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Angiosarcoma of the scalp with metastasis to the gingiva.

Acta Derm Venereol. 2008;88(5):512-3

Authors: Tanabe K, Masuzawa M, Aki R, Masuzawa M, Arai S, Hayakawa K, Katsuoka K, Kobayashi T

PMID: 18779896 [PubMed - in process]

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Sinonasal intravascular papillary endothelial hyperplasia successfully treated by endoscopic excision: A case report and review of the literature.

Auris Nasus Larynx. 2008 Sep 8;

Authors: Wang ZH, Hsin CH, Chen SY, Lo CY, Cheng PW

BACKGROUND: Intravascular papillary endothelial hyperplasia (IPEH) is an abundant, usually intravascular, benign endothelial proliferation that may mimic angiosarcoma clinically and histopathologically. Its occurrence in the sinonasal cavity is extremely rare. To the best of our knowledge, we present the first case with the most extensive IPEH ever found within the sinonasal cavity. METHODS: A 42-year-old man of intravascular papillary endothelial hyperplasia in the sinonasal cavity was reported. He complained of a 1-year history of left-sided nasal obstruction accompanied by unilateral rhinorrhea, repeated epistaxes and frontal headache. Anterior rhinoscopy demonstrated a smooth-surfaced reddish mass occupying the left nasal cavity. Endoscopic surgery was used to clear this uncommon tumor in the sinonasal cavity. A review of the pertinent literature was also presented. CONCLUSIONS: IPEH may be mistaken for an angiosarcoma clinically and histopathologically. Complete endoscope-guided surgical excision is the best choice of therapy for patients with IPEH and is both diagnostic and curative. Awareness of this lesion will prevent incorrect diagnosis and overly aggressive treatment.

PMID: 18783901 [PubMed - as supplied by publisher]

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Paclitaxel in patients with advanced angiosarcomas of soft tissue: A retrospective study of the EORTC soft tissue and bone sarcoma group.

Eur J Cancer. 2008 Sep 2;

Authors: Schlemmer M, Reichardt P, Verweij J, Hartmann JT, Judson I, Thyss A, Hogendoorn PC, Marreaud S, Glabbeke MV, Blay JY

RATIONALE: Angiosarcomas of soft tissue represent a heterogenous group of rare sarcomas with specific clinical behaviour and risk factors. Paclitaxel appears to induce tumour control in a higher proportion of patients with angiosarcoma, as compared to other sarcomas. The objective of this retrospective study was to assess the anti-tumour activity of this compound in a multicentre setting. METHOD: Clinical data from patients with angiosarcomas of soft tissue treated with single agent paclitaxel were collected from the centres of the soft tissue and bone sarcoma group of EORTC, using a standardised data collection form. Paclitaxel could be given every three weeks, or weekly. Statistical analysis was performed using SAS software. RESULTS: Data from 32 patients were collected from 10 centres. There were 17 males, 15 females, with a median age of 60.4 years (range, 25-91). Primary angiosarcomas were located in scalp and face in 8 patients (25%) and at other primary sites in 24 patients (75%). All patients had intermediate (n=13) or high grade (n=19) primary tumours. Thirteen (40%) patients had been pretreated with doxorubicin-based first-line-chemotherapy and three of them (9%) had also received second-line chemotherapy with ifosfamide. Eleven (34%) patients had been irradiated before as treatment for angiosarcoma. In 8 (25%) patients, the angiosarcoma occurred at sites of prior radiation therapy for other malignancies. The response rate was 62% (21/32) in the whole series, 75% (6/8) in scalp angiosarcomas and 58% (14/24) in other primary sites. The median time to progression was 7.6 months (range, 1-42) for the whole group. For the face/scalp group it was 9.5 months, and for patients with angiosarcomas at other sites it was 7.0 months, respectively. CONCLUSION: Paclitaxel was found to be an active agent in angiosarcoma of soft tissue in this retrospective analysis. These results need to be confirmed in a prospective randomised phase II study.

PMID: 18771914 [PubMed - as supplied by publisher]

Papillary endothelial hyperplasia of the adrenal gland: report of a case and review of the literature.

Am Surg. 2008 Sep;74(9):813-6

Authors: Constantinou C, Sheldon D

Papillary endothelial hyperplasia (PEH) is a benign vascular proliferative process most frequently seen in the skin and integument, but may involve any of the visceral organs. It is a rare entity, with less than 30 cases of visceral PEH described in the literature. Adrenal papillary endothelial hyperplasia is an exceedingly rare process and is the basis of this review. A 66-year-old female was referred for evaluation of an asymptomatic 6 cm right adrenal mass. Computed tomography indicated that the lesion was solid and hypervascular. After appropriate workup, the patient underwent laparoscopic adrenalectomy. The pathologic analysis was consistent with adrenal PEH. The patient recovered without incident and is doing well at 1 year follow-up. A review of the world's literature on papillary endothelial hyperplasia (PEH), and in particular adrenal PEH, yields five previous reports of this entity, and no comprehensive review. A compilation of the now six patients with adrenal PEH reveals several common features: five of six patients were female and mean age was 64 years. The disease radiologically mimics adrenal cortical carcinoma mandating a surgical oncological technique. Pathologic differentiation from angiosarcoma can be a difficult task requiring evaluation by an experienced pathologist.

