Review paper Genetic and environmental factors for hyperhomocysteinaemia and its clinical implications in Parkinson’s disease
Elevated homocysteine (Hcy) plasma levels are caused by genetic and environmental factors. Polymorphisms of Hcy metabolizing enzyme genes may result in its plasma increase. Experimental and clinical studies have shown the possible role of hyperhomocysteinaemia in pathogenesis of Parkinson’s disease (PD), Alzheimer’s disease and vascular disorders. The results of clinical studies in PD generally do not support the theoretical hypotheses, and animal studies remain controversial. A major environmental factor responsible for Hcy increase in PD seems to be levodopa therapy. Its metabolism results in Hcy increase and may be reduced with folate and vitamins B6, B12 supplementation or inhibi-tion of catechol-O-methyltransferase (COMT) activity. Therefore, the potential harmful role of ......
POSTED 07/01/2009 at 09:35 AM --
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Think You Understand Alzheimer's?
"Virtual Dementia Tour" mimics the debilitating effects of the disease. (Source: ABC News: Health)...
POSTED 07/01/2009 at 09:18 AM --
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Discovery Of Neural Stem Cell Differentiation Factor
Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin layer around axons in order to accelerate neuronal signal transmission. (Source: Alzheimer's / Dementia News From Medical News Today)...
POSTED 07/01/2009 at 07:00 AM --
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X-rays For Early Alzheimer's Disease Detection
Researchers have demonstrated a new, highly detailed x-ray imaging technique that could be developed into a method for early diagnosis of Alzheimer's disease. The technique has previously been used to look at tumors in breast tissue and cartilage in human knee and ankle joints, but this study is the first to test its ability to visualize a class of minuscule plaques that are a hallmark feature of Alzheimer's disease. (Source: ScienceDaily Headlines)...
POSTED 07/01/2009 at 07:00 AM --
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Behind the headlines - Alzheimer's progression probed
Publication Date: 08 June 2009 'Behind the headlines' is produced by the NHS Knowledge Service and provides an unbiased and evidence-based analysis of health stories that make the news. (Source: Neurological Conditions Specialist Library)...
POSTED 07/01/2009 at 05:19 AM --
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UK Dementia Research Funding Must Triple, Say Experts
The UK's leading dementia charities united with eminent scientists to urge the government to commit to a national dementia research strategy and triple annual investment to £96 million in five years. The Alzheimer's Research Trust and Alzheimer's Society revealed that the UK government lags behind France, Germany and the US in dementia research funding and has no plans for the future. (Source: Health News from Medical News Today)...
POSTED 07/01/2009 at 05:00 AM --
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easyJet pledges to raise 'a million for a million' to help people with dementia
Budget airline easyJet today pledged to raise a million pounds to support the one million people who will develop dementia in the next ten years. (Source: Alzheimers Society)...
POSTED 07/01/2009 at 04:59 AM --
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What you should know about Alzheimer's disease
Alzheimer's disease and other dementias do a number on the mind and body of the individual with the disease and can also take a major toll on the health and finances of the individual's family.
The Alzheimer's Association's latest annual report, "2009... (Source: OrlandoSentinel: Medical Research)...
POSTED 06/30/2009 at 06:00 PM --
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The Age of Alzheimer's
The rise in Alzheimer's patients means more costs associated with this mysterious, prevalent
disease. (Source: Managed Healthcare Executive Magazine Online)...
POSTED 06/30/2009 at 06:00 PM --
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Statins Might Stave off Alzheimer's
In animal study, drug blocks cell death characteristic of the disease Source: HealthDay
Related MedlinePlus Topics: Alzheimer's Disease, Statins (Source: MedlinePlus Health News)...
POSTED 06/30/2009 at 11:00 AM --
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Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease.
Page: 774DOI: 10.1097/NEN.0b013e3181aacbe9Authors: Nelson, Peter T. MD, PhD; Abner, Erin L. MS; Schmitt, Frederick A. PhD; Kryscio, Richard J. PhD; Jicha, Gregory A. MD, PhD; Santacruz, Karen MD; Smith, Charles D. MD; Patel, Ela HT; Markesbery, William R. MD (Source: Journal of Neuropathology & Experimental Neurology)...
