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Thursday, November 20, 2008
 Latest
Glioma News Headlines
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Glioma News Headlines
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All Recent Glioma News Headlines |
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Repeated implantation of interstitial chemotherapy to treat malignant gliomas.
Page: 286DOI: 10.1097/WNQ.0b013e3181823144Authors: Krzeminski, Joseph P. MD *; Piquer, Josep MD +; Riesgo, Pedro MD + (Source: Neurosurgery Quarterly)...
POSTED 11/19/2008 at 01:11 AM --
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Novel anti-angiogenic therapies for malignant gliomas.
Authors: Norden AD, Drappatz J, Wen PY
BACKGROUND: Despite optimum treatment with surgery, radiation therapy, and chemotherapy, most patients with malignant glioma have a poor prognosis. Malignant gliomas are vascular tumours that produce vascular endothelial growth factor (VEGF), which is an important mediator of angiogenesis. Preclinical data indicate that angiogenesis is essential for the proliferation and survival of malignant glioma cells, which suggests that inhibition of angiogenesis might be an effective therapeutic strategy. Anti-angiogenic therapies that target VEGF and the VEGF receptor (VEGFR) are effective adjuncts to the treatment of solid tumours. Normalisation of dilated and leaky tumour vasculature might also enable anti-angiogenic therapy to increase the efficacy of r......
POSTED 11/17/2008 at 05:05 AM --
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Calcium-sensing receptor in cancer: good cop or bad cop?
Abstract The extracellular calcium-sensing receptor (CaR) is a versatile ‘sensor’ for di- and polycationic molecules in the body. CaR
plays a key role in the defense against hypercalcemia by “sensing” extracellular calcium levels in the parathyroid and kidney,
the key organs maintaining systemic calcium homeostasis. Although mutation of CaR gene has so far not been associated with
any malignancy, aberrant functions of CaR have implications in malignant progression. One situation is loss of CaR expression,
resulting in loss of growth suppressing effects of elevated extracellular Ca2+ by CaR, reported in parathyroid adenoma and in colon carcinoma. Another situation is activation of CaR, resulting in increased
production of parathyroid hormone-related peptide (PTHrP), ......
POSTED 11/16/2008 at 05:28 AM --
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The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mrna expression
Conclusions:
Dietary supplementation of DHA containing oil could be an effective way to increase levels of long chain n-3 fatty acids in brain tumors and this increase may be mediated partly by up-regulation of FABP7 expression. (Source: Lipids in Health and Disease)...
POSTED 11/15/2008 at 11:00 PM --
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Targeting of the bmi-1 oncogene/stem cell renewal factor by microrna-128 inhibits glioma proliferation and self-renewal
MicroRNAs (miR) show characteristic expression signatures in various cancers and can profoundly affect cancer cell behavior. We carried out miR expression profiling of human glioblastoma specimens versus adjacent brain devoid of tumor. This revealed several significant alterations, including a pronounced reduction of miR-128 in tumor samples. miR-128 expression significantly reduced glioma cell proliferation in vitro and glioma xenograft growth in vivo. miR-128 caused a striking decrease in expression of the Bmi-1 oncogene, by direct regulation of the Bmi-1 mRNA 3'-untranslated region, through a single miR-128 binding site. In a panel of patient glioblastoma specimens, Bmi-1 expression was significantly up-regulated and miR-128 was down-regulated compared with normal brain. Bmi-1 functions......
POSTED 11/13/2008 at 11:00 PM --
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Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase
Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood. Here, we show that up-regulation of the polyamine system promotes cancer cell survival during hypoxic stress. Hypoxia was found to induce polyamine transport and the key enzyme of polyamine biosynthesis, ornithine decarboxylase (ODC), in a variety of cancer cell lines. Increased ODC protein expression was shown in hypoxic, GLUT-1–expressing regions of tumor spheroids and experimental tumors, as well as in clinical tumor specimens. Hypoxic induction of the polyamine system was dependent on antizyme inhibitor (i.e., a key positive regulator of ODC and polyamine transpo......
