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Choriocarcinoma News Headlines
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All Recent Choriocarcinoma News Headlines |
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Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) gamma by organotin compounds.
Authors: Hiromori Y, Nishikawa J, Yoshida I, Nagase H, Nakanishi T
Organotin compounds such as tributyltin (TBT) and triphenyltin (TPT) are frequent environmental contaminants and are suspected of disrupting endocrine function in vertebrates and invertebrates. Previously, we reported that TBT and TPT function as powerful agonists for peroxisome proliferator-activated receptor (PPAR) gamma and stimulate adipocyte differentiation via the PPARgamma signaling pathway. Our current study investigates the structure-dependent binding of butyltin and phenyltin compounds to PPARgamma and their ability to activate the receptor. A Scatchard analysis with purified recombinant PPARgamma demonstrated that [(14)C]TPT binds to PPARgamma with an equilibrium dissociation constant (K(d)) of 66.6+/-5.2 nM,......
POSTED 06/28/2009 at 01:09 AM --
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Non-Gestational Uterine Choriocarcinoma in a Postmenopausal Woman.
Conclusions: This case further illustrates that choriocarcinoma may be seen in older women after a long menopausal period. Accurate diagnosis and treatment are essential, because the tumor is very chemosensitive and curable even in advanced stages.
PMID: 19556820 [PubMed - as supplied by publisher] (Source: Onkologie)...
POSTED 06/27/2009 at 09:28 AM --
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Primary choriocarcinoma of uterine cervix treated by uterine artery drug pouring and embolism: one case report
We present one rare case proved by cervical biopsy. The patient was an 36-year-old Chinese
woman with irregular vaginal bleeding for 60 days. A cervical tumoral mass was seen in the pelvic examination and biopsy revealed
active hyperplasia of trophoblastic cell. Because of massive vaginal haemorrhage, the patient accepted uterine artery drug
pouring and embolism emergently. This management had gained a satisfactory effect. Thus, Uterine artery drug pouring and embolism
is one new and effective weapon for PCC, which can preserve the patient’s productive ability.
Content Type Journal ArticleDOI 10.1007/s10330-009-0042-6Authors
Yan Wang, Medical College of Qingdao University Department of Gynecology, The Affiliated Yuhuangding Hospital Yantai 264000 ChinaHaiyang Jiang, Medical Coll......
POSTED 06/15/2009 at 01:50 AM --
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Protein processing by the placental protease, cathepsin P
Cathepsin P is a member of a family of placentally expressed cathepsins (PECs). The closest human homolog of cathepsin P is cathepsin L, a broad specificity enzyme that has functions in many tissues in addition to placenta. The gene duplications that gave rise to the PECs provide a rare opportunity to define proteolytic functions in placenta, a transient organ unique to mammals. Peptidyl substrate and inhibitor libraries have shown that cathepsin P has evolved an unusually restricted preference for substrates containing hydrophobic amino acids. Proteomic techniques were used to probe for substrates of this enzyme. Recombinant cathepsin P was incubated with rat choriocarcinoma (Rcho-1) cell proteins to identify substrates using two-dimensional difference gel electrophoresis. Substrate prote......
POSTED 06/14/2009 at 06:00 PM --
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Impact of the diameter of SonoVue microbubbles on binding characteristics of a new contrast agent targeted to choriocarcinoma cells in vitro
Conclusion The binding capacity of the targeted SonoVue microbubbles to JARs is related to the diameter of the microbubble, which is
determined by the shaking method before preparation. Modulating the diameter of SonoVue microbubbles may increase the binding
rate and stability of targeted microbubbles to JARs, thus to improve the image of JARs.
Content Type Journal ArticleDOI 10.1007/s10330-009-0008-8Authors
Lixue Zhou, Sun Yat-sen University Department of Gynecology and Obstetrics, The Second Affiliated Hospital Guangzhou 510120 ChinaRuike Pan, Sun Yat-sen University Department of Gynecology and Obstetrics, The Second Affiliated Hospital Guangzhou 510120 ChinaNa Di, Sun Yat-sen University Department of Gynecology and Obstetrics, The Second Affiliated Hospital Guangzh......
POSTED 05/15/2009 at 12:57 AM --
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Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells
Conclusions:
Progesterone reducesPR and SP4 binding to the MMP-2 promoter, thereby suppressing transcription. Progesterone also promotes SP4 degradation. These novel mechanisms of MMP-2 regulation by progesterone provide the biological rationale for the use of progesterone in clinical settings associated with increased MMP-2 expression. (Source: Reproductive Biology and Endocrinology)...
