuters Health Information (Source: Medscape Medical News Headlines)...
POSTED 08/24/2010 at 12:19 PM --
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LETTERS TO THE EDITORS: Induction of immune tolerance using rituximab in a child with severe haemophilia B with inhibitors and anaphylaxis to factor IX
(Source: Haemophilia)...
POSTED 08/24/2010 at 01:23 AM --
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Scopolamine butylbromide: Anaphylaxis: case report
(Source: Reactions)...
POSTED 08/24/2010 at 12:51 AM --
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Immunoglobulin Eâmediated food allergies among adults with allergic rhinitis
Conclusion: Peanut and shrimp were the most common foods encountered in adults with allergic rhinitis. Peanut was best in predicting other food allergies. Total IgE levels with inhalants plus peanut provided the optimal combination of SE, SP, PPV, and NPV. In vitro testing may be important to identify and prevent anaphylaxis to foods in adults. (Source: Otolaryngology - Head and Neck Surgery)...
POSTED 08/18/2010 at 01:08 AM --
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Ketorolac: Anaphylaxis following IV administration: case report
(Source: Reactions)...
POSTED 08/16/2010 at 02:07 AM --
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Palonosetron: Anaphylaxis: case report
(Source: Reactions)...
POSTED 08/13/2010 at 12:47 AM --
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Inhibitory Effect of Farnesylthiosalicylic Acid on Mediators Release by Mast Cells: Preferential Inhibition of Prostaglandin D2 and Tumor Necrosis Factor-α Release
Abstract There is substantial evidence suggesting that the Ras inhibitor farnesylthiosalicylic acid (FTS) may modulate various aspects
of immune function and inflammation in addition to its well known anti-cancer activity. In this regard, we have recently shown
that FTS suppresses T lymphocyte-mediated immune responses. Mast cells (MC), the main effector cells in the elicitation of
the allergic response, are known to secrete granule-associated mediators and to release prostaglandins and cytokines on FCεRI-cross-linking,
thereby contributing to the pathogenesis of allergic diseases. We hypothesized that MC act as an additional target for FTS.
In the present work we analyze the effects of FTS on MC degranulation, prostaglandin release, and cytokine release in vitro, and on t......
POSTED 08/12/2010 at 01:44 PM --
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Usefulness of the basophil activation test (BAT) in the diagnosis of lifeâthreatening drug anaphylaxis
(Source: Allergy)...
POSTED 08/10/2010 at 12:04 AM --
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Toothpasteâinduced anaphylaxis caused by mint (Mentha) allergy
(Source: Allergy)...
POSTED 08/10/2010 at 12:04 AM --
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IgEâmediated anaphylaxis to pristinamycin â report of a case
(Source: Allergy)...
POSTED 08/10/2010 at 12:04 AM --
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Injection allergen immunotherapy for asthma.
CONCLUSIONS: Immunotherapy reduces asthma symptoms and use of asthma medications and improves bronchial hyper-reactivity. One trial found that the size of the benefit is possibly comparable to inhaled steroids. The possibility of local or systemic adverse effects (such as anaphylaxis) must be considered.
PMID: 20687065 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)...
POSTED 08/06/2010 at 08:33 PM --
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Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies
Conclusions The combination of vorinostat and docetaxel was poorly tolerated with excessive DLTs that required early study termination.
No responses were identified. Vorinostat and docetaxel pharmacokinetics were comparable to previous reports in the literature,
without obvious drug-drug interactions.
Content Type Journal ArticleCategory PHASE I STUDIESDOI 10.1007/s10637-010-9503-6Authors
Bryan J. Schneider, Weill Cornell Medical College Division of Hematology/Oncology, Department of Internal Medicine 525 East 68th Street, 3rd floor New York NY 10065 USAGregory P. Kalemkerian, University of Michigan Ann Arbor MI USADeborah Bradley, Duke University 10 Bryan Searle Drive, 477 Seeley G. Mudd Building Durham NC 27710 USADavid C. Smith, University of Michigan Ann Arbor MI USAMerrill J.......
POSTED 08/04/2010 at 03:45 PM --
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Blunted IgE-mediated activation of mast cells in mice lacking the Serum- and Glucocorticoid-inducible kinase SGK3.
In conclusion, both in vitro and in vivo function of BMMCs are impaired in gene targeted mice lacking SGK3. Thus, SGK3 is critical for proper mast cell function.
PMID: 20686074 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Cell Physiology)...
POSTED 08/03/2010 at 06:00 PM --
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RADAR review: Adrenaline autoinjector (Anapen) for acute allergic anaphylaxis
Source: National Prescribing Service
Area: News
A RADAR (Rational Assessment of Drugs and Research) review on adrenaline autoinjector (Anapen) for acute allergic anaphylaxis has been published and is available via the link below. This review was completed on behalf of the National Prescribing Service (NPS), which is an independent Australian organisation supporting the quality use of medicines.
The authors highlight the following summary points (taken directly from the source):
. Anapen is a new adrenaline autoinjector for the emergency treatment of acute allergic reactions with anaphylaxis.
. Anapen has a substantially different administration technique to that of EpiPen. Specific training is required for each autoinjector.
. Ensure that all patients prescri......
POSTED 08/02/2010 at 06:00 PM --
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[Assessment of the effectiveness and safety of natalizumab for treating relapsing-remitting multiple sclerosis.]
CONCLUSIONS: The treatment's effectiveness and safety in our patient group suggest that natalizumab is a treatment for refractory patients or those with aggressive types of multiple sclerosis, although we do not yet know about its long-term effects and the evolution of the appearance of neutralising antibodies.
PMID: 20685144 [PubMed - as supplied by publisher] (Source: Farmacia Hospitalaria)...
POSTED 08/01/2010 at 06:00 PM --
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Famotidine: Anaphylaxis: case report
(Source: Reactions)...
POSTED 08/01/2010 at 12:35 AM --
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Paclitaxel: Anaphylaxis: case report
(Source: Reactions)...
POSTED 08/01/2010 at 12:35 AM --
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Omeprazole: Anaphylaxis and generalised urticaria: 5 case reports
(Source: Reactions)...
POSTED 08/01/2010 at 12:35 AM --
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