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Bladder Cancer News Headlines
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All Recent Bladder Cancer News Headlines |
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Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population
Conclusion: The strongest result obtained by this study was for an additive effect between smoking status, slow NAT2 variants, MTR 2756*G and MTHFR 677*T alleles, in affecting bladder cancer risk. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
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Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China
Conclusion: It is suggested that NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null, and variant CYP2A6 genotypes may play important roles in the development of bladder cancer in Henan area, China. (Source: Cancer Detection and Prevention)...
POSTED 07/01/2009 at 10:01 AM --
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Vegetarians less likely to develop cancer
• Striking difference found in risk of disease in blood• Scientists acknowledge more research still neededFor years, they have boasted of the health benefits of their leafy diets, but now vegetarians have the proof that has so far eluded them: when it comes to cancer risks, they have the edge on carnivores.Fresh evidence from the largest study to date to investigate dietary habits and cancer has concluded that vegetarians are 45% less likely to develop cancer of the blood than meat eaters and are 12% less likely to develop cancer overall.Scientists said that while links between stomach cancer and eating meat had already been reported, they had uncovered a "striking difference" in the risk of blood cancers including leukaemia, multiple myeloma and non-Hodgkin lymphoma between the groups......
POSTED 06/30/2009 at 06:05 PM --
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Intrathoracic lymph node metastases from extrathoracic carcinoma: the place for surgery.
CONCLUSIONS: HMLNMs of extrathoracic carcinoma may be isolated, probably in the context of a particular lymphatic mode of spread. Our experience demonstrates that operation is mainly diagnostic but resection may safely achieve local control of the disease and deserves being advocated in patients with isolated and resectable HMLNMs.
PMID: 19559225 [PubMed - in process] (Source: The Annals of Thoracic Surgery)...
POSTED 06/30/2009 at 06:00 PM --
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Candidate quality of care indicators for localized bladder cancer
Abstract: The surgical management of clinically localized bladder cancer is challenging, and the quality of care delivered to patients with bladder cancer is a subject of increasing interest. Multiple large studies have examined the association between surgical volume and outcomes after radical cystectomy. These studies generally find lower mortality and complication rates at high-volume centers, though interpretation of the data must be tempered by limitations of the datasets driving the studies. Benefits of regionalization of care also must be weighed against other measures proven to predict outcomes; a delay in time to cystectomy beyond 3 months, for example, is strongly associated with increased mortality. Other candidate process measures supported by existing literature include adequa......
POSTED 06/30/2009 at 06:00 PM --
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Commentary on The results of concurrent chemo-radiotherapy for recurrence after treatment with bacillus Calmette Guerin for non-muscle-invasive bladder cancer: Is immediate cystectomy always necessary? Wo JY, Shipley WU, Dahl DM, Coen JJ, Heney NM, Kaufman DS, Zietman AL, Harvard Radiation Oncology Program, and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
In this study, we specifically evaluated patients with apparently small muscle-invasive recurrences after BCG treatment for T1 bladder cancer. Selective bladder preservation with chemo-radiotherapy is possible, with low morbidity and a high chance of long-term bladder control. If successful in treating T2 recurrences after BCG therapy, it now seems timely to critically evaluate chemo-radiotherapy as an alternative to immediate cystectomy in the management of patients with T1 recurrences after BCG. (Source: Urologic Oncology: Seminars and Original Investigations)...
POSTED 06/30/2009 at 06:00 PM --
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Neoadjuvant Versus Adjuvant Chemotherapy for Muscle-Invasive Bladder Cancer - Abstract
Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, TN 37232-2765, USA. (Source: UroToday)...
POSTED 06/30/2009 at 06:00 PM --
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Pelvic Lymphadenectomy During Radical Cystectomy: A Review of the Literature - Abstract
Urology Unit, Humanitas Gavazzeni Hospital, Via M. Gavazzeni 29, 24125 Bergamo, Italy. (Source: UroToday)...
POSTED 06/30/2009 at 06:00 PM --
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Novel Therapeutics for Patients With Non-Muscle-Invasive Bladder Cancer - Abstract
The University of Texas MD Anderson Cancer Center, Division of Urology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston,... (Source: UroToday)...
