Dubai launches new health scheme for government employees
The Dubai Health Authority has launched its health insurance scheme, Enaya, for government employees and their dependents. The new scheme provides all government employees with the opportunity to have a comprehensive medical check up, which includes screening for blood pressure, diabetes, cholesterol, depression, stress, and various forms of cancer such as skin, breast and cervical cancer. Enaya also provides cover for pre-existing medical conditions. (Source: Healthcare)...
POSTED 07/01/2009 at 02:50 AM --
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Predictors of long-term survival after resection of esophageal carcinoma with nonregional nodal metastases.
CONCLUSIONS: Surgical resection for patients with esophageal cancer associated with nonregional nodal metastases results in 25% survival at five years. Squamous histology, earlier T status, and perioperative chemotherapy are independent positive predictors of long-term survival.
PMID: 19559222 [PubMed - in process] (Source: The Annals of Thoracic Surgery)...
POSTED 06/30/2009 at 06:00 PM --
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Analysis of cervical esophagogastric anastomotic leaks after transhiatal esophagectomy: risk factors, presentation, and detection.
CONCLUSIONS: Higher number of preoperative comorbidities, advanced pathologic stage, postoperative arrhythmia, an increased number of prior esophagogastric surgeries, and active smoking history are risk factors for developing CEGAL, and a side-to-side stapled cervical esophagogastric anastomosis is protective. Screening barium swallow identifies few postoperative complications, but provides quality control.
PMID: 19559221 [PubMed - in process] (Source: The Annals of Thoracic Surgery)...
POSTED 06/30/2009 at 06:00 PM --
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Comparison of conventional and CT-based planning for intracavitary brachytherapy for cervical cancer: target volume coverage and organs at risk doses
Conclusions:
The CT-plan is superior to the conventional plan in target volume coverage and appropriate evaluation of OARs, as the conventional plan overestimates tumor doses and underestimates OAR doses. (Source: Journal of Experimental and Clinical Cancer Research)...
POSTED 06/30/2009 at 06:00 PM --
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Comparing Accuracy in an Unpaired Post-market Device Study with Incomplete Disease Assessment
The sensitivity and specificity of a new medical device are often compared relative to that of an existing device by calculating ratios of sensitivities and specificities. Although it would be ideal for all study subjects to receive the gold standard so true disease status was known for all subjects, it is often not feasible or ethical to obtain disease status for everyone. This paper proposes two unpaired designs where each subject is only administered one of the devices and device results dictate which subjects are to receive disease verification. Estimators of the ratio of accuracy and corresponding confidence intervals are proposed for these designs as well as sample size formulae. Simulation studies are performed to investigate the small sample bias of the estimators and the performan......
POSTED 06/30/2009 at 06:00 PM --
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Laparoscopy in the Treatment of Early Cervical Carcinoma
Recent investigators have used several indications to incorporate laparoscopy in the management of patients with cervical cancer. This manuscript reviews the current literature on the role of modern
operative laparoscopy in early cervical cancer and recommends a simple approach for its use in these
patients. (Source: Diagnostic and Therapeutic Endoscopy)...
POSTED 06/30/2009 at 11:06 AM --
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[Reflection and Reaction] Is the UK ready to embrace HPV testing?
Assessing health technology in cancer screening requires stringent evidence-based criteria with which efficacy can be judged, coupled with sensible health-economic analyses of any new intervention strategy. For efficacy, the highest level of evidence comes from showing—in a randomised controlled trial—that implementation of a new screening technology reduces cancer-specific mortality compared with the existing standard of practice. Although this point has been reached recently for human papillomavirus (HPV) DNA testing in cervical cancer in a landmark study conducted in India, it is unlikely that this high-level evidence will be used on its own to inform policy decisions on cancer control in developed countries. Assessing HPV testing in developed countries is complicated by the fact th......
POSTED 06/29/2009 at 06:00 PM --
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[Reflection and Reaction] Total mesometrial resection for cancer of the cervix: the future surgical procedure, or oblivion?
In the current issue of The Lancet Oncology, Höckel and colleagues report on a prospective case series of 212 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB–IIB cervical cancers who underwent a total mesometrial resection (TMMR) without adjuvant radiation therapy. This surgical procedure is based on resection of the Müllerian compartment; anatomy defined by a common embryological origin. The authors achieved impressive results; at a median follow-up of 41 months, only three pelvic, two pelvic and distant, and five distant recurrences were recorded, for a recurrence-free survival of 94% (95% CI 91–98) and overall survival of 96% (93–99) with low treatment-related morbidity. The authors concluded that TMMR seems to improve locoregional control in ......
POSTED 06/29/2009 at 06:00 PM --
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DNA methylation and histone modification regulate silencing of OPG during tumor progression
The identification of molecules that are down-regulated in malignant phenotype is important for understanding tumor biology and their role in tumor suppression. We compared the expression profile of four normal nasal mucosal (NNM) epithelia and a series of nasopharyngeal cancinoma (NPC) cell lines using cDNA microarray and confirmed the actual expression of the selected genes, and found osteoprotegerin (OPG) to be ubiquitously deficient in NPC cells. We also found OPG to be down-regulated in various cancer cell lines, including oral, cervical, ovarian, lung, breast, pancreas, colon, renal, prostate cancer, and hepatoma. Administration of recombinant OPG (rOPG) brought about a reduction in cancer cell growth through apoptotic mechanism. We generated eleven monoclonal antibodies (MAbs) again......
