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Alzheimers Medical and Health News Headlines
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All Recent Alzheimers Medical Condition News Headlines |
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EXPOSED: "Scandalous Abuse" of the Elderly Being Killed With Psychiatric Medications
(NaturalNews) Elderly dementia patients are being subjected to "scandalous abuse" by being drugged with dangerous antipsychotic drugs, according to a letter by ten influential health organizations, published in The Daily Telegraph."[One hundred thousand] people with dementia in care homes are being inappropriately prescribed a damaging chemical cosh of antipsychotic drugs and new research suggests that there is a significant problem in hospitals too," the letter reads. "Antipsychotics should only ever be a last resort. This over prescription is abuse and it must stop. ... We cannot stand by while this scandalous abuse of vulnerable citizens continues." Although antipsychotic drugs are intended for people with medical conditions such as schizophrenia and bipolar disorder and are not approve......
POSTED 02/08/2010 at 01:00 AM --
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Marijuana ineffective as an Alzheimer's treatment: UBC-Vancouver Coastal Health research
(University of British Columbia) The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study by researchers at the University of British Columbia and Vancouver Coastal Health Research Institute. (Source: EurekAlert! - Medicine and Health)...
POSTED 02/07/2010 at 11:00 PM --
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Marijuana ineffective as an Alzheimer's treatment
The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study. (Source: ScienceDaily Headlines)...
POSTED 02/07/2010 at 11:00 PM --
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Medical Food Shows Promise in the Treatment of Early Alzheimer's
A randomized controlled clinical trial of a medical food that works by increasing synaptic function appears to be effective in improving memory in patients with mild Alzheimer's disease. Medscape Medical News (Source: Medscape Internal Medicine Headlines)...
POSTED 02/07/2010 at 09:41 AM --
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Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
Astrocytes are fundamental for brain homeostasis and are at the fulcrum of neurological diseases including Alzheimer's disease (AD). Here, we monitored changes in astroglia morphology throughout the age-dependent progression of AD. We used an immunohistochemical approach that allows us to determine the domain of glial cytoskeleton, by measuring the surface, volume, and the relationship between astrocytes and neuritic plaques. We investigated astroglia in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the progression of the human disease. The numerical density of astrocytes is affected neither by AD nor by age. We found reduction of surface and volume of GFAP profiles from early ages (6 months; 43.84 and 52.76%, respectively), persisting at 12 (40.73 and 45.3......
POSTED 02/05/2010 at 06:00 PM --
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An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer.
Authors: Jiang C, Feng Y, Huang X, Xu Y, Zhang Y, Zhou N, Shen X, Chen K, Jiang H, Liu D
Abeta(1-42) is the proteolytic cleavage product of cleavage of the amyloid precursor protein by beta- and gamma-secretases. The aggregation of Abeta(1-42) plays a causative role in the development of Alzheimer's disease. To lock Abeta(1-42) in a homogenous state, we embedded the Abeta(1-42) sequence in an unstructured region of Bcl-x(L). Both the N-terminus and the C-terminus of Abeta(1-42) were constrained in the disordered region, whereas the conjunction did not introduce any folding to Abeta(1-42) but maintained the sequence as a monomer in solution. With Bcl-x(L)-Abeta(42), we developed an enzyme-linked immunosorbent assay to compare the affinity of compounds for monomeric Abeta(1-42). Bcl-x(L)......
POSTED 02/05/2010 at 06:00 PM --
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Ageing, neurodegeneration and Parkinson's disease
Age is the largest risk factor for the development and progression of Parkinson’s disease (PD). Ageing affects many cellular processes that predispose to neurodegeneration, and age-related changes in cellular function predispose to the pathogenesis of PD. The accumulation of age-related somatic damage combined with a failure of compensatory mechanisms may lead to an acceleration of PD with age. The formation of Lewy bodies may represent a marker for protective mechanisms against age-related dysfunction and degeneration of the nervous system. Mild parkinsonian signs may be present in older people, which are associated with reduced function. These may be due to age-related decline in dopaminergic activity, incidental Lewy body disease, degenerative pathologies (early PD and Alzheimer&r......
POSTED 02/05/2010 at 03:47 PM --
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UK Sanders-Brown to Host Seminar on Healthy Aging
The University of Kentucky Sanders-Brown Center on Aging and the African-American Dementia Outreach Partnership will host a seminar on "Healthy Aging: Mind, Body and Spirit." The seminar begins at 10:30 a.m. Thursday, Feb. 25, at the North Lexington Family YMCA, 381 W. Loudon Ave. in Lexington. “Increasing awareness of this devastating disease of the brain is an important part of changing community behavior," said Deborah Danner, director of education for the UK Sanders-Brown Center on Aging Alzheimers Disease Center. "Presentations in the community such as this one at the YMCA promote lifestyle modifications that increase the likelihood of maintaining a healthy brain.” (Source: UK College of Medicine News)...
POSTED 02/05/2010 at 09:50 AM --
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Progression to Alzheimer's Linked to Amount of Amyloid in Brain [Clinical & Research News]
(Source: Psychiatr News)...
POSTED 02/05/2010 at 08:01 AM --
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Alzheimer's: How to help a caregiver
Alzheimer's care — Practical tips for how to help an Alzheimer's caregiver. (Source: MayoClinic.com Full Feed)...
