Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity.
Authors: Ayadi L, Khabir A
Abstract Angiosarcomas are rare tumors that predominantly affect adults and elderly patients. Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment. Childhood angiosarcomas are exceedingly rare. The head and neck region and mediastinum seem to be the preferred locations. Most tumors are high-grade tumors. Vasoformative architecture is not always obvious on light microscopy requiring the benefit of immunohistochemical study. The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different. Complete resection is r......
POSTED 02/28/2010 at 06:00 PM --
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Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant
We report the case of a 48-year-old male who developed an angiosarcoma in a ligated native AV fistula. The lesion arose on the background of immunosuppression following a successful ABO-incompatible renal transplant for chronic renal failure.Angiosarcomas are extremely rare tumours but should be considered as a differential diagnosis for an evolving mass near the site of an AV fistula. Diagnosis relies on an index of suspicion and obtaining a definitive histological diagnosis. Both clinicians and patients should be aware that an evolving mass within or around an AV fistula should prompt urgent biopsy. J. Surg. Oncol. © 2010 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)...
POSTED 02/25/2010 at 06:00 PM --
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Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma
We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)...
POSTED 02/23/2010 at 06:00 PM --
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Protracted disseminated skeletal metastases from angiosarcoma of the spleen
Abstract Angiosarcomas are high-grade vascular tumors associated with poor prognosis due to their aggressive nature. Occasional skeletal
manifestations present commonly as osteolytic destruction. The 55-years-old patient presented in this case report had a disease-free
4 years interval between splenectomy after primary angiosarcoma of the spleen and an unusual skeletal metastatic pattern mimicking
benign angiomatosis. Despite lacking radiographic evidence for a highly aggressive osseous process, the histopathological
resemblance of the bone biopsy with the primary tumor manifestation and the fulminant course of disease after onset of disseminated
osseous spread confirmed the malignant character of the vascular tumor. The case demonstrates the highly variable radiograph......
POSTED 02/20/2010 at 12:53 AM --
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Expression of Vascular Notch Ligand Delta-Like 4 and Inflammatory Markers in Breast Cancer.
We examined 296 breast adenocarcinomas and 38 ductal carcinoma in situ tissues that were represented in tissue microarrays. Additional whole sections representing 10 breast adenocarcinomas, 10 normal breast tissues, and 16 angiosarcomas were included. Immunohistochemistry was then performed by using validated antibodies against Dll4, CD68, CD14, DC-SIGN, CD123, neutrophil elastase, CD31, and carbonic anhydrase 9. Dll4 was selectively expressed by intratumoral endothelial cells in 73% to 100% of breast adenocarcinomas, 18% of in situ ductal carcinomas, and all lactating breast cases, but not normal nonlactating breast. High intensity of endothelial Dll4 expression was a statistically significant adverse prognostic factor in univariate (P = 0.002 and P = 0.01) and multivariate analyses (P = ......
POSTED 02/17/2010 at 06:00 PM --
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[Diseases of the hepatobiliary system as a cause of acute abdomen.]
Authors: Schima W, Kölblinger C, Eisenhuber-Stadler E, Kulinna-Cosentini C, Ba-Ssalamah A
Diseases of the liver and biliary system are common causes of acute abdominal pain and gallstone disease predisposes to cholecystitis and cholangiolithiasis. Sonography is the method of choice for the assessment of cholecystitis, whereas magnetic resonance cholangiopancreaticography (MRCP) is the standard technique to detect stones in the common bile duct. Multi-detector computed tomography (MDCT) is ideal for detection of associated complications, including abscess formation and gall stone ileus. Pyogenic, amebic and fungal liver abscesses are reliably diagnosed with MDCT which can also be used for interventional radiologic therapy of liver abscesses by percutaneous aspiration or drainage pr......
POSTED 02/16/2010 at 06:00 PM --
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Angiosarcoma after breast-conserving therapy
With breast-conserving therapy (BCT) as the standard of care for patients with noninvasive and early stage invasive breast cancer, a small incidence of post-BCT angiosarcoma has emerged. The majority of therapeutic interventions have been unsuccessful. To the authors' knowledge, there is no consensus in the medical literature to date regarding the treatment of this malignancy. The current study was conducted to report the long-term outcomes of a novel approach using hyperfractionated and accelerated radiotherapy (HART) for angiosarcoma developing after BCT.The authors retrospectively reviewed the outcomes of 14 patients treated with HART with or without surgery at the University of Florida between November 1997 and March 2006 for angiosarcoma that developed after BCT.At the time of last fo......
POSTED 02/15/2010 at 06:00 PM --
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Preclinical Investigation of PEGylated Tumor Necrosis Factor {alpha} in Dogs with Spontaneous Tumors: Phase I Evaluation.
CONCLUSIONS: Using a clinically relevant, spontaneous large animal model of neoplasia, we have shown that biologically effective doses of PEG-TNF can be administered safely, and that PEG-TNF administration is associated with encouraging biological activity. These results justify the clinical evaluation of PEG-TNF in human cancer. Clin Cancer Res; 16(5); OF1-11.
PMID: 20160058 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)...
