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Adenocarcinoma News Headlines
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All Recent Adenocarcinoma News Headlines |
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Screening and surveillance of Barrett's esophagus.
Authors: Regula J
Screening and surveillance of Barrett's esophagus is a matter of discussion in the current world literature due to uncertainties concerning its cost-effectiveness. Important and valid arguments for and against it are available. Despite the fact that this issue is still to be resolved, screening using standard gastroscopy once in a lifetime and surveillance using repeated endoscopies with multiple blind biopsies are widely practiced by individual gastroenterologists. Further studies that mainly focus on finding better predictors of progression to cancer are needed to be able to prepare clear and useful guidelines. The ultimate aim of screening and surveillance should be decrease in mortality from esophageal adenocarcinoma resulting from Barrett's esophagus.
PMID: 1......
POSTED 07/01/2009 at 11:18 AM --
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Chemoprevention of adenocarcinoma associated with Barrett's esophagus: potential options.
This article focuses on known and postulated targets for prevention of distal esophageal cancer.
PMID: 19439956 [PubMed - indexed for MEDLINE] (Source: Cancer Control)...
POSTED 07/01/2009 at 11:18 AM --
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Duodenal stump cancer after Billroth-II distal gastrectomy for gastric cancer.
Authors: Lee J, Lee K, Kim W
Duodenal cancer is an uncommon neoplasm and it mostly arises from the periampullary area. However, metachronous or even recurrent cancer at the duodenal stump following Billroth II type distal gastrec tomy for gastric cancer is extremely rare and, to our knowledge, has not yet been reported. A 68-year-old man underwent Billroth II distal gastrectomy with D2 lymph node dissection for an advanced gastric cancer. At that time the tumor stage was T2bN3M0, with 44 of 78 retrieved lymph nodes showing metastasis. He was well without recurrence for 3 years; however, he visited our hospital because of the abrupt onset of dizziness and tarry stool. A polypoid tumor that bled easily when touched was found at the end of the afferent loop of the duodenal stump by gastro......
POSTED 07/01/2009 at 11:18 AM --
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New double-stapling technique for esophagojejunostomy and esophagogastrostomy in gastric cancer surgery, using a peroral intraluminal approach with a digital stapling system.
We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler - the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and they are approximated; the stapler device is then fired to form a double-stapled esophagojejunostomy and esophagogastrostomy. Our peroral intraluminal approach does not require a ......
POSTED 07/01/2009 at 11:18 AM --
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Sutent Significantly Improved Progression-Free Survival For Patients With Advanced Pancreatic Islet Cell Tumours
Pfizer announced preliminary results from a randomized Phase 3 trial of Sutent (sunitinib malate) in patients with advanced pancreatic islet cell tumours, also known as pancreatic neuroendocrine tumours, which is a different type of cancer than the more common pancreatic adenocarcinoma. Study findings demonstrated that median progression-free survival (PFS) was 11. (Source: Health News from Medical News Today)...
POSTED 07/01/2009 at 03:00 AM --
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Predictors of long-term survival after resection of esophageal carcinoma with nonregional nodal metastases.
CONCLUSIONS: Surgical resection for patients with esophageal cancer associated with nonregional nodal metastases results in 25% survival at five years. Squamous histology, earlier T status, and perioperative chemotherapy are independent positive predictors of long-term survival.
PMID: 19559222 [PubMed - in process] (Source: The Annals of Thoracic Surgery)...
POSTED 06/30/2009 at 06:00 PM --
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Ferritin Heavy Chain-Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition
The epithelial-mesenchymal transition (EMT) plays a critical role in tumor progression. To obtain a broad view of the molecules involved in EMT, we carried out a comparative proteomic analysis of transforming growth factor-β1 (TGF-β1)–induced EMT in AML-12 murine hepatocytes. A total of 36 proteins with significant alterations in abundance were identified. Among these proteins, ferritin heavy chain (FHC), a cellular iron storage protein, was characterized as a novel modulator in TGF-β1–induced EMT. In response to TGF-β1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP). Abolishing the increase in LIP blocked TGF-β1–induced EMT. In addition, increa......
