Metastatic Liposarcoma to the Parotid
We report an exceptional case of parotid metastasis of myxoid liposarcoma in a 42-year-old man and insist on the worse prognosis of this entity. (Source: Journal of Oncology)...
POSTED 06/09/2009 at 10:11 AM --
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A dramatic case of genital radionecrosis
Abstract
Background Epidermoid carcinoma of the penis presents in 1% of malignant tumors in men. Penis cancer treatment has traditionally been
total or partial amputation. There are authors who consider radiation to be part of penis cancer treatment in select cases—especially
the use of brachytherapy and external radiation.
Clinical case The case of a 48-year-old male who in 2004 presented with an ulcerated lesion of the penis that was left unattended to is
presented. Two years later, he sought medical attention and physical examination revealed an ulcerated penile lesion with
poorly defined edges and limited to the glans.
Diagnosis The lesion was biopsied and the histopathological study reported Epidermoid Carcinoma. After radiological......
POSTED 05/31/2009 at 03:22 AM --
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Anal Squamous Cell Carcinoma in the HIV-Positive Patient
This article describes the disease process and current treatment options.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: Clinics in Colon and Rectal Surgery)...
POSTED 05/28/2009 at 03:29 AM --
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Malignant tumours development in peri-implant tissues in oncologic and non-oncologic patients: a report of two cases
We report two cases of squamous cell carcinoma arising in peri-implant tissues after dental implant placement. A 35-year-old woman was referred to us one month after prosthetic rehabilitation following insertion of an implant in the area 36 four months earlier. She presented with a peri-implant tissue lesion with appearance of inflammatory tissue. Its biopsy was reported as infiltrate epidermoid carcinoma. Second case is a 75-year-old male with resection of epidermoid carcinoma affecting the lower left gingiva and mandible and reconstruction with iliac crest free flap fourteen years ago. Further fixed rehabilitation with osseo-integrated implants was carried out after reconstruction. Second primary malignancy in the tissue around one of the implant was developed. In both cases evolution wa......
POSTED 04/30/2009 at 11:00 PM --
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Bee Propolis Stops Tumors from Neurofibromatosis and Cancer
(NaturalNews) Honeybees are some of the most amazing creatures ever created by nature. They play a vital role in much of the food supply through pollination, and they provide people with a healthy natural alternative to sugar. Some of the most interesting aspects of bees are the substances they make to use themselves. Propolis is a natural resin found in young tree buds. Bees collect it for use as a glue to seal their homes. Propolis is an exceedingly complex product that contains substances that prevent and treat diseases ranging from cancer to the common cold. Recent research has documented the ability of propolis to suppress the growth of human tumors from neurofibromatosis and cancer.Compound from propolis halts tumor process in clinical trialsNeurofibromatosis is a genetic disorder th......
POSTED 04/29/2009 at 02:00 AM --
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[Carcinoma of the lips.]
Authors: Ben Slama L
Epidermoid carcinoma, that is, squamous cell carcinoma of the skin, is the most common malignant tumor of the lips. It occurs especially in men. Its primary causes are sun exposure, smoking, and chronic irritation. Leukoplakia is the most frequent precancerous lesion. Epidermoid carcinoma may appear clinically as a scaly erosion or an ulceration. Standard treatment is surgical excision with reconstruction.
PMID: 19361830 [PubMed - as supplied by publisher] (Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale)...
POSTED 04/07/2009 at 06:00 PM --
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Two New Sesquiterpenoids from Solanum lyratum with Cytotoxic Activities.
Authors: Ren Y, Shen L, Zhang DW, Dai SJ
Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.7-8.1 muM.
PMID: 19336938 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)...
POSTED 03/31/2009 at 11:00 PM --
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Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo.
We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiog......
POSTED 03/27/2009 at 11:00 PM --
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Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas-overexpressing cells
Overexpressions of G protein-coupled receptor (GPCR) with elevated downstream signaling events have been reported in various tumors. However, the cellular mechanism that GPCR overexpression leads to tumor formation is largely unknown. The orphan GPCR mas was originally isolated from a human epidermoid carcinoma. In vivo studies of mas-overexpressing cells suggested that xenograft tumor formation was positively correlated with the levels of mas expression. Histochemical analysis indicated that xenograft tumor consisted of mas-transfected and stromal cells. Biochemical analyses revealed that cells overexpressing mas exhibited significantly increased anchorage-independent growth, whereas there was no significant difference in cell proliferation in comparison with empty vector-transfected cont......
POSTED 03/18/2009 at 07:00 PM --
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A rare case of invasive vaginal carcinoma associated with vaginal prolapse
Conclusions Careful preoperative histological evaluation of cervix in cases of uterine prolapse and postoperative cytologic and colposcopic
follow-up of the vagina after hysterectomies are important because possible association with cervical carcinoma and occurrence
of late vaginal cancer. Surgery and radiotherapy were effectively combined in this case that remains with no recurrence after
2 years follow-up.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1016-1Authors
Thales Paulo Batista, University of Pernambuco Centro de Oncologia, Hospital Universitário Oswaldo Cruz Recife PE BrazilJosé Alves Morais, University of Pernambuco Centro de Oncologia, Hospital Universitário Oswaldo Cruz Recife PE BrazilTarcísio José Cysneiros Costa Rei......
POSTED 03/05/2009 at 08:59 AM --
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Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells.
