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Chondrosarcoma News Headlines
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All Recent Chondrosarcoma News Headlines |
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Use of chemotherapy for patients with bone and soft-tissue sarcomas
For patients with bone sarcomas, chemotherapy has a proven role in the primary therapy of osteogenic sarcoma and Ewing sarcoma but no role for chondrosarcoma. Chemotherapy’s role is currently more limited for patients with soft-tissue sarcomas, as it is generally used to palliate metastatic disease in most subtypes of soft-tissue sarcoma and remains largely investigational in the treatment of operable disease. The chemotherapy regimens for musculoskeletal sarcomas often carry significant potential toxicities, so the efficacy of less intensive and less toxic regimens is a focus of ongoing research. (Source: Cleveland Clinic Journal of Medicine)...
POSTED 02/23/2010 at 11:01 AM --
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Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cell
Conclusions:
Our results indicated that PGE2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway. (Source: Molecular Cancer)...
POSTED 02/22/2010 at 06:00 PM --
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Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway
Thrombin is a multifunctional protease that can activate hemostasis and coagulation through the cleavage of fibrinogen to form fibrin clots. Thrombin also plays a crucial role in migration and metastasis of human cancer cells. However, the effect of thrombin on migration activity in human chondrosarcoma cells is mostly unknown. Here, we found that thrombin increased the migration and expression of matrix metalloproteinase (MMP)-2 and MMP-13 in human chondrosarcoma cells (JJ012 and SW1353 cells). By using pharmacological inhibitors or activators or genetic inhibition by the protease-activated receptor (PAR), we found that the PAR1 and PAR4 receptor but not PAR3 receptor are involved in thrombin-mediated cell migration and MMPs expression. Thrombin-mediated migration and MMPs up-regulation w......
POSTED 02/18/2010 at 06:00 PM --
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Lung variety of primary pulmonary chondrosarcoma- A case report
Abstract Primary pulmonary chondrosarcoma is a rarely encountered primary tumor of the lung. Only a few historical cases are available
in the literature which fulfils the criteria for the primary pulmonary chondrosarcoma. These tumors may involve major bronchi
(tracheobronchial variety) or localized to lung parenchyma (lung variety). Both these tumors can be managed with surgical
treatment with good prognosis. A case of primary pulmonary chondrosarcoma arising from the middle lobe of the right lung has
been described here along with a brief review of the literature.
Content Type Journal ArticleDOI 10.1007/s12055-009-0039-3Authors
Binay Krishna Sarkar, Medical College and Hospitals Department of Cardio Thoracic and Vascular Surgery Kolkata IndiaSayed Mohammed Nadeem, NG ......
POSTED 02/15/2010 at 11:46 AM --
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Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
Currently there is no effective chemotherapy for chordoma. Recent studies report co-expression of insulin-like growth factor-1 receptor (IGF1R) and its cognate ligand in chordoma, but it is unknown whether this receptor tyrosine kinase is activated in these tumours. Additionally, genetic studies have confirmed frequent deletions of chromosome 9p in chordomas, which encompasses the cyclin-dependent kinase inhibitor 2A (CDKN2A) locus. Another gene in this region, methylthioadenosine phosphorylase (MTAP), is an essential enzyme of the purine salvage pathway and has therapeutic relevance because MTAP-deficient cells are particularly sensitive to inhibitors of de novo purine synthesis. We investigated whether these pathways might be potential therapeutic targets for chordoma. Paraffin-embedded ......
POSTED 02/05/2010 at 06:00 PM --
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Synovial chondromatosis of spine: case report and review of the literature.
