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Chordoma News Headlines
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All Recent Chordoma News Headlines |
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Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases.
Conclusion.-Exclusive brachyury expression in more than 90% of chordomas indicates its value as a unique, specific marker with other sensitive markers like cytokeratin, epithelial membrane antigen, and/or S100 protein in substantiating a diagnosis of chordoma, including on small biopsies.
PMID: 20670140 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)...
POSTED 07/31/2010 at 08:54 AM --
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Proton Radiotherapy: The Biological Effect of Treating Alternating Subsets of Fields for Different Treatment Fractions.
CONCLUSION: The effects of field set of the day treatment delivery depend on the tumor site and number of fields treated each day. Modeling these effects may be important for accurate risk assessment.
PMID: 20675067 [PubMed - as supplied by publisher] (Source: Clinical Prostate Cancer)...
POSTED 07/30/2010 at 06:00 PM --
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Prognostic factors for long-term outcome of patients with surgical resection of skull base chordomasâ106 cases review in one institution
Abstract Skull base chordoma are still challenging. Between May 1993 and June 2005, 106 consecutive patients with skull base chordoma
underwent surgical removal at Skull Base Division of Neurosurgery, Beijing Tiantan Hospital, China. Retrospective analysis
included medical charts and images. The age of the patients ranged from 7 to 65 years old, with an average age of 35.6 years.
Sixty patients were male; the other 46 were female (1.3:1). Follow up data were available in 79 cases ranging from 10 to 158
months (average 63.9 months) after operation. The prognostic factors for recurrence and survival were analyzed with KaplanâMeier, Cox regression and tâtest. Overall, 1, 3, 5 and 10 years survival rates were 87.2%, 79.4%, 67.6%and 59.5% respectively. One, 3, 5 and 10 year
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POSTED 07/28/2010 at 12:40 PM --
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Surgical Margins and Local Control in Resection of Sacral Chordomas.
CONCLUSIONS: Surgical margins affect the risk of local recurrence. Previous intralesional surgery was associated with a higher rate of local recurrence. Intraoperative contamination did not affect the risk of local recurrence when wide margins were subsequently attained. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
PMID: 20635173 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)...
POSTED 07/15/2010 at 06:00 PM --
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[Protontherapy: basis, indications and new technologies.]
Authors: Mazal A, Habrand JL, Delacroix S, Datchary J, Dendale R, Desjardins L, Ferrand R, Malka V, Fourquet A
With over 70,000 patients treated worldwide, protontherapy has an evolution on their clinical applications and technological developments. The ballistic advantage of the Bragg peak gives the possibility of getting a high conformation of the dose distribution to the target volume. Protontherapy has accumulated a considerable experience in the management of selected rare malignancies such as uveal melanomas and base of the skull chordomas and chondrosarcomas. The growing interest for exploring new and more common conditions, such as prostate, lung, liver, ENT, breast carcinomas, as well as the implementation of large pediatric programs advocated by many experts has been challeng......
POSTED 07/05/2010 at 06:00 PM --
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Congenital chordoma of the skin in a lamb (first report)
Abstract Chordoma is a rare tumor in human beings and animals that originates from mesoderm-derived notochord. Although many cases
of chordoma have been reported in human, dog, cat, rat, mink, and ferret, no report has been previously described in ruminants.
This case report describes the clinical and histopathological findings of a congenital chordoma located in the occipital skin
area of a 6-day-old, male, Iranian fat-tailed lamb. Histopathologic examination showed non-encapsulated tumor within the deep
dermis. The neoplastic tissue consisted of physaliphorous cells with a fine fibrovascular stroma. The physaliphorous cells
were immunoreactive with antibodies against vimentin, pancytokeratin, and S100 protein. Therefore, chordoma was diagnosed.
To the best of the authors......
POSTED 06/17/2010 at 06:26 AM --
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Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in sacral chordoma
This study was designed to investigate the expression levels and contributions of vascular endothelial growth factor
(VEGF) and matrix metalloproteinase-9 (MMP-9) in the angiogenesis and recurrence of sacral chordoma and their correlations.
