Endoscopic management of sphenoclival neoplasms: Anatomical correlates and patient outcomes
Conclusion: The sphenoclival region poses a significant surgical challenge given its central location at the skull base and proximity to critical structures. This study demonstrates that transnasal endoscopic access to the sphenoclival region is technically feasible and allows successful surgical extirpation of tumors with a low complication rate and acceptable patient outcomes. (Source: Otolaryngology - Head and Neck Surgery)...
POSTED 02/20/2010 at 08:20 AM --
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Primary Chordoma in the Nasal Cavity and Nasopharynx: CT and MR Imaging Findings [HEAD AND NECK]
CONCLUSIONS:
Although no imaging features are pathognomonic, primary chordomas without skull base (clivus) bony changes in the nasal cavity and nasopharynx have some CT and MR imaging findings that are suggestive of diagnosis. The differential diagnosis of the soft tissue mass should be limited to these sites. (Source: American Journal of Neuroradiology)...
POSTED 02/11/2010 at 10:01 AM --
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Chordoma with increased prolactin levels (pseudoprolactinoma) mimicking pituitary adenoma: A case report with review of the literature
Kumar Pavan, Kumar Piyush, Singh Shalini, Kumari Niraj, Datta N RJournal of Cancer Research and Therapeutics 2009 5(4):309-311The article deals with a rare case of chordoma with increased prolactin levels. It could often result in a diagnostic dilemma and problems in differentiating it from a pituitary adenoma. (Source: Journal of Cancer Research and Therapeutics)...
POSTED 02/11/2010 at 07:47 AM --
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Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
Currently there is no effective chemotherapy for chordoma. Recent studies report co-expression of insulin-like growth factor-1 receptor (IGF1R) and its cognate ligand in chordoma, but it is unknown whether this receptor tyrosine kinase is activated in these tumours. Additionally, genetic studies have confirmed frequent deletions of chromosome 9p in chordomas, which encompasses the cyclin-dependent kinase inhibitor 2A (CDKN2A) locus. Another gene in this region, methylthioadenosine phosphorylase (MTAP), is an essential enzyme of the purine salvage pathway and has therapeutic relevance because MTAP-deficient cells are particularly sensitive to inhibitors of de novo purine synthesis. We investigated whether these pathways might be potential therapeutic targets for chordoma. Paraffin-embedded ......
POSTED 02/05/2010 at 06:00 PM --
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Vascularised fibula osteocutaneous flap for cervical spinal and posterior pharyngeal wall reconstruction
We report a case of vascularised fibula osteocutaneous flap used for composite cervical spinal and posterior pharyngeal wall reconstruction, in a patient with recurrent skull base chordoma, resected by an anterior approach via median labio-mandibular glossotomy approach. Bone stability and pharyngeal wall integrity were simultaneously restored (Source: Indian Journal of Plastic Surgery)...
POSTED 01/29/2010 at 07:56 AM --
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Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients.
Conclusions:
Despite progress of surgical techniques and the results obtained with targeted therapy, more effort is needed for better disease control. Specific experience of the multidisciplinar therapeutic team is, however, essential to succeed in improving patients' outcome. (Source: BMC Cancer)...
POSTED 01/27/2010 at 06:00 PM --
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How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons.
CONCLUSION: Investment costs are highest for the combined carbon-ion/proton facility and lowest for the photon facility. Cost differences become smaller when total costs per year and specific treatment costs are compared. Lower fractionation schedule of particle therapy might further reduce its costs.
PMID: 20106540 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)...
POSTED 01/24/2010 at 06:00 PM --
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Surgery for Chordomas of the Craniocervical Junction: Lessons Learned
We present our results and lessons learned from surgeries performed between 1982 and 2007 in the National Hospital for Neurology and Neurosurgery, London. Patients undergoing transfacial, transoral, and transmandibular surgeries for chordomas of the craniocervical junction were enrolled in this study. Chi-square, Fisher exact tests, and log-rank survival analysis were used to determine significant adverse factors ( < 0.05). In our series, 80 operations were performed in 66 patients; 37 patients were male, 29 female. Age at presentation was commonly 40 to 60 years. After surgery, pain was the same or better in 98.1% of patients; 18.6% of patients presented with myelopathy, of whom 27.8% improved, 44.4% remained unchanged, 27.8% deteriorated. Complication rates were as follows......
