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Thursday, December 04, 2008
 Latest
Hepatocellular Carcinoma News Headlines
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Hepatocellular Carcinoma News Headlines
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All Recent Hepatocellular Carcinoma News Headlines |
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Proliferation of human hcc cells and chemically induced mouse liver cancers requires jnk1-dependent p21 downregulation
JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent of their involvement in the development of human liver cancers is unknown. Here, we show that activation of JNK1 but not JNK2 was increased in human primary hepatocellular carcinomas (HCCs). Further, JNK1 was required for human HCC cell proliferation in vitro and tumorigenesis after xenotransplantation. Importantly, mice lacking JNK1 displayed decreased tumor cell proliferation in a mouse model of liver carcinogenesis and decreased hepatocyte proliferation in a mouse model of liver regeneration. In both cases, impaired proliferation was caused by increased expression of p21, a cell-cycle inhibitor, and reduced expression of c-Myc, a negative regulator of p21. Genetic inactivation of p21 in JNK1......
POSTED 12/02/2008 at 11:19 PM --
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Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma
Conclusion: Our study revealed that Capn4 overexpression underlies invasion and metastasis after LT for HCC and might be a candidate biomarker for future diagnosis and a target for therapy. (HEPATOLOGY 2008.) (Source: Hepatology)...
POSTED 12/02/2008 at 11:00 PM --
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[medical_sciences] b-catenin deficiency, but not myc deletion, suppresses the immediate phenotypes of apc loss in the liver
Dysregulated Wnt signaling is seen in approximately 30% of hepatocellular carcinomas; thus, finding pathways downstream of the activation of Wnt... (Source: Proceedings of the National Academy of Sciences)...
POSTED 12/01/2008 at 11:00 PM --
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Analysis of abcg2 expression and side population identifies intrinsic drug efflux in the hcc cell line mhcc-97l and its modulation by akt signaling
In this study, we showed that ABCG2 was intrinsically expressed in a subgroup of HCC tissues and its expression pattern significantly influenced the levels of drug efflux from HCC cell lines. In MHCC-97L HCC cell line with intrinsic ABCG2 expression, we confirmed the importance of SP cells to the drug efflux-related chemotherapy resistance and found that the SP analysis provided an efficient method to evaluate the functional activity of ABCG2 transporter. In this cell line, we discovered that the SP proportion was modulated by the treatments of Akt signaling inhibitors and serum supplement, which led to the finding that Akt signaling was able to regulate the SP cells’ efflux activity via altering the subcellular localization of ABCG2 transporter. We further demonstrated that the Akt ......
POSTED 12/01/2008 at 11:00 PM --
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Gadd45-alpha and gadd45-gamma utilize p38 and jnk signaling pathways to induce cell cycle g2/m arrest in hep-g2 hepatoma cells.
Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells.
Mol Biol Rep. 2008 Dec 2;
Authors: Zhu N, Shao Y, Xu L, Yu L, Sun L
The Gadd45 family of proteins, which includes alpha, beta, and gamma isoforms, has recently been shown to play a role in the G2/M cell cycle checkpoint in response to DNA damage; however, the mechanisms by which Gadd45 proteins inhibit cell cycle control are not fully understood. Using immunohistochemical analysis, we found that protein expression of Gadd45gamma, but not Gadd45alpha, was down-regulated in hepatocellular carcinoma. We thus investigated possible mechanisms by which Gadd45alpha and Gadd45gamma might differentially induce G2/M arrest in the human hepatoma Hep-G2 cell line.......
POSTED 12/01/2008 at 11:00 PM --
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Expression of cellular oncogenes in human primary hepatocellular carcinoma
Abstract With DNA-mRNA hybridization in situ technique, the expression of five oncogenes, c-N-ras, c-Ki-ras. c-Ha-ras, c-myc and c-fos, was observed in two cases of human hepatocellular carcinoma. The expression of c-N-ras & c-fos was greatly enhanced in tumor tissues of the two cases, and about 25%–50% of the tumor cells showed positive expression.
The other three oncogenes namely c-Ki-ras, c-Ha-ras & c-myc, were not detected in these two carcinomas or in the non-cancerous liver tissues adjacent to the carcinomas. It is surmised
that c-N-ras and c-fos may play coordinative role in maintaining the malignant phenotype of human primary hepatocellular carcinoma.
Content Type Journal ArticleCategory Basic InvestigationsDOI 10.1007/BF02997557Authors
Dechun Li, The Peking Uni......
