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Epidermoid Carcinoma News Headlines
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All Recent Epidermoid Carcinoma News Headlines |
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A Review of Penile Cancer
Conclusion. Penile carcinoma is a rare pathology which affects elderly persons and is diagnosed late. (Source: Advances in Urology)...
POSTED 02/16/2010 at 09:49 AM --
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gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells.
Authors: Stiuso P, Giuberti G, Lombardi A, Dicitore A, Limongelli V, Cartenì M, Abbruzzese A, Caraglia M
We previously demonstrated that the gamma-glutamyl 16 amine derivative of vasoactive intestinal peptide (VIP) acts as structural VIP agonist with affinity and potency higher than VIP. Herein, we have evaluated the effects of VIP and gamma-Gln16-diaminopropane derivative of VIP (VIP-DAP3) on the proliferation and protection from oxidative stress induced by hydrogen peroxide (H(2)O(2)) on epidermoid carcinoma cell lines. We have found that 10(-11) M VIP-DAP3 completely antagonized the inhibition induced by H(2)O(2) on both cell proliferation and S-phase distribution while these effects were only partially antagonized by equimolar concentrations of VIP. Moreover, both oxidative st......
POSTED 02/09/2010 at 06:00 PM --
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Complex tracheal lesion: correction with an intercostal muscle pedicle flap
We report the case of a patient diagnosed with epidermoid carcinoma in the distal third of the esophagus. The patient was submitted to esophagectomy by video-assisted thoracoscopy and laparoscopy. During the operation, the left main bronchus was injured, and this required immediate surgical correction. In the postoperative period, the patient presented with acute respiratory failure and profuse air leak through the thoracic drains and through the cervical surgical wound. The patient underwent a second surgical procedure, during which a large lesion was discovered in the membranous wall of the trachea. The lesion was corrected with an intercostal muscle pedicle flap. (Source: Jornal Brasileiro de Pneumologia)...
POSTED 01/30/2010 at 09:33 AM --
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Integrative molecular characterization of head and neck cancer cell model genomes
Cell lines are invaluable model systems for the investigation of cancer. Knowledge of the molecular alterations that exist within cell models is required to define the mechanisms governing cellular phenotypes.Five tongue squamous cell carcinomas cell lines and 1 submaxillary salivary gland epidermoid carcinoma cell line were analyzed for copy number and mRNA expression by tiling-path DNA microarrays and Agilent Whole Human Genome Oligoarrays, respectively.Integrative analysis of genetic and expression alterations revealed the molecular landscape of each cell line. Molecular results for individual cell lines and across all samples have been summarized and made available for easy reference.Our integrative genomic analyses have defined the DNA and RNA alterations for each individual line. The......
POSTED 12/15/2009 at 06:00 PM --
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Identification of MYO18A as a Novel Interacting Partner of the PAK2/{beta}PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration.
Authors: Hsu RM, Tsai MH, Hsieh YJ, Lyu PC, Yu JS
Monitoring Editor: Jonathan Chernoff The p21-activated kinase (PAK) 2 is known to be involved in numerous biological functions, including the regulation of actin reorganization and cell motility. To better understand the mechanisms underlying this regulation, we herein used a proteomic approach to identify PAK2-interacting proteins in human epidermoid carcinoma A431 cells. We found that MYO18A, an emerging member of the myosin superfamily, is a novel PAK2 binding partner. Using a siRNA knockdown strategy and in vitro binding assay, we discovered that MYO18A binds to PAK2 through the betaPIX/GIT1 complex. Under normal conditions, MYO18A and PAK2 colocalized in lamellipodia and membrane ruffles. Interestingly, knockdown of MYO18A in cells......
POSTED 11/17/2009 at 06:00 PM --
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Impact of target volumes and radiation technique on loco-regional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary
Conclusions: Retrospective comparisons between bilateral and unilateral neck radiotherapies did not show differences in terms of loco-regional control and survival. However, patient’s local regional control and survival are significantly improved after 3D-CRT or IMRT. (Source: Radiotherapy and Oncology)...
POSTED 11/05/2009 at 06:00 PM --
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Impact of target volumes and radiation technique on loco-regional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary.
CONCLUSIONS: Retrospective comparisons between bilateral and unilateral neck radiotherapies did not show differences in terms of loco-regional control and survival. However, patient's local regional control and survival are significantly improved after 3D-CRT or IMRT.
PMID: 19892420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)...
POSTED 11/03/2009 at 06:00 PM --
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[Definitive treatment of anal canal carcinoma with radiotherapy: Adverse impact of a pre-radiation resection. A retrospective study of 57 patients treated with curative intent.]
CONCLUSION: Radiotherapy and chemoradiation with cisplatine-based chemotherapy cure a vast majority of patients with epidermoid carcinoma of the anal canal. Therapeutic factors that may interfere with the definition of the target volume and the patients' repositioning may decrease the efficacy of radiotherapy. Pre-radiotherapy surgical resection should be avoided.
