Low-grade chondrosarcoma of bone: experiences from the Vienna Bone and Soft Tissue Tumour Registry
Abstract In a retrospective single-centre study, 70 low-grade chondrosarcoma (LCS) (31 female/39 male patients with a mean age of 40 years)
were reviewed to evaluate surgical management. The mean overall follow-up was 81 months (median: 73 months, range: 6â317 months).
Seventeen lesions (24.3%) in the trunk and 53 (75.7%) in the extremities were treated by curettage (48.6%) or resection (51.5%).
Local recurrence occurred in eight patients (11.4%) 18 months postoperatively (median: 18 months, range: 0â41 months). Recurrence-free
survival was significantly better for patients with extremity lesions compared to truncal lesions, but was not affected by
resection margin. The anatomical site âtrunkâ and an âintralesionalâ resection m......
POSTED 08/27/2010 at 12:12 PM --
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Custom-made endoprostheses for the femoral amputation stump: AN ALTERNATIVE TO HIP DISARTICULATION IN TUMOUR SURGERY.
Authors: Kalson NS, Gikas PD, Aston W, Miles J, Blunn G, Pollock R, Skinner J, Briggs TW, Cannon SR
Disarticulation of the hip in patients with high-grade tumours in the upper thigh results in significant morbidity. In patients with no disease of the proximal soft tissue a femoral stump may be preserved, leaving a fulcrum for movement and weight-bearing. We reviewed nine patients in whom the oncological decision would normally be to disarticulate, but who were treated by implantation of an endoprosthesis in order to create a functioning femoral stump. The surgery was undertaken for chondrosarcoma in four patients, pleomorphic sarcoma in three, osteosarcoma in one and fibrous dysplasia in one. At follow-up at a mean of 80 months (34 to 132), seven patients were alive and free from disea......
POSTED 07/31/2010 at 06:00 PM --
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Myxoid chondrosarcoma of the scrotum: a case report and review of the literature.
We present a clinical case report of an extraskeletal myxoid chondrosarcoma originating in the scrotum.
PMID: 20694088 [PubMed - in process] (Source: Canadian Urological Association Journal)...
POSTED 07/31/2010 at 06:00 PM --
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Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis.
CONCLUSIONS: Immunohistochemical markers may have an independent value in predicting the prognosis for patients with chondrosarcoma.
PMID: 20660237 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)...
POSTED 07/29/2010 at 06:27 PM --
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IMAGING DIAGNOSIS—SPINAL CORD CHONDROSARCOMA ASSOCIATED WITH SPIROCERCOSIS IN A DOG
A 7-year-old neutered female Boerboel cross was examined for progressive left pelvic limb lameness. There was no left patellar reflex but the remaining pelvic limb reflexes were hyperreflexic. Radiographically, there was a poorly mineralized opacity occupying the intervertebral foramen at L4[ndash]L5. On computed tomography images there was a hyperattenuating intramedullary lesion at L4[ndash]L5 that continued caudally, lateralized to the left and became extramedullary, terminating at L5[ndash]L6. In addition, well marginated, hyperattenuating lesions were noted at two muscular sites. The dog underwent euthanasia and a caudal esophageal mass was found at post mortem examination. The tumors in the spinal cord, the esophagus, and the skeletal muscles were diagnosed histologically as low-grad......
POSTED 07/22/2010 at 06:00 PM --
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Nitric Oxide Synthases, Cyclooxygenase-2, Nitrotyrosine, and Angiogenesis in Chondrosarcoma and Their Relation to Prognosis
Conclusions:
Immunohistochemical markers may have an independent value in predicting the prognosis for patients with chondrosarcoma. (Source: JBJS [Am])...
POSTED 07/21/2010 at 12:31 PM --
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Primary Breast Chondrosarcoma
(Source: The Breast Journal)...
POSTED 07/18/2010 at 06:00 PM --
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Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas
In conclusion, our results indicate that high ezrin expression correlates with aggressive features of chondrosarcomas. Further analyses on the pathways downstream of ezrin are warranted. (Source: APMIS)...
POSTED 07/18/2010 at 06:00 PM --
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[Protontherapy: basis, indications and new technologies.]
Authors: Mazal A, Habrand JL, Delacroix S, Datchary J, Dendale R, Desjardins L, Ferrand R, Malka V, Fourquet A
With over 70,000 patients treated worldwide, protontherapy has an evolution on their clinical applications and technological developments. The ballistic advantage of the Bragg peak gives the possibility of getting a high conformation of the dose distribution to the target volume. Protontherapy has accumulated a considerable experience in the management of selected rare malignancies such as uveal melanomas and base of the skull chordomas and chondrosarcomas. The growing interest for exploring new and more common conditions, such as prostate, lung, liver, ENT, breast carcinomas, as well as the implementation of large pediatric programs advocated by many experts has been challeng......
POSTED 07/05/2010 at 06:00 PM --
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Bisphenol-A interferes with Estradiol-Mediated Protection in Osteoarthritic Chondrocytes.
In conclusion, BPA interferes with E2's functions in chondrocytes and may promote OA.
PMID: 20600708 [PubMed - as supplied by publisher] (Source: Toxicology Letters)...
