Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
This study, therefore, identifies sufficient IFN- production by PDC as an important determinant of vaccine efficacy. (Source: Blood)...
POSTED 03/11/2010 at 11:02 AM --
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PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: Results of a randomized phase IIa trial
Conclusions: Two applications of ingenol mebutate gel, 0.05%, are safe and have efficacy in patients with superficial basal cell carcinoma. (Source: Australasian Journal of Dermatology)...
POSTED 03/10/2010 at 06:00 PM --
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AAD: Signal Inhibitor Active in Basal Cell Carcinoma (CME/CE)
MIAMI BEACH (MedPage Today) -- More than half of patients with locally advanced or metastatic basal cell carcinoma responded to an investigational signal transduction inhibitor, data from a phase I clinical trial showed. (Source: MedPage Today Dermatology)...
POSTED 03/10/2010 at 09:03 AM --
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Complications of ambulatory major dermatological surgery in patients older than 85 years
Conclusions No intra or post-surgical mortality or life-threatening local complications were detected. Most post-surgical local complications appeared after wide excisions and complex reconstruction techniques that prolonged the length of the surgery. (Source: Journal of the European Academy of Dermatology and Venereology)...
POSTED 03/09/2010 at 06:00 PM --
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Invasive Orbital Basal Cell Carcinoma [Ophthalmic Images]
(Source: Archives of Opthalmology)...
POSTED 03/08/2010 at 02:50 PM --
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Link Between Vitamin D And Skin Cancer
A Henry Ford Hospital study has shown a link between Vitamin D levels and basal cell carcinoma, a finding that could lead researchers to better understand the development of the most common form of skin cancer. In a small study, researchers at Henry Ford and Wayne State University found elevated levels of Vitamin D enzymes and proteins in cancerous tissue taken from 10 patients compared to normal skin tissue taken from them... (Source: Health News from Medical News Today)...
POSTED 03/06/2010 at 02:00 AM --
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Link Between Vitamin D And Skin Cancer
A Henry Ford Hospital study has shown a link between Vitamin D levels and basal cell carcinoma, a finding that could lead researchers to better understand the development of the most common form of skin cancer... (Source: Nutrition/Agriculture News From Medical News Today)...
POSTED 03/06/2010 at 02:00 AM --
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Link between vitamin D and basal cell carcinoma probed: Study sheds light on development of most common form of skin cancer
A new has shown a link between Vitamin D levels and basal cell carcinoma, a finding that could lead researchers to better understand the development of the most common form of skin cancer. In a small study, researchers found elevated levels of Vitamin D enzymes and proteins in cancerous tissue taken from 10 patients compared to normal skin tissue taken from them. (Source: ScienceDaily Headlines)...
POSTED 03/05/2010 at 07:00 AM --
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Basal cell carcinoma – Epidemiology from 269 cases
(Source: Journal of the European Academy of Dermatology and Venereology)...
POSTED 03/04/2010 at 06:00 PM --
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Henry Ford Hospital study shows link between vitamin D, skin cancer
(Henry Ford Health System) A Henry Ford Hospital study has shown a link between Vitamin D levels and basal cell carcinoma, a finding that could lead researchers to better understand the development of the most common form of skin cancer.In a small study, researchers at Henry Ford and Wayne State University found elevated levels of Vitamin D enzymes and proteins in cancerous tissue taken from 10 patients compared to normal skin tissue taken from them. (Source: EurekAlert! - Medicine and Health)...
POSTED 03/03/2010 at 11:00 PM --
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A Critical Reappraisal of Off-Label Indications for Topical Photodynamic Therapy with Aminolevulinic Acid and Methylaminolevulinate.
Authors: Piergiacomo CP, Mariachiara A, Sereni E, Bernhard O
Photodynamic therapy (PDT) with methylaminolevulinate (MAL) has demonstrated high efficacy, minimal side effects, and improved cosmetic outcome in the treatment of its EU-approved clinical indications, i.e. actinic keratoses (AKs), basal cell carcinoma, and Bowen's disease. In addition, PDT with MAL or 5-aminolevulinic acid (ALA) is approved in the US for the treatment of AK. However, besides anti-tumoral activity, PDT has also demonstrated various anti-inflammatory and anti-infectious effects as well as those on the metabolism of connective tissue, keratinization of normal keratinocytes and maturation processes of sebaceous glands and hair follicles. These findings have expanded the spectrum of possible applications of PDT t......