POSTED 05/08/2009 at 11:00 PM --
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Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies.
This study raises questions regarding the validity of using the placental cell lines that are currently available as model systems for immunological interactions between fetal trophoblast and maternal leucocytes bearing receptors for HLA molecules.
PMID: 19368562 [PubMed - indexed for MEDLINE] (Source: Immunology)...
POSTED 04/30/2009 at 06:00 PM --
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Differential expression of SOX2 and SOX17 in testicular germ cell tumors.
This study examined SOX2 and SOX17 expression patterns in a total of 67 cases, including 41 pure GCTs (32 seminomas and 9 embryonal carcinomas) and 26 mixed GCTs (9 foci of seminoma, 21 of embryonal carcinoma, 17 of yolk sac tumor, 19 of teratoma, and 5 of choriocarcinoma). All seminoma components showed diffuse SOX17 nuclear expression and were negative for SOX2. All but one of the embryonal carcinomas showed diffuse SOX2 nuclear expression with the one showing a focal reaction, whereas all were negative for SOX17. SOX17 was variably expressed in all yolk sac tumor components, but SOX2 was negative. Teratomas showed variable SOX2 and SOX17 expressions in the epithelial elements. Choriocarcinomas were negative for SOX2 and SOX17. SOX2 and SOX17 expression patterns can distinguish between s......
POSTED 04/30/2009 at 06:00 PM --
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Primary Pulmonary Choriocarcinoma Presenting with a Hemothorax.
Page: 663DOI: 10.1097/JTO.0b013e31819cce6cAuthors: Seol, Hyun-Joo MD *; Lee, Ju-Han MD +; Lee, Ki Yeol MD ++; Kim, Je-Hyeong MD [S]; Lee, Nak-Woo MD [//]; Park, Hyung-Joo MD [P] (Source: Journal of Thoracic Oncology)...
POSTED 04/25/2009 at 10:37 AM --
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Aspiration biopsy cytomorphology of primary pulmonary germ cell tumor metastatic to the brain
Extragonadal germ cell tumors are uncommon and such tumors originating from the lung parenchyma are extremely rare. This is a case of 68-year-old female who was admitted with complaints of right-sided weakness, inability to maintain her balance, right-sided headache, and bloody sputum. Her workup revealed two enhancing brain lesions and large lung mass involving the left lower lobe. Fine-needle aspiration (FNA) of the lung followed by craniotomy was performed and the patient was initially diagnosed with lung adenocarcinoma metastatic to the brain based on the cytomorphology of the lung FNA and histology of the brain mass. However, retrospective investigation revealed markedly elevated alpha fetoprotein (AFP) of which the cytopathologist was unaware at the time of diagnosis. A review of the......
POSTED 04/15/2009 at 11:00 PM --
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Estrogens and Human Papilloma Virus Oncogenes Regulate Human Ether-a-go-go-1 Potassium Channel Expression
Ether-à-go-go-1 (Eag1) potassium channels are potential tools for detection and therapy of numerous cancers. Here, we show human Eag1 (hEag1) regulation by cancer-associated factors. We studied hEag1 gene expression and its regulation by estradiol, antiestrogens, and human papillomavirus (HPV) oncogenes (E6/E7). Primary cultures from normal placentas and cervical cancer tissues; tumor cell lines from cervix, choriocarcinoma, keratinocytes, and lung; and normal cell lines from vascular endothelium, keratinocytes, and lung were used. Reverse transcription-PCR (RT-PCR) experiments and Southern blot analysis showed Eag1 expression in all of the cancer cell types, normal trophoblasts, and vascular endothelium, in contrast to normal keratinocytes and lung cells. Estradiol and antiestrogen......
POSTED 04/14/2009 at 11:00 PM --
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SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors
The correct diagnosis of metastatic germ cell tumors is critical, because these tumors can be effectively treated and are even cured with modern therapy. Their histopathologic diagnosis can be challenging without immunohistochemical markers, which currently have limitations. SALL4 is a novel stem cell marker essential to maintain pluripotency and self-renewal of embryonic stem cells. In the current study, the authors investigated the utility of SALL4 as a potential diagnostic marker for metastatic germ cell tumors.Ninety metastatic germ cell tumors from testis, ovary, and extragonadal sites were stained with a monoclonal SALL4 antibody. In addition, 170 metastatic nongerm cell malignancies, including 158 carcinomas (6 head and neck, 8 thyroid, 12 lung, 8 breast, 7 hepatocellular, 3 cholang......
