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Epidermoid Carcinoma News Headlines
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All Recent Epidermoid Carcinoma News Headlines |
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Effects of Bleomycin for Epidermoid Carcinoma of Head and Neck
Bleomycin, a new antitumor agent was applied in the therapy of 100 cases of head and neck cancer. Out of the 75 cases given BLM therapy only, tumor disappeared in 10 cases and in 5 cases there was no recurrence for more than 6 months. The frequency of tumor regression was 67.5% for previously untreated cases and 42.0% for previously otherwise treated cases. Local injection of BLM were given to 5 cases of small recurrent foci which appeared after radiotherapy, of which 3 cases did not show recurrence for more than one year.
Tumor regression seemed to be enhanced by simultaneous irradiation.
Histological findings were often comparable to those induced by curative irradiation. They indicated a marked destruction of the tumor and occasional local cure.
Eight cases of interstitial pneumonia, of......
POSTED 08/24/2010 at 01:19 AM --
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CARCINOGENESIS FROM INHALED 239PuO2 IN BEAGLES: EVIDENCE FOR RADIATION HOMEOSTASIS AT LOW DOSES?
Authors: Fisher DR, Weller RE
From the early 1970's to the late 1980's, Pacific Northwest National Laboratory conducted life-span studies in beagle dogs on the biological effects of inhaled plutonium (PuO2, PuO2, and Pu[NO3]4) to help predict risks associated with accidental intakes in workers. Years later, the purpose of the present follow-up study was to reassess the dose-response relationship for lung cancer in the PuO2 dogs compared to controls-with particular focus on the dose-response at relatively low lung doses. A PuO2 aerosol (2.3 mum activity-median aerodynamic diameter, 1.9 mum geometric standard deviation) was administered to six groups of 20 young (18-mo-old) beagle dogs (10 males and 10 females) by inhalation at six different activity levels, as previously described in La......
POSTED 08/17/2010 at 12:13 AM --
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Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells
Conclusions:
This study for the first time identifies effects of alpha-santalol in G2/M phase arrest and describes detailed mechanisms of G2/M phase arrest by this agent, which might be contributing to its overall cancer preventive efficacy in various mouse skin cancer models. (Source: BMC Research Notes)...
POSTED 08/02/2010 at 06:00 PM --
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Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells
Conclusions:
This study for the first time identifies effects of α-santalol in G2/M phase arrest and describes detailed mechanisms of G2/M phase arrest by this agent, which might be contributing to its overall cancer preventive efficacy in various mouse skin cancer models. (Source: BMC Research Notes)...
POSTED 08/02/2010 at 06:00 PM --
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Multiplexed Evaluation of a Cell-Based Assay for the Detection of Antidrug Neutralizing Antibodies to Panitumumab in Human Serum Using Automated Fluorescent Microscopy
The method described here employs a high-content cell-based assay format for the detection of neutralizing antibodies (NAbs) to panitumumab, a fully human monoclonal antagonistic antibody to the human epidermal growth factor (EGF) receptor in human serum (screening assay). A specificity assay was also developed and qualified to confirm that the neutralizing activity was attributable to the presence of NAbs and not due to serum interference (serum interference assay). The ArrayScan IV HCS reader was used for the measurement of tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) and STAT-1 redistribution between the cytoplasm and nucleus in the human epidermoid carcinoma cell line A431. Assay conditions were developed by (1) optimizing the response of the A431 cells to re......
POSTED 07/15/2010 at 06:57 PM --
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Four new phenanthrenes from Monomeria barbata Lindl.
Authors: Yang M, Cai L, Tai Z, Zeng X, Ding Z
Three biphenanthrene compounds (1-3) and a triphenanthrene compound (4), together with six known biphenanthrene compounds (5-10), were isolated from the tubers of Monomeria barbata Lindl. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D-, 2D-NMR, and HR-ESI-MS). These four new compounds were tested in vitro for the cytotoxic activity against liver carcinoma (HepG-2), promyelocytic leukaemia (HL60), ovarian carcinoma (Skov-3) and epidermoid carcinoma (A431) cancer cell lines and the antioxidant activity in DPPH radical scavenging. Compounds 1-4 exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging.
PMID: 20600684 [PubMed......
POSTED 06/27/2010 at 06:00 PM --
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Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria
The antiproliferative effects of n-hexane, chloroform and aqueous methanol extracts prepared from the whole plant of Centaurea arenaria M.B. ex Willd. were investigated against cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF7) and skin epidermoid carcinoma (A431) cells, using the MTT assay. The chloroform extract displayed high tumour cell proliferation inhibitory activity (higher than 85% at 10 [mgr]g/mL concentration), and was therefore subjected to a bioassay-guided multistep separation procedure. Flavonoids (eupatilin, eupatorin, 3[prime]-methyleupatorin, apigenin and isokaempferid), lignans (arctigenin, arctiin and matairesinol), the sesquiterpene cnicin, serotonin conjugates (moschamine and cis-moschamine), [beta]-amyrin and [beta]-sitosterin-[beta]-D-glycopyranoside, identi......
