|
|
|
|
Chordoma News Headlines
|
|
|
|
|
|
|
All Recent Chordoma News Headlines |
|
|
|
|
[Sacral chordoma: A rare tumour of the buttocks.]
We report the case of a 62-year-old patient presenting a bulky tumefaction, nodular in places, not very painful, and extending towards the anal area, scrotum and the posterior aspect of the upper left thigh. Histopathological examination of a macrobiopsy sample of this tumefaction pointed to chordoma. On magnetic resonance imaging (MRI), the tumour presented multiple ramifications extending towards the scrotal area, the sciatic area and the posterior aspect of the left thigh. Palliative tumorectomy was performed. Given the very slow progression of the tumour and the risk of adverse effects in such a large tumoral exposure field, radiotherapy was ruled out. DISCUSSION: This is a typical observation of a rare tumour that dermatologists may encounter.
PMID: 19560615 [PubMed - in process] ......
POSTED 05/31/2009 at 06:00 PM --
|
Presacral Tumors: Diagnosis and Management
Clinics in Colon and Rectal Surgery 2009; 22: 084-093DOI: 10.1055/s-0029-1223839ABSTRACTPresacral tumors are uncommon lesions that can be difficult to diagnose because of their nonspecific presenting signs and symptoms. Cross-sectional imaging is essential in evaluating these lesions to determine the optimal surgical approach and the extent of resection. Surgery is the mainstay of treatment as it establishes the diagnosis and prevents the adverse consequences associated with malignant degeneration and secondary bacterial infection. The outcomes for patients with benign presacral tumors are favorable. Although there have been substantial improvements in the prognosis of patients with malignant presacral tumors, the development of newer adjuvant therapies are likely to further improve the on......
POSTED 05/28/2009 at 03:29 AM --
|
Pulmonary vein metastasis of a sacral chordoma extending into the left atrial cavity.
Page: 557DOI: 10.2459/JCM.0b013e32832bca61Authors: Prompona, Maria a; Linn, Jennifer b; Burdorf, Lars c; Assmann, Gerald d; Reichart, Bruno c; Reiser, Maximilian a; Nikolaou, Konstantin a (Source: Journal of Cardiovascular Medicine)...
POSTED 05/27/2009 at 06:44 PM --
|
Emisacrectomy, experience in 11 cases
Abstract Emisacrectomy is a challenging surgery in the treatment of tumours that affect the sacrum. Authors report their experience
in 11 cases affected by tumours of the sacrum (9 chordomas, 1 ependymoma, 1 monostotic bladder metastasis) operated on at
the Orthopaedic Department of A.S.O S. Giovanni Battista Molinette in Turin, Italy, from 1998 through 2005 discussing planning
surgery, level of osteotomy, functional and oncological results and complications of the treatment at a median follow-up of
5 years (range 2–9), describing the surgical and medical teaching learned from the treatment of these patients. Despite the
potential complications, emisacrectomy can be performed successfully and is an important procedure in the treatment of sacral
tumours.
Content T......
POSTED 05/26/2009 at 02:42 AM --
|
Comparison of cytological features of myxopapillary ependymomas on crush preparations
Myxopapillary ependymoma (ME) is a rare neoplasm found predominantly in the sacro-coccygeal region in adults and is characterized by its distinct epithelial and stromal components. From 1990 to April 2008, a total of 10 ME cases were recorded at our institution. Six out of 10 cases underwent frozen section examination with concomitant crush preparations, which forms the basis of this study. The clinical and cytologic findings in all six cases were reviewed. There were four males and two females. The age ranges from 15 to 36 years with a mean age of 27 years. The epithelial component of ME is strikingly similar for all six cases showing tumor cells appearing singly or in loose clusters, most with papillary branching. There was also presence of indistinct cell boundaries, tapered cytoplasmic......
POSTED 05/19/2009 at 11:00 PM --
|
[CT and MRI of intrinsic space-occupying lesions of the bony skull base.]
This article gives an overview of the appearance of the most common primary bony skull base masses in CT and MRI. From the authors' point of view these are fibrous dysplasia, chordomas, chondrosarcomas, Langerhans cell histiocytosis and multiple myelomas, which must be differentiated from pseudolesions. The possibilities of CT and MRI in making a specific diagnosis, differential diagnosis and the kind of making the final diagnosis are described.