POSTED 06/30/2009 at 10:35 AM --
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U.S. urged to compare Alzheimer, ADD, other therapies
WASHINGTON (Reuters) - An Institute of Medicine committee urged the U.S. government on Tuesday to fund studies comparing treatments for Alzheimer's disease, attention deficit disorder and other conditions as part of a new effort to determine which strategies work best. (Source: Reuters: Health)...
POSTED 06/30/2009 at 10:21 AM --
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Charities warn dementia funding must triple
Dementia research funding needs to be tripled to prevent the burden of the disease causing a financial crisis, Alzheimer's disease charities have warned. (Source: HealthcareRepublic Pharmacist News)...
POSTED 06/29/2009 at 07:12 PM --
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Charities warn dementia funding must triple
Dementia research funding needs to be tripled to prevent the burden of the disease causing a financial crisis, Alzheimer's disease charities have warned. (Source: Healthcare Republic News)...
POSTED 06/29/2009 at 07:12 PM --
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Relationship between ALS and the degree of cognitive impairment, markers of neurodegeneration and predictors for poor outcome. A prospective study
Conclusion: In our prospective study, age, disease severity and CSF beta-amyloid levels taken together were a risk factor suggesting shorter survival times. Dementia is relatively frequent in ALS and may be a consequence of either FTLD or result from co-existing Alzheimer disease. (Source: European Journal of Neurology)...
POSTED 06/29/2009 at 06:00 PM --
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Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification
Conclusions: The diffuse appearance of NFT in the cerebral cortex with the highest severity in the temporal pole was found to be a neuropathological characteristic of DNTC. (Source: Psychiatry and Clinical Neurosciences)...
POSTED 06/29/2009 at 06:00 PM --
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Apathy: A Common Psychiatric Syndrome in the Elderly
This article reviews the definition of apathy, prevalence and associated adverse outcomes, causation, the approach to patients with apathy, and available treatment options with particular attention to studies conducted in a nursing home setting. The purpose of this article is to increase the recognition of apathy by physicians working in the nursing home. (Source: Journal of the American Medical Directors Association)...
POSTED 06/29/2009 at 11:20 AM --
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Carotid Artery Ultrasound and Echocardiography Testing to Lower the Prevalence of Alzheimer's Disease
The use of two clinic office techniques, carotid artery ultrasound and echocardiography (CAUSE), to detect deficient brain blood flow delivery in the healthy, cognitively normal, older individual is proposed. Evidence indicates that persistent heart-to-brain blood flow deficit involving low cardiac output or low ejection fraction and carotid artery narrowing can promote cognitive impairment and that such impairment may lead to Alzheimer's disease (AD) or vascular dementia (VaD). A number of independent epidemiologic studies reported cardiovascular and cerebrovascular disease to be risk factors to AD and VaD. The clinical rationale for CAUSE is to detect and prevent progression of cognitive dysfunction in elderly persons and is based on the general understanding that mild cognitive impairme......
POSTED 06/29/2009 at 10:32 AM --
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Abstract #1: Cognitive Function Data in Newly Diagnosed AED-Naïve Epilepsy Patients Across a Broad Age Range
Conclusions: These data may be useful in the analysis and interpretation of cognitive assessment data from clinical trials of AEDs and/or studies in similar patient populations.Financial disclosure: This study was sponsored by AstraZeneca. None of the authors has a financial relationship with the sponsor. (Source: Neurotherapeutics)...
POSTED 06/29/2009 at 10:32 AM --
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Abstract #3: APP Secretases As Therapeutic Targets for Traumatic Brain Injury
Traumatic brain injury (TBI) is a significant risk factor for the development of Alzheimer's disease, and post mortem studies show that 30% of TBI fatalities have amyloid-2 (A2) deposits. Remarkably, these deposits occur less than one day after injury. Not only does A2 accumulate after TBI, but so do the necessary amyloid precursor protein (APP) enzymes responsible for A2 production: BACE1 protein (2-secretase) and the gamma-secretase complex protein presenilin-1 (PS-1). In order to understand the role of these secretases in brain trauma, we targeted 2- and gamma-secretases with genetic knockout (BACE1−/−) and pharmacological inhibition (DAPT treatment) in an experimental model of TBI.We exposed WT and BACE1−/− mice and vehicle- and DAPT-treated C57/Bl6 mice to the controlled corti......
POSTED 06/29/2009 at 10:32 AM --
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