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Choriocarcinoma News Headlines
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All Recent Choriocarcinoma News Headlines |
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Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms
Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. To investigate this hypothesis, we carried out a comprehensive analysis by genotyping a relatively large sample size of 51 GTN cases using three independent sex chromosome genetic markers; Amelogenin, Protein Kinase and Zinc Finger have X and Y homologues that are distinguishable by their PCR product size. We found that all cases contained the X-chromosomal complement while ......
POSTED 02/21/2010 at 07:47 AM --
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A case of jejunal choriocarcinoma detected by capsule endoscopy and double-balloon endoscopy
Endoscopy 2010; 42: E52-E53DOI: 10.1055/s-0029-1243869© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | FREE: Full text (Source: Endoscopy)...
POSTED 02/16/2010 at 08:24 AM --
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Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias.
CONCLUSION: In the second largest cohort of low-risk GTN patients reported to date, choriocarcinoma pathology and CL(hCG) </=0.37 l/day were major independent predictive factors for MTX resistance risk.
PMID: 20154304 [PubMed - as supplied by publisher] (Source: Ann Oncol)...
POSTED 02/11/2010 at 06:00 PM --
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Persistence and malignant sequelae of gestational trophoblastic disease: Clinical presentation, diagnosis, treatment and outcome
Conclusion: Serial HCG levels remain the best monitor to determine therapeutic response. Categorisation of 'high risk' by five factors is useful in treatment. Albeit a small series, clinical outcome is favourable with a five-year survival of 89.7%. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)...
POSTED 02/10/2010 at 06:00 PM --
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[Fetomaternal hemorrhage caused by intraplacental choriocarcinoma.]
Authors: Touboul C, Faivre E, Boithias C, Mass AE, Senat MV, Fernandez H, Deffieux X
A male infant was born at 41 weeks' gestation to a 34-year-old primiparous woman after an uneventful pregnancy. Physical examination showed extreme paleness. Fetal hemoglobine was 7.6g/dl and Kleihauher exam revealed fetomaternal hemorrhage. Pathology revealed in situ intraplacental choriocarcinoma. Serum human chorionic gonadotrophin level was undetectable 1 month after the delivery both in woman and in newborn. We suggest that a pathological examination of the placenta should be performed in any case of fetomaternal hemorrhage in order to avoid misdiagnosis of intraplacental choriocarcinoma.
PMID: 20074866 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologi......
POSTED 01/11/2010 at 06:00 PM --
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Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity.
This study examined mixtures of 12 food relevant PEs for effects on steroid hormone production, aromatase activity, estrogenic activity, and for interaction with the androgen receptor. The results show that a mixture of all tested PEs increased estradiol production and decreased testosterone production in H295R human adrenal corticocarcinoma cells, indicating an induced aromatase activity. Furthermore, exposure of the H295R cells to isoflavonoids caused a decrease in testosterone production, and various mixtures of PEs significantly stimulated MCF-7 human breast adenocarcinoma cell growth and induced aromatase activity in JEG-3 choriocarcinoma cells. The estrogenic effect in the MCF7 cells of the isoflavonoid mixture and coumestrol was supported by an observed increase in progesterone rece......
POSTED 01/02/2010 at 02:40 AM --
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Pure primary non-gestational ovarian choriocarcinoma: A diagnostic dilemma.
Authors: Gon S, Majumdar B, Barui G, Karmakar R, Bhattacharya A
PMID: 20090265 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)...
POSTED 12/31/2009 at 06:00 PM --
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Role of Regulatory and Angiogenic Cytokines in Invasion of Trophoblastic Cells
Conclusion The expression of IL-6, VEGF, and HIF-1[alpha] in trophoblastic cells is involved in the control of trophoblast invasion and migration. (Source: American Journal of Reproductive Immunology)...
POSTED 12/28/2009 at 06:00 PM --
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Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males
Abstract Primary choriocarcinomas of the liver are rare. Previous reported cases were mostly in infants with only rare adult cases.