Authors: Moody P, Bui MM, Vrionis F, Setzer M, Rojiani AM
Primary synovial chondromatosis is an uncommon, benign entity involving the synovial lining of larger joints. In this metaplastic process, islands of chondrocytes are clustered throughout the synovium, forming nodules that jut into the joint cavity. Clinical manifestations include pain, swelling, and decreased range of motion of associated extremities. Synovial chondromatosis may be confused with other degenerative joint diseases as well as chondrosarcoma. The occurrence of synovial chondromatosis in the spine is rare. Ten cases of this spinal variant have previously been published and this report represents the eleventh case. Here we briefly review the literature and discuss the histopathologic pitfalls and differential diagnos......
POSTED 02/04/2010 at 09:58 AM --
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(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells
Conclusions Our findings demonstrate that EGCG is effective for growth inhibition of a chondrosarcoma cell lines in vitro, and suggest
that EGCG may be a new therapeutic option for patients with chondrosarcoma.
Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0765-3Authors
Guo-Qing Tang, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaTai-Qiang Yan, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaWei Guo, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaTing-Ting Ren, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizh......
POSTED 02/01/2010 at 12:02 PM --
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Pulmonary carcinosarcoma initially presenting as invasive aspergillosis:
a case report of previously unreported combination
We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient. (Source: Diagnostic Pathology)...
POSTED 01/28/2010 at 06:00 PM --
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A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes
Conclusions:
Our results demonstrate that glucosamine and its peptidyl-derivative can interfere with NF-kappaB signaling pathway by inhibiting IKKalpha activity in human chondrocytes. However, the mechanism of action of the two molecules is not completely overlapping. While NAPA can both specifically inhibit the IKKalpha kinase activity and IKKalpha nuclear re-localization, GlcN only acts on IKKalpha nuclear re-localization. (Source: Arthritis Research and Therapy)...
POSTED 01/28/2010 at 06:00 PM --
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Spinal osteochondroma: a report on six patients and a review of the literature
Conclusions Patients suffering from spinal osteochondroma, due to the risk of secondary chondrosarcoma, must be closely evaluated both
clinically and radiologically. If necessary, the patient must be treated surgically following histopathological diagnosis.
Content Type Journal ArticleCategory Orthopaedic SurgeryDOI 10.1007/s00402-010-1058-7Authors
Cuneyd Gunay, Ankara Numune Research and Training Hospital 5th Clinic, Department of Orthopaedic Surgery and Traumatology 06100 Sihhiye/Ankara TurkeyHakan Atalar, Fatih University Department of Orthopaedic Surgery and Traumatology Alparslan Turkes Caddesi No: 57 06510 Emek/Ankara TurkeyYusuf Yildiz, Ankara University Department of Orthopaedic Surgery and Traumatology 06100 Sihhiye/Ankara TurkeyYener Saglik, Ankara University......
POSTED 01/27/2010 at 02:26 PM --
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CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
Conclusions:
Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and MMP1 and is mediated by HIF-1a and ERK. Both invasion and MMP1 can be inhibited with CXCR4 blockade, suggesting that CXCR4/SDF1 signaling may be a therapeutic target for chondrosarcoma. (Source: Molecular Cancer)...
POSTED 01/25/2010 at 06:00 PM --
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[Surgical treatment of head and neck chondrosarcomas.]
CONCLUSION: Low grade head and neck chondrosarcomas have a good prognosis while high grade chondrosarcomas tend to recur, despite radical surgical treatment.
PMID: 20096816 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)...
POSTED 01/20/2010 at 06:00 PM --
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BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress.
This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (2,4-bis(2-fluorophenylacetyl)phloroglucinol; BFPP) in human chondrosarcoma cells. BFPP induced cell apoptosis in two human chondrosarcoma cell lines, JJ012 and SW1353 but not in primary chondrocytes. BFPP triggered endoplasmic reticulum (ER) stress, as indicated by changes in cytosol calcium levels, and increased glucose regulated protein 78 (GRP78) expression, but failed to show the same effects on GRP94 expression. BFPP also increased calpain expression and activity. Transfection of cells with GRP78 or calpain siRNA reduced BFPP-mediated cell apoptosis in JJ012 cells. Importantly, animal studies have revealed a dramatic 50% reduction in tumor volume after 21 days of treatment. This study d......