POSTED 12/01/2008 at 12:55 AM --
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Photodynamic and photobiological action of sulfonated phthalocyanines
Abstract Zinc sulfonated phthalocyanine (ZnSPc) 10–20 mg/kg plus light showed strong inhibition on mouse S-180 and RA795 lung carcinoma,
inhibition rate was 44.8% and 57.4% respectively. Aluminum sulfonated phthalocyanine (AlSPc) 20 mg/kg plus copper vapor laser
or red light, tumor inhibition rate of S-180 was 62.7% and 66.8% respectively, AlSPc 1.25 µg/ml caused severe photohemolyses
of red cells. At the dose of 10 µg/ml plus light, lipid peroxidation of red cell membrane was greatly enhanced. Acetylchollnesterase
(AchEs) of red cell membrane inactivated, liver mitochondrial ATPase and microsomal G-6-Pase inhibited. ZnSPc at the dose
of 1.25 µg/ml caused obvious photodamage on DNA of hepatoma cells.
Content Type Journal ArticleCategory Basic InvestigationDOI 10.100......
POSTED 12/01/2008 at 12:54 AM --
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The usefulness of99tc-pmt delayed hepatobiliary imaging in the diagnosis of small hepatocellular carcinoma
Abstract This investigation was aimed to assess the usefulness of delayed hepatobiliary imaging in the diagnosis of small hepatocellular
carcinoma (HCC). Sixty-two patients with this hepatic cancer were included in the study. 56 males and 6 females, with a mean
age of 50.6 yr. (32–72 years old). All patients were performed by surgery, verified histologically, and these tumors were
smaller than 5cm. Liver scans were performed 5 minutes, 2 hours and 5 hours after the administration of radiopharmaceutices.
In 31 of the 62 patients (50%), the tumor exhibited equal radioactivity uptake or greater radioactivity uptake than the surrounding
liver in delayed imaging. And the sensitivity was 33.3% (2/6), 41.2% (7/17), 60.0% (9/15) and 54.2% (13/24) in the tumor size
was ⩽2 cm, 2......
POSTED 12/01/2008 at 12:54 AM --
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Nidus vespae protein inhibiting proliferation of hepg2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing g1 cell cycle arrest
A protein named NVP(1) was isolated from Nidus vespae. T he aim of the present study was to elucidate whether and how NVP(1) modulates the proliferation of HepG2 cells. NVP(1) at a concentration of 6.6 [mu]g/ml could arrest the cell cycle at stage G1 and inhibit the mRNA expression of cyclinB, cyclinD1 and cyclinE. NVP(1) suppressed cdk2 protein expression, but increased p27 and p21 protein expression. However, NVP(1) did not alter p16 protein expression levels. NVP(1) promoted apoptosis in HepG2 cells as indicated by nuclear chromatin condensation, and in addition, the extracellular signal-regulated kinase (ERK) signaling pathway was activated. Moreover, the p-ERK protein expression level was attenuated when the HepG2 cells were pretreated with ERK inhibitor PD98059. These results demonst......
POSTED 11/30/2008 at 11:00 PM --
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The expressions of hbv x gene and
ets
-2, igf-i, c-
myc
and n-
ras
oncogenes in human hepatocellular carcinoma and tumor-adjacent tissues
Abstract The expressions of HBV X gene andets-2, IGF-II c-myc and N-ras were studied in 7 pairs of human primary hepatocellular carcinoma (PHC) and tumor-adjacent tissues, using RNA hybridization
and immunoblot methods. The results showed that specific 17 and 28 kD HBV X gene products (HBxAg) were existed in a portion
of PHC and tumor-adjacent tissues. The 17 kD HBxAg was detected in the sera of 3 patients who also had 17 kD HBxAg in their
liver tissues. Multiple expressions of oncogenes such asets-2, c-myc and N-ras were observed in PHC and tumor-adjacent tissues that had HBxAg expressed, indicating HBxAg might function as a transactivator
in the course of intracellular proto-oncogene activation. It is also observed that in some tumor-adjacnet tissues the expressions
ofets......
POSTED 11/28/2008 at 12:40 PM --
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Effect of hepatic stimulator substance (hss) extracted from fetal liver on the proliferation of human alexender hepatoma cells
Abstract It’s reported that hepatic stimulator substance (HSS) was extracte from the fetal liver of 4–6 months of fetus, and that the
effect of HSS on the proliferation of human Alexender hepatoma cells was studied in this paper. The results showed that proliferation
of Alexender cells varied with the amount of HSS in the culture medium, and the former was positively correlated with the
latter significantly (P<0.01); The study indicated that HSS from the fetal liver can stimulate the proliferation of human Alexender hepatoma cells.
Content Type Journal ArticleCategory Basic InvestigationDOI 10.1007/BF02997278Authors
Ying Shan, Henan Medical University Hepatitis Division, Herum Institute of Medical Sciences ZhengzhouZhensheng Zhang, Henan Medical University Hepatit......
POSTED 11/28/2008 at 12:40 PM --
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Hepatocellular carcinoma and vinyl chloride
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10552-008-9268-9Authors
Giuseppe Mastrangelo, University of Padova Department of Environmental Medicine and Public Health Via Giustiniani 2 35128 Padova ItalyUgo Fedeli, SER- Epidemiological Department Veneto Region Castelfranco Veneto ItalyDiego Martines, University of Padova Department of Surgical and Gastroenterological Sciences Padova Italy
Journal Cancer Causes and ControlOnline ISSN 1573-7225Print ISSN 0957-5243 (Source: Cancer Causes and Control)...
