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Acute Lymphoblastic Leukemia News Headlines
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All Recent Acute Lymphoblastic Leukemia News Headlines |
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Glucarpidase, Leucovorin, and Thymidine for High-Dose Methotrexate-Induced Renal Dysfunction: Clinical and Pharmacologic Factors Affecting Outcome [Pediatric Oncology]
Conclusion
Early intervention with the combination of leucovorin and glucarpidase is highly effective in patients who develop HDMTX-induced renal dysfunction. Severe toxicity and mortality occurred in patients in whom glucarpidase rescue was delayed and occurred despite thymidine administration. (Source: Journal of Clinical Oncology)...
POSTED 08/30/2010 at 05:02 PM --
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B-cell acute lymphoblastic leukemia as evolution of a 8p11 myeloproliferative syndrome with t(8;22)(p11;q11) and BCR-FGFR1 fusion gene
Rearrangement of fibroblast growth factor receptor 1 (FGFR1) gene, mapped on chromosome band 8p11, is the genetic hallmark of a rare atypical chronic myeloproliferative disorder that is usually characterized by myeloid hyperplasia, eosinophilia and high incidence of T-lymphoblastic lymphoma referred as 8p11 myeloproliferative syndrome (EMS) . (Source: Leukemia Research)...
POSTED 08/27/2010 at 01:28 AM --
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Persistent detection of a novel MLLâSACM1L rearrangement in the absence of leukemia
Abstract: Most chromosomal rearrangements including the mixed lineage leukemia (MLL) gene are manifested as leukemia and predict a poor prognosis. Although more than 50 MLL-rearrangement partners are characterized, MLL-related leukemogenesis remains to be understood. Here we report a case of a 3-year old boy bearing a novel MLL-rearrangement with the suppressor of actin mutations 1-like (SACM1L) gene in the absence of leukemia. Bone marrow cells harboring the MLLâSACM1L rearrangement appeared during chemotherapy for acute lymphoblastic leukemia with hyperdiploidy and were continuously detected over 7 years without clonal expansion. (Source: Leukemia Research)...
POSTED 08/27/2010 at 01:28 AM --
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NFκB modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia
Abstract: Glucocorticoids (GCs) are pivotal agents in the treatment of childhood acute lymphoblastic leukaemia (ALL) but the molecular basis of GC-resistance remains unclear. Expression-array studies have shown that commonly upregulated genes associated with GC-sensitivity include GR, glucocorticoid-induced leucine zipper (GILZ) and IκBα, which all negatively interact with components of the pro-survival NFκB pathway and therefore may be critical determinants of GC-sensitivity. We have investigated these regulators and their effect on NFκB activity in GC-resistant descendents of the B-lineage ALL cell line, PreB 697. We show that while differential up regulation of the modulators (GILZ, GR and IκBα) was demonstrated in GC-sensitive compared to GC-resistant sub-lines, this was not coup......
POSTED 08/27/2010 at 01:28 AM --
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Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia
Abstract: Ki-67 is a nuclear antigen that is expressed in all stages of the cell cycle, except G0, and is widely used as a marker of cellular proliferation in human tumors. We recently showed that elevated levels of Ki-67 circulating in plasma (cKi-67) are associated with shorter survival in patients with acute lymphoblastic leukemia. The current study included 194 patients with CLL and 96 healthy control subjects. cKi-67 levels in plasma were determined using an electrochemiluminescent immunoassay. We normalized the cKi-67 level to the absolute number of lymphocytes in the patient's peripheral blood to establish the plasma cKi-67 index. The cKi-67 index showed significant correlation with lymph node involvement and Rai stage (P=0.05). Higher cKi-67 index values were significantly associat......
POSTED 08/27/2010 at 01:28 AM --
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DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia
In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients. For Arg399Gln polymorphism, the heterozygous (Arg/Gln) and homozygous mutant (Gln/Gln) genotypes were significantly more common in the ALL patients than the controls (OR: 1.6, p=0.04). Particularly, the Gln399Gln genotype significantly increased the risk of disease up to 2.0-fold (OR: 2.0, p=0.04). Besides, Gln399Gln genotype has been found to be associated with considerably increased risk of ALL among females (OR=2.9, p=0.03). In case of codon 194 polymorphism, no significant associations have been f......