POSTED 01/08/2010 at 06:00 PM --
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Cranial Chondrosarcoma and Recurrence
Skull BaseDOI: 10.1055/s-0029-1246218ABSTRACTThe literature regarding recurrences in patients with cranial chondrosarcoma is limited to small series performed at single institutions, raising the question if these data precisely reflect the true recurrence of this tumor for guiding the clinician in the management of these patients. An extensive systematic review of the English literature was performed. The patients were stratified according to treatment modality, treatment history, histological subtype, and histological grade, and the recurrence rates were analyzed. A total of 560 patients treated for cranial chondrosarcoma were included. Five-year recurrence rate among all patients was 22% with median follow-up of 60 months and median disease-free interval of 16 months. Tumor recurrence wa......
POSTED 01/07/2010 at 08:11 AM --
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No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas.
CONCLUSIONS: The data confirm the appropriateness of conservative surgery for central low-grade chondrosarcomas of the proximal humerus and distal femur based on a combination of intralesional curettage and cryogenic parietal sterilization. Candidates for this approach should be chosen on the basis of the affected bone site, local extension staging, and clinicopathologic grading. We recommend supplementary internal fixation. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
PMID: 20054673 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)...
POSTED 01/06/2010 at 06:00 PM --
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Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse.The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed.The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II......
POSTED 01/03/2010 at 06:00 PM --
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Chondrosarcoma of the arytenoid cartilage.
We report a new case of chondrosarcoma of the arytenoid cartilage in a 47-year-old man, and we discuss the clinical features, diagnosis, and management of this uncommon tumor.
PMID: 20155689 [PubMed - in process] (Source: Ear, Nose and Throat Journal)...
POSTED 12/31/2009 at 06:00 PM --
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Prosthetic replacement of the proximal humerus after the resection of bone tumors.
Conclusions: Prosthetic replacement for the patients with bone tumors in the proximal humerus is an appropriate procedure with satisfactory therapeutic outcomes. However, many complications should be noted and long-term curative effects are presently uncertain.
PMID: 20038324 [PubMed - in process] (Source: Ai Zheng)...
POSTED 12/31/2009 at 05:48 AM --
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Accelerated Ca2+ entry by membrane hyperpolarization due to Ca2+-activated K+ channel activation in response to histamine in chondrocytes.
In this study, the functional impact of Ca(2+) activated K(+) (K(Ca)) channels in the regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) in chondrocytes in response to histamine was examined using OUMS-27 cells, as a model of chondrocytes derived from human chondrosarcoma. Application of histamine induced a significant [Ca(2+)](i) rise and also membrane hyperpolarization, and both effects were mediated by the stimulation of H1 receptors. The histamine-induced membrane hyperpolarization was attenuated to approximately 50% by large conductance K(Ca) (BK) channel blockers, and further reduced by intermediate (IK) and small conductance K(Ca) (SK) channel blockers. The tonic component of histamine-induced [Ca(2+)](i) rise strongly depended on the presence of extracellular Ca(2+) ([C......
POSTED 12/29/2009 at 06:00 PM --
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Laryngeal Chondrosarcoma: An Exceptional Localisation of a Not Unfrequent Bone Tumor
After osteosarcoma, chondrosarcoma is the second most common primary bone tumor accounting for 26% of all malignancies. In the laryngeal region however, chondrosarcomas are rather rare. Only 300 cases are reported in literature. Considering laryngeal chondrosarcoma, about 75% occur in the cricoid cartilage, whereas 20% occur in the thyroid cartilage. In this paper we report a case of thyroidal chondrosarcoma, and based on a thorough literature search we suggest some practical guidelines concerning diagnosis and therapy. (Source: Sarcoma)...
POSTED 12/29/2009 at 07:48 AM --
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