POSTED 06/06/2010 at 06:00 PM --
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Synthesis and Anticancer Evaluation of Naphthoquinone Esters with 2'-Cyclopentyl and 2'-Cyclohexyl Substituents.
Authors: Kongkathip N, Pradidphol N, Hasitapan K, Kongkathip B
Twelve novel naphthoquinone esters containing cyclopentyl and cyclohexyl substituents at C-2' of the propyl chain were synthesized by starting from 1-hydroxy-2-naphthoic acid via alkylation with cyclopentyl ester and cyclohexyl ester. They were evaluated for cytotoxicity against three cancer cell lines (human epidermoid carcinoma (KB), human cervical carcinoma (HeLa), and human hepatocellular carcinoma (HepG(2))). In comparison to naphthoquinone esters with the 2',2'-dimethyl group, the naphthoquinones with a 2'-cyclopentyl substituent showed stronger activity than those with a 2'-cyclohexyl substituent, but less than that with the 2',2'-dimethyl group. This work provides new information about the effect of 2'-position subs......
POSTED 06/06/2010 at 06:00 PM --
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The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors
Conclusions:
Cetuximab and trastuzumab distribute slowly, but at higher doses achieve a relatively uniform distribution after about 24 hours, most likely due to their long half-lives in the circulation. There remains poor distribution within hypoxic regions of tumors. (Source: BMC Cancer)...
POSTED 06/02/2010 at 06:00 PM --
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AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold
Conclusion:
The dynamic phosphorylation of AKAP12 "biosensed" by AKAR2-AKAP12 reveals the scaffold in association with the cell membrane, undergoing rapid phosphorylation by PKA. The perinuclear, cytoplasmic accumulation of phosphorylated scaffold reflects the phosphorylated, PKA-activated form of AKAP12, which catalyzes the resensitization and recycling of desensitized, internalized G-protein-coupled receptors. (Source: Journal of Molecular Signaling)...
POSTED 04/21/2010 at 06:00 PM --
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In vitro cytotoxic activity of Baccharis dracunculifolia and propolis against HEp-2 cells.
Authors: Bufalo MC, Candeias JM, Sousa JP, Bastos JK, Sforcin JM
Baccharis dracunculifolia is the most important vegetal source of propolis in southeast Brazil, and researchers have been investigating its biological properties. Propolis is a complex resinous hive product collected by bees from several plants, showing a very complex chemical composition. It has been employed since ancient times due to its therapeutic properties, such as antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antitumour activities, among others. The goal of this work was to compare the cytotoxic action of B. dracunculifolia, propolis and two isolated compounds (caffeic and cinnamic acids) on human laryngeal epidermoid carcinoma (HEp-2) cells in vitro. These cells were incubated with different......
POSTED 04/21/2010 at 06:00 PM --
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Penetrating scalp Marjolin's ulcer involving bone and dura mater in a Nigerian hospital: Case report and literature review
Marjolin's ulcers are epidermoid carcinomas developing in non-healing scar tissue . Marjolin's ulcer of the scalp is an occasional form of cutaneous cancer seen in our environment. Owing to the behaviour of the lesion and late presentation the treatment results are often disappointing. They are commonly found in the lower limbs, occasionally around the head and upper limbs, and rarely on the trunk. Marjolin's ulcers of the scalp have been variously reported , but not in the paediatric age group in this environment . (Source: Burns : Journal of the International Society for Burn Injuries)...
POSTED 04/13/2010 at 07:59 AM --
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Squamous cell carcinoma arising from the pleura after pneumonectomy for squamous cell carcinoma of the lung
Conclusions: Cancer can arise in areas of chronic inflammation such as osteomyelitis with a draining sinus, Crohn's disease, or chronic gastritis. Cases of squamous cell carcinoma arising from the pleura in patients with a chronically draining empyema cavity are extremely rare. We believe this is the sixth report in the literature of squamous cell carcinoma arising from the pleura in a patient with a chronic postpneumonectomy bronchopleural fistula. In vivo video footage of the involved pleura is available (http://video.google.com/videoplay?docid=7638947955392235731). (Source: American Journal of Surgery)...
POSTED 03/31/2010 at 10:12 AM --
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Crucial role of vinexin for keratinocyte migration in vitro and Epidermal wound healing in vivo.