POSTED 08/27/2010 at 01:28 AM --
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The MIF â173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
Abstract: Migration inhibitory factor (MIF) has recently been defined as a novel pro-tumorigenic factor that promotes cell proliferation, migration, and invasion. The MIF â173C allele results in increased MIF promoter activity and is associated with a higher serum MIF level. We hypothesized that this polymorphism may contribute to childhood acute lymphoblastic leukemia (ALL) susceptibility. We genotyped the MIF â173G/C polymorphism (rs755622) in 346 ALL cases and 516 cancer-free controls in a Chinese population and found that the variant genotype GC and the combined genotypes GC/CC were associated with a significantly higher risk of childhood ALL [adjusted odds ratio (OR)=1.39, 95% confidence interval (CI)=1.01â1.93 for GC and adjusted OR=1.38, 95% CI=1.01â1.89 for GC/CC]. In addit......
POSTED 08/27/2010 at 01:28 AM --
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Genetic variation and the risk of acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy, and has long been one of the best characterized tumors at the genetic level . ALL may be of B or T lymphoid lineage, and comprises a group of disorders characterized by recurring chromosomal alterations including aneuploidy (hyper- and hypodiploidy) and chromosomal rearrangements that commonly dysregulate hematopoietic transcription factors and tyrosine kinases . These alterations are important initiating events in leukemogenesis, and influence treatment outcome, yet usually do not alone cause leukemia in experimental models. There has consequently been considerable interest in recent years in leveraging genome-wide technologies to profile inherited and somatic (tumor-acquired) genetic alterations in the leukemia gen......
POSTED 08/27/2010 at 01:28 AM --
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Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies
Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal translocations to IGH and non-IG loci in B-cell neoplasms, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. In addition, cases with genomic amplification of TERT locus were identified. Tumors bearing chromosomal aberrations involving TERT showed higher TERT transcriptional expression and increased telomerase activity. These data suggest that deregulation of TERT gene by chromosomal abnormalities leading to increased telom......
POSTED 08/26/2010 at 11:02 AM --
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Acute Lymphoblastic Leukemia: An Unusual Cause of Nephromegaly in Infancy
Content Type Journal ArticleDOI 10.1007/s12098-010-0165-3Authors
Mukta Mantan, Department of Pediatrics, Maulana Azad Medical College and associated Hospitals, University of Delhi, Delhi, 110002 IndiaGulshan Raj Sethi, Department of Pediatrics, Maulana Azad Medical College and associated Hospitals, University of Delhi, Delhi, 110002 India
Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)...
POSTED 08/26/2010 at 02:46 AM --
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Genomic profiling of high-risk acute lymphoblastic leukemia
Authors: J R Collins-Underwood
& C G Mullighan (Source: Leukemia)...
POSTED 08/25/2010 at 06:00 PM --
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High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
Authors: S Morisot, A S Wayne, O Bohana-Kashtan, I M Kaplan, C D Gocke, R Hildreth, M Stetler-Stevenson, R L Walker, S Davis, P S Meltzer, S J Wheelan, P Brown, R J Jones, L D Shultz
& C I Civin (Source: Leukemia)...
POSTED 08/25/2010 at 06:00 PM --
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[Clinical Picture] Cutaneous septic emboli from Candida tropicalis
An 11-year-old girl with acute lymphoblastic leukemia presented 1 month after induction chemotherapy with febrile neutropenia, a new diastolic murmur, and a subtle asymptomatic persistent rash. (Source: The Lancet Infectious Diseases)...
POSTED 08/22/2010 at 06:00 PM --
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Augmentation of the Antileukemia Potency of Total-Body Irradiation (TBI) by a Novel P-site Inhibitor of Spleen Tyrosine Kinase (SYK).
