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Fibrosarcoma News Headlines
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All Recent Fibrosarcoma News Headlines |
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Right foot congenital infantile fibrosarcoma treated only with chemotherapy
(Source: Pediatric Blood and Cancer)...
POSTED 08/26/2010 at 12:19 AM --
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Cell Adhesive Peptide Screening of the Mouse Laminin alpha1 Chain G Domain.
Authors: Hozumi K, Akizuki T, Yamada Y, Hara T, Urushibata S, Katagiri F, Kikkawa Y, Nomizu M
Cell adhesive peptides have been widely applied for therapeutic drugs, drug delivery systems, and biomaterials. Previously, we identified various cell adhesive sequences in the G domains of four laminin alpha chains (alpha2-alpha5) by the systematic soluble peptide screening. We also identified five cell-binding sequences in the laminin alpha1 chain G domain using synthetic peptide-polystyrene beads. Here, we re-screened cell adhesive peptides in the laminin alpha1 chain G domain by the systematic soluble peptides screening. The 110 soluble peptides were evaluated for their cell adhesive activities using human fibrosarcoma HT1080 cells and human dermal fibroblasts. Fourteen peptides were newly......
POSTED 08/16/2010 at 06:00 PM --
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Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.
Authors: Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK
Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding lectin, has been reported to display remarkable anti-proliferative and apoptosis-inducing activities toward a variety of cancer cells; however, the precise molecular mechanisms by which PCL induces cancer cell death are still elusive. In the current study, we found that PCL could induce apoptosis and autophagy in murine fibrosarcoma L929 cells. Subsequently, we demonstrated that inhibition of Ras could promote L929 cell death, suggesting that Ras-Raf signaling pathway plays the key negative regulator in PCL-induced apoptosis. And, we showed that Ras-Raf signaling pathway was also involved in PCL-induced autophagy as the negative regulator. In addition, we f......
POSTED 08/12/2010 at 06:00 PM --
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Images in Cardiac Surgery: Fibrosarcoma of the Left Superior Pulmonary Vein with Extension to the Left Atrium
(Source: Journal of Cardiac Surgery)...
POSTED 07/31/2010 at 06:00 PM --
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Low grade fibromyxoid sarcoma: a case report and review of the literature
We present the case of a 50-year-old male who developed a large mass in the posterior aspect of his lower left thigh. The tumor was excised with preservation of the neurovascular structures surrounded by the mass. The tumour measured 11x10x9 cm and on pathology evaluation was diagnosed as LGFMS. Due to the relative rarity of LGFMS, there is no dedicated protocol regarding follow-up recommendations. In order to early diagnose possible metastasis it is important to inform the patients about the longstanding metastatic potential of the disease. (Source: Journal of Orthopaedic Surgery and Research)...
POSTED 07/28/2010 at 06:00 PM --
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Long-Term Survival With Heart Transplantation for Fibrosarcoma of the Heart [CASE REPORTS]
We report a case of a 25-year-old woman with sarcoma of the heart who received a transplant and is clinically well after 7 years. We believe that transplantation must be considered in this kind of pathology for selected cases. (Source: The Annals of Thoracic Surgery)...
POSTED 07/27/2010 at 01:48 PM --
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Effect of phloroglucinol on oxidative stress and inflammation.
Authors: Kim MM, Kim SK
The aim of this study is to investigate the inhibitory effect of phloroglucinol on oxidative stress and inflammation. Phloroglucinol is a monomer of phlorotannins abundant in brown algae. A few effects of phloroglucinol have been reported, but any information on its effect on anti-inflammation related to oxidative stress has not been reported in detail until now. In our study phloroglucinol exhibited inhibitory effects not only on oxidative stress but also on the production of inflammatory mediators such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and prostaglandin E(2) in RAW264.7 cells stimulated by lipopolysaccharide. Furthermore, in HT1080 cells, a human fibrosarcoma cell line, phloroglucinol decreased the expression of matrix metallopro......
POSTED 07/23/2010 at 06:00 PM --
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Fibrosarcoma of the oral cavity
Vijay Wadhwan, Minal S Chaudhary, Madhuri GawandeIndian Journal of Dental Research 2010 21(2):295-298Fibrosarcoma has been defined as a malignant tumor of the fibroblasts that shows no other evidence of cellular differentiation and is capable of recurrence and metastasis. Fibrosarcomas are rare but may occur anywhere in the body, most commonly in the retroperitoneum, thigh, knee and distal extremities. Fibrosarcoma is uncommon in the head and neck region and constitutes about 1% of all the malignancies affecting the human race. Of all the fibrosarcomas occurring in humans, only 0.05% occurs in the head and neck region. Of this, almost 23% is seen in the oral cavity. Fibosarcomas generally have a poor prognosis and the overall survival rate is 20-35% over a perio......