POSTED 02/04/2010 at 08:45 PM --
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Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment
Conclusion: The MoCA-J could be a useful cognitive test for screening MCI, and could be recommended in a primary clinical setting and for geriatric health screening in the community.. (Source: Geriatrics and Gerontology International)...
POSTED 02/04/2010 at 06:00 PM --
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Generation of conditional null alleles for APP and APLP2
Proteolytical cleavage of the [beta]-amyloid precursor protein (APP) generates [beta]-amyloid, which is deposited in the brains of patients suffering from Alzheimer's disease (AD). Despite the well-established key role of APP for AD pathogenesis, the physiological function of APP and its close homologues APLP1 and APLP2 remains poorly understood. Previously, we generated APP-/- mice that proved viable, whereas APP-/-APLP2-/- mice and triple knockouts died shortly after birth, likely due to deficits of neuromuscular synaptic transmission. Here, we generated conditional knockout alleles for both APP and APLP2 in which the promoter and exon1 were flanked by loxP sites. No differences in expression were detectable between wt and floxed alleles, whereas null alleles were obtained upon crossing ......
POSTED 02/04/2010 at 06:00 PM --
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Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease
With longevity, postoperative cognitive decline in the elderly has emerged as a major health concern for which several factors have been implicated, one of the most recent being the role of anaesthetics. Interactions of anaesthetic agents and different targets have been studied at the molecular, cellular and structural anatomical levels. Recent in vitro nuclear magnetic resonance spectroscopy studies have shown that several anaesthetics act on the oligomerisation of amyloid [beta] peptide. Uncontrolled production, oligomerisation and deposition of amyloid [beta] peptide, with subsequent development of amyloid plaques, are fundamental steps in the generation of Alzheimer's disease. Amyloid [beta] peptide is naturally present in the central nervous system, and is found at higher tissue conce......
POSTED 02/04/2010 at 06:00 PM --
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Presenilins and the gamma-secretase: still a complex problem
This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer's disease and in the metabolism of the amyloid-beta precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined. (Source: BioMed Central)...
POSTED 02/04/2010 at 06:00 PM --
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Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice.
Authors: Li L, Tsai HJ, Li L, Wang XM
Overload of intracellular calcium caused by amyloid-beta peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer's disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca(2+) entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by Abeta(25-35) in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that Abeta(25-35) enhanced the inward Ba(2+) and Ca(2+) currents. The currents were partially inhibited by Ni(2+) and completely suppressed by Cd(2+), indicating that Abeta(25-35) disrupts intracellular calcium homeostasis via the modulation of both L- and T-type channels. Furthermore, icariin nearly complete suppressed the ab......
POSTED 02/04/2010 at 05:12 PM --
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People with Alzheimer's Wandering Off
Across The Country, Numerous Incidents Reported of People with Alzheimer's Wandering Off and Tragically Dying. (Source: Disabled World)...
POSTED 02/04/2010 at 04:55 PM --
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The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice.
Authors: Cho JY, Um HS, Kang EB, Cho IH, Kim CH, Cho JS, Hwang DY
Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/APPsw Tg mice were treated with alpha-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred. The results indicated that (i) the combination-applied (COMA) Tg group with exercise training (ET) and alpha-lipoic acid administr......
POSTED 02/04/2010 at 05:48 AM --
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The enhancement of amyloid precursor protein and beta-site amyloid cleavage enzyme 1 interaction: Amyloid-beta production with aging.
Authors: Zou L, Yang R, Zhang P, Dai Y
Aging is considered a high risk factor for Alzheimer's disease (AD), which is one of the most prevalent neurodegenerative disorders in the elderly population. The major pathologic feature of AD is senile plaques mainly containing amyloid-beta (Abeta) components. However, little direct evidence has shown aging in association with Abeta. Here we show that the protein-protein interaction of amyloid precursor protein (APP) and beta -site amyloid cleavage enzyme 1 (BACE1) is enhanced by the fluorescence resonance energy transfer (FRET) assay during the aging process, and the APP-BACE1 complex accumulates in the endosome in the IMR-90 fibroblast (NHF) cellular aging models. Moreover, enhanced Abeta is observed in aged cells, rat brain homogenates and hu......
POSTED 02/04/2010 at 05:48 AM --
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Age Concern And Help The Aged Comment On Dementia Research, UK
Michelle Mitchell, Charity Director for Age Concern and Help the Aged, said: 'The fact that dementia research remains so disproportionately underfunded will be deeply concerning to older people, their families and anyone who has experienced this cruel disease. 'The financial burden of this disease is already very high and this will increase further as the population ages unless we find a cure or learn how to prevent dementia. 'Dementia is not going to go away and it is therefore of paramount importance to both sufferers now and society as a whole, that we invest in research... (Source: Health News from Medical News Today)...
POSTED 02/04/2010 at 03:00 AM --
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Age Concern And Help The Aged Comment On Dementia Research, UK
Michelle Mitchell, Charity Director for Age Concern and Help the Aged, said: 'The fact that dementia research remains so disproportionately underfunded will be deeply concerning to older people, their families and anyone who has experienced this cruel disease... (Source: Alzheimer's / Dementia News From Medical News Today)...
POSTED 02/04/2010 at 03:00 AM --
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