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Carcinosarcoma News Headlines
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All Recent Carcinosarcoma News Headlines |
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The role of lymphadenectomy in uterine carcinosarcomas (malignant mixed mullerian tumours): a critical literature review
Conclusions Our review data fully justifies the rationale of lymphadenectomy, which beyond staging information seems to offer a measurable
survival benefit.
Content Type Journal ArticleDOI 10.1007/s00404-010-1649-0Authors
G. Vorgias, Department of Gynaecology, Metaxa Memorial Cancer Hospital, Botassi 51, 18537 Piraeus, GreeceS. Fotiou, Department of Obstetrics and Gynaecology, University of Athens School of Medicine, Aretaieion Hospital, Athens, Greece
Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)...
POSTED 08/18/2010 at 12:39 PM --
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Tamoxifen: Uterine carcinosarcoma in an elderly patient: case report
(Source: Reactions)...
POSTED 08/13/2010 at 12:47 AM --
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Adult variant of atypical teratoid/rhabdoid tumor: Immunohistochemical and ultrastructural confirmation of a rare tumor in the sella tursica.
We describe the diagnostic problems associated with an AT/RT arising in the sellar region in a 46-year-old female. Vimentin, keratin, synaptophysin, CD34, SMA, PLAP, GFAP, S-100, NSE, desmin, MYF-4, LCA, and CD99 were performed on tissue obtained from the paraffin block. INI1 protein expression was immunohistochemically determined on tumor tissue. Electron microscopy was performed from the tissue block. The tumor was composed of large atypical "rhabdoid" cells having macronucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry showed that the tumor cells were positive for vimentin, CD34, CD99, and reacted variably for keratin, synaptophysin, NSE, and SMA. All were negative for GFAP, S-100, desmin, MYF-4, and LCA. The tumor cells lacked nuclear expression of INI1. Electron micros......
POSTED 08/09/2010 at 06:00 PM --
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Adrenocortical carcinosarcoma: a case report and review of the literature
Adrenocortical carcinosarcoma is an extremely rare and aggressive variant of adrenocortical carcinoma characterized by the presence of both carcinomatous and sarcomatous components, with the latter often showing heterologous differentiation. Due to the rarity and unusual histology, it may pose a diagnostic challenge. In order to increase awareness and identify potential diagnostic pitfalls, we report the ninth case of non-functioning adrenocortical carcinosarcoma in a 45-year-old man who presented with worsening epigastric pain and a left large retroperitoneal mass in close proximity to the body/tail of pancreas and third portion of the duodenum with displacement of the kidney without parenchymal invasion and multiple liver nodules detected by computed tomographic scan. On en bloc resectio......
POSTED 08/04/2010 at 06:00 PM --
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Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings
Abstract (Source: Journal of Obstetrics and Gynaecology Research)...
POSTED 07/31/2010 at 06:00 PM --
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High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma
Conclusions Cervical CS is a peculiar tumor with many different clinicopathologic characteristics from cervical SCC. Dysregulation of
apoptosis may confer tumor cells of cervical CS with survival and growth advantages, and thereby facilitate the aggressive
behavior of cervical CS.
Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1610-2Authors
Xiao-Ling Gan, Sichuan University Departments of Gynecology and Obstetrics, West China Secondary Hospital 20 Renmingnan Road Chengdu 610041 Sichuan Peopleâs Republic of ChinaJin-Ke Li, Sichuan University Departments of Gynecology and Obstetrics, West China Secondary Hospital 20 Renmingnan Road Chengdu 610041 Sichuan Peopleâs Republic of ChinaTing-He Yu, Sichuan University Laboratory of Biomedi......
POSTED 07/29/2010 at 11:05 AM --
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Ovarian malignant Mullerian mixed tumor (heterologous) whose epithelial component is composed predominantly of signet ring cell carcinoma
Conclusion To the best of our knowledge, there have been no descriptions in the English literature of MMMT composed predominantly of
signet ring cell carcinoma. An MMMT in this case, should be differentiated from Krukenberg tumor, metastatic signet ring cell
carcinoma, and signet ring stromal tumor.
Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1591-1Authors
Tadashi Terada, Shizuoka City Shimizu Hospital Department of Pathology Miyakami 1231, Shimizu-ku Shizuoka 424-8636 Japan
Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)...
POSTED 07/23/2010 at 07:25 AM --
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Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases
Conclusions. Urinary bladder carcinosarcoma commonly presented as high grade, advanced stage and aggressive behavior with a poor prognosis. Emphasis on early detection, including identification of risk factors is needed to improve the outcome for patients with this malignancy. (Source: Sarcoma)...
POSTED 07/19/2010 at 12:13 AM --
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Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings
We report a case of teratoid carcinosarcoma of the ovary occurring in a 40-year-old female. The resected tumor measuring over 20 cm in diameter consisted of cystic and solid components and was very fragile. Microscopic examination showed a heterogenous mixed tumor composed of malignant epithelial, malignant mesodermal and malignant neuroectodermal components. The cells of ganglioneuroblastoma-like area were positive for neural markers (Synaptophysin, S-100 protein, neuron-specific enolase). There was no tumor immunoreactivity to [alpha]-fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin, and inhibin. In spite of aggressive combination chemotherapy and three times of laparotomy, the patient died of disease 3 years 10 months after the initial treatment. This quite rare ovari......
POSTED 07/11/2010 at 06:00 PM --
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A Promising New Combo for a Rare Uterine Cancer
The optimal management of carcinosarcoma of the uterus is challenging. Dr. Maurie Markman reviews a study indicating paclitaxel and carboplatin combination therapy is active against this rare cancer. Medscape Hematology-Oncology (Source: Medscape Today Headlines)...
