Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study
Conclusions:
These studies indicate that proteasome inhibition tailored to block NF-kappaB activation of lung adenocarcinoma specifically targets the effusion-inducing phenotype of this tumor. Although the drug has limited activity against advanced solid lung cancer, it may prove beneficial for patients with MPE. (Source: Molecular Cancer)...
POSTED 03/09/2010 at 06:00 PM --
|
Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.
Authors: Abadi AH, Gary BD, Tinsley HN, Piazza GA, Abdel-Halim M
The synthesis of novel tadalafil analogues in which the benzodioxole moiety is replaced by 2-bromophenyl; the chiral carbons swing from R,R to R,S, S,R and S,S; the piperazinedione ring is maintained or reduced to the 5-membered imidazolidinedione or thioxoimidazolinone is described. The prepared analogues were evaluated for their capacity to inhibit the cyclic guanosine monophosphate (cGMP) selective phosphodiesterase 5 (PDE5) isozyme and the growth of human HT-29 colon adenocarcinoma cells. The R absolute configuration of C-5 in the beta-carboline-hydantoin and C-6 in the beta-carboline-piperazinedione derivatives was found to be essential for the PDE5 inhibition. In addition, tadalafil analogues that were synthesized f......
POSTED 03/09/2010 at 03:12 PM --
|
Molecular detection of host cytokine expression in
Hosseini M Eshagh, Oghalaie A, Habibi G, Nahvijoo A, Hosseini Z M, Tashakoripoor M, Mohammadi MIndian Journal of Medical Microbiology 2010 28(1):40-44Background: Helicobacter pylori (Hp) is a bacterium recognised as a main causative agent for the development of chronic active gastritis, peptic ulcer disease, gastric adenocarcinoma and primary gastric lymphoma. Objective: Determination of the levels of IFN-γ (pro-inflammatory) and IL-4 (anti inflammatory) cytokine expression as indicators of Th1 and Th2 immune responses in gastric cancer (GC) and non gastric cancer (Non GC) dyspeptic patients by gene specific RT-PCR. Materials and Methods: Biopsy specimens were collected from three groups of gastric cancer (GC=18), non ulcer dyspepsia (NUD = 38) and peptic ulcer patients (PU......
POSTED 03/09/2010 at 11:15 AM --
|
Prognostic significance of focal neuroendocrine differentiation in prostate cancer: Cases with autopsy-verified cause of death
Conclusions : Focal NED seems to be a powerful negative prognostic parameter in prostate adenocarcinomas. The outcome of the disease in prostate cancer can be accurately predicted based on focal NED of the tumor cells either alone or in combination with Gleason score. (Source: Indian Journal of Urology)...
POSTED 03/09/2010 at 10:12 AM --
|
Metastasis of colon cancer to the thyroid gland: A case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach
Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms. However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging. In particular, metastasis of colon cancer to the thyroid gland is very rare. In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated. FNA cytology showed necrosis and atypical tall columnar cells; since, the patient at age 60 had undergone surgery for a sigmoid-rectal cancer metastasizing to the liver and subsequently to the lung, a suspicion of metastasis from colon cancer was raised. This was corroborated by cell-block immunocytochemistry showing a cytokeratin (CK) 7 negative/CK20-positive staining pattern; thyreoglobulin and TTF-1 ......
POSTED 03/08/2010 at 06:00 PM --
|
Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?
Conclusions:
Our findings points to the involvement of inflammation in the destruction of the blood MDCs and PDCs. Furthermore, the preservation of the blood DCs compartment in PDAC patients seems to benefit their ability to control the disease and survival. (Source: BMC Cancer)...
POSTED 03/08/2010 at 06:00 PM --
|
Adenocarcinoma of Colon Presenting As Cushing's Syndrome [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)...
POSTED 03/08/2010 at 05:01 PM --
|
Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704 [Gastrointestinal Cancer]
Conclusion
Cellular levels of histone modifications define previously unrecognized subsets of patients with pancreatic adenocarcinoma with distinct epigenetic phenotypes and clinical outcomes and represent prognostic and predictive biomarkers that could inform clinical decisions, including the use of fluorouracil chemotherapy. (Source: Journal of Clinical Oncology)...
POSTED 03/08/2010 at 05:01 PM --
|
Endoscopic Resection for Barrett's Esophagus Usually Avoids Surgery
In patients with Barrett's high-grade dysplasia or early esophageal adenocarcinoma, endoscopic resection improves staging and "dramatically" reduces esophagectomy rates, Australian physicians report. Reuters Health Information (Source: Medscape Gastroenterology Headlines)...
POSTED 03/08/2010 at 12:04 PM --
|
NSAID, Statin Use May Cut Cancer Risk With PPI-Treated Barrett's Esophagus
A study shows that nonsteroidal anti-inflammatory drugs and statins can nearly halve the risk for esophageal adenocarcinoma in patients taking proton-pump inhibitors for Barrett's esophagus. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)...