PMID: 19436984 [PubMed - as supplied by publisher] (Source: Der Radiologe)...
POSTED 05/13/2009 at 06:00 PM --
|
Skull base chordomas: efficacy of surgery followed by carbon ion radiotherapy
Conclusions Surgical removal of the tumour around the brainstem and the optic nerve combined with post-operative carbon ion radiotherapy
will improve the survival rate and quality of life of patients with complicated skull base chordomas.
Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0383-5Authors
Satoshi Takahashi, Keio University School of Medicine Department of Neurosurgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 JapanTakeshi Kawase, Keio University School of Medicine Department of Neurosurgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 JapanKazunari Yoshida, Keio University School of Medicine Department of Neurosurgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 JapanAzusa Hasegawa, National Institute of Radiological Sciences Rese......
POSTED 05/12/2009 at 01:03 AM --
|
Neuronavigational guidance in craniofacial approaches for large (para)nasal tumors involving the anterior skull base and upper clival lesions
Conclusion: Craniofacial approaches with intraoperative neuronavigational guidance in a multidisciplinary setting allow safe resection of large tumors of the upper clivus and the paranasal sinuses involving the anterior skull base. Complex skull base surgery with the involvement of bony structures appears to be an ideal field for advanced navigation techniques given the lack of intraoperative shift of relevant structures. (Source: European Journal of Surgical Oncology)...
POSTED 05/10/2009 at 10:32 AM --
|
Proton therapy for tumors of the skull base
Abstract Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while
achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors,
10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas,
and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates
are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference
in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the
major morbidity and mortali......
POSTED 05/04/2009 at 12:38 AM --
|
Extended endoscopic approaches for midline skull-base lesions
Abstract The endoscopic transsphenoidal approach has been reported in the literature as a useful tool to treat sellar and parasellar
lesions. The endoscope permits a panoramic view instead of the narrow microscopic view, and it allows the inspection and removal
of the lesions of sellar, parasellar, and suprasellar compartments by angled-lens endoscopes. On the basis of the experience
gained with the use of the endoscope, we have performed extended endoscopic endonasal transsphenoidal approach in 13 of 200
(total endoscopic transphenoidal approaches since September 1997) patients for the last 5 years. Extended endoscopic transsphenoidal
approach was performed for three patients with pituitary adenoma, two patients with craniopharyngioma, one patient with metastatic
les......
POSTED 05/01/2009 at 01:44 AM --
|
Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas
Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas
Modern Pathology advance online publication, May 1, 2009. doi:10.1038/modpathol.2009.63
Authors: Asem AE Shalaby, Nadege Presneau, Bernadine D Idowu, Lisa Thompson, Timothy RW Briggs, Roberto Tirabosco, Timothy C Diss
& Adrienne M Flanagan (Source: Modern Pathology AOP)...
POSTED 04/30/2009 at 11:00 PM --
|
Parasagittal osteotomy for en bloc resection of multilevel cervical chordomas.
Authors: Chou D, Acosta F, Cloyd JM, Ames CP
En bloc resection of chordoma has been shown to be critical for prolonging long-term survival and disease-free intervals in patients. Cervical spine chordomas pose special challenges because of the vertebral arteries and critical nerve roots involved. Multilevel chordomas pose even greater challenges because of the need to remove multiple segments of the spine in 1 piece without tumor violation. Although there have been 2 case reports describing multilevel spondylectomy for cervical chordoma, to the authors' knowledge, there are no reports of parasagittal osteotomies for en bloc resection of multilevel cervical chordomas. The use of these osteotomies allows us to avoid intralesional resection and adhere to the oncological principle of en blo......
POSTED 04/30/2009 at 06:00 PM --
|
Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature
This article reports an unusual presentation wherein the first evidence of distant failure from a locally controlled, recurrent skull base chordoma was a metastasis to the mandible. We present a case report from a tertiary-care academic skull base referral center and a review of literature. A 33-year-old woman with a locally recurrent spheno-occipital chordoma that was stabilized with multimodality therapy presented with a right mandibular mass. Immunohistochemical stains demonstrated the tumor cells staining positive for vimentin, cytokeratin, epithelial membrane antigen (EMA), and S100 consistent with metastatic chordoma. Positron emission tomography–computed tomography imaging further revealed widespread distant failure. Chordomas are rare tumors with only four previous reports of......