Here, we presented five adult cases. The patients were all males, with an average age of 41.6 years (from 36 to 48 years).
Clinical presentations included right upper abdominal pain or abdominal distension. All patients presented with a large hepatic
mass on ultrasonography that measured 11 cm on average in the greatest diameter. Elevated serum human chorionic gonadotropin
(HCG) levels were noted in all cases. At presentation, the tumor was confined to the liver in two patients and therefore surgically
resected. The other three patients presented with extrahepatic metastases on imaging study and therefore only received chemothera......
POSTED 12/16/2009 at 01:01 AM --
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Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumours.
Conclusions Differential expression of the GATA-4 target genes suggested cell-specific functions of GATA-4 in the germ and somatic cells. The GATA-4 expression in early fetal gonocytes, CIS and seminoma cells but the absence in more mature germ cells, is consistent with the early fetal origin of CIS cells and sug-gests that GATA-4 is involved in early germ cell differentiation.
PMID: 19969558 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)...
POSTED 12/06/2009 at 06:00 PM --
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Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines.
In this study, cultures of fusigenic (BeWo) and non-fusigenic (JEG-3) human choriocarcinoma cell lines were used to investigate the expression of mTOR and its downstream signalling components. The effects of an inducer of syncytialisation (forskolin) on mTOR, eIF4E binding proteins (4EBPs) and ribosomal protein S6 kinases (S6Ks) in BeWo cells were also assessed. RT-PCR studies revealed that mTOR, 4EBP and S6Ks are expressed at mRNA level in both JEG-3 and BeWo cells. Semi-quantitative RT-PCR analysis revealed that in early stages of syncytialisation (50 microM forskolin for 48 h), the expression of mTOR and 4EBP was down-regulated when compared to unstimulated cells. In fully syncytialised cells (50 microM forskolin for 72 h) the expression of both genes was similar to basal levels. Intere......
POSTED 12/04/2009 at 09:58 PM --
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Germ cell tumor of the colon with an adenocarcinomatous component
Abstract A case of combined germ cell tumor and adenocarcinoma that arose in the colon of a 62-year-old man is described. The clinical
and pathological findings are presented. The patient had widespread metastases at diagnosis and poor prognosis after operation
(right hemicolectomy) was performed in spite of receiving chemotherapy. Pathologically, the germ cell tumor was composed of
a yolk sac tumor and choriocarcinoma. Further, all the metastatic lesions showed a germ cell phenotype. An extragonadal germ
cell tumor is extremely rare. To our knowledge, only a few cases have been reported in the English-language literature. Our
present report will contribute to the understanding of the characteristics of this rare neoplasm.
Content Type Journal ArticleCategory Case Report......
POSTED 12/04/2009 at 04:14 PM --
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Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion
Conclusions:
MMP-2 is regulated by PKA through several binding sites and transcription factors including Ets-2, p53, C/EBP, C/EBP lambda and AP-2 alpha. Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2. (Source: Reproductive Biology and Endocrinology)...
POSTED 11/24/2009 at 06:00 PM --
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Antineoplastics: CNS involvement with thromboses in a patient with choriocarcinoma?: case report
(Source: Reactions)...
POSTED 11/22/2009 at 08:04 AM --
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Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters
Conclusions NF is probably a specific substrate of BCRP, and BCRP has a major active role in NF transport in JAr cells. For the first
time, we showed, that P-gp, MRPs, and the OATP2B1, probably have a negligible contribution to NF transport in JAr cells.
Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1286-7Authors
Valeria Feinshtein, Ben-Gurion University of the Negev Department of Clinical Pharmacology, Faculty of Health Sciences Beer-Sheva IsraelGershon Holcberg, Ben-Gurion University of the Negev Division of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences 151 Beer Sheva 84101 IsraelAlaa Amash, Ben-Gurion University of the Negev The Shraga Segal Department of Microbiology and Immunology, Faculty......
