Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer.
CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study.
PMID: 20222170 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 03/12/2010 at 11:04 AM --
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Assessing screening practices among health care workers at a tertiary-care hospital in Sao Paulo, Brazil
CONCLUSIONS: A sizeable proportion of health care workers underwent screening procedures that are not recommended or for which there was insufficient evidence of a benefit. Conversely, certain recommended procedures were performed on a small proportion of such workers. These results indicate that the Brazilian National Ministry of Health must develop nationwide evidence-based screening recommendations and disseminate such recommendations among health care professionals in Brazil. (Source: Clinics)...
POSTED 03/12/2010 at 08:39 AM --
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Gefitinib in Combination with Capecitabine as Second-Line Therapy in Patients with Advanced Colorectal Cancer (aCRC): A Phase I/II Study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
Conclusion: The combination of gefitinib and capecitabine resulted in significant skin toxicities such as exanthema and HFS. As 2nd-line treatment of patients with aCRC, this combination showed no substantial efficacy.
PMID: 20215798 [PubMed - as supplied by publisher] (Source: Onkologie)...
POSTED 03/12/2010 at 06:28 AM --
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I Have Colon Polyps: Now What?
M. D. Anderson Cancer Center are encouraging men and women to learn more about colon polyps and how they affect a person's risks for cancer. "Finding out you have colon polyps doesn't have to be frightening," said Gottumukkala S. Raju, M.D., professor in the Department of Gastroenterology, Hepatology and Nutrition at M. D. Anderson. "Most colon polyps are not cancer. Yet, certain kinds of polyps may make you more likely to develop colon cancer." The colon is part of the large intestine. A colon polyp is a growth on the inside lining of the colon... (Source: Health News from Medical News Today)...
POSTED 03/12/2010 at 05:00 AM --
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Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
In this study, we explored the specific role of mTORC2 in colon cancer using a short hairpin RNA expression system to silence the mTORC2-associated protein rictor. We found that downregulation of rictor in HT29 and LS174T colon cancer cells significantly reduced cell proliferation. Knockdown of rictor also resulted in a G1 arrest as observed by cell cycle analysis. We further observed that LS174T cells deficient for rictor failed to form tumors in a nude mice xenograft model. Taken together, these results show that the inhibition of mTORC2 reduces colon cancer cell proliferation in vitro and tumor xenograft formation in vivo. They also suggest that specifically targeting mTORC2 may provide a novel treatment strategy for colorectal cancer. (Source: Molecular Cancer)...
POSTED 03/11/2010 at 06:00 PM --
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Obesity linked to poor colon cancer prognosis
Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a new study. (Source: ScienceDaily Headlines)...
POSTED 03/11/2010 at 11:31 AM --
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Folic Acid-Conjugated Chitosan Nanoparticles Enhanced Protoporphyrin IX Accumulation in Colorectal Cancer Cells
Bioconjugate Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Bioconjugate Chemistry)...
POSTED 03/11/2010 at 10:29 AM --
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Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells
Shortwave (MHz range) radiofrequency (RF) energy is nonionizing, penetrates deeply into biological tissues with no adverse side effects, and heats metallic nanoparticles efficiently. Targeted delivery of these nanoparticles to cancer cells should result in hyperthermic cytotoxicity upon exposure to a focused, noninvasive RF field. We have demonstrated that gold nanoparticles conjugated with cetuximab (C225) are quickly internalized by Panc-1 (pancreatic adenocarcinoma) and Difi (colorectal adenocarcinoma) cancer cells overexpressing epidermal growth factor receptor (EGFR). Panc-1 or Difi cells treated with naked gold nanoparticles or nonspecific IgG-conjugated gold nanoparticles demonstrated minimal intracellular uptake of gold nanoparticles by transmission electron microscopy (TEM). In co......
POSTED 03/11/2010 at 07:51 AM --
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Mortality and cancer incidence among physicians of traditional Chinese medicine: a 20-year national follow-up study
Conclusion
Like other healthcare workers, we noted that physicians of TCM had significantly reduced risks of all-causes mortality and cancer incidence. Nonetheless, reasons truly responsible for significantly increased risks of liver and bladder neoplasm among physicians of TCM warrant further investigations. (Source: Occupational and Environmental Medicine)...
POSTED 03/11/2010 at 06:32 AM --
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Digestive CARE™ Is Seeking Online Votes For Top Colonscopy-Related Song Titles During National Colorectal Cancer Awareness Month
Digestive CARE™, a medical group of more than 50 gastroenterologists in Broward and Palm Beach County, announced that it is receiving hundreds of online votes in its "Bottom Line Song Title Contest" to bring awareness to National Colorectal Cancer Awareness Month (March 2010). Digestive CARE™ is urging people to go to the Web site http://www.DigestiveCareOnline... (Source: Health News from Medical News Today)...
