Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor {alpha} and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets [Pediatric Oncology]
Conclusion
To our knowledge, our data provides the first, comprehensive high-resolution genomic analysis of pediatric DIPG. Our findings of recurrent involvement of the PDGFR pathway as well as defects in DNA repair pathways coupled with gain of PARP-1 highlight two potential, biologically based, therapeutic targets directed specifically at this devastating disease. (Source: Journal of Clinical Oncology)...
POSTED 03/08/2010 at 05:01 PM --
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Cancer of the Nervous System: 2010 [Editorial]
(Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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New Insights Into Susceptibility to Glioma [Neurological Review]
The study of inherited susceptibility to cancer has been one of the most informative areas of research in the past decade. Most of the cancer genetics studies have been focused on the common tumors such as breast and colorectal cancers. As the allelic architecture of these tumors is unraveled, research attention is turning to other rare cancers such as glioma, which are also likely to have a major genetic component as the basis of their development. In this brief review we discuss emerging data on glioma whole genome–association searches to identify risk loci. Two glioma genome-wide association studies have so far been reported. Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).......
POSTED 03/08/2010 at 02:50 PM --
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Recent Advances in Therapy for Glioblastoma [Neurological Review]
This article will review recent advances in therapy for glioblastoma, including surgery, radiotherapy, cytotoxic chemotherapies, molecularly targeted agents, and immunotherapy; the role of antiangiogenic agents in the treatment of glioblastoma is discussed in a separate article in this issue of the Archives. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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New Strategies in the Management of Leptomeningeal Metastases [Neurological Review]
The management of patients with leptomeningeal metastases (LM) is multifaceted and complex. Even with an aggressive approach, therapeutic outcomes are uniformly disappointing. This is because of the relentless growth of the central nervous system (CNS) and/or the systemic cancers, or their lethal complications. Advances in the understanding of the homing of cancer cells to the CNS, and of cancer metastasis in general, and more effective anticancer drugs that are adequately delivered to the CNS and cerebrospinal fluid (CSF) are needed to improve outcomes for patients with LM. These advances may lead to better treatments for this disease and, ultimately, its prevention. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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A Phase 1 Trial of ABT-510 Concurrent With Standard Chemoradiation for Patients With Newly Diagnosed Glioblastoma [Clinical Trials]
Conclusions ABT-510, at subcutaneous doses up to 200 mg/d, is tolerated well with concurrent temozolomide and radiotherapy in patients with newly diagnosed glioblastoma, and low-density arrays provide a useful method of exploring gene expression profiles. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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Morphological Characteristics of Brain Tumors Causing Seizures [Original Contribution]
Conclusions The influence of size and location of the tumors on their propensity to cause seizures varies with the grade of the tumor. In high-grade gliomas, rapidly growing tumors, particularly those situated in deeper structures, present with non–seizure-related symptoms. In low-grade gliomas, lesions in the temporal lobe or the insula grow large without other symptoms and eventually cause seizures. Quantitative image analysis allows for the mapping of regions in each group that are more or less susceptible to seizures. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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Efficacy and Safety of Levetiracetam in Patients With Glioma: A Clinical Prospective Study [Original Contribution]
Conclusion The results of this study provide good evidence that levetiracetam is efficacious and safe in patients with epilepsy due to glioma. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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Papilledema as the Sole Magnetic Resonance Imaging Finding in Leptomeningeal Metastasis [Images in Neurology]
(Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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Diffuse Brain Stem Glioma [Images in Neurology]
(Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma [Observation]
Conclusion The initial results are promising and indicate that FET PET is a valuable and applicable tool for the imaging of high-grade glioma. (Source: Archives of Neurology)...
POSTED 03/08/2010 at 02:50 PM --
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21. MR perfusion imaging in diagnostics of brain pathologies
The knowledge of parameters which describe oxygen and nutrients supply to tissues is essential from standpoint of diagnostics and follow-up of pathologies of brain. Due to their low spatial resolution MR angiographic techniques cannot visualize blood flow inside bulk tissue. In order to obtain the hemodynamic parameters which describe perfusion, MR perfusion imaging use drop in tissue signal during the first pass of contrast agent. Decrease in MR signal is proportional to intravascular concentration of contrast agent, which provides basis for calculation of regional cerebral volume (rCBV), regional cerebral flow (rCBF) and mean transition time (MTT) and corresponding maps of these parameters. Such maps can pinpoint to changes in perfusion of brain tissue which can be consequence or cause o......