POSTED 01/23/2010 at 08:11 AM --
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Pediatric cervical chordoma: report of two cases and a review of the current literature
Conclusion Although en bloc resection is the ideal modality for treatment of chordoma, such a procedure is often associated with a significant
risk of surgical morbidity due to the tumor location. Therefore, piecemeal resection followed by postoperative adjuvant radiotherapy,
including proton radiotherapy or radiosurgery, should be considered in such cases.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00381-009-1076-3Authors
Gwi Hyun Choi, Yonsei University Department of Neurosurgery, Spine and Spinal Cord Institute, College of Medicine 134 Shinchon-dong, Seodaemun-gu Seoul 120-752 Republic of KoreaMoon-Sool Yang, Yonsei University Department of Neurosurgery, Spine and Spinal Cord Institute, College of Medicine 134 Shinchon-dong, Seodaemun-gu Seoul 120......
POSTED 01/22/2010 at 04:08 AM --
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Vascularised fibula osteocutaneous flap for cervical spinal and posterior pharyngeal wall reconstruction
We report a case of vascularised fibula osteocutaneous flap used for composite cervical spinal and posterior pharyngeal wall reconstruction, in a patient with recurrent skull base chordoma, resected by an anterior approach via median labio-mandibular glossotomy approach. Bone stability and pharyngeal wall integrity were simultaneously restored (Source: Indian Journal of Plastic Surgery)...
POSTED 01/21/2010 at 07:58 AM --
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Cytopathologic features of orbital intraosseous chordoid meningioma
Chordoid meningioma (CM) is characterized by a striking histologic resemblance to chordoma and propensity for aggressive behavior or recurrence (WHO grade II designation). Orbital intraosseous CM is extremely uncommon and only one case report has been documented. A case is presented here in which squash smears of a left orbital tumor in a 53-year-old male revealed small clusters or cord-like structures of bland tumor cells embedded in a myxoid or mucinous background. Whorl-like structures were also identified. The tumor cells possessed uniformly round nuclei with a smooth nuclear outline, fine granular chromatin, and small nucleoli. Occasional intranuclear inclusions, coarse collageneous cytoplasmic filaments were observed. Many spindle-shaped cells with similar nuclear findings were also ......
POSTED 01/19/2010 at 06:00 PM --
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[Surgical treatment of clival chordomas.]
CONCLUSIONS: Extradural approaches imply anatomical regions which are familiar for otolaryngologists. Specific knowledge about the limitations of each approach is essential in order to avoid unnecessary morbidity and incomplete resections.
PMID: 20096394 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)...
POSTED 01/19/2010 at 06:00 PM --
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Differential diagnosis of dumbbell lesions associated with spinal neural foraminal widening: imaging features
Computed tomography (CT) and magnetic resonance imaging (MRI) reliably demonstrate typical features of schwannomas or neurofibromas in the vast majority of dumbbell lesions responsible for neural foraminal widening. However, a large variety of unusual lesions which are causes of neural foraminal widening can also be encountered in the spinal neural foramen. Radiologic findings can be helpful in differential diagnosis of lesions of spinal neural foramen including neoplastic lesions such as benign/malign peripheral nerve sheath tumors (PNSTs), solitary bone plasmacytoma (SBP), chondroid chordoma, superior sulcus tumor, metastasis, and nonneoplastic lesions such as infectious process (tuberculosis, hydatid cyst), aneurysmal bone cyst (ABC), synovial cyst, traumatic pseudomeningocele, arachnoi......
