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Acromegaly Medical and Health News Headlines
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All Recent Acromegaly Medical Condition News Headlines |
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Preoperative assessment of neurosurgical patients
Abstract: The aims of the preoperative assessment of neurosurgical patients include exchange of information, reassuring the anxious patient, establishing whether raised intracranial pressure is present and optimizing any co-existing medical problems, which may or may not be related to the neurological condition. The patientâs neurological status must be assessed and documented preoperatively as it will impact on the anaesthetic and is vital for assessing the patient in the postoperative period. Patients often have co-morbidity and are commonly taking hypoglycaemic, anticonvulsant, anticoagulant, antihypertensive, corticosteroid, and chronic pain medication, all of which may influence the conduct of anaesthesia. Fluid and electrolyte disturbances are common as a result of the underlying c......
POSTED 08/28/2010 at 12:08 AM --
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World's Tallest Man Undergoes Gamma Knife Surgery
World's Tallest Man Stretches OutâOver Eight Feetâfor Needed Gamma Knife Surgery - Minimally invasive treatment long on potential benefits for Sultan Kosen of Turkey, 27, sufferer of persistent acromegaly. (Source: Disabled World)...
POSTED 08/26/2010 at 12:33 PM --
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World's Tallest Man Stretches Out Over Eight Feet for Needed Gamma Knife Surgery
Minimally invasive treatment long on potential benefits for Sultan Kosen of Turkey, 27, sufferer of persistent acromegaly
ATLANTA, Aug. 26 (HSMN NewsFeed) -- Much of Sultan Kosen's eight feet, two-inch stature rose up in an 17-year period starting at ... Devices, OncologyElekta, Gamma Knife, acromegaly, radiosurgery, radiotherapy (Source: HSMN NewsFeed)...
POSTED 08/26/2010 at 08:26 AM --
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Coincidence of Multiple Endocrine Neoplasia Type 2A With Acromegaly.
Authors: Saito T, Miura D, Taguchi M, Takeshita A, Miyakawa M, Takeuchi Y
Medullary thyroid carcinoma (MTC) occurs as a part of multiple endocrine neoplasia (MEN) type 2. Acromegaly, a pituitary adenoma, occurs as a part of MEN1. Rarely, MEN2 and MEN1 coexist in a single patient simultaneously. A 40-year-old man with a history of pituitary adenomectomy for acromegaly had a surgical resection of thyroid carcinoma clinically diagnosed as MTC. His mother, who had MTC and pheochromocytoma, had a germline mutation in the RET gene that could cause the subtype, MEN2A. Identification of gene mutations in RET and MEN1 were examined in the subject. The resected tumor was pathologically diagnosed as MTC. Genomic examinations revealed the RET mutation C634F, which was identical to the mutation of ......
POSTED 08/24/2010 at 06:00 PM --
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[Treatment of acromegaly.]
Authors: Dénes J, Korbonits M, Hubina E, Góth M
Growth hormone (GH) hypersecretion leads to acromegaly which is associated with several co-morbidities and increased mortality. Despite of the typical clinical features and modern diagnostic tools, it often takes years from the onset of the disease until the diagnosis. The aims of the treatment are to reduce or control the tumor growth, inhibit the GH hypersecretion, normalize the insulin-like growth factor-I (IGF-I) levels, treat the co-morbidities and therefore reduce mortality. There are three approaches for therapy: surgery, medical management (dopamine agonist, somatostatin analogues and GH receptor antagonist), and radiotherapy. Efficient therapy of the disease is based on the appropriate multidisciplinary team management.
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POSTED 08/18/2010 at 09:42 AM --
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Review: Acromegaly
Source: BMJ
Area: News
The British Medical Journal has published a review on acromegaly, in which the following questions are addressed:
. How common is acromegaly?
. How is it diagnosed?
. How is it managed?
Acromegaly is a clinical disorder of adults characterised by changes in the face and extremities caused by excess growth hormone secretion. (Source: NeLM - News)...
POSTED 08/16/2010 at 06:00 PM --
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Acromegaly
(Source: BMJ Online First)...
POSTED 08/16/2010 at 10:10 AM --
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Quantification of day-to-day variability in growth hormone levels in acromegaly
This study quantified the magnitude of day-to-day GH variability
in patients with acromegaly by performing an analysis of previously obtained plasma GH profiles. The analysis was performed
at the Michigan Clinical Research Unit at the University of Michigan. A total of nine 48 h Q10 min GH profiles obtained in
nine patients with active acromegaly were examined. The study was planned after data collection and analysis was conducted
using AltmanâBland methods. Day 1 vs. Day 2 values were examined. 95% confidence intervals of the D2 vs. D1 ratios were calculated
on all individual subject data as well as on a single 0800 h GH sample and composite mean data for 2-, 5-, 9-, and 24-h sampling
protocols. Confidence interval range was 0.66â1.50 for the 0800 h sample an......
POSTED 08/09/2010 at 02:39 PM --
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Acromegaly: Numerous treatments for hormonal disorder
Acromegaly — Comprehensive overview covers symptoms, causes, treatment of this hormonal disorder. (Source: MayoClinic.com Full Feed)...
POSTED 08/03/2010 at 08:45 PM --
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Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas: An International Collaborative Study.
Conclusions: AIPmut pituitary adenomas have clinical features that may negatively impact treatment efficacy. Predisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.