An immunohistochemical method was used to investigate the expression of VEGF, MMP-9, and microvascular density (MVD) in 36
patients with sacral chordoma. Their differences in expressions were statistically analyzed and their correlations with angiogenesis
and recurrence were evaluated. The mean MVD of sacral chordomas was significantly higher than that of the adjacent normal
tissues (P = 0.033). Immunoreactivity for VEGF and MMP-9 was significantly higher in sacral chordoma tissues than in adjacent normal
tissues (P = 0.008, P&......
POSTED 06/16/2010 at 02:17 AM --
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Chordoma of the sacrum: âEn blocâ high partial sacrectomy
Content Type Journal ArticleCategory Open Operating Theatre (OOT)DOI 10.1007/s00586-010-1459-xAuthors
Peter Paul VargaAron Lazary
Journal European Spine JournalOnline ISSN 1432-0932Print ISSN 0940-6719 (Source: European Spine Journal)...
POSTED 06/01/2010 at 01:47 AM --
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Humerus metastasis from a sacrococcygeal chordoma: a case report
Conclusion:
Chordoma is a rare tumor and rarely metastasizes, but it should be considered in differential diagnosis of epithelioid bone tumors. The only currently effective treatment for this tumor is carbon ion therapy. There is currently no effective medical therapy available for advanced chordoma and the tumor is poorly sensitive to radiotherapy. (Source: BioMed Central)...
POSTED 05/27/2010 at 06:00 PM --
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Chordoma coexisting with Rathke's cleft cyst: Case report and literature review
Both chordoma and Rathke's cleft cyst are relatively rare diseases in the central nervous system. In this paper we report the first case of a chordoma coexisting with a Rathke's cleft cyst. A 49-year-old man presented with a 19-month history of distending pain, movement dysfunction and diplopia of the left eye. The preoperative diagnosis was consistent with chordoma with cystic change. Final pathological diagnosis of chordoma coexisting with Rathke's cleft cyst was made according to histological and immunohistochemical studies and the clinical and radiological features are discussed. Considering the close relationship between the notochordal tissue and Rathke's pouch during early embryogenic development, a possible mechanism is also discussed with the literature review. (Source: Neuropatho......
POSTED 05/18/2010 at 06:00 PM --
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Middle Turbinate Preservation in Endoscopic Transsphenoidal Surgery of the Anterior Skull Base
Skull BaseDOI: 10.1055/s-0030-1253582ABSTRACT Endoscopic endonasal skull base surgery is a growing field in which the nasal corridors are used to address skull base lesions. Whether the middle turbinates must be removed for adequate exposure is controversial and not well addressed in the literature. This is a prospective, observational study of 163 consecutive cases of purely endoscopic endonasal transsphenoidal surgeries performed at a single tertiary care institution. The primary study outcome measurement is the feasibility of middle turbinate preservation in endoscopic transsphenoidal skull base surgery. The pathologies included 99 pituitary tumors, 15 craniopharyngiomas, 11 meningiomas, 11 Rathke's cleft cysts, 7 encephaloceles, 5 cerebrospinal fluid leak repairs, 9 clival chordomas, a......
POSTED 05/11/2010 at 08:31 AM --
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Chordoid meningioma: a clinicopathologic study of 11 cases at a single institution
Abstract Chordoid meningioma is an uncommon variant of meningioma, which histologically bears a great resemblance to chordoma and often
follows an aggressive clinical course. We examine clinicopathologic features of 11 cases of this rare tumor to further elucidate
its behavior. Thirteen specimens of chordoid meningioma belonging to 11 patients were obtained at a single institution from
1995 to 2009. Correlations of histologic parameters, immunohistochemical study, and clinical features were assessed. This
series included six men and five women with a mean age of 60.8 years at first surgery. Aside from one patient (case 5) who
died of disease immediately after the first operation, the mean postoperative follow-up period for the other 10 patients was
41.4 months. T......
POSTED 05/09/2010 at 04:49 AM --
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Derivation and Characterization of an Extra-Axial Chordoma Cell Line (EACH-1) from a Scapular Tumor
Conclusions:
The diagnosis of the extra-axial chordoma is difficult but can be resolved by the detection of a strong brachyury expression. In addition, the derivation of a human extra-axial chordoma cell line could be a useful tool for the basic research of this rare neoplasm.
