Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals.
Authors: Katoh Y, Katoh M
GLI family members are zinc-finger transcription factors, which are involved in embryogenesis and carcinogenesis through transcription regulation of GLI1, CCND1, CCND2, FOXA2, FOXC2, RUNX2, SFRP1, and JAG2. GLI1 transcription is upregulated in a variety of human tumors, such as basal cell carcinoma, lung cancer, breast cancer, gastric cancer, pancreatic cancer, and esophageal cancer. Hedgehog signaling via Smoothened cascade and receptor tyrosine kinase (RTK) signaling via PI3K-AKT cascade induce stabilization of GLI1 protein, whereas G-protein coupled receptor (GPCR) signaling via Gs-PKA cascade induces degradation of GLI1 protein. Here we report integrative genomic analyses of the GLI1 gene. The GLI1 and ARHGAP9 genes are located in a tail-to-tail manner wit......
POSTED 06/27/2009 at 08:38 AM --
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At a Glance - Dental sinus versus basal cell carcinoma
Contributed by Dr Jean Watkins, a sessional GP in Hampshire (Source: HealthcareRepublic Clinical Articles)...
POSTED 06/25/2009 at 07:00 PM --
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A relative value unit–based cost comparison of treatment modalities for nonmelanoma skin cancer: Effect of the loss of the Mohs multiple surgery reduction exemption
Conclusion: Tumor destruction by EDC or imiquimod and office-based procedures, such as traditional surgical excision or Mohs surgery, are the lowest cost options for treatment of nonmelanoma skin cancer. (Source: Journal of the American Academy of Dermatology)...
POSTED 06/25/2009 at 02:32 AM --
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Immunocryosurgery for basal cell carcinoma: results of a pilot, prospective, open-label study of cryosurgery during continued imiquimod application
Conclusions 'Immunocryosurgery' is a promising non-surgical combination modality to treat 'high-risk-for-recurrence BCCs'. Initial evidence is suggestive of an at least additive effect of the two combined modalities. Further studies comparing immunocryosurgery directly with cryosurgery and imiquimod monotherapies will confirm the reported results. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)...
POSTED 06/24/2009 at 06:00 PM --
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Adenoid Basal Cell Carcinoma Simulating Ameloblastoma
The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)...
POSTED 06/21/2009 at 06:00 PM --
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ORIGINAL INVESTIGATION: Cutaneous Malignancies Among HIV-Infected Persons
Conclusions At present, the most common cutaneous malignancies among HIV-infected persons are NADCs. Cutaneous NADCs do not appear to be significantly associated with immune function or HAART but rather are related to traditional factors such as aging and skin color. (Source: Archives of Internal Medicine)...
POSTED 06/21/2009 at 06:00 PM --
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Squamous cell carcinoma does not increase subsequent basal cell carcinoma risk
Patients who develop both basal cell carcinoma and squamous cell carcinoma are less likely to develop subsequent basal cell carcinoma than patients with basal cell carcinoma only, a UK study has found. (Source: MedWire News - Dermatology)...
POSTED 06/18/2009 at 07:00 PM --
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New radioactive patch appears to zap skin cancer
A radioactive skin patch just might become a safe and effective way to treat a form of skin cancer called basal cell carcinoma, researchers at the Society of Nuclear Medicine meeting report. (Source: CTV Health)...
POSTED 06/18/2009 at 12:02 PM --
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New skin cancer patch: Possible alternative to surgery
(Society of Nuclear Medicine) A new study shows that a radioactive skin patch can safely and successfully treat basal cell carcinoma, one of the most common types of skin cancers, according to researchers at the SNM's 56th Annual Meeting. (Source: EurekAlert! - Medicine and Health)...
POSTED 06/14/2009 at 11:00 PM --
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Periocular Skin Cancers Tend To Be Basal Cell Carcinoma
AUSTIN, TEX. — A chart review aimed at quantifying the incidence and type of periocular skin cancers showed that the vast majority were basal cell carcinomas, and that there was a slight predominance of the cancers in men. (Source: Family Practice News)...
POSTED 06/14/2009 at 06:00 PM --
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Measurements of the anatomical distribution of erythemal ultraviolet: a study comparing exposure distribution to the site incidence of solar keratoses, basal cell carcinoma and squamous cell carcinoma
Nathan Downs, Alfio Parisi
(Paper from Photochem. Photobiol. Sci.)
Nathan Downs, Photochem. Photobiol. Sci., 2009, DOI: 10.1039/b901741k
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)...
POSTED 06/11/2009 at 06:00 PM --
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Cellular dichotomy between anchorage-independent growth responses to bFGF and TPA reflects molecular switch in commitment to carcinogenesis
We have investigated gene expression patterns underlying reversible and irreversible anchorage-independent growth (AIG) phenotypes to identify more sensitive markers of cell transformation for studies directed at interrogating carcinogenesis responses. In JB6 mouse epidermal cells, basic fibroblast growth factor (bFGF) induces an unusually efficient and reversible AIG response, relative to 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced AIG which is irreversible. The reversible and irreversible AIG phenotypes are characterized by largely nonoverlapping global gene expression profiles. However, a subset of differentially expressed genes were identified as common to reversible and irreversible AIG phenotypes, including genes regulated in a reciprocal fashion. Hepatic leukemia factor (HLF......
POSTED 06/11/2009 at 06:00 PM --
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Basal Cell Carcinoma Presenting Late in a Shotgun Scar
(Source: American Journal of Clinical Dermatology)...
