Clinical Chemistry and Laboratory Medicine 47 (S1): S13-S74 Abstract Cardiovascular diseases Clinical toxicology How to define and determine reference intervals and decision limits in laboratory medicine Biobanking concepts – need for an integrated European solution Vitamin D metabolites in cancer, immunological and cardiovascular diseases From stem cells to cardiovascular therapy Screening and identifying small to large molecules in clinical chemistry by mass spectrometry Quality management in Europe – implementation of ISO-15189 Diabetes mellitus, atherosclerosis, renal failure – ‘post translational pathologies’ Pediatric reference ranges Standardization activities in endocrinology Proteomics and human diseases Translational research: re-engineering the laboratory medicine ente......
POSTED 07/01/2009 at 01:41 PM --
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Clinical Chemistry and Laboratory Medicine 47 (S1): S77-S105 Abstract Use of biomarkers in heart disease Standardisation of HbA1c The power of networking Personnalized health care – what it takes to be a leader Integrated diagnostics – what do you think the next generation of healthcare will look like? Biochips can save lives: cardiovascular disease The future and importance of solution business What is new on cardiac troponin? Diagnostic performance and clinical value of holotranscobalamin, measured by the AxSYM Active-B12 assay, for vitamin B12 status Directing the spotlight on renal disease Automation solutions for laboratories in hospital networks Beyond blood Complementary role of serology and NAT in the diagnosis of viral hepatitis New developments in prostate cancer management A......
POSTED 07/01/2009 at 01:41 PM --
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Cancer/tumour markers
Clinical Chemistry and Laboratory Medicine 47 (S1): S154-S174 (Source: Clinical Chemistry and Laboratory Medicine)...
POSTED 07/01/2009 at 01:41 PM --
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Obama Pitches Health Care Reform In Va.
At an emotional forum in Virginia, President Barack Obama hugged a
cancer patient Wednesday and vowed to bring greater efficiency and
accessibility to the nation's health care system. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)...
POSTED 07/01/2009 at 01:38 PM --
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GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells
Biological Chemistry 390 (7): 601-609 Abstract The disialoganglioside GD3 is an oncofetal marker of a variety of human tumors including melanoma and neuroblastoma, playing a key role in tumor progression. GD3 and 9-O-acetyl-GD3 are overexpressed in approximately 50% of invasive ductal breast carcinoma, but no relationship has been established between disialoganglioside expression and breast cancer progression. In order to determine the effect of GD3 expression on breast cancer development, we analyzed the biosynthesis of gangliosides in several breast epithelial cell lines including MDA-MB-231, MCF-7, BT-20, T47-D, and MCF10A, by immunocytochemistry, flow cytometry, and real-time PCR. Our results show that, in comparison to tumors, cultured breast cancer cells express a limited pattern of ......
POSTED 07/01/2009 at 01:20 PM --
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Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice
Biological Chemistry 390 (7): 611-618 Abstract Human adenocarcinomas overexpress a hypoglycosylated, tumor-associated form of the mucin-like glycoprotein MUC1 containing abnormal mono- and disaccharide antigens, such as Tn, sialyl-Tn, and TF, as well as stretches of unglycosylated protein backbone in the variable number of tandem repeats (VNTR) region. Both peptide and glycopeptide epitopes generated from the VNTR are candidates for cancer vaccines and we performed experiments to evaluate their relative potential to elicit tumor-MUC1-specific immunity. We show here that immunization with the 100 amino acid-long VNTR peptide (MUC1p) elicits weaker responses in MUC1 transgenic mice compared to wild type mice suggesting self-tolerance. In contrast, when glycosylated with tumor-associated Tn a......
POSTED 07/01/2009 at 01:20 PM --
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Protein Linked To Change In Tissue That Surround And Support Breast Tumors
A protein known to be overly active in breast cancer can exist in a form that seems to change the structural composition of mammary tissue, potentially making it more conducive to tumor progression, say researchers. (Source: ScienceDaily Headlines)...
POSTED 07/01/2009 at 01:19 PM --
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Hungry Cells: Tumor Metabolism Discovery Opens New Detection And Treatment Possibilities For Rare Form Of Colon Cancer
People who suffer from Peutz-Jeghers syndrome, a rare inherited cancer syndrome, develop gastrointestinal polyps and are predisposed to colon cancer and other tumor types. Carefully tracing the cellular chain-of-command that links nutrient intake to cell growth (and which is interrupted in Peutz-Jeghers syndrome), allowed researchers to exploit the tumors' weak spot. (Source: ScienceDaily Headlines)...
POSTED 07/01/2009 at 01:19 PM --
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Congressional Committee Hears of "Erratic" Placement of Radiation Seeds in Prostate Cancer Patients
Medscape Medical News (Source: Medscape Today Headlines)...
POSTED 07/01/2009 at 01:10 PM --
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Lower GI Cancer - The Multimodality Treatment Paradigm
A scientific meeting organised by Dr Charles Kelly and the BIR’s Oncology Committee on behalf of the British Institute of Radiology.
This meeting will examine the treatment of lower gastrointestinal cancer with an emphasis on new and exciting innovations in cancer care. From the introduction of imaging advances in the GI tract, through the latest surgical techniques and molecular targets for colon cancer and GIST to the emerging role of brachytherapy in rectal cancer and life after the ACT2 trial, the latest techniques will be reviewed and examined and their roles critically appraised. The latest national and international trials of rectal brachytherapy will be introduced and summarised. We will be joined by international speakers to give a wide-ranging perspective on treatment advances.......
POSTED 07/01/2009 at 12:16 PM --
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Cancer Education: What is it for, who is it for, how is it changing?