POSTED 06/29/2009 at 06:00 PM --
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The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis
We previously demonstrated that Bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N']copper(II) [Cu(isaepy)2] was an efficient inducer of the apoptotic mitochondrial pathway. Here, we deeply dissect the mechanisms underlying the ability of Cu(isaepy)2 to cause mitochondriotoxicity. In particular, we demonstrate that Cu(isaepy)2 increases NADH-dependent oxygen consumption of isolated mitochondria and that this phenomenon is associated with oxy-radical production and insensitive to adenosine diphosphate. These data indicate that Cu(isaepy)2 behaves as an uncoupler and this property is also confirmed in cell systems. Particularly, SH-SY5Y cells show: (i) an early loss of mitochondrial transmembrane potential; (ii) a decrease in the expression levels of respiratory complex components and (i......
POSTED 06/29/2009 at 06:00 PM --
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Effectiveness of Cultivando La Salud: A Breast and Cervical Cancer Screening Promotion Program for Low-Income Hispanic Women
How effectively could a lay health worker-delivered educational intervention increase breast and cervical cancer screening among low-income Hispanic women who did not adhere to recommended guidelines? American Journal of Public Health (Source: Medscape Today Headlines)...
POSTED 06/29/2009 at 05:41 PM --
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AIDS-related cancers
Abstract: Immunodeficiency, regardless of the underlying cause, is associated with an increased risk of malignancy. In the case of HIV infection, the majority of these cancers are associated with oncogenic virus infection. Whilst the overall risk of all cancers is increased two to three times in people living with HIV infection, there are three AIDS-defining cancers whose relative risk is dramatically higher in this population. These are Kaposi sarcoma, high-grade B-cell non-Hodgkin lymphoma (including primary cerebral lymphoma) and invasive cervical cancer. Since the introduction of highly active antiretroviral therapy the incidence of the AIDS-defining malignancies has declined in populations with access to these medications, whilst the effects on the incidence of other cancers has been ......
POSTED 06/29/2009 at 11:17 AM --
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MIMS Women's Health In Primary Care Conference
Accurate Diagnosis, Effective Treatment And Strategic Management
MIMS Women's Health's Sell-Out Event Comes To Manchester
A One-Day Conference | 17 September 2009 |The Midland Hotel, ManchesterBook Before 16 July & Save Up To £90
Update your understanding of clinical conditions presenting in primary care including contraception, urinary incontinence, osteoporosis, HRT and the menopause, atrophic vaginitis, and cervical cancer.
Dr Sally Hope furthers your understanding of osteoporosis, discusses what FRAX means in practice and assesses the impact that the current NICE and National Osteoporosis Society guidelines have on your day-to-day work.
Dr Julian Spinks offers a comprehensive update on urinary incontinence, considers the treatments available to effect......
POSTED 06/29/2009 at 10:30 AM --
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Screening: Cervical cancer in rural India
Nature Reviews Clinical Oncology 6, 384 (2009). doi:10.1038/nrclinonc.2009.85
Author: Anthony B. Miller
A study of cervical cancer screening in 52 villages in India has shown that a single round of human papillomavirus testing was linked to a significant reduction in the number of deaths from cervical cancer, compared with other screening methods. This has implications for primary screening in low-resource settings. (Source: Nature Clinical Practice Oncology)...
POSTED 06/29/2009 at 10:02 AM --
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GPs reject cervical cancer blame
The Department of Health has been accused of spinning the findings of an independent review on cervical screening in order to blame GPs for failing to spot women with the disease. (Source: Pulse Today Clinical Updates)...
POSTED 06/29/2009 at 09:54 AM --
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First International Conference On Cancer Of Unknown Primary To Be Held London October 15
When a patient is diagnosed with metastatic disease the primary site of the cancer is usually, but not always, evident. When the origin of the cancer is not identified it is described as a Cancer of Unknown Primary site, or CUP. Each year in the UK over 10,000 people are diagnosed with CUP. This is a higher incidence than known cancers such as pancreatic, ovarian, uterine, kidney, brain, cervical or blood (leukaemia) cancers. (Source: Cancer / Oncology News From Medical News Today)...
POSTED 06/29/2009 at 04:00 AM --
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MSPs seek answers as cervical cancer vaccine fears grow
THE Scottish Government has been challenged to explain why it introduced the cervical cancer vaccination programme in a series of questions by MSPs. (Source: Scotsman.com News - Health)...
POSTED 06/28/2009 at 06:34 PM --
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The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma
Conclusion:
SNP of XRCC1 gene at codon 399 influences the response of cervical carcinoma to platinum-based NAC. This is probably due to changes in expression of XRCC1 protein, affecting response to chemotherapy. (Source: Journal of Experimental and Clinical Cancer Research)...
POSTED 06/28/2009 at 06:00 PM --
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Molecular characterization of EGFR, PDGFRA and VEGFR-2 in cervical adenosquamous carcinoma
Conclusion:
This is the most extensive analysis of EGFR, PDGFRA and VEGFR-2 in cervical adenosquamous carcinomas. Despite the absence of EGFR and PDGFRA activating mutations, the presence of overexpression of these three important therapeutic targets in a subset of cases may be important in predicting the sensitivity of adenosquamous carcinoma to specific anti-RTKs drugs. (Source: BMC Cancer)...
POSTED 06/28/2009 at 06:00 PM --
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Variation in the cervical cancer screening compliance among women with disability
Conclusions
In Taiwan, women with disability were found to be at higher risk of lower compliance than women without disability. The gap between women with and without disability persisted across different levels of physician availability. (Source: Journal of Medical Screening)...
POSTED 06/28/2009 at 06:00 PM --
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