POSTED 03/08/2010 at 07:36 AM --
|
Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts.
We examined the differences between the clinicopathological characteristics of the Mod and the Wel groups.Results The lymph node involvement (p (Source: BMC Surgery)...
POSTED 03/07/2010 at 06:00 PM --
|
Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas.
CONCLUSION: Different from the traditional point of view, the well differentiated cancer tissues have more alterations of important tumor-related genes than the poorly differentiated cancer tissues.
PMID: 20205286 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 03/06/2010 at 06:00 PM --
|
The role of oxidative DNA damage, DNA repair, GSTM1, SOD2 and OGG1 polymorphisms in individual susceptibility to Barrett's esophagus
Determination of the genetic alterations, which play a role in the etiology of Barrett’s esophagus (BE), could help identify high-risk individuals for esophageal adenocarcinoma (EA). The aim of the present study was to investigate the role of oxidative DNA damage, glutathione (GSH) concentration as oxidative stress parameters and DNA repair capacity, GSTM1, SOD1 Ala16Val and OGG1 Ser326Cys genetic polymorphisms as individual susceptibility parameters in the etiology of BE. The study groups comprised BE patients who were clinically diagnosed (n = 40) and a healthy control group (n = 40). Basal DNA damage, pyrimidine and purine base damage after H2O2 induction, H 2O2 sensitivity, DNA repair capacity, oxidized pyrimidine and purine base damage repair were evaluated in peripheral blood l......
POSTED 03/05/2010 at 05:44 AM --
|
Aetiology and classification of adenocarcinoma of the gastro-oesophageal junction/cardia
(Source: Gut)...
POSTED 03/05/2010 at 05:12 AM --
|
Chemotherapy-induced reversible posterior leucoencephalopathy syndrome
We describe the case of a 55-year-old woman with advanced pancreatic adenocarcinoma, who developed clinical and radiological manifestations consistent with this syndrome as a complication of gemcitabine monotherapy. (Source: Internal Medicine Journal)...
POSTED 03/04/2010 at 06:00 PM --
|
Uterine Tumors with Neuroectodermal Differentiation. A Report of 4 Cases.
We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic p......
POSTED 03/04/2010 at 06:00 PM --
|
Fixed-dose-rate gemcitabine: a viable first-line treatment option for advanced pancreatic and biliary tract cancer.
Conclusions. Currently available evidence, including this updated analysis, supports the use of FDR-Gem as a first-line option in advanced PDAC, and possibly in BTC, patients and prompts the continued evaluation of this approach in combination regimens.
PMID: 20189980 [PubMed - in process] (Source: The Oncologist)...
POSTED 03/04/2010 at 05:04 PM --
|
Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells
Carcinosarcoma of the pancreas is extremely rare and its histogenesis is still unclear. This is a report on a 64-year-old female patient with an intraductal carcinosarcoma arising from intraductal papillary-mucinous carcinoma (IPMC) in the pancreas tail. The carcinosarcoma grew as a polypoid mass within the main pancreatic duct. Histologically, the tumour consisted of adenocarcinoma covering the luminal surface of the lesion with minimal stromal invasion, and osteosarcoma occupying the stroma. Immunohistochemical and gene mutation analyses revealed that both the carcinomatous and sarcomatous tumour cells of the carcinosarcoma, as well as the IPMC cells, expressed TP53 and had identical mutations in KRAS and TP53 genes, indicating that these two neoplastic components of the carcinosarcoma s......
POSTED 03/04/2010 at 09:42 AM --
|
Dendreon Presents Updated IMPACT Results Confirming Provenge Improves Overall Survival in Patients With Metastatic Castrate-Resistant Prostate Cancer
-- Data to be Presented at ASCO-GU Annual Symposium
--
SEATTLE, March 3 /PRNewswire-FirstCall/ -- Dendreon Corporation
(NASDAQ: DNDN) today announced updated results
from its pivotal Phase 3 IMPACT (IMmunotherapy for Prostate
AdenoCarcinoma... (Source: Drugs.com - Clinical Trials)...
POSTED 03/04/2010 at 07:52 AM --
|
Dendreon Presents Updated IMPACT Results Confirming PROVENGE Improves Overall Survival In Patients With Metastatic Castrate-Resistant Prostate Cancer
Dendreon Corporation (Nasdaq: DNDN) announced updated results from its pivotal Phase 3 IMPACT (IMmunotherapy for Prostate AdenoCarcinoma Treatment) study demonstrating that PROVENGE® (sipuleucel-T) extends overall survival in men with metastatic, castrate-resistant (hormone-refractory) prostate cancer (CRPC)... (Source: Pharma Industry News From Medical News Today)...
POSTED 03/04/2010 at 07:00 AM --
|