POSTED 06/07/2009 at 01:15 PM --
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Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
Conclusions:
Given the power of this study, we did not detect any contribution of genetic variants in the FGFR2 or FGFR4 genes to inherited predisposition to skin cancer among Caucasian women. (Source: BMC Cancer)...
POSTED 06/05/2009 at 11:00 PM --
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Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts
Mutations in Patched (PTCH) have been associated with tumors characteristic both for children [medulloblastoma (MB) and rhabdomyosarcoma (RMS)] and for elderly [basal cell carcinoma (BCC)]. The determinants of the variability in tumor onset and histology are unknown. We investigated the effects of the time-point and dosage of Ptch inactivation on tumor spectrum using conditional Ptch-knockout mice. Ptch heterozygosity induced prenatally resulted in the formation of RMS, which was accompanied by the silencing of the remaining wild-type Ptch allele. In contrast, RMS was observed neither after mono- nor biallelic postnatal deletion of Ptch. Postnatal biallelic deletion of Ptch led to BCC precancerous lesions of the gastrointestinal epithelium and mesenteric tumors. Hamartomatous gastrointesti......
POSTED 06/02/2009 at 11:00 PM --
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Randomized Comparison of Mohs Micrographic Surgery and Surgical Excision for Small Nodular Basal Cell Carcinoma: Tissue-Sparing Outcome
Mohs micrographic surgery (MMS) is recognized globally as the criterion standard for high-risk basal cell carcinoma (BCC). The main advantage of MMS over conventional surgery is the chance of complete tumor removal, but it is also thought, based on experience, to be tissue sparing. To determine whether MMS leaves smaller surgical defects than standard surgery. This was a randomized trial involving 30 patients with a clinical diagnosis of BCC. Patients were randomly assigned to MMS or standard surgery. In the standard surgery group the BCCs were excised with 4-mm margins. In the MMS group, tumors were excised with 2-mm margins and subsequent stages of MMS until the tumor was completely removed. An observer unaware of the treatment allocation calculated the defect size. The main outcome meas......
POSTED 06/02/2009 at 11:00 PM --
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Detection of basal cell carcinoma using color and histogram measures of semitranslucent areas
This study sought to analyze potential areas of semitranslucency with histogram-derived texture and color measures to discriminate BCC from non-semitranslucent areas in non-BCC skin lesions. For 210 dermoscopy images, the areas of semitranslucency in 42 BCCs and comparable areas of smoothness and color in 168 non-BCCs were selected manually. Six color measures and six texture measures were applied to the semitranslucent areas of the BCC and the comparable areas in the non-BCC images. Receiver operating characteristic (ROC) curve analysis showed that the texture measures alone provided greater separation of BCC from non-BCC than the color measures alone. Statistical analysis showed that the four most important measures of semitranslucency are three histogram measures: contrast, smoothness, ......
POSTED 06/01/2009 at 11:00 PM --
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Skin cancer
Abstract: Skin cancer is the most common cancer worldwide. Skin cancers most often arise from the epidermis (basal cell carcinoma and squamous cell carcinoma), but cancer may arise from any structure in the skin, including from the melanocytes (melanoma), blood vessels (e.g. angiosarcoma), adnexal structures (e.g. malignant sweat gland tumours) and the connective tissue (e.g. dermatofibrosarcoma protuberans). The skin can also be the site of lymphoma and metastasis from internal cancers, including carcinoma of the breast, colon and lung. This contribution focuses on the most common skin cancers: melanoma and the ‘non-melanoma’ skin cancers (squamous cell carcinoma and basal cell carcinoma), and briefly discusses infiltration of the skin with lymphoma. (Source: Medicine)...
POSTED 05/31/2009 at 11:00 PM --
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[Desmoplastic trichoepithelioma: A clinicopathological study, including a comparison with morpheiform basal cell carcinoma.]
Authors: Mitcov M, Scrivener Y, Cribier B
BACKGROUND: Desmoplastic trichoepithelioma (DTE) is an uncommon form of adnexal tumour that was described for the first time as a separate clinicopathological entity in 1976. We carried out a retrospective histopathological study of a large series of cases of DTE in order to better characterise this tumour and compare it with sclerodermiform basal cell carcinoma (BCC), which is in fact the most common as well as the most complex type of differential diagnosis. PATIENTS AND METHODS: We included in this study all cases of DTE diagnosed between 1979 and 2001 at our dermatopathology laboratory. The clinical features were taken from the patient files. Diagnosis was confirmed by two different examiners and all microscopic elements were reviewed. The ......
POSTED 05/31/2009 at 06:00 PM --
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Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?
Although deregulated Hedgehog signalling and elevated Gli transcription factor expression are known to promote the development of basal cell carcinoma (BCC), little is known about molecular mechanisms driving the development of specific growth pattern subtypes. Using gene array analysis, we have previously observed that over-expression of GLI1 in human keratinocytes promotes increased expression of the neuronal differentiation markers ARC and ULK1. We asked whether neuronal differentiation is a characteristic of BCC and whether there is any correlation with BCC subtype. Using RT-PCR and immunohistochemistry, we confirmed that the neuronal markers ARC, [beta]-tubulin III, GAP-43 and Neurofilament are expressed in human BCC but not in normal epidermis. Moreover, we found that expression of t......
POSTED 05/27/2009 at 11:00 PM --
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