A scientific meeting organised by Dr Charles Kelly and the BIR’s Oncology Committee on behalf of the British Institute of Radiology.
This joint meeting with the European Association for Cancer Education (www.eaceonline.com) will review the current status of cancer education in the UK, how it is changing with the introduction of innovative projects and how education will be affected by the introduction of relicensing and revalidation. Education and training for all of the cancer professions will be covered using the experiences, challenges and problems encountered by one professional group to try and assist other cancer groups in the near future.
Topics will also include input from Europe, asking if we can learn from the European model, and the NCRN, where education for cancer research fi......
POSTED 07/01/2009 at 12:14 PM --
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Parameters of protection against ultraviolet radiation-induced skin cell damage.
Authors: Cao C, Wan Y
Epidemiological and experimental evidence has supported the notion that solar ultraviolet (UV) radiation is the leading cause of skin cell damage and skin cancer. Non-melanoma skin cancer, one of the malignancies with the most rapidly increasing incidence, is suggested to be directly related to the total exposure to solar UV light. Over the past few years, the mechanisms of cellular responses to UV radiation have received unprecedented attention. Understanding how skin cells respond to UV radiation will undoubtedly help decipher what goes wrong in a variety of clinical skin disorders including skin cancer and will facilitate the development of novel therapeutic strategies. In the past decade, studies have established that UV radiation induces multifarious signal t......
POSTED 07/01/2009 at 11:44 AM --
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Screening and surveillance of Barrett's esophagus.
Authors: Regula J
Screening and surveillance of Barrett's esophagus is a matter of discussion in the current world literature due to uncertainties concerning its cost-effectiveness. Important and valid arguments for and against it are available. Despite the fact that this issue is still to be resolved, screening using standard gastroscopy once in a lifetime and surveillance using repeated endoscopies with multiple blind biopsies are widely practiced by individual gastroenterologists. Further studies that mainly focus on finding better predictors of progression to cancer are needed to be able to prepare clear and useful guidelines. The ultimate aim of screening and surveillance should be decrease in mortality from esophageal adenocarcinoma resulting from Barrett's esophagus.
PMID: 1......
POSTED 07/01/2009 at 11:18 AM --
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Chemoprevention of adenocarcinoma associated with Barrett's esophagus: potential options.
This article focuses on known and postulated targets for prevention of distal esophageal cancer.
PMID: 19439956 [PubMed - indexed for MEDLINE] (Source: Cancer Control)...
POSTED 07/01/2009 at 11:18 AM --
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Epidemiology of the complications of gastroesophageal reflux disease.
Authors: Belhocine K, Galmiche JP
The complications of gastroesophageal reflux disease (GERD) include ulcers, strictures, Barrett's esophagus and carcinoma. Although the prevalence of GERD is very high, the development of complications remains quite rare and usually occurs in association with factors generally observed in more severe disease such as hiatal hernia, bile reflux or severely disturbed motility. Recent studies have emphasized the role of obesity and genetic factors as aggravating factors in the development of GERD complications. Barrett's esophagus is the most prevalent complication of GERD and seems to be associated with an increased mortality rate. However, cancer incidence is low and most patients die from other causes, especially cardiovascular disease.
PMID: 194399......
POSTED 07/01/2009 at 11:18 AM --
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Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.
CONCLUSION: Our results suggest that lower ED diets do not prevent weight gain but have a weak yet potentially beneficial effect on the prevention of abdominal obesity as measured by waist circumference.
PMID: 19396357 [PubMed - indexed for MEDLINE] (Source: Cancer Control)...
POSTED 07/01/2009 at 11:18 AM --
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New double-stapling technique for esophagojejunostomy and esophagogastrostomy in gastric cancer surgery, using a peroral intraluminal approach with a digital stapling system.
We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler - the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and they are approximated; the stapler device is then fired to form a double-stapled esophagojejunostomy and esophagogastrostomy. Our peroral intraluminal approach does not require a ......
POSTED 07/01/2009 at 11:18 AM --
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Use of DNA combing to study DNA replication in xenopus and human cell-free systems.
We describe (a) the preparation and use of egg extracts and demembranated sperm chromatin templates; (b) a simple method for preparing silanized glass coverslips suitable for DNA combing and fluorescence detection; (c) two alternative replicative DNA labelling schemes and their respective advantages; and (d) a protocol for combining replicative labelling with detection of specific DNA sequences by fluorescent in situ hybridization (FISH). Although most observations made in Xenopus egg extracts are applicable to other eukaryotes, there are differences in cell-cycle regulation between mammalian somatic cells and embryonic amphibian cells, which led to the development of human cell-free systems that can initiate semi-conservative chromosomal DNA replication under cell-cycle control. We have e......
POSTED 07/01/2009 at 11:18 AM --
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Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.
Authors: Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY
Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory distress syndrome, diabetes, thrombosis and cancer. An important mechanism underlying this process is increased paracellular leakage of plasma fluid and protein. Inflammatory stimuli such as histamine, thrombin, vascular endothelial growth factor and activated neutrophils can cause dissociation of cell-cell junctions between endothelial cells as well as cytoskeleton contraction, leading to a widened intercellular space that facilitates transendothelial flux. Such structural changes initiate with agonist-receptor binding, followed by activation of intracellular signalli......
POSTED 07/01/2009 at 11:18 AM --
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Vegetarians less likely to develop cancer than meat eaters
Vegetarians are 12% less likely to develop cancer than meat eaters, according to new research published today (Source: Nursing in Practice)...
POSTED 07/01/2009 at 10:39 AM --
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