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Adenocarcinoma News Headlines
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All Recent Adenocarcinoma News Headlines |
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Tumor budding identified as predictor for unfavorable outcome in lung cancer
(International Association for the Study of Lung Cancer) Lung cancer is the leading cause of cancer deaths worldwide, and the prognosis is generally poor, even if surgery is successful. Furthermore, the incidence of one type of lung cancer, adenocarcinoma, has been increasing in recent years. (Source: EurekAlert! - Medicine and Health)...
POSTED 08/31/2010 at 11:00 PM --
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Endometrioid Adenocarcinoma in the Native Ureter of a Renal Transplant Patient: Case Report and Review of the Literature
Endometriosis is a common and often debilitating gynecological condition in which endometrial cells flourish outside the uterus, typically on the ovaries. Although considered benign, endometriosis may undergo transformation into a cancerous condition known as endometrioid adenocarcinoma. This typically arises from ovarian endometriosis, but may occur in extragonadal sites in nearly 25% of cases. (Source: TheScientificWorldJOURNAL: Newly published articles.)...
POSTED 08/31/2010 at 07:00 PM --
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Morphology: Sister Mary Josephâs nodule as a metastasis of ovarian adenocarcinoma
(Source: International Journal of Dermatology)...
POSTED 08/31/2010 at 06:00 PM --
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The use of immunohistochemistry in the differential diagnosis of primary cutaneous adnexal neoplasms and metastatic adenocarcinomas to the skin
This article reviews the use of immunohistochemistry as an adjunctive tool in the analysis of primary and metastatic carcinomas involving the skin. It also provides an algorithm including selected markers that can be used in this context. (Source: Diagnostic Histopathology)...
POSTED 08/31/2010 at 06:00 PM --
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Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association
Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling upon DHA supplementation are examined in A549 lung adenocarcinoma, WiDr colon carcinoma and MDA-MB-231 breast carcinoma cell lines. Interestingly, EGFR phosphorylation, most notably at the tyrosine 1068 residue, is dramatically upregulated, and EGFR association with the Sos1 guanine nucleotide exchange factor is concomitantly increased upon DHA supplementation. However, guanosine triphosphate-bound Ras and phosphorylated extracellular signal-regulated kinase (Erk)1/2 are parado......
POSTED 08/31/2010 at 10:33 AM --
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Combination of photodynamic therapy with aspirin in humanâderived lung adenocarcinoma cells affects proteasome activity and induces apoptosis
Abstract (Source: Cell Proliferation)...
POSTED 08/31/2010 at 12:20 AM --
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Epirubicin, Oxaliplatin, and Capecitabine With or Without Panitumumab for Advanced Esophagogastric Cancer: Dose-Finding Study for the Prospective Multicenter, Randomized, Phase II/III REAL-3 Trial [Gastrointestinal Cancer]
Conclusion
The recommended dose for EOC + P is epirubicin 50 mg/m2, oxaliplatin 100 mg/m2, capecitabine 1,000 mg/m2/d, and P 9 mg/kg every 3 weeks. This dose has been selected for the ongoing phase II/III REAL-3 study. (Source: Journal of Clinical Oncology)...
POSTED 08/30/2010 at 05:02 PM --
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Immunoreactivity of integrin-linked kinase in primary non-small-cell lung cancer and survival after curative resection [Original articles]
Conclusions: Primary NSCLC tumours show a variable ILK immunoreactivity, dependent on the histological subtype. In SCC, ILK immunoreactivity is a significantly adverse prognostic factor. (Source: European Journal of Cardio-Thoracic Surgery)...
POSTED 08/30/2010 at 01:58 PM --
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A case of cryptococcal pneumonia with false-positive [18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) image mimicking lung metastatic cancer
Conclusion: The FDG-PET image is not particularly helpful in segregating pulmonary infection from lung malignancy in certain cases. Surgical resection is recommended for both diagnosis and treatment of pulmonary cryptococcosis. (Source: Respiratory Medicine CME)...
POSTED 08/28/2010 at 02:52 AM --
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Usefulness of tissue microarrays for assessment of protein expression, gene copy number and mutational status of EGFR in lung adenocarcinoma
Abstract Specific inhibitors targeting the epidermal growth factor receptor (EGFR) can increase survival rates in certain lung adenocarcinoma
patients with mutations in the EGFR gene. Although such EGFR-targeted therapies have been approved for use, there is no general consensus among surgical pathologists
on how the EGFR status should be tested in lung adenocarcinoma tissues and whether the results of immunohistochemistry (IHC),
fluorescence in situ hybridization (FISH), and mutational analysis by molecular methods correlate. We evaluated the EGFR status
in 61 lung adenocarcinomas by IHC (using total and mutant-specific antibodies against EGFR), by FISH analysis on tissue microarrays
(TMAs), and by direct sequencing. The results of each method were compared using Ï
2 and......