Clinical Relevance:
We describe the importance of brachyury staining in the diagnosis of this tumor. The extra-axial chordoma cell line (EACH-1) may also provide a new research tool to establish new ways of diagnosing and treating this rare malignancy. (Source: JBJS [Am])...
POSTED 05/03/2010 at 01:57 PM --
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Surgical excision of extensive sacrococcygeal chordomas assisted by occlusion of the abdominal aorta.
CONCLUSIONS: Occlusion of the abdominal aorta and electrophysiological monitoring are useful methods for assisting in resection of sacrococcygeal chordoma. They can reduce intraoperative hemorrhage and entail little chance of tumor cell contamination. They can also help surgeons to protect the organs in the pelvic cavity and neurological function. Use of these methods could give patients better quality of life.
PMID: 20433296 [PubMed - in process] (Source: Journal of Neurosurgery.Spine)...
POSTED 04/30/2010 at 06:00 PM --
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Derivation and characterization of an extra-axial chordoma cell line (EACH-1) from a scapular tumor.
CONCLUSIONS: The diagnosis of the extra-axial chordoma is difficult but can be resolved by the detection of a strong brachyury expression. In addition, the derivation of a human extra-axial chordoma cell line could be a useful tool for the basic research of this rare neoplasm.
PMID: 20439670 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)...
POSTED 04/30/2010 at 06:00 PM --
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Primary intradural chordoma: report on three cases and review of the literature.
Conclusion: Considering our cases in context with so far published literature, we conclude that intradural chordomas are rare and in this location usually have a better prognosis compared to classical intraosseous chordomas.
PMID: 20423692 [PubMed - in process] (Source: Clinical Neuropathology)...
POSTED 04/30/2010 at 11:52 AM --
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Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery
This study was performed to evaluate the effect of stereotactic radiosurgery (SRS) for skull base chordomas
and chondrosarcomas and to determine the optimal marginal dose for these tumors. Fourteen patients with histologically proven
chordomas or chondrosarcomas underwent 16 sessions of SRS using gamma knife. The marginal doses ranged from 10 to 20 Gy (mean,
15 Gy). Lower marginal doses of 12 Gy on average (range, 10â12.5 Gy) were applied to four patients since they underwent prior
fractionated radiotherapy, and partial treatment for which parts of tumors were excluded from planned target volume because
of their proximity to critical structures was also applied to four patients. The whole tumors were covered with higher marginal
doses of 18 Gy on average (r......
POSTED 04/24/2010 at 03:06 AM --
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[Is CT-guided biopsy of aggressive sacral tumors always able to reach a diagnosis?]
CONCLUSION: Our results suggest that CT-guided biopsy is less useful in the characterization of primary tumors than in metastases. The diagnosis of primary bone lymphomas is especially complicated. Repeating the procedure after inconclusive results probably will not provide additional information, and it is recommendable to perform surgical biopsy in these cases.
PMID: 20416912 [PubMed - as supplied by publisher] (Source: Radiologia)...
POSTED 04/20/2010 at 06:00 PM --
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Image-guided, endoscopic, transcervical resection of cervical chordoma.
Authors: Hsu W, Kosztowski TA, Zaidi HA, Gokaslan ZL, Wolinsky JP
Chordomas are rare tumors that arise from the sacrum, spine, and skull base. Surgical management of these tumors can be difficult, given their locally destructive behavior and predilection for growing near delicate and critical structures. En bloc resection with negative margins can be difficult to perform without damaging adjacent structures and causing significant clinical morbidity. For chordomas of the upper cervical spine, surgical options traditionally involve transoral or submandibular approaches. The authors report the use of the image-guided, endoscopic, transcervical approach to the upper cervical spine as an alternative to traditional techniques for addressing upper cervical spine tumors, particularly for tumo......
POSTED 03/31/2010 at 06:00 PM --
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Bone versus soft-tissue sarcomas in the elderly.
CONCLUSION: Survival rates tend to be lower in older patients with sarcomas, especially when the sarcoma is of bone and high grade.
PMID: 20427836 [PubMed - in process] (Source: Journal of Orthopaedic Surgery)...
POSTED 03/31/2010 at 06:00 PM --
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