POSTED 11/18/2009 at 01:15 PM --
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Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells
This study aimed to investigate the location and function of tau isoform of 14-3-3 proteins in human trophoblast. 14-3-3 tau was localized in human cytotrophoblast cells, but not in syncytiotrophoblast cells in both first trimester and term placenta by immunochemistry stain. Forskolin-induced cell fusion (BeWo cells) confirmed that 14-3-3 tau was decreased during trophoblast differentiation. Forskolin-induced differentiation was stimulated by small-interfering (si) RNA induced down-regulation of 14-3-3 tau, contrarily, it was suppressed by plasmid induced upregulation of 14-3-3 tau in BeWo cells. When BeWo cells were treated with 14-3-3 tau siRNA, an increase in protein concentration of cell cycle inhibitor p27kip1 and a decrease in protein concentration of proliferating cell nuclear antig......
POSTED 11/11/2009 at 06:00 PM --
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Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor, C93.
In this study, we analyzed the expression of FASN in normal and molar placentas, as well as gestational trophoblastic neoplasia, and assessed the effects of a new FASN inhibitor, C93, on cellular proliferation and apoptosis in choriocarcinoma cells. Using a FASN-specific monoclonal antibody, we found that FASN immunoreactivity was detected in the cytotrophoblast and intermediate (extravillous) trophoblast of normal and molar placentas, as well as in placental site nodules. All choriocarcinomas (n = 33), 90% of epithelioid trophoblastic tumors (n = 20), and 60% of placental site trophoblastic tumors (n = 10) exhibited FASN positivity. FASN expression was further confirmed in vitro by Western blot and real-time PCR. Treatment of JEG3 and JAR cells with C93 induced significant apoptosis throu......
POSTED 11/04/2009 at 06:00 PM --
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Long-chain Polyunsaturated Fatty Acids Stimulate Cellular Fatty Acid Uptake in Human Placental Choriocarcinoma (BeWo) Cells
Abstract: Supplementation of long-chain polyunsaturated fatty acids (LCPUFAs) is advocated during pregnancy in some countries although very little information is available on their effects on placental ability to take up these fatty acids for fetal supply to which the fetal growth and development are critically dependent. To identify the roles of LCPUFAs on placental fatty acid transport function, we examined the effects of LCPUFAs on the uptake of fatty acids and expression of fatty acid transport/metabolic genes using placental trophoblast cells (BeWo). Following 24 h incubation of these cells with 100 μM of LCPUFAs (arachidonic acid, 20:4n-6, eicosapentaenoic acid, 20:5n-3, or docosahexaenoic acid, 22:6n-3), the cellular uptake of [14C] fatty acids was increased by 20–50%, and accu......
POSTED 11/01/2009 at 06:00 PM --
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Gastric choriocarcinoma admixed with an alpha-fetoprotein-producing adenocarcinoma and separated adenocarcinoma.
We report a case of gastric choriocarcinoma admixed with an alpha-fetoprotein (AFP)-producing adenocarcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomy with D2 lymph node dissection and Billroth II gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemothera......
POSTED 10/27/2009 at 07:00 PM --
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p53 Mediates Epidermal Growth Factor (EGF) Induction of MMP-2 Transcription and Trophoblast Invasion
Abstract: Trophoblast invasion is a highly restricted process, regulated by growth factors, hormones and cytokines. Trophoblast invasion is attainable due to proteolytic degradation of the epithelial basement membrane and the extracellular matrix by proteolytic enzymes like the matrix metalloproteinases (MMPs) particularly MMP-2. Epidermal growth factor (EGF), a major mediator of implantation, has been documented to induce MMP-2 and trophoblast invasion. The aim of this study was to investigate the transcriptional regulation of MMP-2 in EGF- stimulated invasive trophoblast cells, using JAR choriocarcinoma cell line and 6-8w 1st trimester trophoblasts. MMP-2 expression was induced by EGF within 1 hour. Gelshift and supershift assay were used to explore transcription factors involved in MMP-......
POSTED 10/22/2009 at 07:00 PM --
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