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Angiosarcoma News Headlines
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All Recent Angiosarcoma News Headlines |
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Angiosarcoma of the scalp
Gupta Manjiri Das, Chakrabarti Nilay, Agrawal Pravin, Narurkar SwatiIndian Journal of Plastic Surgery 2009 42(1):118-121Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case of a 55-year-old female patient with a bleeding scalp lesion is presented. Initially thought to be a pyogenic granuloma, on excisional biopsy it was diagnosed as angiosarc......
POSTED 06/29/2009 at 10:07 AM --
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[Sarcomas] Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas
Conclusion
As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas. Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents. (Source: Journal of Clinical Oncology)...
POSTED 06/28/2009 at 06:00 PM --
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[Sarcomas] Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model
Conclusion
This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)...
POSTED 06/28/2009 at 06:00 PM --
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Outcome of Locally Recurrent and Metastatic Angiosarcoma
Conclusion Locally recurrent AS is often treatable; complete resection can potentially prolong survival. In contrast, metastatic patients
have a grave prognosis; however, patients with isolated lymphatic spread and possibly those treated with taxol-based chemotherapeutic
regimens have a favorable outcome.
Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0569-3Authors
G. Lahat, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAA. R. Dhuka, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAS. Lahat, The Sarcoma Research Center, University of Texas MD Anderson Cancer Center Houston TX USAK. D. Smith, University of Texas MD Anderson Cancer Center Departm......
POSTED 06/24/2009 at 01:08 AM --
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Secondary sarcomas after radiotherapy for breast cancer
The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angiosarcoma (AS) using the Surveillance, Epidemiology, and End Results (SEER) database.Women with BCa reported to SEER in 1973 to 2003 were included. Kaplan-Meier curves and proportional hazards models, reported as hazards ratios (HR) with 95% confidence intervals (95% CI), were used. Survival of patients who developed RT-associated AS was compared with that of patients with primary AS of the thorax and upper extremities.The cohort of 563,155 BCa patients was divided into 2 groups: those who received RT (37%) and those who received no RT. RT use increased with time (P 20 year......
POSTED 06/11/2009 at 11:00 PM --
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[CASE STUDIES] Pulmonary Angiosarcoma Presenting as Spontaneous Recurrent Hemothorax
An incidental diagnosis of pulmonary angiosarcoma was made after surgical exploration for repeated episodes of bleeding in an 85-year-old woman. Spontaneous hemothorax is uncommon and deserves detailed investigation. (Source: Asian Cardiovascular and Thoracic Annals)...
POSTED 06/09/2009 at 11:00 PM --
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Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib
A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angio......
POSTED 06/09/2009 at 10:10 AM --
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Spontaneous Regression of Pulmonary Metastases from Breast Angiosarcoma
We present a rare case of pulmonary metastases in a 72-year-old woman with metastatic breast angiosarcoma. She was diagnosed with a breast angiosarcoma in 2005 and underwent a total mastectomy and postoperative radiotherapy. Unfortunately, a year later she was found to have multiple lung and scalp metastases but in a view of her poor general fitness, she was not a candidate for chemotherapy and was kept on regular followup. Despite the absence of any treatment, the followup chest X-ray showed a significant reduction in the number and size of lung nodules and her scalp lesions regressed completely. Seven months after the diagnosis of metastatic disease, the nodules in her scalp remain controlled. (Source: Sarcoma)...
POSTED 06/09/2009 at 10:10 AM --
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Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway
In conclusion, SFRP2 is a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway and may be a favorable target for the inhibition of angiogenesis in solid tumors. [Cancer Res 2009;69(11):4621–8] (Source: Cancer Research)...
POSTED 05/31/2009 at 11:00 PM --
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Skin cancer
Abstract: Skin cancer is the most common cancer worldwide. Skin cancers most often arise from the epidermis (basal cell carcinoma and squamous cell carcinoma), but cancer may arise from any structure in the skin, including from the melanocytes (melanoma), blood vessels (e.g. angiosarcoma), adnexal structures (e.g. malignant sweat gland tumours) and the connective tissue (e.g. dermatofibrosarcoma protuberans). The skin can also be the site of lymphoma and metastasis from internal cancers, including carcinoma of the breast, colon and lung. This contribution focuses on the most common skin cancers: melanoma and the ‘non-melanoma’ skin cancers (squamous cell carcinoma and basal cell carcinoma), and briefly discusses infiltration of the skin with lymphoma. (Source: Medicine)...
POSTED 05/31/2009 at 11:00 PM --
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[Primary breast angiosarcoma: Two cases report.]