POSTED 03/08/2010 at 12:13 PM --
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Suit filed in Missouri excess radiation case
An Arkansas widower has filed a class action lawsuit against Lester E. Cox Medical Centers in the case involving the overradiation of 76 patients with brain cancer at CoxHealth of Springfield, Mo. (Source: Health Imaging News)...
POSTED 03/08/2010 at 08:41 AM --
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Suit filed in Missouri excess radiation case
An Arkansas widower has filed a class action lawsuit against Lester E. Cox Medical Centers in the case involving the overradiation of 76 patients with brain cancer at CoxHealth of Springfield, Mo. (Source: Health Imaging News)...
POSTED 03/08/2010 at 08:41 AM --
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Got brains? UCLA to show hundreds of school kids what gray matter's all about
WHAT:
Ever touched a human brain? More than 250 local K–12 students will get the chance to do just that as part of the UCLA Brain Research Institute's annual Brain Awareness Week. Each day, a group of 60 school kids will visit the campus to learn about what makes the noggin tick – how it functions, what it's made of it, and what happens when it's injured or impaired.
In addition to handling brains, the days' activities will include instructional games, optical illusions, displays of injured brains and tumors, and presentations on research topics and careers in neuroscience, all led by UCLA graduate neuroscience students and undergraduates.
WHEN:
9:30 a.m.–2 p.m., Monday–Friday, March 8–12
WHERE:
UCLA Gonda (Goldschmied) ......
POSTED 03/08/2010 at 02:00 AM --
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Hydrolyzed Vegetable Protein (HVP) recall leaves food consumers wondering: What is this stuff?
(NaturalNews) Hydrolyzed Vegetable Protein (HVP) is one of most common soy-based food "fillers" used to make literally thousands of processed food products. It's found in veggie burgers, gravy mixes, soups and many other grocery products. Last Thursday, one of the largest producers of HVP in the United States, Las Vegas-based Basic Food Flavors Inc., was the subject of an FDA consumer safety warning announcement. Salmonella had been found contaminating the company's HVP production equipment, the FDA said, and a nationwide recall was initiated.Most Hydrolyzed Vegetable Protein isn't purchased directly by consumers; it's used by food production companies as an ingredient in mainstream processed foods. So it shows up in thousands of grocery products -- and most consumers are not aware they're......
POSTED 03/08/2010 at 01:00 AM --
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State officials to meet with authors of Florida childhood cancer study
Signaling a shift in interest toward a study that contends a childhood brain cancer cluster spans most of southern Florida, state health officials have called for a meeting with the authors of the report and federal health officials.
The meeting is... (Source: OrlandoSentinel: Medical Research)...
POSTED 03/06/2010 at 10:28 AM --
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Acreage residents insist new report shows cancer is problem for all of South Florida
A study that identifies the bottom third of Florida as a massive brain cancer cluster has set off a firestorm among Acreage residents worried about their community's reputation.
They insist that the report, which surfaced on the Internet last month, is... (Source: OrlandoSentinel: Medical Research)...
POSTED 03/05/2010 at 12:15 PM --
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Study labels South Florida as massive brain cancer cluster
A study that identifies the bottom third of Florida as a massive brain cancer cluster has set off a firestorm among Acreage residents worried about their community's reputation.
They insist the report, which surfaced on the Internet last month, is... (Source: OrlandoSentinel: Medical Research)...
POSTED 03/05/2010 at 10:41 AM --
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Successful Treatment of Metastatic Brain Tumor by CyberKnife: A Case Report
Stereotactic radiosurgery plays an important role in management of metastatic brain tumors, especially when the tumor has recurred after treatment with previous whole brain radiotherapy. Most metastatic brain tumors less than 1 cm 3 show a complete ...more (Source: The Kaohsiung Journal of Medical Sciences)...
POSTED 03/05/2010 at 09:27 AM --
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