PMID: 20685857 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 08/03/2010 at 06:00 PM --
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Pituitary Adenomas In Childhood, Adolescence and Young Adulthood: Presentation, Management, Endocrine and Metabolic Outcomes.
Conclusions: This is one of the largest reviews of patients aged 21 or younger at diagnosis of pituitary adenoma followed up by a single service. Two-thirds have prolactinomas, all treated with DAs and three underwent surgery. Increased cardiovascular risk factors (obesity and dyslipidaemia) and infertility are important sequelae and active identification and treatment necessary.
PMID: 20685833 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)...
POSTED 08/03/2010 at 06:00 PM --
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Woman With Acromegaly Presenting as Unilateral Vision Loss
A 36-year-old woman presented to the emergency department with loss of vision in the right eye that had initially involved the peripheral field and progressed over 2 months to the central and nasal fields. During this period, she also had headaches, vomiting, and generalized weakness. She had had amenorrhea for 1 year. (Source: Consultant Live)...
POSTED 08/03/2010 at 07:00 AM --
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Acromegaly and Pregnancy: A Retrospective Multicenter Study of 59 Pregnancies in 46 Women.
Conclusion: The following conclusions were reached: 1) pregnancy in women with active or uncontrolled acromegaly may be associated with an increased risk of gestational diabetes and gravid hypertension; 2) pregnancy is occasionally associated with symptomatic enlargement of GH-secreting pituitary macroadenomas; 3) changes in serum GH and IGF-I concentrations are variable during pregnancy, indicating that routine monitoring is not mandatory if the pregnancy is uneventful; and 4) GH-suppressive treatment can be safely withdrawn after conception in most acromegalic women.
PMID: 20660047 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 07/20/2010 at 06:00 PM --
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Female Gonadal Function before and after Treatment of Acromegaly.
Conclusion: Gonadal dysfunction is very common in premenopausal women with acromegaly. The potential causes include the lactogenic effect of prolactin, GH, or both on gonadotropic axis. Tumor mass effect or direct effect of GH or IGF-I on the ovary may also participate in ovarian dysfunction.
PMID: 20660045 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 07/20/2010 at 06:00 PM --
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Increased prevalence of acromegaly in a highly polluted area.
Conclusion: This study confirms the prevalence of acromegaly recently reported. The increased risk of developing this disease in area D suggests that the pathogenetic role of environmental context needs to be better evaluated.
PMID: 20621957 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)...
POSTED 07/08/2010 at 06:00 PM --
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The autopsy was conducted âUnder most inauspicious circumstances:â John Turner, Harvey Cushingâs case XXXII, and his unwitting contributions to the early understanding of acromegaly
Abstract Harvey Cushingâs monograph The Pituitary Body and Its Disorders describes Case XXXII, a 36-year-old man who presented with gigantism in 1910. The detailed post-mortem exam findings are
prefaced with a cryptic statement, describing âinauspicious circumstancesâ surrounding the autopsy. Although contemporary
biographies of Cushing have offered insight into these circumstances, the original surgical file for Case XXXII has not been
previously reviewed. The original Johns Hopkins Hospital surgical records were reviewed, and the case of John Turner, who
Cushing identified by name in his monograph The Pituitary Body and Its Disorders, was selected for further review. A review of the original surgical file revealed a typewritten note by Dr. Crowe, one of
the surgeons......
POSTED 07/07/2010 at 01:00 AM --
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Acromegaly without Imaging Evidence of Pituitary Adenoma.
Conclusion: Acromegaly can be caused by GH-secreting pituitary adenomas that are not evident on conventional MR imaging. Adenomas in some of these patients become evident using volumetric interpolated breath-hold examination MR imaging. Surgical exploration of the pituitary gland in acromegalic patients with endocrine findings consistent with a GH-secreting adenoma but negative MR imaging can lead to identification and removal of an adenoma.
PMID: 20610592 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)...
POSTED 07/06/2010 at 06:00 PM --
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Aberrations in carbohydrate metabolism in patients with diagnosed acromegaly, hospitalized in the Endocrinology and Diabetology Department of Collegium Medicum University of Nicolaus Copernicus in Bydgoszcz in the years 2001-2009.
Conclusions: In patients with acromegaly, the incidence rate of type 2 diabetes is 3-4-times higher than in the rest of the population and increases with age, especially after the age of 60. (Pol J Endocrinol 2010; 61 (3): 260-263).
PMID: 20602299 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)...
POSTED 07/06/2010 at 05:00 PM --
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Growth hormone status predicts left ventricular mass in patients after cure of acromegaly.
CONCLUSIONS: Patients who develop GHD following cure of acromegaly do not demonstrate elevated LV mass, in contrast to patients with a history of acromegaly but normal GH levels or to patients with active acromegaly. This suggests that GH status after treatment of acromegaly correlates with LV mass, and that, in GH sufficient patients, reversal of remodeling may be slower than previously thought. These data suggest that it will be important to determine whether GH replacement alters left ventricular morphology over time.
PMID: 20598930 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research)...
POSTED 06/30/2010 at 06:00 PM --
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The acute effect of a single application of cabergoline on endogenous GH levels in patients with acromegaly on pegvisomant treatment.
CONCLUSION: Endogenous GH is not significantly decreased after a single oral cabergoline application during pegvisomant treatment in acromegaly.
PMID: 20598600 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research)...
POSTED 06/29/2010 at 06:00 PM --
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