POSTED 06/29/2009 at 06:00 PM --
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Survival disparities among African American women with invasive bladder cancer in Florida
The authors sought to understand the effect of patient sex, race, and socioeconomic status (SES) on outcomes for bladder cancer.The Florida Cancer Data System and the Agency for Health Care Administration data sets (1998-2003) were merged and queried. Survival outcomes for patients with bladder cancer were compared between different races, ethnicities, and community poverty levels.A total of 31,100 people with bladder cancer were identified. Overall median survival time was 62.7 months. Statistically significantly longer survival times were observed in men (62.8 months vs 62.3 months for women), whites (63.0 months vs 39.6 months for African Americans [AAs], P < .001), non-Hispanics (62.9 months vs 56.4 months for Hispanics, P < .001), and patients from more affluent communities (74.0 mont......
POSTED 06/29/2009 at 06:00 PM --
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EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
The epidermal growth factor receptor (EGFR) pathway has recently been appreciated as a central mediator of tumorigenesis and an important drug target; however, the influence of genetic variation in this pathway on bladder cancer is not understood. Pathway activation leads to cell proliferation, angiogenesis and is antiapoptotic. We sought to test the hypothesis that bladder cancer susceptibility and survival are modified by inherited variations in the sequence of the EGFR and its pathway members. We tested associations using a population-based study of 857 bladder cancer cases and 1191 controls from New Hampshire. Multifactor dimensionality reduction software was used to predict gene–gene interactions. We detected an increased risk of bladder cancer associated with variant genotypes ......
POSTED 06/29/2009 at 06:00 PM --
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The Role and Extent of Pelvic Lymphadenectomy in the Management of Patients with Invasive Urothelial Carcinoma.
Authors: Lerner SP
OPINION STATEMENT: Lymph node metastases are the most important prognostic variable in determining outcome following radical cystectomy. An anatomic bilateral node dissection includes at a minimum the external and internal iliac and obturator lymph nodes. An extended node dissection may include the distal aortic and vena caval nodes, bilateral common iliac, and pre-sacral nodes, which receive direct lymphatic drainage from the posterior bladder and trigone. This approach sets up the cystectomy, maximizes sensitivity for detection of nodal metastasis, assures optimum local pelvic cancer control, and accurately identifies those high-risk patients with node metastases who may benefit from adjuvant chemotherapy. Lymph node retrieval is affected by several variables of no......
POSTED 06/29/2009 at 06:00 PM --
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[ORIGINAL ARTICLES: GENERAL THORACIC] Intrathoracic Lymph Node Metastases From Extrathoracic Carcinoma: The Place for Surgery
Conclusions
HMLNMs of extrathoracic carcinoma may be isolated, probably in the context of a particular lymphatic mode of spread. Our experience demonstrates that operation is mainly diagnostic but resection may safely achieve local control of the disease and deserves being advocated in patients with isolated and resectable HMLNMs. (Source: The Annals of Thoracic Surgery)...
POSTED 06/28/2009 at 06:00 PM --
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Marginal analysis of panel counts through estimating functions.
Authors: Hu XJ, Lagakos SW, Lockhart RA
We develop nonparametric estimation procedures for the marginal mean function of a counting process based on periodic observations, using two types of self-consistent estimating equations. The first is derived from the likelihood studied in Wellner & Zhang (2000), assuming a Poisson counting process, and gives a nondecreasing estimator, which is the same as the nonparametric maximum likelihood estimator of Wellner & Zhang and thus is consistent without the Poisson assumption. Motivated by the construction of parametric generalized estimating equations, the second type is a set of data-adaptive quasi-score functions, which are likelihood estimating functions under a mixed-Poisson assumption. We evaluate the procedures via simulation, and i......
POSTED 06/28/2009 at 12:16 AM --
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The biochemistry of environmental heavy metal uptake by plants: implications for the food chain.