POSTED 08/28/2010 at 12:55 AM --
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Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review
Conclusions ACC represents a rare solid tumor of the pancreas. Prognosis is dismal, although, compared to the more common ductal adenocarcinoma,
survival appears to be longer. Patients with metastatic disease might benefit from aggressive multimodality treatments.
Content Type Journal ArticleDOI 10.1007/s00423-010-0706-2Authors
Giovanni Butturini, Surgical Department, Verona University Hospital, Piazzale LA Scuro, 10 37134 Verona, ItalyMichele Pisano, Surgical Department, Verona University Hospital, Piazzale LA Scuro, 10 37134 Verona, ItalyAldo Scarpa, Pathological Department, Verona University, Verona, ItalyMirko DâOnofrio, Radiological Department, Verona University, Verona, ItalyAlessandra Auriemma, Oncological Department, Verona University, Verona, ItalyClaudio ......
POSTED 08/28/2010 at 12:55 AM --
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Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
This study confirms that the majority of patients with high potassium channel antibodies have limbic encephalitis without tumours. The identification of leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 as the major targets of potassium channel antibodies, and their associations with different clinical features, begins to explain the diversity of these syndromes; furthermore, detection of contactin-associated protein-2 antibodies should help identify the risk of an underlying tumour and a poor prognosis in future patients. (Source: Brain)...
POSTED 08/27/2010 at 08:47 PM --
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p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma
Conclusion Our results suggest that LMB has anti-cancer potential and provides a new regimen of individualized therapy for lung cancer
treatment.
Content Type Journal ArticleDOI 10.1007/s00280-010-1434-6Authors
Changxia Shao, Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Box 41163, Lubbock, TX 79409, USAChuanwen Lu, Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Box 41163, Lubbock, TX 79409, USALixia Chen, Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Box 41163, Lubbock, TX 79409, USAPatrick P. Koty, Department of Pediatrics, Section of Medical Genet......
POSTED 08/27/2010 at 12:12 PM --
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Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.
CONCLUSION: Alterations in MUC expression occur during colorectal tumorigenesis. The transformation process in MC and SRCC may be different from that in the traditional adenoma-carcinoma sequence.
PMID: 20731025 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)...
POSTED 08/26/2010 at 06:06 PM --
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International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease
Authors: Cristina Magi-Galluzzi, Andrew J Evans, Brett Delahunt, Jonathan I Epstein, David F Griffiths, Theo H van der Kwast, Rodolfo Montironi, Thomas M Wheeler, John R Srigley, Lars L Egevad
& Peter A Humphrey (Source: Modern Pathology AOP)...
POSTED 08/26/2010 at 06:00 PM --
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International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens: rationale and organization
Authors: Lars Egevad, John R Srigley
& Brett Delahunt (Source: Modern Pathology AOP)...
POSTED 08/26/2010 at 06:00 PM --
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Stepwise radical endoscopic resection for eradication of Barrett's oesophagus with early neoplasia in a cohort of 169 patients
Conclusions
SRER of Barrett's oesophagus ≤5 cm containing early neoplasia appears to be an effective treatment modality with a low rate of recurrent lesions during follow-up. The procedure, however, is technically demanding and is associated with oesophageal stenosis in half of the patients. (Source: Gut)...
POSTED 08/26/2010 at 07:47 AM --
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Malignant potential of intraductal papillary mucinous neoplasms of the pancreas
Abstract An intraductal papillary mucinous neoplasm (IPMN) is now a well-recognized disease entity. In general, the prognosis of IPMN
is much more favorable than that of pancreatic ductal adenocarcinoma (PDAC). However, IPMN has a broad biological spectrum
and it sometimes progresses, slowly showing neoplastic transformations. International consensus guidelines have been recently
proposed for the management of IPMN. While they significantly contribute to appropriate management of IPMN, various issues
including the natural history and malignant potential of IPMN are not fully elucidated. This review focuses on the malignant
potential, including the postoperative recurrence of IPMN, coincidence of IPMN with PDAC, and extrapancreatic malignancy that
may affect the long-term s......
POSTED 08/26/2010 at 03:05 AM --
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Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice
Conclusions:
Allergic inflammation does not impact chemical-induced carcinogenesis of the airways. These findings suggest that not all types of airway inflammation influence lung carcinogenesis and cast doubt on the idea of a mechanistic link between asthma and lung cancer. (Source: Respiratory Research)...
POSTED 08/25/2010 at 06:00 PM --
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Is It Important to Test for EGFR Mutations in Patients With Lung Cancer?
Dr. Mark Kris reports on recent studies outlining the best approach to mutation testing and treatment of patients with adenocarcinoma of the lung. Medscape Hematology-Oncology (Source: Medscape Today Headlines)...
POSTED 08/25/2010 at 12:41 PM --
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