PMID: 18807668 [PubMed - in process]

Angiosarcoma of the scalp mimicking a sebaceous cyst.

Dermatol Online J. 2008;14(6):13

Authors: Pan Z, Albertson D, Bhuller A, Wang B, Shehan JM, Sarma DP

A 58-year-old Caucasian woman presented with a cystic lump behind the right ear that was clinically diagnosed as an infected sebaceous cyst. The lesion was treated with incision and drainage followed by antibiotics for 3 months. Because there was no resolution, a biopsy was performed that revealed a high grade angiosarcoma. She expired 2 months later. Cutaneous angiosarcoma is an extremely aggressive tumor. Therefore early diagnosis and management is crucial in providing better patient care.

PMID: 18713594 [PubMed - in process]

Primary cutaneous epithelioid angiosarcoma.

Acta Derm Venereol. 2008;88(4):422-3

Authors: Kikuchi A, Satoh T, Yokozeki H

PMID: 18709328 [PubMed - in process]

Targeted Microbubbles for Imaging Tumor Angiogenesis: Assessment of Whole-Body Biodistribution with Dynamic Micro-PET in Mice.

Radiology. 2008 Aug 11;

Authors: Willmann JK, Cheng Z, Davis C, Lutz AM, Schipper ML, Nielsen CH, Gambhir SS

Purpose: To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice. Materials and Methods: Animal protocols were approved by the Institutional Administrative Panel on Laboratory Animal Care. Lipid-shell perfluorocarbon-filled MBs, targeted to VEGFR2 via anti-VEGFR2 antibodies, were radiolabeled by conjugating the radiofluorination agent N-succinimidyl-4-[(18)F]fluorobenzoate (SFB) to the anti-VEGFR2 antibodies. These MBs were then injected intravenously into nude mice (n = 4) bearing angiosarcomas, and the whole-body biodistribution of these probes was assessed for 60 minutes by using dynamic micro-PET. Results were compared with ex vivo gamma counting (n = 6) and immunofluorescence staining (n = 6). Control studies in angiosarcoma-bearing mice were performed with injection of the radiolabeled antibodies alone (n = 3) or free SFB (n = 3). A mixed-effects regression of MB accumulation on fixed effects of time and tissue type (tumor or muscle) and random effect of animal was performed. Results: VEGFR2-targeted MBs rapidly cleared from the blood circulation (50% blood clearance after approximately 3.5 minutes) and accumulated in the liver (mean, 33.4% injected dose [ID]/g +/- 13.7 [standard deviation] at 60 minutes) and spleen (mean, 9.3% ID/g +/- 6.5 at 60 minutes) on the basis of micro-PET imaging. These findings were confirmed with ex vivo gamma counting. Uptake of targeted MBs was significantly higher (P < .0001) in tumor than in adjacent skeletal muscle tissue. Immunofluorescence staining demonstrated accumulation of the targeted MBs within hepatic Kupffer cells and splenic macrophages. Biodistribution of the radiolabeled antibodies and free SFB differed from the distribution of the targeted MBs. Conclusion: Dynamic micro-PET allows assessment of in vivo biodistribution of VEGFR2-targeted MBs. (c) RSNA, 2008.

PMID: 18695212 [PubMed - as supplied by publisher]

Hepatic artery aneurysm secondary to epithelioid angiosarcoma.

Can J Surg. 2008 Aug;51(4):E81-2

Authors: Davis VW, Somani K, Chaba TP, Andruchow J, Shapiro AM

PMID: 18815634 [PubMed - in process]

Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta).

J Med Primatol. 2008 Jul 30;

Authors: Mejía AF, Gierbolini L, Jacob B, Westmoreland SV

Background Pediatric hepatic angiosarcoma is a rare condition in children with poor prognosis. Microscopically this neoplasm has a particular 'Kaposi-form' arrangement. Hemangiosarcoma in non-human primates is a rare finding. Methods Gross and microscopic examination of a 3-year-old rhesus were performed. Immunohistochemistry was used to characterize the hepatic hemangiosarcoma. Results The gross necropsy revealed hemoabdomen and a 4 x 3 x 3 cm mass in the liver with multiple smaller masses throughout the hepatic parenchyma. Histopathology confirmed a poorly differentiated hemangiosarcoma. Other organs submitted were free of metastases. Conclusions Hemangiosarcoma in non-human primates has been rarely reported. Diagnosis was confirmed by expression of endothelial-specific markers CD31 and vWF by immunohistochemistry. Due to the young age of this monkey and the particular solid pattern throughout the mass this neoplasm resembles pediatric hepatic angiosarcoma in humans.

PMID: 18671765 [PubMed - as supplied by publisher]