POSTED 03/11/2010 at 03:00 AM --
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Digestive CARE™ Is Seeking Online Votes For Top Colonscopy-Related Song Titles During National Colorectal Cancer Awareness Month
Digestive CARE™, a medical group of more than 50 gastroenterologists in Broward and Palm Beach County, announced that it is receiving hundreds of online votes in its "Bottom Line Song Title Contest" to bring awareness to National Colorectal Cancer Awareness Month (March 2010). Digestive CARE™ is urging people to go to the Web site http://www.DigestiveCareOnline... (Source: Cancer / Oncology News From Medical News Today)...
POSTED 03/11/2010 at 03:00 AM --
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Obesity and Colon Cancer a Deadly Combination
(Ivanhoe Newswire) -- Obese patients with colon cancer may have a greater chance of dying from the disease compared to those at a normal weight. (Source: Medical Headlines From Ivanhoe.com)...
POSTED 03/10/2010 at 11:00 PM --
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Mayo Researchers Link Obesity To Worse Outcome In Patients Being Treated For Colon Cancer
It's long been known that obesity is linked to increased risk of developing colon cancer, but now researchers at the Mayo Clinic campus in Minnesota have found that obesity is associated with worse outcomes in patients who have already been diagnosed and treated for the cancer... (Source: Cancer / Oncology News From Medical News Today)...
POSTED 03/10/2010 at 07:00 PM --
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Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer
Conclusions:
Our findings highlight an involvement of VEGF-A, VEGR1 and VEGFR2 in events occurring at the invasive tumour front and a potential prognostic role of VEGFR1 expression in mismatch repair-proficient colorectal cancers. The VEGF-A ligand to VEGFR1 or VEGFR2 ratio may represent an alternative evaluation system for identifying patients with poorer clinical outcome. (Source: BMC Cancer)...
POSTED 03/10/2010 at 06:00 PM --
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Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer
Approximately 40% of colorectal cancer (CRC) families with a diagnosis of hereditary nonpolyposis CRC on the basis of clinical criteria are not a consequence of mismatch repair (MMR) deficiency. Such families provide supporting evidence for the existence of a hitherto unidentified highly penetrant gene mutation. To gain further understanding of MMR-competent familial colorectal cancer (FCC), we studied seven large families with an unexplained predisposition for CRC to identify genetic regions that could harbor CRC risk factors. First, we conducted a genome-wide linkage scan using 10K single-nucleotide polymorphism (SNP) arrays to search for disease loci. Second, we studied the genomic profiles of the tumors of affected family members to identify commonly altered genomic regions likely to h......
POSTED 03/10/2010 at 06:00 PM --
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CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice
Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM levels of CCL2 dramatically inhibit migration of T cells. The aim was to test whether subphysiological doses of CCL2 can ameliorate murine colitis and inflammation-induced colorectal cancer.TNBS (2,4,6 trinitrobenzene sulfonic acid) colitis and dextran sodium sulfate (DSS) colitis were induced in Balb/c and C57BL/6 mice, respectively. Mice were treated daily with intraperitoneal CCL2 injections. Disease activity was assessed clinically, histologically, and by measuring inflammatory cytok......
POSTED 03/10/2010 at 06:00 PM --
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Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance.
CONCLUSION: This particular finding could help in the differential diagnosis of this benign lesion from other pancreatic masses.
PMID: 20208329 [PubMed - in process] (Source: JOP)...
POSTED 03/10/2010 at 02:50 PM --
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Intraductal Papillary Mucinous Neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.
Authors: Bussom S, Saif MW
The diagnosis and treatment of intraductal papillary mucinous tumors (IPMN) of the pancreas has evolved over the last decade. IPMN is a disease of the ductal epithelium and represent a spectrum of disease, ranging from benign to malignant lesions, making the early detection and characterization of these lesions important. As with villous adenomas of the colon, not all IPMNs will develop into adenocarcinoma. Definitive management is surgical resection for appropriate candidates, as benign lesions harbor malignant potential. Growing controversy revolves around issues of natural history, management of small-branch-duct lesions, ability to predict malignancy and/or progression, and surveillance strategies. Given these controversies, novel methods are needed to he......
POSTED 03/10/2010 at 02:50 PM --
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AZ Researchers Get $1.5M to Study Vitamin D Effect on Cancer
A $1.5 million grant will enable researchers at the Arizona Cancer Center to study the relationship between vitamin D and colon cancer. (Source: Health)...
POSTED 03/10/2010 at 12:52 PM --
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Current Status of Chromoendoscopy and Narrow Band Imaging in Colonoscopy
Clinics in Colon and Rectal Surgery 2010; 23: 021-030DOI: 10.1055/s-0030-1247853ABSTRACTColonoscopy, the preferred procedure for colon cancer screening, has well-documented limitations. To improve colonoscopy's effectiveness, augmented endoscopy techniques, such as chromoendoscopy and narrow band imaging (NBI) have been evaluated. Both techniques are inexpensive, safe, and relatively easy to perform. Chromoendoscopy has an increasingly important role in surveillance of IBD, but significant work is needed to determine the optimal staining techniques and mucosal surface pattern analysis before this technique can be incorporated into routine clinical practice. NBI is a much newer technology with far less data. Well-designed prospective randomized controlled trials have failed to identify a be......
POSTED 03/10/2010 at 11:13 AM --
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