POSTED 11/13/2008 at 11:00 PM --
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Correction: pdgfb-mediated model of spinal glioma
(Source: Cancer Research)...
POSTED 11/13/2008 at 11:00 PM --
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Monitoring of gliomas in vivo by diffusion mri and 1h mrs during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids
The measurement of water diffusion by diffusion-weighted MRI (DWI) in vivo offers a non-invasive method for assessing tissue responses to anti-cancer therapies. The pathway of cell death after anti-cancer treatment is often apoptosis, which leads to accumulation of mobile lipids detectable by 1H MRS in vivo. However, it is not known how these discrete MR markers of cell death relate to each other. In a rodent tumour model [i.e. ganciclovir-treated herpes simplex thymidine kinase (HSV-tk) gene-transfected BT4C gliomas], we studied the interrelationships between water diffusion (Trace{D}) and mobile lipids during apoptosis. Water diffusion and water-referenced concentrations of mobile lipids showed clearly increasing and interconnected trends during treatment. Of the accumulating 1H MRS-visi......
POSTED 11/13/2008 at 11:00 PM --
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In vivo (19)f mri and (19)f mrs of (19)f-labelled boronophenylalanine-fructose complex on a c6 rat glioma model to optimize boron neutron capture therapy (bnct).
This study shows the ability of (19)F MRI to selectively map the bio-distribution of (19)F-BPA in a C6 rat glioma model, as well as providing a useful method to perform pharmacokinetics of BNCT carriers.
PMID: 19001698 [PubMed - in process] (Source: Physics in Medicine and Biology)...
POSTED 11/13/2008 at 08:26 AM --
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[letters] technetium tc99m tetrofosmin single-photon emission ct for the assessment of glioma proliferation
(Source: American Journal of Neuroradiology)...
POSTED 11/12/2008 at 11:00 PM --
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[brain] analysis of 11c-methionine uptake in low-grade gliomas and correlation with proliferative activity
CONCLUSION: MET uptake in DAs may be closely associated with tumor viability, which depends on increased amino acid transport by an activated carrier-mediated system. DAs with lower MET uptake were considered more quiescent lesions, whereas DA with higher MET uptake may act more aggressively. (Source: American Journal of Neuroradiology)...
POSTED 11/12/2008 at 11:00 PM --
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[spine] intraoperative 3t mr imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" mr-operating room suite
SUMMARY: We assessed feasibility, safety, and timing of an original intraoperative MR procedure in 3 cases of resection of spinal cord glioma by using a clinical 3T MR system connected to an adjacent operating room in a design being coined "twin" or "dual" MR–operating room suite. (Source: American Journal of Neuroradiology)...
POSTED 11/12/2008 at 11:00 PM --
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The guanine nucleotide exchange factors trio, ect2, and vav3 mediate the invasive behavior of glioblastoma.
The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma.
Am J Pathol. 2008 Nov 13;
Authors: Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, Rutka JT
Malignant gliomas are characterized by their ability to invade normal brain tissue. We have previously shown that the small GTPase Rac1 plays a role in both migration and invasion in gliomas. Here, we aim to identify Rac-activating guanine nucleotide exchange factors (GEFs) that mediate glioblastoma invasiveness. Using a brain tumor expression database, we identified three GEFs, Trio, Ect2, and Vav3, that are expressed at higher levels in glioblastoma versus low-grade glioma. The expression of these GEFs is also associated with poor......
POSTED 11/12/2008 at 11:00 PM --
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Extracts of marine sponge
polymastia janeirensis
induce oxidative cell death through a caspase-9 apoptotic pathway in human u138mg glioma cell line
Summary We have studied the apoptotic pathway activated in response to marine sponge extracts of Polymastia janeirensis. The effect on intracellular ROS production was also examined. Exposure of U138MG glioma cell line to doses higher than 5 μg/mL
has decreased glioma cell viability, with an IC50 <15 μg/mL for both aqueous and organic extracts. However, extracts at higher doses (50 and 100 μg/mL) have stronger cytotoxic
effects, decreasing more than 90% of glioma cell viability. The antioxidant Trolox® (100 μM) reversed the cell death percentage
induced by extracts at 10 and 25 μg/mL. The type of cell death induced by such high doses was predominantly necrosis, while
a high percentage of apoptotic glioma cells was found at 10 μg/mL. Mo......