POSTED 06/30/2009 at 06:00 PM --
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miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non-Small Cell Lung Cancer
MicroRNAs (miRNA) are negative regulators of gene expression at the posttranscriptional level, which are involved in tumorigenesis. Two miRNAs, miR-15a and miR-16, which are located at chromosome 13q14, have been implicated in cell cycle control and apoptosis, but little information is available about their role in solid tumors. To address this question, we established a protocol to quantify miRNAs from laser capture microdissected tissues. Here, we show that miR-15a/miR-16 are frequently deleted or down-regulated in squamous cell carcinomas and adenocarcinomas of the lung. In these tumors, expression of miR-15a/miR-16 inversely correlates with the expression of cyclin D1. In non–small cell lung cancer (NSCLC) cell lines, cyclins D1, D2, and E1 are directly regulated by physiologic c......
POSTED 06/30/2009 at 06:00 PM --
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TORAKOCHIRURGIA Results of pneumonectomy in non-small cell lung cancer patients
Conclusions: A man older than 67, with right sided large cell carcinoma that has stage higher than IIa, is the worst candidate for pneumonectomy concerning complications and long-term survival. Thus, pneumonectomy is a procedure of high risk of death and complications with a poor long-term survival and should be limited only to selected patients. (Source: Articles of Polish Journal of Cardio-Thoracic Surgery - TERMEDIA publishing house)...
POSTED 06/30/2009 at 08:45 AM --
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Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers
Aberrant promoter hypermethylation is one of the major mechanisms in carcinogenesis and some critical growth regulatory genes have shown commonality in methylation across solid tumors. Twenty-six genes, 14 identified through methylation in colon and breast cancers, were evaluated using primary lung adenocarcinomas (n = 175) from current, former and never smokers. Tumor specificity of methylation was validated through comparison of 14 lung cancer cell lines to normal human bronchial epithelial cells derived from bronchoscopy of 20 cancer-free smokers. Twenty-five genes were methylated in 11–81% of primary tumors. Prevalence for methylation of TNFRSF10C, BHLHB5 and BOLL was significantly higher in adenocarcinomas from never smokers than smokers. The relation between methylation of indi......
POSTED 06/29/2009 at 06:00 PM --
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Primary adenosquamous carcinoma of the colon: Report of five cases
This report presents five cases of Ad-SCC of the colon to explore the clinicopathological
features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the
infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis
and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00595-008-3884-6Authors
Yingchun Dong, Medical School of Nanjing University, Nanjing Stomatology Hospital Department of Anesthesiology Nanjing PR ChinaJiandong Wang, Nanjing Jinling Hospital Department of Pathology 305 Zhongshan Dong Lu Nanjing 210002 PR ChinaHenghui Ma, Nanjing Jinling Hospital Department ......
POSTED 06/29/2009 at 08:55 AM --
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Gefitinib and a ventriculo-peritoneal shunt to manage carcinomatous meningitis from non-small-cell lung cancer: Report of two cases
We report the successful treatment
of two cases of carcinomatous meningitis caused by NSCLC, using gefitinib and a ventriculo-peritoneal (V-P) shunt. The first
patient was a 43-year-old woman with pT1N0M0 adenocarcinoma. Multiple brain and vertebral metastases were found 13 months
after surgery. She had undergone gamma-knife radiosurgery for the brain metastases, radiotherapy for the vertebral metastases,
and two regimens of systemic chemotherapy, before carcinomatous meningitis was diagnosed. She was given gefitinib, and then
a V-P shunt was placed. She continued to take gefitinib and was free of subjected symptoms for 5 months until she died. The
second patient was a 64-year-old woman with cT4N0M0 adenocarcinoma. After local chemotherapy using cisplatin and OK-432 for
carcinomatos......
POSTED 06/29/2009 at 08:55 AM --
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Cronkhite-Canada syndrome complicated with huge intramucosal gastric cancer
This report documents a 59-year-old Japanese man with CCS who underwent a total gastrectomy for gastric tumors. The
resected specimen showed a huge gastric adenocarcinoma with numerous polyps throughout the stomach. The cancer was pathologically
limited to within the mucosa and its histological structure resembled that of hyperplasia in CCS polyps, which led us to suppose
that the carcinoma had arisen from hyperplastic CCS polyps. These results urged us to study the phenotypic expression of mucins,
which revealed MUC2(−) and MUC5AC(+) and supported the diagnosis of the tumor as a gastric-type well-differentiate adenocarcinoma.
