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Carcinosarcoma News Headlines
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All Recent Carcinosarcoma News Headlines |
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Rapid-growth carcinosarcoma of the esophagus arising from 0-IIc squamous cell carcinoma after definitive chemoradiotherapy: a case report
Abstract A case of carcinosarcoma arising from the area of intraepithelial spread of relapsed esophageal squamous cell carcinoma (SCC)
after definitive chemoradiotherapy (CRT) is reported herein. A 71-year-old man was referred to our hospital because of a superficial
esophageal carcinoma. Definitive CRT was performed because the patient refused surgical treatment. Complete response was recognized
after CRT, but tumor relapse was diagnosed 3 months later. The relapsed tumor initially revealed a minimal depression with
a small white nodule. This nodule developed to a sessile elevated mass after 1 month and finally to a polypoid tumor 3.2 ×
2.3 × 1.5 cm in size within 125 days. A subtotal esophagectomy with two-field lymph node dissection was performed. Histologically,
the ......
POSTED 06/17/2009 at 04:43 AM --
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Malignant neoplasms of the uterus following radiation therapy for cervical carcinoma: a clinical study of 47 cases
Conclusion The main uterine neoplasms development after radiation therapy for cervical carcinoma is endometrial carcinomas, of which
there is a preponderance of high-risk histological subtypes and a poor prognosis. Most of the uterine sarcomas occurred following
radiation therapy for cervical carcinoma are carcinosarcomas and the prognosis is very poor.
Content Type Journal ArticleDOI 10.1007/s10330-009-0074-yAuthors
Shaokang Ma, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical College Beijing 100021 ChinaLingying Wu, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical College Beijing 100021 China
Journal The Chinese-German Journal of Clinical On......
POSTED 06/15/2009 at 01:50 AM --
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Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism
Conclusion These results confirm the antitumor effects of celecoxib in W256 cancer model, contributing to elucidating its antitumoral
mechanism and corroborating scientific literature about its effect on other types of cancer.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1031-8Authors
Amanda Leite Bastos-Pereira, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilDaiana Lugarini, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilAdriana de Oliveira-Christoff, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilThiago Vinicius Ávila, Federal University of Paraná, Bio......
POSTED 06/09/2009 at 07:38 AM --
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Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.
Authors: Saegusa M, Hashimura M, Kuwata T, Okayasu I
Uterine carcinosarcomas (UCSs) are considered to represent true examples of the epithelial-mesenchymal transition. Akt plays a key role in the induction of epithelial-mesenchymal transition, but little is known about its involvement in tumorigenesis. Here we examined the functional roles of the Akt/beta-catenin pathway in UCSs. In clinical samples, phospho-Akt (pAkt) expression was found to be significantly increased in mesenchymal compared with epithelial components, exhibiting both positive and negative correlations with nuclear beta-catenin and E-cadherin, respectively. Expression levels of the transcription factor Slug were also significantly up-regulated in the mesenchymal components and strongly correlated with both pAkt and nu......
POSTED 05/31/2009 at 06:00 PM --
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Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection?
We report a carcinosarcoma of the pancreas with liver metastasis combined with gastrointestinal stromal tumour (GIST) of the stomach in a 72-year-old woman who presented with right upper quadrant pain, nausea and vomiting. A radical resection including pancreaticoduodenectomy, left hepatic lobe resection and local resection of the gastric mass was performed. The tumour in the head of pancreas was found to be grossly yellow-white, and it infiltrated the common bile duct and duodenum; the mass of the liver metastasis is solitary. Pathologic examination showed two components separated from each other: one component was a conventional infiltrating pancreatic ductal adenocarcinoma, and the other component showed sarcomatous growth pattern composed of pleomorphic spindle cells. The neoplasm of t......
POSTED 05/27/2009 at 11:00 PM --
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Clinical manifestation of esophageal carcinosarcoma: a Taiwan experience
This study aimed to investigate its clinicopathologic features and endoscopic characteristics. The data of patients diagnosed to have esophageal carcinosarcoma pathologically in the past 30 years (January 1976[ndash]December 2007) were reviewed. Of 3318 cases of esophageal malignancy, 12 were diagnosed as esophageal carcinosarcoma, with an incidence of 0.36%. All of the cases were male with a mean age of 62.3 years. Of the 12 tumors, 8 were polypoid type, and 4 were ulcerative type. In the endoscopic ultrasonography examination, the tumors show heterogeneous hypoechoic lesions with irregular outer margins and internal multicystic components. Four patients (33.3%) had previous head and neck squamous cell carcinoma that occurred metachronously. This is the first report about the characterist......
POSTED 05/14/2009 at 11:00 PM --
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Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma - Report of an unusual case
The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods.The SCC was typical, but few cells showed a spindle-shaped pattern. The relapse tumor was a spindle-shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm-actin+, desmin+, caldesmon+, vimentin+, keratin-).The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed in the primary. A fluorescence in situ hybridization (5p) focally detected 3 chromosmomal copies, corresponding to gains on 5p in CGH of leiomyosarcoma.Leiomyosarcoma afte......
POSTED 05/12/2009 at 11:00 PM --
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Miscellaneous Uterine Malignant Neoplasms Detected during Hysteroscopic Surgery
Conclusion: Resectoscopic surgery in women with miscellaneous uterine malignant lesions not adversely affect 5-year survival and long-term prognosis. (Source: The Journal of Minimally Invasive Gynecology)...