Authors: Peralta-Videa JR, Lopez ML, Narayan M, Saupe G, Gardea-Torresdey J
Plants absorb a number of elements from soil, some of which have no known biological function and some are known to be toxic at low concentrations. As plants constitute the foundation of the food chain, some concerns have been raised about the possibility of toxic concentrations of certain elements being transported from plants to higher strata of the food chain. Special attention has been given to the uptake and biotransformation mechanisms occurring in plants and its role in bioaccumulation and impact on consumers, especially human beings. While this review draws particular attention to metal accumulation in edible plants, researched studies of certain wild plants and their consumers are included. Furthermore......
POSTED 06/27/2009 at 11:02 PM --
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A human PBPK/PD model to assess arsenic exposure risk through farmed tilapia consumption.
Authors: Ling MP, Liao CM
The purpose of this study was to develop a biologically based risk assessment model for human health through consumption of arsenic (As) contaminated farmed tilapia (Oreochromis mossambicus) from blackfoot disease (BFD)-endemic area in Taiwan for estimating the consumption advice. We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human. Risk analysis indicates that consumption of farmed tilapia poses no significant threat from As-induced lung and bladder cancers. The predicted risk-based median consumption advice was no more than 5-17 meals month(-1) (or 2-6 g day(-1)).
PMID: 19452117 [PubMed - in process] (Source: Bulletin of Environmental Contamination......
POSTED 06/27/2009 at 08:47 PM --
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Nanoparticle imaging for genitourinary cancers.
Authors: Eisner BH, Feldman AS
Lymphotrophic nanoparticle enhanced magnetic resonance imaging is a promising new diagnostic modality for lymph node staging in genitourinary malignancies. The technique utilizes ultrasmall superparamagnetic iron oxide particles to provide detailed characterization of lymph nodes for detection of metastatic disease. Early results have are promising for bladder, penile, prostate, and testicular cancer. This review provides an overview of the current state of lymphotrophic enhanced magnetic resonance imaging in genitourinary cancers.
PMID: 19414924 [PubMed - indexed for MEDLINE] (Source: Cancer Biomarkers : Section A of Disease Markers)...
POSTED 06/27/2009 at 08:27 AM --
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Positive CHMP Opinion For JAVLOR(R) In Metastatic Treatment Of Bladder Cancer After Failure Of A Prior Platinum-Containing Regimen
Laboratoires Pierre Fabre announce that the Committee for Medicinal Products for Human Use (CHMP), the scientific advisory committee of the European Medicines Agency (EMEA), has issued a positive opinion supporting approval and is recommending to grant marketing authorisation for JAVLOR(R) as monotherapy in metastatic treatment of bladder cancer (advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen). (Source: Pharma Industry News From Medical News Today)...
POSTED 06/27/2009 at 03:00 AM --
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Antiproliferative Activity of the Diterpenes Jatrophone and Jatropholone and Their Derivatives
Planta MedDOI: 10.1055/s-0029-1185834AbstractThe antiproliferative activity of the diterpenes jatropholone A and B, 16 semi-synthetic derivatives thereof, and that of jatrophone and its three derivatives was assessed on human cell cultures. The cells used comprised normal lung fibroblasts (MRC-5), gastric adenocarcinoma (AGS), leukemia (HL-60), lung cancer (SK‐MES‐1), and bladder carcinoma (J82). Jatropholone A () was inactive against all the tumor cell lines; however, its acetylation rendered a compound with antiproliferative activity. The epimeric jatropholone B () was active against all the cancer cell lines, and its derivatives presented different effects on the selected cell lines. While jatrophone () showed strong anticancer activity, its derivatives 9,13-dihydroxyisabell......
POSTED 06/26/2009 at 07:53 PM --
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Transfer of occupational health problems from a developed to a developing country: Lessons from the Japan-South Korea experience
Many corporations move their manufacturing facilities or technologies from developed to developing countries. Stringent regulations have made it costly for industries to operate in developed, industrialized countries. In addition, labor costs are high in these countries, and there is increasing awareness among the general public of the health risks associated with industry. The relocation of hazardous industries to developing countries is driven by economic considerations: high unemployment, a cheaper labor force, lack of regulation, and poor enforcement of any existing regulations make certain countries attractive to business. The transfer of certain industries from Japan to Korea has also brought both documented occupational diseases and a new occupational disease caused by chemicals wit......
POSTED 06/26/2009 at 06:00 PM --
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