Authors: Zhang X, Bommareddy A, Chen W, Khalifa S, Kaushik RS, Fahmy H, Dwivedi C
Sarcophine-diol (SD), a structural modifications of sarcophine, has shown chemopreventive effects on 7,12-dimethylbenz(a)anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor developments in mice. Tumorigenesis is associated with uncontrolled cell growth and loss of apoptosis. In the present study, the effects of SD on cell growth and apoptosis in human epidermoid carcinoma A431 cells were determined to assess whether SD could inhibit cell growth and/or induce apoptosis, thus elucidating possible mechanism of action. MTT assay was used for cell viability; bromodeoxyuridine incorporation assay was used for cell proliferation; fluorescence-activated cell sorting analysis of annex......
POSTED 02/28/2009 at 11:00 PM --
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[Tumoral pathology of salivary glands. Our experience]
CONCLUSIONS: We have found two main differences with previously reported studies: the elevated mean age of patients with malignant tumours and, probably as a result of this advanced age, the high incidence of squamous cell carcinoma due to metastatic dissemination of skin cancers.
PMID: 19401079 [PubMed - in process] (Source: Acta Otorrinolaringologica Espanola)...
POSTED 02/28/2009 at 06:00 PM --
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[Isolated mandibular B-cell lymphoma revealed by inferior alveolar nerve anesthesia.]
DISCUSSION: Our observation is unusual in its clinical presentation. Mandibular lymphomas most often present as a painless swelling, sometimes ulcerated in the mouth. They are very rarely diagnosed after an isolated hypoesthesia of V3. Lymphomas are the second most frequent head and neck lymphomas after epidermoid carcinomas, but the frequency seems to be increasing. In almost all the cases, they present as B-cell tumours of the DLBCL subtype in the WHO classification. Mandibular localizations account for only 0.6% of the cases. They are often misdiagnosed as a dental problem. The complete remission rate after chemotherapy ranges from 60 to 80% at one year. Nevertheless, the prognosis remains bad with a survival rate of only 50% at five years.
PMID: 19193387 [PubMed - as supplied by pu......
POSTED 02/01/2009 at 11:00 PM --
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Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II
The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n-hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 µg/mL). The IC50 values of these extracts were determined, and their direct cytotoxic effects were measured. High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than......
POSTED 01/22/2009 at 11:00 PM --
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The histopathological typing of 48 cases of ESO-phageal adenocarcinoma and its tissue origin
Abstract Of 2487 cases of esophageal carcinoma pathologically confirmed after resection in 1978–1988 in Shantou, adenocarcinoma accounted
for 1.93% (48 cases). These were divided into 6 types; Ordinary well - differentiated adenocarcinoma, 10 cases; Ordinary poorly
- differentiated adenocarcinoma, 11 cases; Adeno - squamous carcinoma, 18 cases; Muco - epidermoid carcinoma, 4 cases; “Basal
Cell - Like Carcinoma”, 4 cases; Cylindroma - Like carcinoma, 1 case. Mucohistochemistry and immuno-histochemistry studies
revealed some differences among these types; And their prognosis also varied. The tissue origin of these tumors were discussed.
Content Type Journal ArticleCategory Clinical ObservationsDOI 10.1007/BF03014411Authors
Zhizhi Huang, Medical College of Shantou Un......
POSTED 01/03/2009 at 12:42 AM --
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[Institutional report - Thoracic general] Sixty tracheal resections - single center experience
This study evaluates the clinical outcome following surgery of our patients for the last seven years. Between 2001 and 2008 we performed tracheal resections in 60 patients. There were 46 cases of postintubation stenosis and 14 tumors. The range of resected rings was 1–8. The maximal resection length performed in our series (4 cm) was achieved using only basic releasing maneuvers such as anterior dissection of the trachea and cervical flexion. Emergency tracheal resection with no complications was performed in 12 patients who presented with severe dyspnea due to very tight stenosis. One patient died during the surgical intervention from a stroke. There were two postoperative deaths, both in patients with tracheo-esophageal fistula. As major complications we mention one patient wi......
POSTED 01/01/2009 at 11:00 PM --
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Metastatic Liposarcoma to the Parotid
We report an exceptional case of parotid metastasis of myxoid liposarcoma in a 42-year-old man and insist on the worse prognosis of this entity. (Source: Journal of Oncology)...
POSTED 12/15/2008 at 06:51 AM --
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Discovering novel 3-nitroquinolines as a new class of anticancer agents1
Conclusion: This study was the first to identify new structural types of antiproliferative agents against the EGFR-overexpressing tumor cell lines by the incorporation of the nitro group at the 3-position of the quinoline core structure, providing promising new templates for the further development of anticancer agents. (Source: Acta Pharmacologica Sinica)...
POSTED 12/13/2008 at 11:00 PM --
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Photodynamie activity on human larynx epidermoid carcinoma cell line, HEp-2
Content Type Journal ArticleCategory Research ReportsDOI 10.1007/BF02999864Authors
S. Ganesan, Anna University Department of Physics 600 025 Madras IndiaV. Masitamani, Anna University Department of Physics 600 025 Madras India
Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560
Journal Volume Volume 11
Journal Issue Volume 11, Numbers 3-4 / September, 1994 (Source: Medical Oncology)...
POSTED 12/05/2008 at 03:17 AM --
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Radiation-induced carcinoma of the rectum
We present a case
of carcinoma of the rectum arising as two separate primaries 46 years after irradiation for an epidermoid carcinoma of the
cervix. There were many pathologic changes related to the radiation therapy.
Content Type Journal ArticleDOI 10.1007/BF02989000Authors
Antonio Martins, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New YorkStephen S. Sternberg, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New YorkFadi F. Attiyeh, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New York
Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706
Journal Volume Volume 23
Journal Issue Volume 23, Number 8 / November, 1980 (Source: Diseases of the Colon & Rectum)...
POSTED 11/28/2008 at 08:08 AM --
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