POSTED 04/28/2009 at 08:46 PM --
|
Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40
Daugaard S, Christensen LH, Høgdall E. Markers assisting the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. APMIS 2009. Chondroid tumors comprise a heterogenous group of benign to overt malignant neoplasms, which may be difficult to differentiate from one another by histological examination. A group of 43 such tumors was stained with nine relevant antibodies in an attempt to find consistent marker profile(s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, ......
POSTED 04/27/2009 at 11:00 PM --
|
Optimal Treatment Planning for Skull Base Chordoma: Photons, Protons, or a Combination of Both?
Conclusions: There are dosimetric advantages to using either PH1 or PP plans, with the latter yielding the best target coverage and conformality. (Source: International Journal of Radiation Oncology * Biology * Physics)...
POSTED 04/07/2009 at 06:00 PM --
|
[HEAD & NECK] Extraosseous Chordoma of the Nasopharynx
CONCLUSIONS: Extraosseous nasopharyngeal chordoma is a rare but important lesion to be considered in the differential diagnosis of nasopharyngeal masses. When a midline nasopharyngeal mass is found with an associated clival sinus tract, extraosseous chordoma moves to the top of the differential diagnosis list. Complete removal of the soft-tissue tumor and the clival sinus tract is the treatment of choice in such cases. (Source: American Journal of Neuroradiology)...
POSTED 04/06/2009 at 11:00 PM --
|
Intradural cranial chordoma.
CONCLUSION: The cases presented in this study indicate that intradural chordomas can also be aggressive such as typical chordomas. Long-term follow-ups with a large number of patients with this condition are essential for elucidating the prognosis of intradural chordomas.
PMID: 19329163 [PubMed - as supplied by publisher] (Source: Surgical Neurology)...
POSTED 03/26/2009 at 11:00 PM --
|
Proton therapy in chordoma of the base of the skull: a systematic review
Abstract Chordoma is a rare, slow-growing, locally aggressive, primary bone tumor that arises from the skull base region in approximately
25–35% of cases. The therapeutic approach to chordoma has traditionally been surgery, followed by radiation therapy. The advent
of charged particle radiotherapy has let us consider protons as the postoperative treatment of choice, but no controlled studies
have yet confirmed the superiority of protons over photons. During January 2008, two independent researchers conducted a systematic
review of the current data on the treatment of base of the skull chordoma C with proton therapy (PT) and, for comparison,
with other irradiation techniques (conventional radiation therapy, ion therapy, fractionated stereotactic radiation therapy,
and rad......
POSTED 03/25/2009 at 01:50 AM --
|
Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma.
Conclusions: c-MET expression was observed in most spinal chordomas and correlated with the expression of CAM5.2, suggesting a relationship to an epithelial phenotype.
PMID: 19302530 [PubMed - as supplied by publisher] (Source: Histopathology)...
POSTED 03/18/2009 at 11:00 PM --
|
Oronasopharyngeal chordomas
Conclusion Primary oronasopharyngeal chordomas are rare tumors that may present without bony erosion of the skull base. A wide excision
with drilling of the involved bony structures may offer an oncologic cure.
Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0253-1Authors
Jeroen R. Coppens, University of Utah Department of Neurosurgery Salt Lake City UT 84132 USAH. Ric Harnsberger, University of Utah Department of Radiology Salt Lake City UT 84132 USAMichael A. Finn, University of Utah Department of Neurosurgery Salt Lake City UT 84132 USAPramod Sharma, Ear, Nose, and Throat Center Salt Lake City UT 84102-1307 USAWilliam T. Couldwell, University of Utah Department of Neurosurgery Salt Lake City UT 84132 USA
Journal Acta Neurochirurgic......
POSTED 03/18/2009 at 02:09 AM --
|
|
|
|
|
|
 |
|
|
|
|
|
IMPORTANT NOTICE:
The information provided on this site is intended for your general knowledge only and is not a substitute for professional
medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a
qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition.
|
|
|
|
|
|
|
|
Featured Product! |
 |
|
Total Balance
Men's Plus |
|
"The restoration and maintenance of normal organ and brain function, a strong immune system, and the balancing of hormones is the key to vibrant health and in avoiding premature-aging!" |
|
CLICK HERE
for more info... |
|
|