POSTED 11/28/2008 at 08:15 AM --
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Early experience with pet/ct scan in the evaluation of pediatric abdominal neoplasms
Conclusions: Preliminary data indicate that PET/CT is a promising tool in the evaluation of pediatric abdominal malignancies. The delineation of the exact role of this diagnostic modality will require additional experience. (Source: Journal of Pediatric Surgery)...
POSTED 11/27/2008 at 01:45 PM --
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Trim24 (tif1alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer.
Trim24 (Tif1alpha): An essential 'brake' for retinoic acid-induced transcription to prevent liver cancer.
Cell Cycle. 2008 Dec 5;7(23)
Authors: Khetchoumian K, Teletin M, Tisserand J, Herquel B, Ouararhni K, Losson R
Retinoic acid (RA), the active derivative of vitamin A, is an important signaling molecule that controls various developmental processes and influence the proliferation and differentiation of a variety of cell types. RA exerts its biological functions primarily through binding to and activating nuclear RA receptors (RARs, which include the RARalpha, beta and gamma isotypes RARA, RARB and RARC). Aberrant expression or impaired function of these nuclear receptors has been linked to diverse types of cancer. RARs are RA-dependent transcription factors that regulate gen......
POSTED 11/27/2008 at 12:07 PM --
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Liver transplantation in patients with hepatocellular carcinoma.
Authors: Polak WG, Soyama A, Slooff MJ
Liver transplantation has a de fi nitive place in the treatment of patients with hepatocellular carcinoma (HCC) in a cirrhotic liver. Patients with a tumor load within the Milan criteria have excellent survival comparable to survival in patients with benign indications. When tumor load exceeds the Milan criteria survival decreases. Staging of patients with HCC in a cirrhotic liver is de fi cient due to the restrictions of the current imaging modalities. The exact place of tumor controlling therapies during the waiting time for transplantation is not yet clear. No evidence of suf fi cient level is available as to the ef fi cacy of pre-, per- or postoperative chemotherapy. Promising new drugs are currently tested. This counts also for the use of new......
POSTED 11/27/2008 at 08:55 AM --
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Perfusion computed tomographic assessment of early hepatocellular carcinoma in cirrhotic liver disease: initial observations.
Page: 855DOI: 10.1097/RCT.0b013e318161dc58Authors: Ippolito, Davide MD *+; Sironi, Sandro MD *+; Pozzi, Massimo MD ++; Antolini, Laura MD *[S]; Ratti, Laura MD ++; Meloni, Franca MD [//]; Invernizzi, Francesca MD *+; Valsecchi, Maria Grazia MD *[S]; Fazio, Ferruccio MD *[P]# (Source: Journal of Computer Assisted Tomography)...
POSTED 11/27/2008 at 03:21 AM --
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Synergistic antitumoral activity and induction of apoptosis by novel pan bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.
Conclusion: ApoG2 is a potential non-toxic target agent that induces apoptosis by upregulating Noxa, while inhibiting anti-apoptotic proteins and promoting the effect of chemotherapy agent ADM in HCC.
PMID: 19026166 [PubMed - in process] (Source: Acta Pharmacologica Sinica)...
POSTED 11/27/2008 at 01:37 AM --
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Validation of putative housekeeping genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative rt-pcr.
Conclusion:
Of six genes studied, HMBS was found to be the single best reference gene for gene expression studies in HCC. The appropriate choice of combination of more than one reference gene to improve qRT-PCR accuracy depends on the kind of liver tissue or cells under investigation. Quantitative assessment and control of qRT-PCR inhibitors using an external RNA control can reduce the variation of qRT-PCR assay and facilitate the evaluation of gene stability. Our results may facilitate the choice of reference genes for expression studies in HCC. (Source: BioMed Central)...
POSTED 11/26/2008 at 11:00 PM --
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Stereotactic body radiation therapy with or without transarterial chemoembolization for patients with primary hepatocellular carcinoma: preliminary analysis
Conclusion:
SBRT for small HCC and SBRT combined with TACE for advanced HCC with PVTT showed feasible treatment modalities with minimal side effects in selected patients with primary HCC. (Source: BMC Cancer)...
POSTED 11/26/2008 at 11:00 PM --
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Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in egyptian liver disease patients associated with hcv-genotype-4
Conclusions: Aberrant expressions of AKT, GSK3-B, and BCL2 are common events in HCV-associated LD and HCC. AKT, GSK3-B and IL-6 are significantly associated with cirrhosis and could be used as biomarkers for both early detection and molecular target therapy for the prevention of HCC development. TNFRII, GSK3-B and s-AFP could be used as prognostic factors that can predict the clinical outcome of HCC patients. (Source: Journal of Gastroenterology and Hepatology)...
POSTED 11/26/2008 at 11:00 PM --
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