POSTED 07/23/2010 at 12:25 AM --
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GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase
GI24, an immunoglobulin superfamily member, has been cloned from a placenta cDNA library as a gene product that promoted activation of matrix metalloproteinase (MMP)-2 mediated by membrane type (MT) 1[ndash]MMP. Co-expression of GI24 with MT1-MMP in HEK293T cells increased the cell-surface level of MT1-MMP concomitant with the cleavage of the GI24 at the juxtamembrane site to shed the extracellular domain. HT1080 fibrosarcoma cells stably transfected with the GI24 gene expressed a higher level of MT1-MMP and showed more invasive ability in collagen gel than the control cells. GI24 was cleaved in HT1080 cells, which was blocked by the administration of MMP inhibitor BB94 or transfection of small interfering RNA (siRNA) targeting MT1-MMP. GI24 expression is relatively high in some squamous c......
POSTED 07/12/2010 at 06:00 PM --
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3-caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression.
In conclusion, we demonstrated that the anti-invasive effects of CDCQ occur through the inhibition of AP-1 and signaling pathways involving PKCdelta and three MAPKs, leading to the downregulation of MMP-9 expression. Thus, CDCQ is an effective anti-metastatic agent that functions by downregulating MMP-9 gene expression.
PMID: 20599481 [PubMed - as supplied by publisher] (Source: Toxicology Letters)...
POSTED 06/30/2010 at 06:00 PM --
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Lymphotoxin-[beta] receptor activation by lymphotoxin-[alpha]1[beta]2 and LIGHT promotes tumor growth in an NF[kappa]B-dependent manner
Lymphotoxin beta receptor (LT[beta]R) activation on mouse fibrosarcoma cells (BFS-1) results in enhanced solid tumor growth paralleled by increased angiogenesis induced by the expression of pro-angiogenic CXCL2. In our study, we demonstrate that both functional ligands of the LT[beta]R, namely LT[alpha]1[beta]2 and LIGHT, are involved in the activation of LT[beta]R in solid fibrosarcomas. To identify whether the lymphocyte population is involved in the activation of LT[beta]R in these fibrosarcoma tumors, we used conditional LT[beta]-deficient mice that specifically lack LT[beta] expression either on T cells (T-LT[beta]-/-) or on B cells (B-LT[beta]-/-). Solid tumor growth was reduced in both mouse strains when compared to tumor growth in wild-type mice, indicating the participation of bot......
POSTED 06/25/2010 at 06:00 PM --
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Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1act/Tubulin Interaction Is an Important Determinant of Mitotic Stability in Cultured HT1080 Human Fibrosarcoma Cells.
Authors: Cao JN, Shafee N, Vickery L, Kaluz S, Ru N, Stanbridge EJ
Activation of the mitogen-activated protein kinase (MAPK) pathway plays a major role in neoplastic cell transformation. Using a proteomics approach, we identified alpha tubulin and beta tubulin as proteins that interact with activated MAP/extracellular signal-regulated kinase kinase 1 (MEK1), a central MAPK regulatory kinase. Confocal analysis revealed spatiotemporal control of MEK1-tubulin colocalization that was most prominent in the mitotic spindle apparatus in variant HT1080 human fibrosarcoma cells. Peptide arrays identified the critical role of positively charged amino acids R108, R113, R160, and K157 on the surface of MEK1 for tubulin interaction. Overexpression of activated MEK1 caused defects in spindle arrange......
POSTED 06/21/2010 at 06:00 PM --
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Soft tissue sarcomas in the first year of life
Abstract: Background: Soft tissue sarcomas (STS) occurring in the first year of life represent a rare entity. Challenges in delivering optimal therapy may affect the outcome in this very young population.Methods: We searched the SEER database for records of infants less than 1year of age, with a reported diagnosis of STS who were diagnosed from 1973 to 2006. We analysed their clinical features and survival. These patients were also compared to older patients (1â18years old) in order to understand the differences between the two groups.Results: The incidence rate of STS in the first year of life was 16.0 per million. As an entity, they represented 7.3% of malignancies reported in the first year of life. One fifth of these tumours (20.9%) were reported to be metastatic at diagnosis. The mo......
POSTED 06/09/2010 at 06:00 PM --
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Right foot congenital infantile fibrosarcoma treated only with chemotherapy
No Abstract. (Source: Pediatric Blood and Cancer)...