POSTED 07/08/2010 at 01:24 PM --
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[Magnetic resonance imaging of ovarian carcinosarcoma: correlation to the clinicopathological findings.]
CONCLUSION: MRI is useful in the detection and staging of ovarian carcinosarcoma.
PMID: 20650791 [PubMed - in process] (Source: Journal of Southern Medical University)...
POSTED 06/30/2010 at 06:00 PM --
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Carcinosarcoma of the esophagus treated with chemoradiotherapy: report of four cases
Abstract Esophageal carcinosarcoma is a rare neoplasm. Esophagectomy with lymph node dissection has often been performed, although
the efficacy of chemotherapy or radiotherapy is not yet confirmed. Four cases of esophageal carcinosarcoma who underwent chemoradiotherapy
are presented. Complete response of the primary tumor was observed in one case; tumor size decreased in three cases. Two patients
have been observed to be disease free, another patient died of metastatic disease, and the other had recurrence. Six cases
of carcinosarcoma treated with chemoradiotherapy were retrieved from the literature and analyzed with the four cases in the
current study. Reduction of the tumor was observed in seven of the ten cases. Disease progression or local recurrence was
observed in th......
POSTED 06/14/2010 at 09:22 AM --
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MicroRNA signatures differentiate uterine cancer tumor subtypes.
CONCLUSIONS: We hypothesize that further understanding the miRNAs that separate these subtypes of EC will lead to biological insights into the different behavior of these tumors.
PMID: 20542546 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)...
POSTED 06/07/2010 at 06:00 PM --
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The Pathology of EMT in Mouse Mammary Tumorigenesis
Abstract Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms
such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts
of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered
mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular
biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
Content Type Journal ArticleDOI 10.1007/s10911-010-9184-yAuthors
Robert Darrell Cardiff, University of California, Davis Center for Comparative Medi......
POSTED 06/03/2010 at 02:56 AM --
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Phase II Evaluation of Paclitaxel and Carboplatin in the Treatment of Carcinosarcoma of the Uterus: A Gynecologic Oncology Group Study [Gynecologic Cancer]
Conclusion
Paclitaxel plus carboplatin demonstrates antitumor activity against uterine carcinosarcoma with acceptable toxicity and warrants further evaluation in phase III randomized trials. (Source: Journal of Clinical Oncology)...
POSTED 05/27/2010 at 05:02 PM --
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The role of lymphadenectomy in uterine leiomyosarcoma: review of the literature and recommendations for the standard surgical procedure
Abstract Uterine sarcomas are rare and aggressive gynaecologic malignancies with poor prognosis, arising from myometrial or endometrial
tissue. These rare cancers can be aggressive, and account for a greatly disproportionate amount of deaths from uterine cancers.
The histological uterine sarcomas classification includes carcinosarcomas (malignant mesodermal mixed tumors), accounting
for 40% of cases, leiomyosarcomas (40%) and endometrial stromal sarcomas (10â15%). Each group of these tumors presents differences
in diagnosis, prognostic factors, treatment, and outcome. Uterine leiomyosarcomas typically affects women in their sixth decade
of life, presenting with atypical symptoms such as abnormal uterine bleeding and abdominal pain. The optimal treatment of
uterine leiomy......
POSTED 05/25/2010 at 11:48 AM --
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Increased Incidence of Visceral Metastases in Scottish Patients With BRCA1/2-Defective Ovarian Cancer: An Extension of the Ovarian BRCAness Phenotype [Gynecologic Cancer]
Conclusion
Although sporadic EOC commonly remains confined to the peritoneum, BRCA1/2-deficient ovarian cancer frequently metastasizes to viscera. These data extend the ovarian BRCAness phenotype, imply BRCA1/2-deficient ovarian cancer is biologically distinct, and suggest that patients with visceral metastases should be considered for BRCA1/2 sequencing. (Source: Journal of Clinical Oncology)...
POSTED 05/18/2010 at 05:01 PM --
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Paclitaxel-Carboplatin Combo Promising Against Rare Uterine Cancer
An outpatient regimen of paclitaxel and carboplatin has activity against carcinosarcoma of the uterus, researchers report in the April 26th online issue of the Journal of Clinical Oncology. Reuters Health Information (Source: Medscape Medical News Headlines)...
POSTED 05/18/2010 at 12:08 PM --
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Spindle cell sarcoma of esophagus: A rare case presentation
We report a rare case of spindle cell sarcoma of esophagus in a 55-year-old woman, managed with radical radiotherapy alone. (Source: Journal of Cancer Research and Therapeutics)...
POSTED 05/16/2010 at 07:46 AM --
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Genomic profile of endometrial tumors depends on morphological subtype, not on tamoxifen exposure
Tamoxifen has been a very effective treatment for breast cancer for several decades, however, at the same time increases the risk of endometrial cancer, especially after prolonged exposure. In addition, tamoxifen has been associated with a higher proportion of unfavorable uterine tumor subtypes (carcinosarcomas and serous adenocarcinomas) with worse survival. We investigated whether endometrial tumors, which developed after prolonged tamoxifen treatment for breast cancer, are genetically different from endometrial tumors without preceding tamoxifen exposure. Array CGH was used on archival formalin-fixed paraffin embedded endometrial tumors to determine genomic aberrations. We compared the genomic profiles of 52 endometrial tumors from breast cancer patients after long-term ([ge]2 years) ta......
POSTED 05/06/2010 at 06:00 PM --
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