Tamoxifen use negatively affects cognitive functioning
Tamoxifen use is associated with worse verbal memory and executive functioning after 1 year of adjuvant therapy, researchers from the Netherlands report. (Source: MedWire News - Breast Cancer)...
POSTED 03/12/2010 at 07:49 AM --
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Sentinel Lymph Node Biopsy in Breast Cancer: A Systematic Review.
Authors: Stamatakos M, Stefanaki C, Kontzoglou K, Safioleas M
Lymphatic mapping and sentinel lymphadenectomy have become an important tool for axillary lymph node staging in women with early-stage breast cancer. Many issues such as indications, usefulness, or best method of performing a sentinel node biopsy need to be addressed. Multiple studies now confirm that sentinel lymphadenectomy accurately stages the axilla and is associated with less morbidity than axillary dissection. Blue dye, radiocolloid, or both can be used to identify the sentinel node, and several injection techniques may be used successfully. Many patient factors previously thought to affect accuracy of the procedure have now been shown to be of limited significance. This paper's main purpose is to present the pros and......
POSTED 03/12/2010 at 06:28 AM --
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Pfizer Says Sutent Fails In Breast Cancer Studies
From Associated Press (March 11, 2010)
NEW YORK -- Pfizer Inc. said Thursday the cancer drug Sutent did
not meet key goals in two late-stage studies focusing on advanced
breast cancer.
The drug is already sold as a treatment for advanced... (Source: Drugs.com - Pharma News)...
POSTED 03/12/2010 at 06:17 AM --
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Two Phase 3 Trials of Sunitinib With Commonly Used Chemotherapies in Advanced Breast Cancer Did Not Meet The Primary Endpoint
Detailed Results to be Presented at Future Medical
Meeting
NEW YORK--(BUSINESS WIRE)--Mar 11, 2010 - Pfizer Inc. announced
today that two Phase 3 studies of Sutent® (sunitinib malate) in
advanced breast cancer did not meet their primary... (Source: Drugs.com - Clinical Trials)...
POSTED 03/12/2010 at 05:43 AM --
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Technology May Reduce Need For Repeat Cancer Surgery
Every year more than 100,000 women in the United States undergo a lumpectomy, a conservative procedure to remove cancerous tumors while preserving the breast. The surgeon's goal is to attain a tumor-free, or negative, surgical margin the first time they operate. Current surgical tools may cause heat damage to the tissue samples needed for examination by a pathologist in order to identify the presence of cancerous cells on the edges of tumors... (Source: Health News from Medical News Today)...
POSTED 03/12/2010 at 05:00 AM --
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'Microtentacles' on tumor cells appear to play role in how breast cancer spreads
(University of Maryland Medical Center) Researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center have discovered that "microtentacles," or extensions of the plasma membrane of breast cancer cells, appear to play a key role in how cancers spread to distant locations in the body. Targeting these microtentacles, which are linked to a protein called "tau," might prove to be a new way to prevent or slow the growth of these secondary cancers, the scientists say. (Source: EurekAlert! - Medicine and Health)...
POSTED 03/11/2010 at 11:00 PM --
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Tamoxifen counteracts the allergic immune response and improves allergen-induced dermatitis in mice
Tamoxifen (TX) represents the prototype selective oestrogen receptor modulator. In addition to its use in breast cancer, TX possesses immunomodulatory functions and displays beneficial effects in models of systemic lupus erythematosus. We hypothesized that TX might inhibit type I allergic reactions, which are also characterized by deviations in humoral immunity. To evaluate the effects of TX on the allergic immune response in appropriate mouse models. Balb/c mice were sensitized with ovalbumin (OVA)-alum by the intraperitoneal route, and humoral parameters, T cell cytokine patterns and OVA-induced ear swelling responses were determined in a preventive (start of TX treatment before sensitization) and a therapeutic setting (start after sensitization), respectively. In addition, the impact of......
POSTED 03/11/2010 at 06:00 PM --
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Potential prognostic value of heat shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers
Conclusions:
The co-expression of HSP90 with PI3K-p110alpha or expression of HSP90 along with PTEN loss have potential as molecular prognostic markers to predict early relapse in patients with invasive breast cancers. (Source: Breast Cancer Research)...
POSTED 03/11/2010 at 06:00 PM --
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Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients
Conclusions:
Histologically normal breast tissues adjacent to breast tumours frequently exhibit methylation changes in multiple genes. These methylation changes may play a role in the earliest stages of the development of breast neoplasia. (Source: BioMed Central)...
POSTED 03/11/2010 at 06:00 PM --
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Is Postmastectomy Radiation Necessary for All Breast Cancer Patients?
New data suggest that the indications for postmastectomy radiation in early-stage breast cancer need to be re-examined. Medscape Medical News (Source: Medscape Today Headlines)...