POSTED 04/30/2009 at 11:00 PM --
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[Tamoxifen in the adjuvant setting for breast cancer: Reflexions about the risk of uterine carcinosarcoma]
Authors: Leung F, Terzibachian JJ, Govyadovskiy A, Bourtembourg A, Maillet R, Riethmuller D
A descriptive analysis of available data on reported cases of uterine carcinosarcomas associated with tamoxifen therapy is undertaken. The role of aromatase inhibitors as alternative to tamoxifen therapy in the adjuvant setting of breast cancer is discussed. The eventual implications of the presumed association of uterine carcinosarcoma and tamoxifen therapy on the choice of the therapeutic agent in the adjuvant setting of hormone-sensitive breast cancer are discussed.
PMID: 19394886 [PubMed - in process] (Source: Gynecologie, Obstetrique & Fertilite)...
POSTED 04/30/2009 at 06:00 PM --
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Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma
We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules. He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site. FNAC from the pleural lesions showed myxoid background substance with entrapped cuboidal epithelial cells with atypical nuclei, which were interpreted as mesothelial cells. These cells in contrast to the usual mesothelial cells were not arranged in sheets but rather were huddled in places and formed a pseudoacinar pattern and blended with the myxoid substance.After the diagnosis of a mesothelioma, p......
POSTED 04/15/2009 at 11:00 PM --
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Treatment of early uterine sarcomas: disentangling adjuvant modalities
Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas and "other" sarcomas. The pathological subtype demands a tailored approach. Surgical resection is regarded as the mainstay of treatment. Total abdominal hysterectomy and bilateral salpingo-oophorectomy represents the standard treatment of uterine sarcomas. Pelvic and para-aortic lymph node dissection in carcinosarcomas is recommended, given their high incidence of lymph node metastases, and may have a role in endometrial stromal sarcomas. Adjuvant radiation therapy has historically been of little survival value, but it appears to improve loc......
POSTED 04/07/2009 at 11:00 PM --
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Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumor
We report a case of 78-year-old woman histopathologically diagnosed after surgery. Macroscopically, the tumor was
a dark-greenish solid mass with a short stalk, filling the gallbladder cavity, and it measured 11.5 × 4.0 × 3.5 cm in diameter.
Microscopically, the tumor was composed of abundant loose stroma and a glandular component. Some of the glandular cells had
hyperchromatic nuclei with disturbed polarity and were positively stained by p53 (30%) and Ki-67 (30–40%). Part of the stromal
component revealed hypercellularity with an irregular nucleus, mitosis (2–3 cells/10 high-power fields), and positivity for
Ki-67 (20%) and p53 (50%). We diagnosed this peculiar tumor as “fibroadenoma of the gallbladder with borderline malignancy”.
We present the de......
POSTED 04/07/2009 at 12:57 AM --
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Carcinosarcoma of the gallbladder.
Authors: Agarwal T, Jain M, Goel A, Visayaragavan P, Gupta RK
Carcinosarcoma of the gallbladder is an uncommon neoplasm. We herein report the case of a patient with carcinosarcoma of the gallbladder, treated by simple cholecystectomy for a tumor which was confined to the gallbladder.
PMID: 19332928 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)...
POSTED 03/31/2009 at 11:00 PM --
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Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases.
We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor.
PMID: 19332899 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)...
POSTED 03/31/2009 at 11:00 PM --
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Carcinosarcoma of the colon: a rare cause of colovesical fistula.
Authors: Patel DH, Dang S, Bentley FR, Julka RN, Olden KW, Aduli F
Carcinosarcomas are relatively rare tumors composed of both carcinomatous and sarcomatous components. The most common sites involved by this tumor are the head and neck, respiratory tract, uterus, ovaries, and fallopian tubes. Within the gastrointestinal tract this tumor most often occurs in the esophagus, followed by the stomach. Carcinosarcomas are very aggressive tumors associated with a poor prognosis. The first case of carcinosarcoma of the colon was reported in 1986. The case reported here is the only one involving an associated colovesical fistula.
PMID: 19385296 [PubMed - indexed for MEDLINE] (Source: The American Surgeon)...
POSTED 03/31/2009 at 06:00 PM --
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Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case
Abstract A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could
find no evidence of a specific infection. The leukocyte count was 18 000/mm3, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml
and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy.
Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor
was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative
for G-CSF. This is the first report of a carcinosarcoma of the gallbl......
POSTED 03/12/2009 at 05:24 AM --
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Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma.
Authors: Pristauz G, Moinfar F, Chromecki T, Bader AA, Winter R, Tamussino K
PMID: 19309402 [PubMed - in process] (Source: Histopathology)...
POSTED 02/28/2009 at 11:00 PM --
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Differential expression of topoisomerase II alpha protein in salivary gland carcinomas: histogenetic and prognostic implications
Background:
Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase II alpha (topoII alpha), located at chromosome 17q21-22, is considered a major mediator of cell proliferation and DNA replication. The purpose of this study was to evaluate the expression of topoII in various types of salivary gland tumors and its biological significance.
Methods:
The protein expression of topoII alpha was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors). The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise spec......
POSTED 02/26/2009 at 11:00 PM --
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Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reports.
Page: 31 (Source: Reactions Weekly)...
POSTED 02/15/2009 at 06:38 AM --
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Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reports
(Source: Reactions)...
POSTED 02/15/2009 at 06:14 AM --
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