POSTED 03/03/2010 at 06:00 PM --
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A giant polypoid Basal cell carcinoma of the lower extremity.
We report a case of giant basal cell carcinoma of the leg which is not associated with neglect and no signs of metastasis, despite being more than 10 cm in diameter. The present paper includes a brief review of the literature.
PMID: 20187672 [PubMed - in process] (Source: Archives of Iranian Medicine)...
POSTED 03/02/2010 at 06:04 AM --
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Radioactive skin patch offers less-invasive treatment option for basal cell carcinoma
Basal cell carcinoma (BCC) can be treated in a less-invasive manner than surgery via a skin patch that
delivers radiotherapy, according to research from India. (Source: Modern Medicine)...
POSTED 02/28/2010 at 06:00 PM --
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Description of the efficacy and safety of three new biologics in the treatment of rheumatoid arthritis.
Authors: Storage SS, Agrawal H, Furst DE
English articles on abatacept, golimumab, and tocilizumab in rheumatoid arthritis published between 2002 and 2009 were reviewed systematically. All randomized clinical trials, open-label extensions, meta-analyses, and reviews were examined. There were thirteen articles on abatacept, four on golimumab, and seven on tocilizumab. All three drugs were effective in methotrexate-naïve, methotrexate-incomplete responders, and tumor-necrosis-factor-failure rheumatoid arthritis patients. Of the three, only abatacept has been tested in a head-to-head trial with infliximab, in which it was found to be equivalent to infliximab. Golimumab resulted in a more modest improvement than the others in methotrexate-naïve patients, although no direct compar......
POSTED 02/28/2010 at 06:00 PM --
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Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome)
We report a case of testicular thecoma in an 11-year-old Japanese boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome). He presented with left testicular swelling and underwent a radical orchiectomy on suspicion of a malignant paratesticular tumor. The tumor arose from the testis exophytically and was diagnosed as a thecoma histopathologically. Ovarian thecoma-fibroma group tumors are closely associated with Gorlin syndrome or with abnormalities in PTCH, a candidate gene for the syndrome. The occurrence of an extremely rare testicular thecoma in this case (the second in the literature) suggests that such an etiological association may also exist in the pathogenesis of testicular tumors. (Source: Journal of Pediatric Surgery)...
POSTED 02/28/2010 at 06:00 PM --
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Markers expression of cell proliferation and apoptosis in basal cell carcinoma
CONCLUSION - The findings allow us to conclude that Bcl-2 and p53 show a tendency to indicate the severity of basal cell carcinoma. In contrast, Ki-67, due to its variable behavior, cannot be considered a marker of severity. Also, PCNA was not a good marker of cell proliferation. (Source: Anais Brasileiros de Dermatologia)...
POSTED 02/28/2010 at 08:01 AM --
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Basal cell carcinoma on the toe.
Authors: Suzuki Y, Nakamura-Wakatsuki T, Satoh M, Nishibu A, Kawakami Y, Oyama N, Yamamoto T
PMID: 20178711 [PubMed - in process] (Source: Dermatol Online J)...
POSTED 02/27/2010 at 05:58 AM --
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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
Conclusion:
We hypothesise that prolonged and repeated UVB exposure selects for skin cells bearing stable FOXM1 protein causes aberrant cell cycle checkpoint thereby allowing ectopic cell cycle entry and subsequent genomic instability. The aberrant upregulation of FOXM1 serves as a first hit where cells acquire genomic instability which in turn predisposes cells to a second hit whereby DNA-damage checkpoint response (eg. p53 or p16) is abolished to allow damaged cells to proliferate and accumulate genetic aberrations/mutations required for cancer initiation. (Source: Molecular Cancer)...
POSTED 02/25/2010 at 06:00 PM --
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Dermoscopic features of a collision tumour composed of a pigmented basal cell carcinoma and a melanoma
(Source: Journal of the European Academy of Dermatology and Venereology)...
POSTED 02/24/2010 at 06:00 PM --
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Roles for Aberrant CXCR3 Signaling in Basal Cell Carcinoma. A Case for Dual Activity.
Authors: Yu Y, Merlino G
This Commentary summarizes the findings of Lo et al. with respect to aberrant CXCR3 signaling in proliferation and survival of BCC.
PMID: 20185576 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)...
POSTED 02/24/2010 at 06:00 PM --
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