PMID: 19854092 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)...
POSTED 10/21/2009 at 07:00 PM --
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Essential Oil of Artemisia Capillaris Induces Apoptosis in KB Cells via Mitochondrial Stress and Caspase Activation Mediated by MAPK-Stimulated Signaling Pathway
This study examined whether or not the essential oil isolated from A. capillaris induces apoptosis in the human oral epidermoid carcinoma cells along with the possible mechanism(s) of the essential oil-mediated cytotoxicity. The essential oil induced cell death of KB cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of condensed and/or fragmented nuclei, and the generation of a cleaved PARP product. Treating the cells with the oil also caused changes in the mitochondrial level of the Bcl-2 family proteins such as Bcl-2 and Bax, thereby inducing the release of cytochrome c into the cytosol. Additional experiments using caspase or mitogen-activated protein kinase inhibitors suggested the involvement of the p38/NF-[kappa]B and JNK/Bcl-2......
POSTED 10/12/2009 at 06:00 PM --
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Is frozen section reliable in transoral CO2 laser-assisted cordectomies?
Abstract Endoscopic resection of laryngeal tumors is replacing external approaches. One drawback of endoscopic resection is the difficulty
of interpretation of histological specimens because of thermal effect of laser on tissues. Our goal is to assess the reliability
of frozen section in this setting by comparing its results with those of routine histology. We, retrospectively, reviewed
the charts of all consecutive patients, who underwent cordectomies in our institution between January 2000 and 2008, using
the CO2 laser Acublade system (Lumenis, Santa Clara, CA). Age, sex, staging of the tumor, previous treatments, type of cordectomy,
frozen section and routine histology results were analyzed. Ninety-seven patients fulfilled the inclusion criteria; 22.7%
had severe dyspla......
POSTED 09/28/2009 at 11:04 PM --
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[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine Fibrosarcoma
Conclusion These results demonstrated the promising potential of [11C]gefitinib to serve as a PET ligand for in vivo imaging of NFSa-bearing mice.
Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0265-5Authors
Ming-Rong Zhang, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanKatsushi Kumata, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanAkiko Hatori, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanNobuhiko Takai, National Institute of Radiological Sciences Heavy-Ion Radiobiology Rese......
POSTED 09/28/2009 at 08:05 PM --
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EGCG induces apoptosis in human laryngeal epidermoid carcinoma Hep2 cells via mitochondria with the release of apoptosis-inducing factor and endonuclease G
Abstract: (−)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, was tested for in vitro cytotoxicity against human laryngeal epidermoid carcinoma of the larynx Hep2 cells. EGCG-induced apoptotic cell death accompanied by a change in the cell cycle. However, EGCG did not result in caspase activation, nor did a caspase inhibitor block cell death. Furthermore, EGCG caused no change in the intracellular levels of reactive oxygen species (ROS). The levels of p53 were increased in the EGCG-treated cells, with a corresponding decrease in Bcl-2 and Bid protein levels as well as an increase in the Bax level. In addition, EGCG induced the cytoplasmic release of cytochrome c from the mitochondria accompanied by a decreased mitochondrial membrane potential, and subsequently upregulate......
POSTED 09/24/2009 at 07:00 PM --
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Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells.
Authors: Kondratov KA, Chernorudskiy AL, Amosova AP, Kornilova ES
Tyrphostin AG1478 is known as a specific and reversible inhibitor of tyrosine kinase (TK) activity of the EGF receptor (EGFR). It is attractive as an anti-cancer agent for cancers with elevated EGFR TK levels. However, post-application effects of AG1478 are not well studied. We have analyzed EGFR phosphorylation after termination of AG1478 application using human epidermoid carcinoma A431 cells. It was found that AG1478 inhibitory action is fast but not fully reversible: removal of tyrphostin resulted in incomplete restoration of the overall EGFR phosphorylation. Analyzing the state of two individual autophosphorylation sites of internalized EGFR, Y1045 and Y1173, we demonstrated that phosphorylation of Y1173 involved in......
POSTED 09/17/2009 at 07:00 PM --
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Reconstruction of the pulmonary artery for lung cancer: Long-term results
Conclusions: Pulmonary artery reconstruction is safe, with excellent long-term survival. Our results support this technique as an effective option for patients with lung cancer. (Source: The Journal of Thoracic and Cardiovascular Surgery)...
POSTED 09/09/2009 at 06:00 PM --
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[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells.
Authors: Nigam N, Bhui K, Prasad S, George J, Shukla Y
Since skin cancer incidence and prevalence is constantly rising up the charts despite all efforts, search for newer, better agents for protection and treatment is required. Ginger (Zingiber officinale Roscoe), a monocotyledonous herb, is widely used as a herbal medicine, given the presence of homologous phenolic ketones, of which [6]-gingerol is the major one. The quantity of [6]-gingerol in the fresh ginger rhizome was found to be 104-965 microg/g in common varieties of ginger available in Indian market. Herein, [6]-gingerol was assessed for its anti-apoptotic effects in human epidermoid carcinoma A431 cells. [6]-Gingerol treatment exhibited considerable cytotoxicity as indicated by growth inhibition of A431 cells mediated via gen......