Authors: Uckun FM, Dibirdik I, Qazi S
Abstract A novel spleen tyrosine kinase (SYK) P-site inhibitor, 1,4-Bis (9-O dihydroquinidinyl) phthalazine/hydroquinidine 1,4-phathalazinediyl diether (C-61), (but not vehicle) markedly enhanced H(2)O(2)-induced apoptosis of primary leukemia cells from each of five relapsed B-lineage acute lymphoblastic leukemia (ALL) patients, as measured by in vitro TUNEL assays. A highly radiation-resistant subclone of the murine B-lineage leukemia cell line BCL-1 was next used to investigate the in vivo radiosensitizing effects of C-61. C-61 enhanced the antileukemia potency of 7 Gy total-body irradiation (TBI) in the context of syngeneic bone marrow transplantation (BMT) at 20% of its nonobservable adverse effect level (NOAEL) that does not exhibit detectable......
POSTED 08/22/2010 at 06:00 PM --
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CD71 (Transferrin Receptor): An Effective Marker for Erythroid Precursors in Bone Marrow Biopsy Specimens.
This study defined the immunohistochemical profile of CD71, as compared with glycophorin A (CD235a) and hemoglobin, in 65 bone marrow biopsy specimens, including normal marrow specimens and cases of myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, plasma cell neoplasm, and metastatic carcinoma. Immunoreactivity for CD71 was restricted to erythroid precursors in normal and dyspoietic marrow samples and exhibited a membranous and cytoplasmic staining pattern. The vast majority of mature erythrocytes lack expression of CD71, greatly facilitating interpretation. CD71 is a highly effective marker for the detection of cells of erythroid lineage in bone marrow biopsy specimens.
PMID: 20716799 [PubMed - in process] (Source: American Journal of Clinical Pathology)...
POSTED 08/21/2010 at 01:48 PM --
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Detection of clonal immunoglobulin and Tâcell receptor gene rearrangements in childhood acute lymphoblastic leukemia using a lowâcost PCR strategy
(Source: Pediatric Blood and Cancer)...
POSTED 08/21/2010 at 12:17 AM --
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Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group
Children with Down syndrome (DS) have an increased risk of acute lymphoblastic leukemia (ALL) and an inferior outcome. We reviewed data from 2811 children with ALL enrolled in Children's Oncology Group P9900, which included prospective testing for the major cytogenetic lesions in childhood ALL: ETV6-RUNX1, TCF3-PBX1, BCR-ABL1, and MLL translocations and trisomies of chromosomes 4 and 10. Eighty (3%) B-precursor ALL patients had DS. Age, sex, white blood cell count, and risk group were similar between DS-ALL and non–DS-ALL but significantly more patients with DS-ALL were white (91.2% vs 76.4%, P = .001). Children with DS-ALL had lower rates of the favorable cytogenetic lesions ETV6-RUNX1 (2.5% vs 24%, P < .001) and trisomies 4 and 10 (7.7% vs 24%, P < .001). Five-year event-free......
POSTED 08/19/2010 at 11:02 AM --
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correspondence: The potential use of basigin (CD147) as a prognostic marker in Bâcell precursor acute lymphoblastic leukaemia
(Source: British Journal of Haematology)...
POSTED 08/19/2010 at 01:22 AM --
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Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome-Negative Precursor B-Lineage Acute Lymphoblastic Leukemia [Hematologic Malignancies]
Conclusion
The incorporation of rituximab into the hyper-CVAD regimen appears to improve outcome for younger patients with CD20-positive Ph-negative precursor B-lineage ALL. (Source: Journal of Clinical Oncology)...
POSTED 08/18/2010 at 05:01 PM --
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Absence of Biallelic TCR{gamma} Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia [Pediatric Oncology]
Conclusion
Lymphoblasts from children with T-ALL should be evaluated at diagnosis for deletion within the TCR locus. Patients lacking biallelic deletion, which confers a high probability of induction failure with contemporary therapy, should be assigned to alternative therapy in the context of a prospective clinical trial. (Source: Journal of Clinical Oncology)...
POSTED 08/18/2010 at 05:01 PM --
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