POSTED 02/15/2010 at 06:00 PM --
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Aortic Angiosarcoma: A Rare Cause for Leaking Thoracic Aneurysm
We report the case of a 56-year-old man whose initial presentation and investigations lead to emergency endovascular stenting
of a descending thoracic aneurysm with a contained leak. Initial response was favourable, yet the patient presented again
with worsening symptoms. The circum-aortic haematoma expanded by 50% on subsequent imaging, but no endoleak was identified.
When altered bone marrow signal was identified on magnetic resonance imaging, the possibility of malignancy was considered.
A metastatic skin lesion was then biopsied, which demonstrated morphological and immunohistochemical features consistent with
metastases from a pleomorphic sarcoma of the aorta.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00270-009-9776-3Authors
S. L. Hales, St. Mary’s Hospi......
POSTED 02/10/2010 at 12:52 AM --
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[Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta.]
We report a case revealed by skin metastasis. CASE REPORT: An 85-year-old man presented skin tumours associated with deterioration of his general condition and intense pain of the right lower limb. Physical examination showed three nodules of the lumbar area associated with an ipsilateral livedo extending to the right lower limb. The course of the disease involved distal ischaemia. Arterial ultrasound, aortography and CAT showed ectasia of the abdominal aorta with thrombosis and right subpopliteal occlusion. Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7. Stain for CD34 was negative. Histological investigation of the livedo showed a vascular embolus with epithelial-type cells positive f......
POSTED 01/31/2010 at 06:00 PM --
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Med Sci Monit 2010; 16(2):CR61-66 "Results of hepatic resection for primary hepatic angiosarcoma in adults"
Conclusions: Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture. (Source: Medical Science Monitor)...
POSTED 01/29/2010 at 09:18 AM --
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Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience
The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified. Clinicopathologic factors were reviewed. Characteristics of primary and secondary angiosarcoma were compared.Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified. The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma - 43 years versus 73 years (P < 0.0001). Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001). Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years. Median tumor size was 7.0 cm f......
POSTED 01/28/2010 at 06:00 PM --
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Primary Cardiac Angiosarcoma in a Young Woman
Case Rep Oncol 2010;3:2429 (DOI:10.1159/000273112) (Source: Karger Publishers)...
POSTED 01/22/2010 at 05:00 PM --
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Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses
Conclusions: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common. Very few reliable data are available concerning specificity of CD31 on cytological material. (Source: Cytopathology)...
POSTED 01/21/2010 at 06:00 PM --
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Angiosarcoma-like metastatic carcinoma of the liver.
Authors: Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T
Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described. The first case was a 53-year-old female with cystic liver tumors which were found 22 months after surgery for ureteral cancer. The second case was an 81-year-old female with multiple tumors in the liver and the pancreas, and a post-mortem examination was carried out. She had undergone surgery for skin cancer three years before. Both cases had an angiosarcoma-like appearance macroscopically and microscopically. Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but ca......
POSTED 01/21/2010 at 06:00 PM --
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Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall
Abstract Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and
outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected
from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity
between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of
71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy
1949–1988 developed angiosarcomas in edematous arms (Stewart–Treves syndrome) after median 11 years, and 17 females treated
by segm......
POSTED 01/19/2010 at 11:45 AM --
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Hepatic epithelioid hemangioendothelioma: review of three cases
We report the imaging features in three cases of histologically proven hepatic EHE. The imaging features suggestive of EHE will be emphasized, especially for multinodular lesions suggesting liver metastases in patients with no known primary extrahepatic malignancy. (Source: Clinical Imaging)...
POSTED 12/31/2009 at 06:00 PM --
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Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen.
We report on a 15-year-old boy who presented with right TMJ swelling and subsequently developed epigastric and right upper quadrant pain. The TMJ swelling proved to be odontogenic myxofibroma and the abdominal pain was a result of primary splenic angiosarcoma with hepatic metastasis. We report for the first time the synchronous presentation of PAS and odontogenic myxofibroma in a paediatric patient, and we describe the radiological features along with the histological diagnosis and clinical outcome. Uptake in (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography is also described for the first time for both these tumours.
PMID: 20139242 [PubMed - in process] (Source: The British Journal of Radiology)...
POSTED 12/31/2009 at 06:00 PM --
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Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung
We report
a case with focus on immunocytochemistry of imprint cytological specimens here. A 43-year-old Japanese man presented with
cough. Brushing cytology of the tumor using a bronchoscope showed a malignant neoplasm. Subsequently, left lower lobectomy
was undertaken. Imprint cytological material of the neoplastic cells noted some clusters of round, or oval, to polygonal epithelioid
cells. Histological examination showed the proliferation of epithelioid neoplastic cells containing erythrocytes in the cytoplasm.
The immunocytochemistry in imprint cytological specimens showed a focal positive reaction for von Willebrand factor, and the
immunohistochemistry of the surgically resected lung tumor showed a focal positive reaction for Fli-1, von Willebrand factor,
CD31, and CD34. Finally......
POSTED 12/23/2009 at 05:03 PM --
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Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib
(Source: British Journal of Dermatology)...
POSTED 12/21/2009 at 06:00 PM --
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