Authors: Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N
Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies. Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001. Based on a literature review, we analyse the epidemiological, pathological, clinical, diagnostic and treatment aspect of this type of cancer. Mastectomy is the reference treatment and the benefit of radiotherapy and chemotherapy remains to be demonstrated.
PMID: 19410492 [PubMed - in process] (Source: Cancer Radiotherapie)...
POSTED 05/31/2009 at 06:00 PM --
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Detecting angiosarcoma: Case study underscores importance of quick, accurate diagnosis
A quick and accurate diagnosis of angiosarcoma, followed by decisive treatment with a
multidisciplinary approach can help avoid regional and distant metastases of the tumor and lead to a favorable
prognosis, one expert says. (Source: Modern Medicine)...
POSTED 05/30/2009 at 12:32 PM --
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Angiosarcoma in children – still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study
BIEN E., STACHOWICZ-STENCEL T., BALCERSKA A., GODZINSKI J., KAZANOWSKA B., PEREK-POLNIK M., MADZIARA W., RYBCZYNSKA A., KURYLAK A., ZALEWSKA-SZEWCZYK B. & PEREGUD-POGORZELSKI J. (2009) European Journal of Cancer CareAngiosarcoma in children [ndash] still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study Angiosarcoma is a rare, highly malignant vascular neoplasm with little data available on its clinical course and management in children. Ten children with angiosarcoma (M/F: 6/4; aged 2, 3[ndash]16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006. Primary tumour exceeded 5 cm in seven patients and affected mainly deep tissues (heart-2, head/neck, bladder, brain, liver and upper limb [ndash] on......
POSTED 05/20/2009 at 11:00 PM --
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Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib
A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angio......
POSTED 05/20/2009 at 06:46 PM --
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[Intravascular papillary endothelial hyperplasia of the ankle: A case report.]
We report a case of cutaneous IPEH in the ankle of a 30-year-old girl, which was successfully treated by excision. The pathologic findings, differential diagnosis and a review of recent literature are discussed.
PMID: 19443095 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)...
POSTED 05/11/2009 at 06:00 PM --
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Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution
Conclusion: RIS is a biologically aggressive tumour with high rates of local relapse despite aggressive attempts at curative surgery. (Source: European Journal of Surgical Oncology)...
POSTED 05/10/2009 at 10:32 AM --
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Aortic angiosarcoma with cutaneous metastases.
We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass. Despite postresection recurrence, a 3-year survival was achieved with aggressive multidisciplinary management.
PMID: 19476753 [PubMed - in process] (Source: Vascular)...
POSTED 04/30/2009 at 06:00 PM --
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Hepatic angiosarcoma: a rare liver tumor in a hemodialysis patient.
Authors: Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y
PMID: 19473625 [PubMed - in process] (Source: Clinical Nephrology)...
POSTED 04/30/2009 at 06:00 PM --
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Primary angiosarcoma of the ovary complicated by hemoperitoneum: a case report and review of the literature
Conclusion Primary ovarian angiosarcoma is extremely rare, often presenting in later stages with nonspecific symptoms. Immunohistochemical
staining of pathological specimens can aid in the diagnosis. The optimal regimen for adjuvant chemotherapy is unknown, and
the prognosis is very poor.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1092-2Authors
Leslie Bradford, University of Wisconsin Hospital and Clinics Department of Obstetrics and Gynecology 600 Highland Ave, H4/648 Madison WI 53703 USAKathryn Swartz, Meriter Hospital Department of Pathology Madison WI USAStephen Rose, University of Wisconsin Hospital and Clinics Department of Obstetrics and Gynecology 600 Highland Ave, H4/648 Madison WI 53703 USA
Journal Archives of Gynecology an......
POSTED 04/25/2009 at 02:28 AM --
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Pancoast tobias syndrome revealing primary epithelioid pleuro-pericardial angiosarcoma: A case report and review of the literature
We report a unique case of primary epithelioid angiosarcoma of the pleura and the pericardium in
a 28-year-old man who was admitted for Pancoast Tobias syndrome. Thoracoscopy revealed a multifocal neoplasm and pleural biopsy
showed a malignant tumor which histological and immunophenotypical features were characteristic of epithelioid angiosarcoma.
Content Type Journal ArticleDOI 10.1007/s12055-009-0009-9Authors
Coulibaly Béma, CHU Timone Service d’Anatomie pathologique et de Neuropathologie 264 rue Saint Pierre 13385 Marseille cedex 05 FrancePayan Marie-José, CHU Timone Service d’Anatomie pathologique et de Neuropathologie 264 rue Saint Pierre 13385 Marseille cedex 05 FranceThomas Pascal, Hôpital Sainte Marguerite Service de Chirurgie thoracique et des maladies de l’œsopha......
POSTED 04/25/2009 at 02:23 AM --
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