POSTED 11/11/2008 at 02:00 AM --
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Beyond vessels: occurrence and regional clustering of vascular endothelial (ve-)cadherin-containing junctions in non-endothelial cells
Abstract The genes encoding transmembrane glycoproteins of the cadherin family, i.e., the Ca2+-dependent cell-cell adhesion molecules, are typically expressed in cell-type- or cell-lineage-specific patterns. One of them,
vascular endothelial (VE)-cadherin, is widely considered to be specific for vascular endothelia in which it is either the
sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial
cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably
those of metastatic tumors. Surprisingly, however, we have recently noted the frequent synthesis, surface exposure, and junction
assembly of VE-cadherin in certain other cells, in which this ......
POSTED 11/11/2008 at 01:56 AM --
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Thallium-201 spect in prognostic assessment of malignant gliomas treated with postoperative radiotherapy
Conclusions Differences of201T1 uptake in malignant gliomas could predict outcome.201T1-SPECT is potentially useful in the management of patients with malignant gliomas.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/BF02984645Authors
Takatoshi Semba, Ehime University School of Medicine Department of Radiology 454, Shitsukawa, Toon 791-0295 Ehime JapanYoshifumi Sugawara, Ehime University School of Medicine Department of Radiology 454, Shitsukawa, Toon 791-0295 Ehime JapanTakashi Ochi, Ehime University School of Medicine Department of Radiology 454, Shitsukawa, Toon 791-0295 Ehime JapanTakashi Fujii, Ehime University School of Medicine Department of Radiology 454, Shitsukawa, Toon 791-0295 Ehime JapanTeruhito Mochizuki, Ehime University School of Medici......
POSTED 11/09/2008 at 03:47 AM --
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What is the place of bevacizumab and irinotecan in the treatment of glioblastoma and other malignant gliomas?.
Page: 717DOI: 10.1097/WCO.0b013e3283184625Authors: Omuro, Antonio M a; Delattre, Jean-Yves b (Source: Current Opinion in Neurology)...
POSTED 11/07/2008 at 05:52 AM --
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Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Page: 728DOI: 10.1097/WCO.0b013e328318402aAuthors: Gerstner, Elizabeth R a,d,e; Sorensen, A Gregory b,e; Jain, Rakesh K c; Batchelor, Tracy T a,c,d,e (Source: Current Opinion in Neurology)...
POSTED 11/07/2008 at 05:52 AM --
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Emerging antiangiogenic treatments for gliomas - efficacy and safety issues.
Page: 736DOI: 10.1097/WCO.0b013e3283131370Authors: Dietrich, Jorg a,b,c; Norden, Andrew D a,b; Wen, Patrick Y a,b (Source: Current Opinion in Neurology)...
POSTED 11/07/2008 at 05:52 AM --
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Tlr ligands in the local treatment of established intracerebral murine gliomas.
In this study, we compared various TLR ligands for their ability to affect murine GL261 cells in vitro and to eradicate established intracerebral murine gliomas in vivo. Our data show that GL261 cells express TLR2, TLR3, and TLR4 and respond to the corresponding TLR ligands with increasing MHC class I expression and inducing IL-6 secretion in vitro, while TLR5, TLR7, and TLR9 are essentially absent. Remarkably, CpG-oligonucleotides (CpG-ODN, TLR9) appeared to inhibit GL261 cell proliferation in a cell-type specific, but CpG-motif and TLR9-independent manner. A single intratumoral injection of CpG-ODN most effectively inhibited glioma growth in vivo and cured 80% of glioma-bearing C57BL/6 mice. Intratumoral injection of Pam3Cys-SK4 (TLR1/2) or R848 (TLR7) also produced a significant surviva......
POSTED 11/07/2008 at 05:40 AM --
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