POSTED 03/11/2010 at 01:09 PM --
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Sentinel Node Mapping in Lung Cancer: The Japanese Experience
In this study, the following topics regarding SN identification in lung cancer patients will be introduced: (1) devices for SN identification using a radioisotope tracer; (2) movement of Tc-99 tin colloid after injection; (3) characteristics of patients in whom SNs could not be identified; (4) results of ex vivo SN identification; (5) reliability of in vivo SN identification; (6) algorithm for reducing mediastinal lymph node dissection; (7) SN identification using SPECT/CT; (8) differences in SN identification between large and small radioisotope particles; (9) size of metastatic and nonmetastatic mediastinal lymph nodes in non-small cell lung cancer; (10) SN navigation segmentectomy for clinical stage IA non-small cell lung cancer; and (11) lymphatic flow at segmental lymph nodes. (Source......
POSTED 03/11/2010 at 12:09 PM --
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Pfizer says Sutent fails to meet key goals in 2 late-stage breast cancer studies
NEW YORK (AP) — Pfizer Inc. said Thursday the cancer drug Sutent did not meet key goals in two late-stage studies focusing on advanced breast cancer.
The drug is already sold as a treatment for advanced kidney cancer and gastrointestinal stromal... (Source: OrlandoSentinel: Medical Research)...
POSTED 03/11/2010 at 09:27 AM --
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Anti-CENP-B antibodies are associated with prolonged survival in breast cancer
Future Oncology , March 2010, Vol. 6, No. 3, Pages 471-477. (Source: Future Oncology)...
POSTED 03/11/2010 at 09:06 AM --
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Clinical application of breast cancer risk assessment models
Future Oncology , March 2010, Vol. 6, No. 3, Pages 355-365. (Source: Future Oncology)...
POSTED 03/11/2010 at 09:06 AM --
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Exploring the Structural Requirements for Inhibition of the Ubiquitin E3 Ligase Breast Cancer Associated Protein 2 (BCA2) as a Treatment for Breast Cancer
Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)...
POSTED 03/11/2010 at 08:36 AM --
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Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells
Shortwave (MHz range) radiofrequency (RF) energy is nonionizing, penetrates deeply into biological tissues with no adverse side effects, and heats metallic nanoparticles efficiently. Targeted delivery of these nanoparticles to cancer cells should result in hyperthermic cytotoxicity upon exposure to a focused, noninvasive RF field. We have demonstrated that gold nanoparticles conjugated with cetuximab (C225) are quickly internalized by Panc-1 (pancreatic adenocarcinoma) and Difi (colorectal adenocarcinoma) cancer cells overexpressing epidermal growth factor receptor (EGFR). Panc-1 or Difi cells treated with naked gold nanoparticles or nonspecific IgG-conjugated gold nanoparticles demonstrated minimal intracellular uptake of gold nanoparticles by transmission electron microscopy (TEM). In co......
POSTED 03/11/2010 at 07:51 AM --
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Research Shows Removing Healthy Breast Does Not Improve Breast Cancer Survival, NYT Columnist Writes
Recent studies show that more women with cancer in one breast are opting for removal of both breasts, even though removal of the healthy breast does little to improve survival rates, New York Times columnist Tara Parker-Pope writes. In 2006, roughly 6% of women who underwent surgery for breast cancer chose to remove both the cancerous and healthy breasts, a procedure known as contralateral prophylactic mastectomy, Pope says... (Source: Health News from Medical News Today)...
POSTED 03/11/2010 at 07:00 AM --
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Research Shows Removing Healthy Breast Does Not Improve Breast Cancer Survival, NYT Columnist Writes
Recent studies show that more women with cancer in one breast are opting for removal of both breasts, even though removal of the healthy breast does little to improve survival rates, New York Times columnist Tara Parker-Pope writes... (Source: Breast Cancer News From Medical News Today)...
POSTED 03/11/2010 at 07:00 AM --
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Breast Cancer Incidence Among Iraqi Women Profiled
Breast cancer continues to rise in Iraq, and scientists have established the Iraqi National Cancer Research Program to better understand the underlying molecular and environmental causes in an effort to curb the incidence of cancer. "Breast cancer is the most common type of malignancy recorded in the cancer registries of almost all countries within the Eastern Mediterranean Region. In Iraq, the continuous rise in the incidence rate is associated with an obvious trend to affect premenopausal women," said Nada A.S. Alwan, M.D., Ph.D... (Source: Health News from Medical News Today)...
POSTED 03/11/2010 at 05:00 AM --
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Breast Cancer Incidence Among Iraqi Women Profiled
Breast cancer continues to rise in Iraq, and scientists have established the Iraqi National Cancer Research Program to better understand the underlying molecular and environmental causes in an effort to curb the incidence of cancer. "Breast cancer is the most common type of malignancy recorded in the cancer registries of almost all countries within the Eastern Mediterranean Region... (Source: Breast Cancer News From Medical News Today)...
POSTED 03/11/2010 at 05:00 AM --
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