POSTED 07/01/2010 at 06:00 PM --
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Correction: C-Propeptides of Procollagens I{alpha}1 and II that Differentially Accumulate in Enchondromas versus Chondrosarcomas Regulate Tumor Cell Survival and Migration
(Source: Cancer Research)...
POSTED 06/30/2010 at 11:08 PM --
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Imaging diagnosisâspinal cord chondrosarcoma associated with spirocercosis in a dog
(Source: Veterinary Radiology and Ultrasound)...
POSTED 06/30/2010 at 06:00 PM --
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Pediatric cancer spectrum in Kenya: a histopathologic review
Conclusion Comparison with several previous African and western pediatric cancer databases is undertaken, revealing significant trends
useful for the care of children with cancer in the region.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2639-9Authors
Franklin C. Margaron, BethanyKids at Kijabe Hospital Box 20 Kijabe 00220 KenyaDan Poenaru, BethanyKids at Kijabe Hospital Box 20 Kijabe 00220 KenyaAlan Northcutt, BethanyKids at Kijabe Hospital Box 20 Kijabe 00220 Kenya
Journal Pediatric Surgery InternationalOnline ISSN 1437-9813Print ISSN 0179-0358 (Source: Pediatric Surgery International)...
POSTED 06/30/2010 at 11:45 AM --
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Omental Flap and Titanium Plates Provide Structural Stability and Protection of the Mediastinum After Extensive Sternocostal Resection [HOW TO DO IT]
We describe a patient with extensive anterolateral defect after sternocostal resection of chondrosarcoma. Successful reconstruction was performed by using three metallic transverse plates and an omental flap wrapped onto the plates. This method simplifies reconstruction in comparison with previously described techniques concerning complete solid coverage and leaves several options intact in the event of future recurrences. (Source: The Annals of Thoracic Surgery)...
POSTED 06/29/2010 at 01:11 PM --
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Malignant primary chest-wall tumours: techniques of reconstruction and survival [Original articles]
Conclusions: Wide resection with tumour-free margins is necessary in PMCWT to minimise local recurrence and to contribute to long-term survival. The STRATOS system, developed for chest-wall replacement, allows a firm reconstruction, simple to handle and to fix, avoiding instability or paradoxical movement also in wide chest-wall resections. (Source: European Journal of Cardio-Thoracic Surgery)...
POSTED 06/28/2010 at 12:38 PM --
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New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasis
Conclusions:
The established JJ012 models replicate the site, morphology, and many behavioural characteristics of human chondrosarcoma. Local tumour invasion of bone and spontaneous lung metastasis offer valuable assessment tools to test the potential of novel agents for future chondrosarcoma therapy. (Source: Cancer Cell International)...
POSTED 06/27/2010 at 06:00 PM --
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Curettage and Cryosurgery for Low-grade Cartilage Tumors Is Associated with Low Recurrence and High Function.
CONCLUSIONS: Our observations show curettage with cryosurgery is associated with low recurrence of Grade 1 chondrosarcoma and high functional scores. Curettage with cryosurgery is a reasonable alternative to wide or radical excision as the treatment for Grade 1 chondrosarcomas, and allows for more radical surgery in the event of local recurrence. LEVEL OF EVIDENCE: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
PMID: 20574801 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)...
POSTED 06/23/2010 at 06:00 PM --
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Periosteal Chondrosarcoma of the Foot: A Case Report
Abstract: A 19-year-old girl presented with painless swelling of the first left toe of 6 years' duration. Magnetic resonance imaging (MRI) of the lesion demonstrated a soft tissue mass adjacent to the surface of the bone with slight erosion of the underlying cortex. Surgical excision was performed and the histopathological diagnosis was low-grade periosteal chondrosarcoma, which is quite uncommon in this location. (Source: Journal of Foot and Ankle Surgery)...
POSTED 06/23/2010 at 06:00 PM --
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A Challenging Case of Primary Orbital Mesenchymal Chondrosarcoma.
We present a case of a 23-year-old man with primary orbital mesenchymal chondrosarcoma (OMC) with an uncommon management. This anecdotic report could be a contribution to the understanding of this unusual tumor.
PMID: 20572753 [PubMed - as supplied by publisher] (Source: Orbit)...
POSTED 06/22/2010 at 06:00 PM --
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Pedicle frozen autograft reconstruction in malignant bone tumors
Conclusions The pedicle frozen autograft, which was newly developed to solve drawbacks of previously reported free frozen autografts,
achieved success for reconstruction of malignant bone tumors. This is a new, simple, effective surgical technique for biological
reconstruction that is still investigated but has potential for development.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-010-1458-0Authors
Hiroyuki Tsuchiya, Kanazawa University Department of Orthopaedic Surgery, Graduate School of Medical Science 13-1 Takara-machi Kanazawa 920-8641 JapanHideji Nishida, Kanazawa University Department of Orthopaedic Surgery, Graduate School of Medical Science 13-1 Takara-machi Kanazawa 920-8641 JapanPhutsapong Srisawat, Phramongkutklao Hospital and......
POSTED 06/18/2010 at 05:55 AM --
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