A literature search revealed that 32 gastric carcinomas which developed in patients with CCS were mostly limited to within
the submucosa in spite of their hu......
POSTED 06/29/2009 at 08:47 AM --
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New double-stapling technique for esophagojejunostomy and esophagogastrostomy in gastric cancer surgery, using a peroral intraluminal approach with a digital stapling system
We describe a new double-stapling technique for esophagojejunostomy and
esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control
stapler — the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared
with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance
by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal
esophagus and connected to the anvil and they are approximated; the stapler device is then fired to form a double-stapled
esophagojejunostomy and esophagogastrostomy. Our peroral intraluminal approach does not re......
POSTED 06/29/2009 at 08:47 AM --
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11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness
Conclusions While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness
of clinical stage IA lung adenocarcinoma as well as FDG-PET.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0278-9Authors
Hidekatsu Shibata, Kumamoto University Department of Thoracic Surgery, Graduate School of Medical and Pharmaceutical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanHiroaki Nomori, Kumamoto University Department of Thoracic Surgery, Graduate School of Medical and Pharmaceutical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanKimiichi Uno, Nishidai Clinic Tokyo JapanKen-ichi Iyama, Kumamoto University Department of Pathology, Graduate School of Medical and Pharmaceutical Sciences Kumamoto J......
POSTED 06/29/2009 at 08:46 AM --
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Synchronous Gastrointestinal Stromal Tumor and Adenocarcinoma at the Gastroesophageal Junction
We report the case of a 75-year-old man who had a concurrent gastrointestinal stromal tumor and adenocarcinoma at the gastroesophageal junction. The two tumo ...more (Source: The Kaohsiung Journal of Medical Sciences)...
POSTED 06/29/2009 at 05:50 AM --
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Laparoscopic right hemicolectomy for intestinal intussuception
Conclusion When operative intervention is required, intussuception may be managed using a minimally invasive technique. However, large
bowel intussuception in adults may have a malignant cause thus laparoscopic resection should only be performed by surgeons
experienced in laparoscopic resections for colorectal malignancies as oncological safety must be the primary concern. This
laparoscopic approach facilitates rapid recovery and earlier time to adjuvant therapy if required.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11845-009-0383-8Authors
F. Kiernan, Adelaide and Meath Hospital Division of Minimally Invasive Surgery, Department of General Surgery Tallaght Dublin 24 IrelandM. Joyce, Adelaide and Meath Hospital Division of Minimally Invasive Surgery......
POSTED 06/29/2009 at 05:43 AM --
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Editorial - Ductal Adenocarcinoma of the Prostate: Clinical Features and Implications After ...
BERKELEY, CA (UroToday.com) - On occasion, urologists will encounter subtypes of prostate cancer (CaP) other than adenocarcinoma. (Source: UroToday)...
POSTED 06/28/2009 at 06:05 PM --
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[ORIGINAL ARTICLES: GENERAL THORACIC] Predictors of Long-Term Survival After Resection of Esophageal Carcinoma With Nonregional Nodal Metastases
Conclusions
Surgical resection for patients with esophageal cancer associated with nonregional nodal metastases results in 25% survival at five years. Squamous histology, earlier T status, and perioperative chemotherapy are independent positive predictors of long-term survival. (Source: The Annals of Thoracic Surgery)...
POSTED 06/28/2009 at 06:00 PM --
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Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling.
In this study, two different PDAC cell lines were used to examine the effect of small interfering (si) RNAs to uPAR, uPA and PAI-2 on proliferation, apoptosis, migration and MAP kinase activation. In both PDAC cell lines, siRNA to uPAR significantly inhibited cell proliferation and migration and stimulated apoptosis, to a greater extent than uPA siRNA. When either PDAC cell line was treated with uPAR siRNA, the level of phosphorylated ERK (p-ERK) decreased substantially, whereas phosphorylated p38 (p-p38) increased when compared to non-silencing control, uPA siRNA or PAI-2 siRNA treatment. This resulted in enhancement of the p-p38/p-ERK ratio which favors cancer cell arrest. Interestingly, uPAR protein expression was suppressed by p-ERK inhibition and stimulated with p-p38 inhibition, sugg......
POSTED 06/27/2009 at 11:02 PM --
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