Authors: Kioka N, Ito T, Yamashita H, Uekawa N, Umemoto T, Motoyoshi S, Imai H, Takahashi K, Watanabe H, Yamada M, Ueda K
In the process of tissue injury and repair, epithelial cells rapidly migrate and form epithelial sheets. Vinexin is a cytoplasmic molecule of the integrin-containing cell adhesion complex localized at focal contacts in vitro. Here, we investigated the roles of vinexin in keratinocyte migration in vitro and wound healing in vivo. Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay, but did not affect cell proliferation. Induction of cell migration by scratching the confluent monolayer culture of these cells activated both EGFR and ERK, and their inhibitors AG1478 and U0126 substantiall......
POSTED 03/29/2010 at 06:00 PM --
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Inhibition of RANKL increases the anti-tumor effect of the EGFR inhibitor panitumumab in a murine model of bone metastasis
Abstract: Bone metastases cause severe skeletal complications and are associated with osteoclast-mediated bone destruction. RANKL is essential for osteoclast formation, function, and survival, and is the primary effector of tumor-induced osteoclastogenesis and osteolysis. RANKL inhibition by its soluble decoy receptor osteoprotegerin (OPG) prevents tumor-induced osteolysis and decreases skeletal tumor burden. Because osteoclast-mediated bone resorption releases growth factors from the bone matrix, the host bone microenvironment induces a vicious cycle of bone destruction and tumor proliferation and survival. A prediction of this vicious cycle hypothesis is that targeting the host bone microenvironment by osteoclast inhibition would reduce tumor growth and survival and may enhance the anti-......
POSTED 03/25/2010 at 07:00 PM --
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Synthesis and in-vitro Cytotoxicity of Poly-functionalized 4-(2-Arylthiazol-4-yl)-4H-chromenes
A new series of 4-aryl-4H-chromenes bearing a 2-arylthiazol-4-yl moiety at the 4-position were prepared as potential cytotoxic agents. The in-vitro cytotoxic activity of the synthesized 4-aryl-4H-chromenes was investigated in comparison with etoposide, a well-known anticancer drug, using MTT colorimetric assay. Among them, the 2-(2-chlorophenyl)thiazol-4-yl analog 4b showed the most potent activity against nasopharyngeal epidermoid carcinoma KB, medulloblastoma DAOY, and astrocytoma 1321N1, and compound 4d bearing a 2-(4-chlorophenyl)thiazol-4-yl moiety at the 4-position of the chromene ring exhibited the best inhibitory activity against breast cancer cells MCF-7, lung cancer cells A549, and colon adenocarcinoma cells SW480 with IC50 values less than 5 [mu]M. The ability of compound 4b to ......
POSTED 03/21/2010 at 07:00 PM --
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Andrographolide regulates epidermal growth factor receptor and transferrin receptor trafficking in epidermoid carcinoma (A-431) cells
Conclusion and implications: This study sheds light on how andrographolide may affect receptor trafficking by inhibiting receptor movement from the late endosomes to lysosomes. The down-regulation of EGFR from the cell surface also indicates a new mechanism by which andrographolide may induce cancer cell death. (Source: British Journal of Pharmacology)...
POSTED 03/02/2010 at 06:00 PM --
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A Review of Penile Cancer
Conclusion. Penile carcinoma is a rare pathology which affects elderly persons and is diagnosed late. (Source: Advances in Urology)...
POSTED 02/16/2010 at 09:49 AM --
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gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells.
Authors: Stiuso P, Giuberti G, Lombardi A, Dicitore A, Limongelli V, Cartenì M, Abbruzzese A, Caraglia M
We previously demonstrated that the gamma-glutamyl 16 amine derivative of vasoactive intestinal peptide (VIP) acts as structural VIP agonist with affinity and potency higher than VIP. Herein, we have evaluated the effects of VIP and gamma-Gln16-diaminopropane derivative of VIP (VIP-DAP3) on the proliferation and protection from oxidative stress induced by hydrogen peroxide (H(2)O(2)) on epidermoid carcinoma cell lines. We have found that 10(-11) M VIP-DAP3 completely antagonized the inhibition induced by H(2)O(2) on both cell proliferation and S-phase distribution while these effects were only partially antagonized by equimolar concentrations of VIP. Moreover, both oxidative st......
POSTED 02/09/2010 at 06:00 PM --
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Complex tracheal lesion: correction with an intercostal muscle pedicle flap
We report the case of a patient diagnosed with epidermoid carcinoma in the distal third of the esophagus. The patient was submitted to esophagectomy by video-assisted thoracoscopy and laparoscopy. During the operation, the left main bronchus was injured, and this required immediate surgical correction. In the postoperative period, the patient presented with acute respiratory failure and profuse air leak through the thoracic drains and through the cervical surgical wound. The patient underwent a second surgical procedure, during which a large lesion was discovered in the membranous wall of the trachea. The lesion was corrected with an intercostal muscle pedicle flap. (Source: Jornal Brasileiro de Pneumologia)...
POSTED 01/30/2010 at 09:33 AM --
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