Gamma-secretase activating protein is a therapeutic target for Alzheimerâs disease
Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease
Nature 467, 95 (2010). doi:10.1038/nature09325
Authors: Gen He, Wenjie Luo, Peng Li, Christine Remmers, William J. Netzer, Joseph Hendrick, Karima Bettayeb, Marc Flajolet, Fred Gorelick, Lawrence P. Wennogle & Paul Greengard
Accumulation of neurotoxic amyloid-β is a major hallmark of Alzheimer’s disease. Formation of amyloid-β is catalysed by γ-secretase, a protease with numerous substrates. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme. Knowledge of the mechanisms underlying its selectivity is critical for the development of clinically effective γ-secretase inhibitors that can reduce amyloid-β......
POSTED 09/02/2010 at 02:52 AM --
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Help us become Santander's next Charity of the Year
Do you work for Santander? Or know anyone who does? Alzheimerâs Society has been shortlisted to be Santanderâs next Charity of the Year. (Source: Alzheimers Society)...
POSTED 09/02/2010 at 01:21 AM --
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Protein that Fuels Alzheimer's Disease Discovered, Promising New Treatments Expected
Fisher Scientists Discover Protein that Fuels Alzheimer's Disease, Promising New Treatments Expected. (Source: Disabled World)...
POSTED 09/01/2010 at 10:20 PM --
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Active minds delay dementia but speed decline once it hits
Cognitive stimulation has early benefits, according to a 12-year study of those 65 and up, but after Alzheimer's hits may make it worse. (Source: USATODAY.com Health)...
POSTED 09/01/2010 at 07:22 PM --
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Mental Stimulation Delays The Decline In Thinking Skills, But May Accelerate Dementia Later On
Mentally stimulating activities that challenge and engage the brain, such as crossword puzzles, reading, or listening to the radio may help slow down cognitive decline - the gradual deterioration of thinking skills - but may encourage the acceleration of dementia later on during old age, says a report in Neurology, the journal of the American Academy of Neurology. Study author, Robert S... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 06:00 PM --
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Mental 'exercise' linked to faster dementia progression
NEW YORK (Reuters Health) - While staying mentally active in old age has been linked to a delayed onset of dementia, seniors who engage in such brain "exercise" may actually have a faster rate of decline once Alzheimer's is diagnosed, researchers reported Wednesday. (Source: Reuters: Health)...
POSTED 09/01/2010 at 04:22 PM --
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Finding Suggests New Aim for Alzheimerâs Drugs
A discovery by Paul Greengard, an 84-year-old scientist and Nobel winner, has illuminated a new direction. (Source: NYT Health)...
POSTED 09/01/2010 at 04:00 PM --
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'Brain Exercise' May Worsen Existing Alzheimer's (CME/CE)
(MedPage Today) -- Keeping mentally active may help stave off Alzheimer's disease, but once patients are diagnosed with the condition, "brain exercise" may actually speed up cognitive decline, researchers said -- adding that that may not be a bad thing. (Source: MedPage Today State Required CME)...
POSTED 09/01/2010 at 03:13 PM --
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Finding Suggests New Target for Alzheimerâs Drugs
A discovery by Paul Greengard, an 84-year-old scientist and Nobel winner, has illuminated a new direction. (Source: NYT Health)...
POSTED 09/01/2010 at 12:34 PM --
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For the intellectually active, Alzheimer's diagnosis begins a steep slide
The vaunted protection that intellectually active adults get from Alzheimer’s disease has a dark downside, a study released Wednesday has found. Once dementia symptoms become evident and Alzheimer’s disease is diagnosed in such patients, their... (Source: OrlandoSentinel: Medical Research)...
POSTED 09/01/2010 at 09:33 AM --
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Intellect Neurosciences to Participate in Rodman & Renshaw 2010 Annual Global Investment Conference in New York on September 14, 2010
NEW YORK, Sept. 1, 2010 (GLOBE NEWSWIRE) -- Intellect Neurosciences, Inc. (OTCBB:ILNS), a biopharmaceutical company with an internal preclinical and clinical-stage pipeline and licenses with major pharmaceutical companies covering products in late-stage trials to treat and prevent Alzheimer's disease (AD), has announced that Daniel G. Chain, Ph.D., the company's chief executive officer and chairman of the board, will speak at the Rodman & Renshaw Annual Global Investment Conference in New York City on September 14, 2010 (Source: Medical News (via PRIMEZONE))...
POSTED 09/01/2010 at 08:10 AM --
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Homewatch CareGivers Releases New "Guide To Living With Dementia" To Help Families Cope With The Numerous Issues Associated With Dementia
As part of its ongoing program to help caregivers and provide families with the information they need to make informed decisions, Homewatch CareGivers has released its latest resource, entitled "Guide to Living with Dementia. " This new guide is available for free download from the company's website. Homewatch CareGivers is the world's largest and most experienced international provider of in home care services for people of all ages, celebrating 30 years of caring in 2010... (Source: Health News from Medical News Today)...
POSTED 09/01/2010 at 08:00 AM --
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Alzheimerâs Society survey shows vital need for well-thought through Northern Ireland dementia strategy
90 per cent of people do not think people with dementia in Northern Ireland are getting enough help and support, new research by Alzheimerâs Society found today. (Source: Alzheimers Society)...
POSTED 09/01/2010 at 02:46 AM --
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The Role of Self-Efficacy in the Alzheimer's Family Caregiver Stress Process: A Partial Mediator between Physical Health and Depressive Symptoms
(Source: Clinical Gerontologist)...
POSTED 09/01/2010 at 01:22 AM --
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Scientists identify protein that spurs formation of Alzheimer's plaques
(Rockefeller University) Scientists have discovered how the cancer drug Gleevec attacks beta-amyloid, the primary component of senile plaques in Alzheimer's disease. The finding suggests that drugs modeled on Gleevec could provide new treatments for this disease. (Source: EurekAlert! - Social and Behavioral Science)...
POSTED 08/31/2010 at 11:00 PM --
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Best Friends Approach when Caring for Those with Alzheimer's and Memory Loss
There is a quiet revolution taking place amongst caregivers of those with Alzheimer's and dementia, and it's really quite simple. (Source: Disabled World)...
POSTED 08/31/2010 at 09:50 PM --
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Biomarkers of Alzheimer's disease and exercise: One step closer to prevention
(Source: Annals of Neurology)...
POSTED 08/31/2010 at 06:00 PM --
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Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
Abstract (Source: Annals of Neurology)...
POSTED 08/31/2010 at 06:00 PM --
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Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation.
Conclusions: cAPPL mRNA and protein is widely distributed in the central nervous system of the crab and the time course of expression suggests a role of cAPPL during long-term memory formation. (Source: BioMed Central)...
POSTED 08/31/2010 at 06:00 PM --
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Cognitive Activity Impacts Alzheimer's Disease Progression
Cognitively stimulating activity may slow cognitive decline prior to dementia onset in Alzheimer's
disease but lead to faster decline after onset, according to a study published online Sept. 1 in
Neurology. (Source: Modern Medicine)...
POSTED 08/31/2010 at 06:00 PM --
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