POSTED 08/19/2009 at 05:34 PM --
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Immunohistochemical expression of ubiquitin and telomerase in cervical cancer
Abstract Ubiquitin and telomerase immunohistochemical expression patterns in cervical cancer were compared with normal cervical tissue
samples. Eighty-one cervical cancer cases and 22 normal exo–endocervical tissue were examined with polyclonal antibody for
ubiquitin and 44G12 clone for telomerase using tissue microarrays. The results were interpreted using a semiquantitative scale
The average age of patients was 50.67 years. The most frequent histological types were moderately differentiated epidermoid
carcinoma (43.5%), according to the degree of differentiation, and endocervical adenocarcinoma (42.1%). Immunohistochemical
findings were as follows: 98.7% of cervical cancers showed immunoexpression for ubiquitin and 52.6% for telomerase. Statistically
significant d......
POSTED 08/19/2009 at 03:30 AM --
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Bioactivity-Guided Isolation of Cytotoxic Sesquiterpenes and Flavonoids from Anthemis ruthenica
Planta MedDOI: 10.1055/s-0029-1185942AbstractA new eudesmanolide sesquiterpene, sivasinolide 6--angelate (), was isolated from the aerial parts of together with the known compounds chrysanin (), tanacin (), 3-hydroxycostunolide (), centauridin (), and centaureidin (). The compounds were obtained by means of bioactivity-guided fractionation from the CHCl extract of the herb, which displayed high cytotoxic activity. The structures were determined by UV, HR‐ESI‐MS, and high-field 1D and 2D NMR spectral analyses, affording complete H- and C‐NMR assignments for all compounds. The cytotoxic activities of the isolated sesquiterpenes and flavonoids were assessed against cervical adenocarcinoma HeLa, breast adenocarcinoma MCF7, and skin epidermoid carcinoma A431 cells using ......
POSTED 07/29/2009 at 05:52 AM --
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Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells
The formation of a barrier by tight junctions is important in epithelia of various tissues. Substance P (SP) and insulin-like growth factor (IGF)-1 synergistically promote barrier function in the corneal epithelium. We have now examined the effects of SP and IGF-1 on expression of the tight-junction protein zonula occludens (ZO)-1 in A431 human epidermoid carcinoma cells. Reverse transcription-polymerase chain reaction (RT-PCR) and immunoblot analyses revealed that SP and IGF-1 increased the amounts of ZO-1 mRNA and protein in these cells in a concentration-dependent manner, with neither SP nor IGF-1 alone having such an effect. The SP- and IGF-1-induced up-regulation of ZO-1 was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and both of these effects were b......
POSTED 07/27/2009 at 06:00 PM --
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Overexpression of DPAGT1 Leads to Aberrant N-Glycosylation of E-Cadherin and Cellular Discohesion in Oral Cancer
Cancer cells are frequently characterized by aberrant increases in protein N-glycosylation and by disruption of E-cadherin–mediated adherens junctions. The relationship between altered N-glycosylation and loss of E-cadherin adhesion in cancer, however, remains unclear. Previously, we reported that complex N-glycans on the extracellular domains of E-cadherin inhibited the formation of mature adherens junctions. Here, we examined whether dysregulated N-glycosylation was one of the underlying causes for cellular discohesion in oral cancer. We show that dense cultures of human salivary epidermoid carcinoma A253 cells exhibited elevated expression of DPAGT1, the gene that initiates protein N-glycosylation. Overexpression of DPAGT1 correlated with the production of E-cadherin–bearing......
POSTED 07/14/2009 at 06:00 PM --
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Pyripyropenes, Fungal Sesquiterpenes Conjugated with alpha-Pyrone and Pyridine Moieties, Exhibits Anti-angiogenic Activity against Human Umbilical Vein Endothelial Cells.
Authors: Hayashi A, Arai M, Fujita M, Kobayashi M
In the course of our search for anti-angiogenic substances, pyripyropenes A (1), B (2), and D (3) were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs) from a marine-derived fungus of Aspergillus sp. Pyripyropenes showed potent anti-proliferative activity against HUVECs with IC(50) values of the range of 0.1-1.8 muM, which were cytostatic at 0.05 to 20 muM. The selective index was more than 55-fold in comparison with those of several tumor cell lines. Compound 1 inhibited vascular endothelial growth factor (VEGF)-induced migration and tubular formation of HUVECs, while 1 showed no effect on the VEGF-induced phosphorylations of extracellular signal-regulated kinase (ERK)1/2,......
POSTED 06/30/2009 at 06:00 PM --
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