POSTED 12/31/2009 at 06:00 PM --
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Primary intracranial myxoma of the lateral skull base: a rare entity in clinical practice.
Authors: Oruckaptan HH, Sarac S, Gedikoglu G
Myxomas are rare benign tumors arising from mesenchymal tissues throughout the body. These tumors are usually seen in the atrium of the heart and the jawbone. Involvement of the skull base with intracranial extension is extremely rare, and only a few cases of primary intracranial myxomas have been described in the literature. Arare case of primary myxoma of the temporal bone is presented in this article. The patient underwent a skull base surgery with a pre-diagnosis of possible chondrosarcoma. The tumor pathology revealed a diagnosis of myxoma with bone and meningeal involvement. Despite the radical surgery, the tumor showed a local recurrence in three years. A second surgery with subtotal petrosectomy was required. In the article, the etio......
POSTED 12/31/2009 at 06:00 PM --
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Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression
Emerging evidence suggests that microRNA (miRNA) expression signatures in cancer may have important diagnostic, prognostic, and therapeutic value, but there is no data on miRNA expression in chordoma. The purpose of this study was to identify the role of miRNAs in human chordoma. We analyzed miRNA expression in chordoma-derived cell lines and chordoma tissue by using miRNA microarray technology with unsupervised hierarchical clustering analysis. The relative expression levels of these miRNAs were confirmed by real-time quantitative RT-PCR and Northern blot analysis. To characterize the potential role of miRNA-1, miRNA-1 was stably transfected into a chordoma cell line, UCH1. The expression of miRNA-1 targeted gene Met in chordoma tissues was also studied. We observe that human chordoma tis......
POSTED 12/28/2009 at 06:00 PM --
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Primary Chordoma of the Lung [CASE REPORTS]
We report the case of a 79-year-old woman referred to our institution for persistent cough and right-sided chest pain. A computed tomographic scan revealed a 2-cm round nodule in the right lower lobe. A wedge resection of the lesion was achieved by video-assisted thoracic surgery. Pathologic examination was consistent with the diagnosis of chordoma. Magnetic resonance imaging of the whole spine and skull basis was normal. Therefore, a diagnosis of primary lung chordoma, an exceptional condition, could be established. (Source: The Annals of Thoracic Surgery)...
POSTED 12/18/2009 at 05:25 PM --
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Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordoma
Abstract Cranial chordomas are rare tumors that have been difficult to study given their low prevalence. Individual case series with
decades of data collection provide some insight into the pathobiology of this tumor and its responses to treatment. This meta-analysis
is an attempt to aggregate the sum experiences and present a comprehensive review of their findings. We performed a comprehensive
review of studies published in English language literature and found a total of over 2,000 patients treated for cranial chordoma.
Patient information was then extracted from each paper and aggregated into a comprehensive database. The tumor recurrences
in these patients were then stratified according to age (<21 vs. >21 years), histological findings (chondroid vs. typical)......
POSTED 12/02/2009 at 02:36 AM --
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Clival chordomas: clinical management, results, and complications in 71 patients.
Conclusions Radical excision is the ideal surgical goal in the treatment of clival chordomas and can be achieved with reasonable risks. Several different surgical approaches may be necessary to accomplish this.
PMID: 19929198 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)...
POSTED 11/19/2009 at 06:00 PM --
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[Cervical chordomas.]
Authors: Rosell Ferrer R, Aguilà Artal A, Escamilla Carpintero Y
PMID: 19914595 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)...
POSTED 11/12/2009 at 06:00 PM --
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An interesting diagnosis for a presacral mass: Case report
We present an unusual cause of a presacral mass being extramedullary haematopoiesis, found incidentally in a 71 year old female. Extramedullary haematopoiesis is defined as the production of myeloid and erythroid elements outside of the bone-marrow. This diagnosis is extremely rare in the presacral area especially in a patient with no haematological abnormalities. A review of the literature is presented. (Source: International Seminars in Surgical Oncology)...
POSTED 11/07/2009 at 06:00 PM --
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