POSTED 06/07/2010 at 06:00 PM --
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Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma
We examined PDGF-B and PDGF-R[beta] expression in four human gastric carcinoma cell lines (TMK-1, MKN-1, MKN-45, and KKLS) and in 38 surgical specimens of gastric carcinoma. PDGF-B and PDGF-R[beta] expression was examined by immunofluorescence in surgical specimens and in human gastric carcinoma cells (TMK-1) implanted orthotopically in nude mice. Groups of mice (n = 10, each) received saline (control) or PDGF-R tyrosine kinase inhibitor imatinib. PDGF-B and PDGF-R[beta] mRNA expression was significantly higher in patients with lymph node metastasis than in those without and was also significantly higher in diffuse-type carcinoma than in intestinal-type carcinoma. In surgical specimens, tumor cells expressed PDGF-B, but PDGF-R[beta] was expressed predominantly by stromal cells. Under cultu......
POSTED 06/06/2010 at 06:00 PM --
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Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop
Conclusions:
Our results imply that FLT1 is induced as an indirect downstream effect of FUS-DDIT3 expression in MLS. This could be a consequence of the ability of FUS-DDIT3 to hijack parts of normal adipose tissue development and reprogram primary cells to a liposarcoma-like phenotype. The findings of nuclear FLT1 protein and expression of corresponding ligands in MLS and normal tissues may have implications for tissue homeostasis and tumor development through auto- or intracrine signaling. (Source: BMC Cancer)...
POSTED 05/31/2010 at 06:00 PM --
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Primary pituitary fibrosarcoma presenting with multiple metastases: A case report and literature review
We report a 26-year-old female with pathologically confirmed PPF, who presented with features of elevated intracranial pressure, oculomotor nerve palsy, field defects and panhypopituitarism. Despite the combination therapy, which included tumor removal, radiotherapy, and chemotherapy, magnetic resonance imaging demonstrated multiple intracranial and extracranial metastases at a seven-month follow-up, and the survival duration from diagnosis was only 11 months. Based on a review of the literature, we propose preliminary etiologic classification criteria for PF as well as a new therapeutic approach to reduce PPF recurrence and metastasis, including extended surgical resection and postoperative whole-brain radiotherapy. (Source: Neurology India)...
POSTED 05/26/2010 at 08:40 AM --
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Sclerosing Epithelioid Fibrosarcoma-A Report of Two Cases with Cytogenetic Analysis of FUS Gene Rearrangement by FISH Technique.
We present 2 cases of SEF with cytogenetic analysis for FUS rearrangement. The tumors occurred in 12 and 58 year old patients, respectively and consisted of a well to partially circumscribed, non-encapsulated mass, comprising monomorphic, polygonal cells arranged in aggregates, cords and single file arrays in a variably sclerotic stroma. The cells exhibited minimal nuclear atypia with moderate amount of clear to eosinophilic cytoplasm and rare mitotic figures. One case also showed bland spindle cell areas with myxoid change, as seen in LGFMS. By immunohistochemistry (IHC), the tumor cells were diffusely positive for vimentin, focally for S-100 in 1 case and negative for cytokeratin (CK), epithelial membrane antigen (EMA), HMB-45, desmin, smooth muscle actin (SMA), H-caldesmon, Myo D-1, CD3......
POSTED 05/24/2010 at 06:00 PM --
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Diagnosis of congenital fibrosarcoma facilitated by pre- and postnatal MRI
Abstract: Congenital fibrosarcoma is a rare soft tissue tumor, which may present at birth. Hereby we report the prenatal MRI findings of a congenital extremity fibrosarcoma and correlate it with the postnatal MRI findings. (Source: European Journal of Radiology Extra)...
POSTED 05/19/2010 at 06:00 PM --
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The possibility of a fully automated procedure for radiosynthesis of fluorine-18-labeled fluoromisonidazole using a simplified single, neutral alumina column purification procedure.
Authors: Nandy S, Rajan MG, Korde A, Krishnamurthy NV
A novel fully automated radiosynthesis procedure for [(18)F]Fluoromisonidazole using a simple alumina cartridge-column for purification instead of conventionally used semi-preparative HPLC was developed. [(18)F]FMISO was prepared via a one-pot, two-step synthesis procedure using a modified nuclear interface synthesis module. Nucleophilic fluorination of the precursor molecule 1-(2'-nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulphonylpropanediol (NITTP) with no-carrier added [(18)F]fluoride followed by hydrolysis of the protecting group with 1M HCl. Purification was carried out using a single neutral alumina cartridge-column instead of semi-preparative HPLC. The maximum overall radiochemical yield obtained was 37.49+/-1.68......
POSTED 05/18/2010 at 06:00 PM --
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