POSTED 04/12/2009 at 11:00 PM --
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Primary sinonasal choriocarcinoma
Abstract: Primary choriocarcinoma of sinonasal tract has not been previously documented. The aim of the study was to report, for the first time, 2 cases of primary sinonasal choriocarcinoma. The differential diagnosis is discussed and also the theories concerning the histogenesis of this neoplasm are briefly reviewed. Two male patients of 44 and 49 years of age complained of epistaxis and nasal obstruction of 2-week duration. Computerized axial tomographic scan of the head revealed an opacity of the left nasal cavity in one patient and a destructive lesion of the maxillary sinus in the other. Histopathologically, the lesions disclosed a dual cell population composed of cytotrophoblastic cells with uniform, round nuclei, clear cytoplasm, admixed with large multinucleated syncytiotrophoblast......
POSTED 03/31/2009 at 11:00 PM --
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Uveal metastasis from testicular choriocarcinoma presenting as scleritis.
Authors: Dotchin S, Lakosha H, Heathcote JG, Dickinson J
PMID: 19491960 [PubMed - in process] (Source: Canadian Journal of Ophthalmology)...
POSTED 03/31/2009 at 06:00 PM --
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Primary sinonasal choriocarcinoma.
Authors: Bell DM, Porras G, Tortoledo ME, Luna MA
Primary choriocarcinoma of sinonasal tract has not been previously documented. The aim of the study was to report, for the first time, 2 cases of primary sinonasal choriocarcinoma. The differential diagnosis is discussed and also the theories concerning the histogenesis of this neoplasm are briefly reviewed. Two male patients of 44 and 49 years of age complained of epistaxis and nasal obstruction of 2-week duration. Computerized axial tomographic scan of the head revealed an opacity of the left nasal cavity in one patient and a destructive lesion of the maxillary sinus in the other. Histopathologically, the lesions disclosed a dual cell population composed of cytotrophoblastic cells with uniform, round nuclei, clear cytoplasm, admixed w......
POSTED 03/26/2009 at 11:42 AM --
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Testicular choriocarcinoma metastatic to skin and multiple organs. Two case reports and review of literature
Two cases of males with subcutaneous masses as the first clinical sign of testicular choriocarcinoma are reported. The urine and serum human chorionic gonadotropin (hCG) test confirmed high level hCG from male choriocarcinoma. These cases, although very rare, can be a great diagnostic and therapeutic challenge and should be considered in the differential diagnosis of subcutaneous masses occurring in young males. Chen X, Xu L, Chen X, Teng X, Zheng S. Testicular choriocarcinoma metastatic to skin and multiple organs. Two case reports and review of literature. (Source: Journal of Cutaneous Pathology)...
POSTED 03/24/2009 at 07:00 PM --
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Recent developments in testicular germ cell tumor research
Testicular germ cell tumors of adolescents and adults (TGCTs; the so-called type II variant) are the most frequent malignancies found in Caucasian males between 20 and 40 years of age. The incidence has increased over the last decades. TGCTs are divided into seminomas and nonseminomas, the latter consisting of the subgroups embryonal carcinoma, yolk-sac tumor, teratoma, and choriocarcinoma. The pathogenesis starts in utero, involving primordial germ cells/gonocytes that are blocked in their differentiation, and develops via the precursor lesion carcinoma in situ toward invasiveness. TGCTs are totipotent and can be considered as stem cell tumors. The developmental capacity of their cell of origin, the primordial germ cells/gonocyte, is demonstrated by the different tumor histologies of the ......
POSTED 03/19/2009 at 11:00 PM --
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[DIAGNOSIS IN ONCOLOGY] Oral Lesion As the First Manifestation of Choriocarcinoma of the Testicle
(Source: Journal of Clinical Oncology)...
POSTED 03/17/2009 at 11:00 PM --
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Prenatal Findings in a Case of Massive Fetomaternal Hemorrhage Associated with Intraplacental Choriocarcinoma
Fetal Diagn Ther 2009;25:158-162 (DOI:10.1159/000209201) (Source: Fetal Diagnosis and Therapy)...
POSTED 03/16/2009 at 09:48 AM --
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Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives
Future Oncology , March 2009, Vol. 5, No. 2, Pages 217-231. (Source: Future Oncology)...
POSTED 03/16/2009 at 06:19 AM --
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